Article
Endocrinology & Metabolism
Pavel Hruska, Jan Kucera, Matej Pekar, Pavol Holeczy, Miloslav Mazur, Marek Buzga, Daniela Kuruczova, Peter Lenart, Jana Fialova Kucerova, David Potesil, Zbynek Zdrahal, Julie Bienertova-Vasku
Summary: The study compared the proteomic profiles of mature adipocytes from different adipose tissue depots, with findings showing that subcutaneous adipocytes are more active in vesicular transport, secretion, and lipid metabolism, while visceral adipocytes have higher protein expression related to mitochondrial energy metabolism and translational or biosynthetic activity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Cell Biology
Attila Vamos, Rini Arianti, Boglarka Agnes Vinnai, Rahaf Alrifai, Abhirup Shaw, Szilard Poliska, Andrea Guba, Eva Csosz, Istvan Csomos, Gabor Mocsar, Cecilia Lanyi, Zoltan Balajthy, Laszlo Fesus, Endre Kristof
Summary: The rs1421085 T-to-C single-nucleotide polymorphism (SNP) of the human FTO gene leads to a shift in adipocyte type from brown to white. Adipocytes carrying the CC genotype have lower thermogenic gene expression and decreased thermogenesis compared to those with the TT genotype.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Mi-Jeong Lee, Vishwajeet Puri, Susan K. Fried
Summary: This study investigated the remodeling of cellular metabolism and structures during browning of primary human adipocytes derived from both visceral and subcutaneous adipose tissues. It found that metabolic and structural remodeling in browning adipocytes is similar to previous findings in human adipocytes in vivo, supporting their use for mechanical studies investigating browning with translational relevance.
Article
Cell Biology
Abhirup Shaw, Beata B. Toth, Robert Kiraly, Rini Arianti, Istvan Csomos, Szilard Poliska, Attila Vamos, Ilma R. Korponay-Szabo, Zsolt Bacso, Ferenc Gyory, Laszlo Fesues, Endre Kristof
Summary: Recent studies have shown that irisin can stimulate the release of a novel adipokine, CXCL1, from neck area derived adipocytes via upregulation of the NF kappa B pathway, potentially playing an important role in improving tissue vascularization.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Agnieszka Miklosz, Bartlomiej Lukaszuk, Elzbieta Supruniuk, Kamil Grubczak, Aleksandra Starosz, Magdalena Kusaczuk, Monika Naumowicz, Adrian Chabowski
Summary: This study investigated the phenotypic and metabolic characteristics of adipocytes derived from ADMSCs in lean and obese postmenopausal women. The results showed that obesity influenced the functionality of progenitor adipocytes, suggesting a memory effect, and there were pronounced changes in the adipocytes derived from different depots.
Article
Agriculture, Dairy & Animal Science
Qiushi Xu, Yunhui Fan, Juan J. Loor, Yusheng Liang, Xudong Sun, Hongdou Jia, Chenxu Zhao, Chuang Xu
Summary: This study evaluated the effects of all-trans retinoic acid (ATRA) on bovine adipocytes, showing that ATRA inhibited preadipocyte proliferation and postconfluent preadipocyte differentiation, while promoting basal lipolysis in mature adipocytes.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Multidisciplinary Sciences
Vera J. M. Nies, Dicky Struik, Sihao Liu, Weilin Liu, Janine K. Kruit, Michael Downes, Tim van Zutphen, Henkjan J. Verkade, Ronald M. Evans, Johan W. Jonker
Summary: This study found that FGF1 can increase glucose uptake in adipocytes by activating GLUT4 protein. Furthermore, prolonged exposure to FGF1 can stimulate adipocyte glucose uptake by transcription of GLUT1 protein.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Rheumatology
Delong Li, Guangfeng Ruan, Yan Zhang, Yang Zhao, Zhaohua Zhu, Qianhua Ou, Hong Huang, Jieli Chen, Weiyu Han, Su'an Tang, Jia Li, Liang Wang, Tianyu Chen, Xiaochun Bai, Daozhang Cai, Changhai Ding
Summary: This study investigated the therapeutic effect and mechanism of metformin on knee osteoarthritis (OA). The results showed that metformin had a protective effect by reducing apoptosis and catabolism of chondrocytes, suppressing infiltration and pro-inflammatory polarization of synovial macrophages, and reducing leptin secretion from adipose tissue in obese mice.
Article
Chemistry, Medicinal
Attila Vamos, Abhirup Shaw, Klara Varga, Istvan Csomos, Gabor Mocsar, Zoltan Balajthy, Cecilia Lanyi, Zsolt Bacso, Maria Szatmari-Toth, Endre Kristof
Summary: This study investigates the molecular events during the transition from beige to white adipocytes in humans. It found that the removal of mitochondria and the responsiveness to adrenergic stimulus differ between beige adipocytes converting to white and control white adipocytes. Preventing this transition may help maintain elevated thermogenesis and energy expenditure.
Article
Cell Biology
Neha Mathur, Mai C. K. Severinsen, Mette E. Jensen, Lars Naver, Maren Schrolkamp, Matthew J. Laye, Matthew J. Watt, Soren Nielsen, Rikke Krogh-Madsen, Bente Klarlund Pedersen, Camilla Scheele
Summary: Abdominal obesity is associated with cardiometabolic disease and an accumulation of lipids in the visceral adipose depot. This study found intrinsic differences between human visceral and subcutaneous adipose stem and progenitor cells, with dysfunction mainly occurring at a post-progenitor stage and inflammation playing a major role in adipogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Lynette J. J. Oost, Steef Kurstjens, Chao Ma, Joost G. J. Hoenderop, Cees J. J. Tack, Jeroen H. F. de Baaij
Summary: Low levels of Mg2+ are associated with insulin resistance in people with T2D. In Mg2+-deficient adipocytes, insulin-dependent glucose uptake is decreased. Mg2+ deficiency may contribute to insulin resistance in people with T2D.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuelei Zhao, Xuexin Li, Ye Tian, Jindi Zhao, Wensai Yu, Lifan Zhang, Wei Wei, Jie Chen
Summary: This study found that nonivamide can induce browning of porcine adipocytes, inhibit adipogenesis and promote lipolysis, as well as up-regulate thermogenesis gene markers and mitochondrial biogenesis-related genes.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Nutrition & Dietetics
Boglarka Agnes Vinnai, Rini Arianti, Ferenc Gyory, Zsolt Bacso, Laszlo Fesus, Endre Kristof
Summary: This study investigated how the availability of extracellular thiamine affects the expression of thermogenic marker genes and proteins during adipocyte differentiation. Higher thiamine levels led to increased expression of thiamine transporters and enhanced thermogenic competency in differentiated adipocytes from the neck area. Gradually increasing concentrations of thiamine resulted in elevated mitochondrial biogenesis and thermogenic gene expression in a concentration-dependent manner.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Tomomi Minemura, Atsunori Fukuhara, Michio Otsuki, Iichiro Shimomura
Summary: The study reveals that LDHA regulates Glut1 expression and basal glucose uptake in adipocytes. Knockout or inhibition of LDHA leads to decreased Glut1 protein levels and reduced glucose uptake.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biology
Jingyi Chi, Zeran Lin, William Barr, Audrey Crane, Xiphias Ge Zhu, Paul Cohen
Summary: The study revealed that the association between beige adipocytes and dense sympathetic neurites in mouse subcutaneous fat is established during early postnatal period, with Prdm16 playing a crucial role in guiding sympathetic growth. However, this patterning is not essential for maintaining the sympathetic structure in mature animals.
Article
Biochemistry & Molecular Biology
Paul Schossig, Ebru Coskun, Ruza Arsenic, David Horst, Jalid Sehouli, Eva Bergmann, Nadine Andresen, Christian Sigler, Antonia Busse, Ulrich Keller, Sebastian Ochsenreither
Summary: This study identified and prioritized suitable tumor-associated antigens for adoptive T cell-receptor therapy in epithelial ovarian cancer. KIF20A, CT45, and LY6K were identified as the most promising targets based on their high expression and peptide presence in ligandome analysis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Annabelle M. Warren, Mathis Grossmann, Mirjam Christ-Crain, Nicholas Russell
Summary: Hyponatremia is a common electrolyte disorder, with Syndrome of Inappropriate Antidiuresis (SIAD) being the most frequent cause. This is mediated by the nonosmotic release of arginine vasopressin (AVP), promoting water retention. The underlying causes of SIAD include malignancy, pulmonary pathology, and central nervous system pathology. Fluid restriction is the first-line treatment, but there is controversy regarding second-line therapy.
Editorial Material
Cardiac & Cardiovascular Systems
Sigrun Halvorsen, Julinda Mehilli, Christian Mueller
EUROPEAN HEART JOURNAL
(2023)
Article
Endocrinology & Metabolism
Anissa Pelouto, Julie C. Refardt, Mirjam Christ-Crain, Adrienne A. M. Zandbergen, Ewout J. Hoorn
Summary: Current guidelines recommend treating symptomatic hyponatremia with fixed volumes of hypertonic saline regardless of body weight. Our study found that this approach is associated with overcorrection in patients with low body weight and undercorrection in patients with high body weight. Prospective studies are needed to develop individualized dosing models.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Clara Odilia Sailer, Odile Gaisl, Svetlana Beglinger, Martina Frech-Dorfler, Vivienne Sommer, Maya Horst Luthy, Mirjam Christ-Crain
Summary: This study found that plasma copeptin ratio can predict the treatment response to desmopressin in children with monosymptomatic nocturnal enuresis. A lower copeptin ratio indicates a better treatment response to desmopressin.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Letter
Cardiac & Cardiovascular Systems
Eleni Michou, Desiree Wussler, Christian Mueller
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Letter
Cardiac & Cardiovascular Systems
Danielle M. M. Gualandro, Christian Puelacher, Christian Mueller
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Endocrinology & Metabolism
Sophie Monnerat, Julie Refardt, Laura Potasso, Christian Meier, Mirjam Christ-Crain
Summary: This study investigated the impact of increasing sodium levels on bone turnover in outpatients with chronic SIAD. The results showed a positive correlation between sodium levels and bone formation index (P1NP/CTX), suggesting that an increase in sodium is associated with enhanced bone formation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Laura Potasso, Sophie Monnerat, Julie Refardt, Gregor Lindner, Volker Burst, Bettina Winzeler, Mirjam Christ-Crain
Summary: This study evaluated the role of simplified apparent strong ion difference in serum, urine chloride and potassium score, and fractional uric acid excretion in the differential diagnosis of thiazide-associated hyponatremia (TAH). The results showed that these markers can help identify patients with volume-depleted TAH requiring fluid substitution vs patients with SIAD-like TAH requiring fluid restriction.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Geriatrics & Gerontology
Markus S. Anker, Alessia Lena, Eric J. Roeland, Jan Porthun, Sebastian Schmitz, Sara Hadzibegovic, Philipp Sikorski, Ursula Wilkenshoff, Ann-Kathrin Froehlich, Luisa Valentina Ramer, Matthias Rose, Jan Eucker, Tienush Rassaf, Matthias Totzeck, Lorenz H. Lehmann, Stephan von Haehling, Andrew J. S. Coats, Tim Friede, Javed Butler, Stefan D. Anker, Hanno Riess, Ulf Landmesser, Lars Bullinger, Ulrich Keller, Johann Ahn
Summary: The patient-reported ability to walk 4 m and wash oneself is an independent predictor of survival and associated with decreased functional status in pre-terminal cancer patients.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Oncology
Viktoria Ingwersen, Joerg Hofmann, Marion Muche, Philipp Le Coutre, Thomas Schneider, Corinna Leng, Thomas Burmeister, Georg Maschmeyer, Ulrich Keller, Stefan Schwartz
Summary: This study retrospectively analyzed 22 immunocompromised patients and found that hepatitis E virus (HEV) could cause chronic infections in these patients. Some patients achieved viral clearance with ribavirin therapy, but others still could not clear the virus and may develop liver failure.
ONCOLOGY RESEARCH AND TREATMENT
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sebastian Martin, David Viertl, Anna Janz, Stefan Habringer, Ulrich Keller, Margret Schottelius
Summary: This study investigates the influence of corticosteroids on CXCR4 regulation in diffuse large B cell lymphoma (DLBCL). The results show that corticosteroids consistently induce an upregulation of CXCR4 expression in DBLCL cells, suggesting that they do not lead to downregulation of CXCR4 and may even have a beneficiary effect in DLBCL patients prior to [Lu-177]Lu-PentixaTher RLT.
Article
Psychology, Educational
Lindie van der Westhuizen, Katrin Arens, Ulrich Keller, Samuel Greiff, Antoine Fischbach, Christoph Niepel
Summary: This study investigated the relationships between math and verbal achievements and corresponding domain-specific academic self-concepts (ASCs) and interests in first-grade and third-grade children. The findings suggest that social comparisons play a critical role in the formation of ASCs and interests for both grade levels.
CONTEMPORARY EDUCATIONAL PSYCHOLOGY
(2023)