Article
Cardiac & Cardiovascular Systems
Tatjana Josefs, Debapriya Basu, Tomas Vaisar, Britt Arets, Jenny E. Kanter, Lesley-Ann Huggins, Yunying Hu, Jianhua Liu, Noemie Clouet-Foraison, Jay W. Heinecke, Karin E. Bornfeldt, Ira J. Goldberg, Edward A. Fisher
Summary: The study found that hypertriglyceridemia and reduced HDL-C did not affect atherosclerosis lesion size or macrophage content, suggesting that atherosclerosis regression in mice is primarily driven by LDL-C reduction and not impacted by hypertriglyceridemia and plasma HDL-C levels.
CIRCULATION RESEARCH
(2021)
Article
Endocrinology & Metabolism
Kathryn M. Spitler, Shwetha K. Shetty, Emily M. Cushing, Kelli L. Sylvers-Davie, Brandon S. J. Davies
Summary: Hepatocyte-specific loss of ANGPTL4 does not improve triglyceride phenotypes during high-fat feeding, but these mice show improved glucose tolerance after chronic high-fat diet. Additionally, Angptl4(LivKO) mice have decreased fasting plasma triglyceride levels after an 18-h fast, but not after a 6-h fast.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Review
Biochemistry & Molecular Biology
Kaleigh Katzer, Jessica L. Hill, Kara B. McIver, Michelle T. Foster
Summary: Lipedema is a painful fat disorder affecting approximately 11% of females, characterized by disproportionate accumulation of subcutaneous adipose tissue in the lower body. Estrogen may play a contributory role in the pathophysiology of lipedema.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Ren Zhang, Kezhong Zhang
Summary: Research on ANGPTL proteins, particularly the role of A8 expression in the liver and WAT, in TG partitioning has shown to be crucial for regulating LPL activity, which varies during fed and fasting cycles.
PROGRESS IN LIPID RESEARCH
(2022)
Editorial Material
Endocrinology & Metabolism
Melissa A. Linden, Susan J. Burke, Humza A. Pirzadah, Tai-Yu Huang, Heidi M. Batdorf, Walid K. Mohammed, Katarina A. Jones, Sujoy Ghosh, Shawn R. Campagna, J. Jason Collier, Robert C. Noland
Summary: Glucocorticoid therapy can cause iatrogenic diabetes, and activating lipolysis plays a crucial role in its development. Inhibiting lipolysis can reduce glucocorticoid-induced obesity and hyperglycemia. The role of lipolysis differs between skeletal muscle and liver.
MOLECULAR METABOLISM
(2023)
Review
Cardiac & Cardiovascular Systems
Ira J. Goldberg, Ainara G. Cabodevilla, Dmitri Samovski, Vincenza Cifarelli, Debapriya Basu, Nada A. Abumrad
Summary: Lipoprotein lipase mediates the transfer of lipids to parenchymal cells through or around endothelial cells, controlled at multiple points from synthesis to inhibition. Various pathways, including fatty acid transporter CD36 and other receptors, facilitate the transit of lipids into muscle and adipose tissues. Endothelial cells play a crucial role in lipid delivery, but there are still aspects of this process that require further investigation.
Article
Nutrition & Dietetics
Takumi Nagasawa, Takao Kimura, Akihiro Yoshida, Katsuhiko Tsunekawa, Osamu Araki, Kazumi Ushiki, Hirotaka Ishigaki, Yoshifumi Shoho, Itsumi Suda, Suguru Hiramoto, Masami Murakami
Summary: The study demonstrated that supplementing rice gruel with KGM powder led to reductions in circulating levels of free fatty acids and triglycerides, while increasing lipoprotein lipase and GPIHBP1 levels. This indicates a novel pleiotropic effect of KGM on lipid metabolism.
Article
Cell Biology
Bailey A. Loving, Maoping Tang, Mikaela C. Neal, Sachi Gorkhali, Robert Murphy, Robert H. Eckel, Kimberley D. Bruce
Summary: As individuals age, dysfunctional microglia may contribute to the onset of neurodegenerative diseases through impaired phagocytosis, cholesterol efflux, and enhanced secretion of pro-inflammatory cytokines. Specifically, microglia lacking lipoprotein lipase exhibit a pro-inflammatory lipid profile, increased cholesterol ester content, and reduced cholesterol efflux, leading to excessive accumulation of lipid droplets. Activation of PPAR pathways by agonists can rescue this phenotype, suggesting a potential therapeutic strategy for aging and neurodegenerative diseases.
Retraction
Chemistry, Multidisciplinary
Laura Fisher
Summary: The paper "MicroRNA-135a alleviates lipid accumulation and inflammation of atherosclerosis through targeting lipoprotein lipase" by Juan Li et al., published in RSC Advances in 2019, has been retracted.
Article
Biochemistry & Molecular Biology
Najia Jin, William F. Matter, Laura F. Michael, Yuewei Qian, Tarun Gheyi, Leticia Cano, Carlos Perez, Celia Lafuente, Howard B. Broughton, Alfonso Espada
Summary: The study shows that angiopoietin-like proteins 3 and 8 (ANGPTL3/8) can inhibit the enzymatic activities of lipoprotein lipase (LPL) by promoting furin-mediated cleavage of LPL. This effect is stronger than using ANGPTL3 or ANGPTL8 alone.
ACS CHEMICAL BIOLOGY
(2021)
Article
Biology
AbdulRahman A. I. Alyahya, Mohammed Asad, Mohammed Alrouji, Kamal Eldin Ahmed Abdelsalam, Adel Mashan Rashed Al-Mutairi, Monjid Ahmed Ibrahim Ahmed
Summary: The methanolic extract of Holarrhena pubescens seeds has hypolipidemic and antihyperlipidemic effects, possibly mediated through the inhibition of lipase enzyme activity.
Article
Nutrition & Dietetics
Yusuke Yamamoto, Toshihiro Sakurai, Zhen Chen, Nao Inoue, Hitoshi Chiba, Shu-Ping Hui
Summary: The effects of lysophosphatidylethanolamine (lysoPE) on lipogenesis and lipolysis were investigated in this study, and the underlying mechanism was analyzed using LC-MS/MS and real-time PCR. The results revealed that lysoPE 18:2 is involved in lipid droplet formation by suppressing lipolysis and fatty acid biosynthesis, potentially playing a pathological role in the induction of fatty liver disease.
Article
Agriculture, Dairy & Animal Science
Jun Li, Yaling Wang, Pengkun Yang, Haoyuan Han, Guizhi Zhang, Huifen Xu, Kai Quan
Summary: Overexpression of ATGL in goat mammary epithelial cells (GMECs) can decrease lipid droplet accumulation and cellular TG content by accelerating lipolysis, thus affecting lipid metabolism.
ANIMAL BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sander Kersten
Summary: Fasting and starvation have been significant environmental factors that have shaped human energy metabolism. Humans adapt to fasting through time-dependent changes in energy metabolism, including the breakdown of liver glycogen, muscle protein, and fat stores. This paper provides an overview of the effects of fasting on adipose tissue metabolism, including the inhibition of lipoprotein lipase activity and activation of adipose triglyceride lipase.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2023)
Article
Biochemistry & Molecular Biology
Liyan Yu, Hongguang Liu, Xiaoxia Ma, Vidya Devanathadesikan Seshadri, Xuan Gao
Summary: The study found that Myrtenal has anti-atherosclerotic activity in high-fat diet-induced atherosclerosis rat models. Myrtenal-treated groups showed the ability to modulate the lipid metabolic pathway, reducing blood lipid levels and inflammatory cytokines.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Article
Hematology
Amy Pei-Ling Chiu, Andrea Wan, Nathaniel Lal, Dahai Zhang, Fulong Wang, Israel Vlodavsky, Bahira Hussein, Brian Rodrigues
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2016)
Review
Biochemistry & Molecular Biology
Amy Pei-Ling Chiu, Andrea Wan, Brian Rodrigues
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2016)
Article
Endocrinology & Metabolism
Dahai Zhang, Fulong Wang, Nathaniel Lal, Amy Pei-Ling Chiu, Andrea Wan, Jocelyn Jia, Denise Bierende, Stephane Flibotte, Sunita Sinha, Ali Asadi, Xiaoke Hu, Farnaz Taghizadeh, Thomas Pulinilkunnil, Corey Nislow, Israel Vlodavsky, James D. Johnson, Timothy J. Kieffer, Bahira Hussein, Brian Rodrigues
Article
Cardiac & Cardiovascular Systems
Sean S. Lee, Kyoung Ae Kong, Daehoon Kim, Yeong-Min Lim, Pil-Sung Yang, Jeong-Eun Yi, Minsuk Kim, Kihwan Kwon, Wook Bum Pyun, Boyoung Joung, Junbeom Park
EUROPEAN HEART JOURNAL
(2017)
Article
Cardiac & Cardiovascular Systems
Amy Pei-Ling Chiu, Denise Bierende, Nathaniel Lal, Fulong Wang, Andrea Wan, Israel Vlodavsky, Bahira Hussein, Brian Rodrigues
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Melissa M. Page, Sos Skovso, Haoning Cen, Amy P. Chiu, Derek A. Dionne, Daria F. Hutchinson, Gareth E. Lim, Marta Szabat, Stephane Flibotte, Sunita Sinha, Corey Nislow, Brian Rodrigues, James D. Johnson
Article
Cardiac & Cardiovascular Systems
Fulong Wang, Thomas Pulinilkunnil, Stephane Flibotte, Corey Nislow, Israel Vlodaysky, Bahira Hussein, Brian Rodrigues
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Karanjit Puri, Nathaniel Lal, Rui Shang, Sanjoy Ghosh, Stephane Flibotte, Roger Dyer, Bahira Hussein, Brian Rodrigues
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2019)
Article
Biophysics
Hyueyun Kim, Young-Ho Ahn, Bom Sahn Kim, Sanghui Park, Joo Chun Yoon, Junbeom Park, Chang Mo Moon, Dong-Ryeol Ryu, Jihee Lee Kang, Ji Ha Choi, Eun-Mi Park, Kyung Eun Lee, Minna Woo, Minsuk Kim
BIOSENSORS & BIOELECTRONICS
(2020)
Article
Biotechnology & Applied Microbiology
Hyueyun Kim, Young-Ho Ahn, Chang Mo Moon, Jihee Lee Kang, Minna Woo, Minsuk Kim
Summary: Tumor cells can transfer mitochondria to adjacent cells through tunneling nanotubes, which can induce apoptosis. Mitochondria released endonuclease G into neighboring tumor cells, leading to cell death. Unsealed mitochondria showed synergistic apoptotic effects when combined with doxorubicin.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Minna Woo, Minsuk Kim
Summary: Insulin sensitizers and PTEN deficiency accelerate the onset of sinus node dysfunction in hypertensive animals, while also affecting autophagy processes. Mice deficient in ULK1 show similar outcomes, indicating the importance of autophagy in cardiac effects caused by insulin sensitization.
TRANSLATIONAL AND CLINICAL PHARMACOLOGY
(2021)
Article
Engineering, Biomedical
Minae An, Kihwan Kwon, Junbeom Park, Dong-Ryeol Ryu, Jung-A. Shin, Jihee Lee Kang, Ji Ha Choi, Eun-Mi Park, Kyung Eun Lee, Minna Woo, Minsuk Kim
Article
Cardiac & Cardiovascular Systems
Minae An, Dong-Ryeol Ryu, Jang Won Park, Ji Ha Choi, Eun-Mi Park, Kyung Eun Lee, Minna Woo, Minsuk Kim
CARDIOVASCULAR RESEARCH
(2017)
Review
Cardiac & Cardiovascular Systems
Fulong Wang, Jocelyn Jia, Brian Rodrigues
CANADIAN JOURNAL OF CARDIOLOGY
(2017)
Article
Cardiac & Cardiovascular Systems
Nathaniel Lal, Amy Pei-Ling Chiu, Fulong Wang, Dahai Zhang, Jocelyn Jia, Andrea Wan, Israel Vlodavsky, Bahira Hussein, Brian Rodrigues
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2017)