Review
Endocrinology & Metabolism
Anna Giovenzana, Debora Carnovale, Brett Phillips, Alessandra Petrelli, Nick Giannoukakis
Summary: Research indicates that neutrophils play a significant role in the pathogenesis of diabetes mellitus, particularly type 1 and type 2 diabetes, by being the first white blood cells to react and accumulate in target tissues. Their functional alteration, including NETosis, contributes to disease progression. Potential therapeutic approaches focus on limiting neutrophil-mediated damage to prevent subclinical disease from progressing to clinical hyperglycaemia.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2022)
Correction
Surgery
Matteo Rottoli, Gianluca Pellino, Marta Tanzanu, Caterina Baldi, Alice Frontali, Michele Carvello, Caterina Foppa, Christos Kontovounisios, Paris Tekkis, Francesco Colombo, Jorge Sancho-Muriel, Matteo Frasson, Piergiorgio Danelli, Valerio Celentano, Antonino Spinelli, Yves Panis, Gianluca M. Sampietro, Gilberto Poggioli
UPDATES IN SURGERY
(2022)
Article
Oncology
Caterina Foppa, Sara Tamburello, Annalisa Maroli, Michele Carvello, Laura Poliani, Luigi Laghi, Alberto Malesci, Marco Montorsi, Jose Perea, Antonino Spinelli
Summary: This study compared predictors for disease progression/recurrence between early-onset rectal cancer (EORC) and late-onset rectal cancer (LORC) patients. The results showed that EORC patients had differences in tumor characteristics and treatment, and age of onset was identified as an independent unfavorable predictor.
Article
Gastroenterology & Hepatology
Michele Carvello, Silvio Danese, Antonino Spinelli
Summary: A deeper understanding of the inflammatory process in luminal ileocecal Crohn's disease has led to a clearer understanding of its disease course. This has allowed for the identification of ideal treatment timeframes for medical and surgical interventions. While surgical treatment is clearly beneficial for complicated disease, there is ongoing debate regarding different approaches, including early surgery, for uncomplicated disease. The rationale for traditional step-up medical therapy has been questioned, and early surgery has been shown to be a cost-effective option for this subset of patients.
CLINICS IN COLON AND RECTAL SURGERY
(2022)
Article
Medicine, Research & Experimental
Sarah K. Popp, Federica Vecchio, Debra J. Brown, Riho Fukuda, Yuri Suzuki, Yuma Takeda, Rikako Wakamatsu, Mahalakshmi A. Sarma, Jessica Garrett, Anna Giovenzana, Emanuele Bosi, Antony R. A. Lafferty, Karen J. Brown, Elizabeth E. Gardiner, Lucy A. Coupland, Helen E. Thomas, Beng H. Chong, Christopher R. Parish, Manuela Battaglia, Alessandra Petrelli, Charmaine J. Simeonovic
Summary: Platelet-neutrophil aggregates (PNAs) play a role in facilitating neutrophil activation and migration during the pathogenesis of type 1 diabetes (T1D). Elevated PNAs were observed in T1D patients and mice, as well as in isolated islets/insulitis, accompanied by increased islet-associated neutrophil extracellular trap (NET) products. Histones and NETs induced islet cell damage, which was prevented by the drug mCBS. PNAs could therefore serve as a biomarker for T1D autoimmunity and potentially be used for early diagnosis.
Review
Gastroenterology & Hepatology
C. La Raja, C. Foppa, A. Maroli, C. Kontovounisios, N. Ben David, M. Carvello, A. Spinelli
Summary: DCAA shows a significant decrease in pelvic sepsis compared to ICAA, but there is no significant difference in postoperative complications and risk of definitive stoma between the two approaches. Further studies focusing on oncologic and functional outcomes are needed.
TECHNIQUES IN COLOPROCTOLOGY
(2022)
Review
Immunology
Alessandra Petrelli, Sarah K. Popp, Riho Fukuda, Christopher R. Parish, Emanuele Bosi, Charmaine J. Simeonovic
Summary: Type 1 diabetes (T1D) is an autoimmune disease characterized by the destruction of insulin-producing beta cells, with neutrophils playing a significant role in the disease development. Neutrophils release NETs in the pancreas and form PNAs with platelets, facilitating activation and recruitment to the pancreas.
FRONTIERS IN IMMUNOLOGY
(2022)
Letter
Endocrinology & Metabolism
Francesca D'Addio, Paolo Fiorina
Article
Endocrinology & Metabolism
Paola Carrera, Ilaria Marzinotto, Riccardo Bonfanti, Luca Massimino, Silvia Calzavara, Mariagrazia Favellato, Tatiana Jofra, Valeria De Giglio, Clara Bonura, Angela Stabilini, Valeria Favalli, Simone Bondesan, Maria Pia Cicalese, Andrea Laurenzi, Amelia Caretto, Giulio Frontino, Andrea Rigamonti, Chiara Molinari, Marina Scavini, Federica Sandullo, Ettore Zapparoli, Nicoletta Caridi, Silvia Bonfiglio, Valeria Castorani, Federica Ungaro, Alessandra Petrelli, Graziano Barera, Alessandro Aiuti, Emanuele Bosi, Manuela Battaglia, Lorenzo Piemonti, Vito Lampasona, Georgia Fousteri
Summary: This study used a type 1 diabetes genetic risk score to screen for monogenic diabetes in individuals with weak evidence of autoimmunity. The absence of islet autoantibodies or the presence of a single autoantibody with a low risk score may indicate a monogenic form of diabetes, and next-generation sequencing can improve diagnostic accuracy.
Article
Surgery
Antonio Luberto, Jacopo Crippa, Caterina Foppa, Annalisa Maroli, Matteo Sacchi, Francesca De Lucia, Michele Carvello, Antonino Spinelli
Summary: This study aimed to evaluate the use of abdominal drainage (AD) after ileal pouch-anal anastomosis (IPAA). The results showed that the use of AD after IPAA did not have an impact on surgical outcomes, questioning the actual benefit of routine placement of AD.
UPDATES IN SURGERY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Francesca D'Addio, Laura Montefusco, Maria Elena Lunati, Ida Pastore, Emma Assi, Adriana Petrazzuolo, Virna Marin, Chiara Bruckmann, Paolo Fiorina
Summary: Apoptotic pathways play a vital role in maintaining tissue and organ homeostasis. Dysregulation of cell death signaling can lead to various diseases, including cancer and chronic degenerative diseases. Therefore, targeting apoptotic factors has become a focus of research, and the IGFBP3/TMEM219 apoptotic axis has shown promising results in disease conditions such as intestinal disorders and diabetes.
Article
Endocrinology & Metabolism
Laura Montefusco, Ida Pastore, Maria Elena Lunati, Paolo Fiorina
Review
Endocrinology & Metabolism
G. Bendotti, L. Montefusco, I. Pastore, E. Lazzaroni, M. E. Lunati, P. Fiorina
Summary: This review discusses the anti-inflammatory and immunological properties of SGLT-2 inhibitors and how these properties contribute to their beneficial effects in diabetes.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Meeting Abstract
Gastroenterology & Hepatology
J. Geldof, N. Iqbal, J. F. LeBlanc, R. Sawyer, C. Buskens, W. Bemelman, K. Gecse, L. Lundby, A. L. Lightner, S. Danese, A. Spinelli, M. Carvello, O. Faiz, J. Warusavitarne, P. Lung, D. De Looze, A. D'Hoore, S. Vermeire, A. Hart, P. Tozer
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Endocrinology & Metabolism
Antonio Rossi, Laura Montefusco, Ida Pastore, Maria Elena Lunati, Sabrina Argenti, Milena Muratori, Enrica Chebat, Gian Vincenzo Zuccotti, Maurizio Gallieni, Paolo Fiorina
Summary: This study presents a case of using Hybrid Closed Loop system in a patient undergoing automated peritoneal dialysis, showing improved glucose control and satisfactory safety profile.
ACTA DIABETOLOGICA
(2022)