Article
Cell Biology
Bhavana Gupta, Adam C. Errington, Ana Jimenez-Pascual, Vasileios Eftychidis, Simone Brabletz, Marc P. Stemmler, Thomas Brabletz, David Petrik, Florian A. Siebzehnrubl
Summary: The study reveals that the transcription factor ZEB1 plays a crucial role in the self-renewal of active RGL cells in the adult mammalian hippocampus, with its deletion leading to a shift towards symmetric cell division and an increase in newborn neurons while decreasing newly generated astrocytes. ZEB1 is identified as a positive regulator of the ets-domain transcription factor ETV5, which is essential for asymmetric division.
Review
Behavioral Sciences
Joana Martins-Macedo, Antonio J. Salgado, Eduardo D. Gomes, Luisa Pinto
Summary: Psychiatric disorders have a significant impact on patients' lives, with common symptoms including motivational, cognitive and emotional deficits. Current treatments are often ineffective due to adverse side effects or low efficacy rates. Understanding neuro-and gliogenesis mechanisms is crucial for defining effective treatments, as they play a key role in cognitive and emotional behavior.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Neurosciences
Shengming Wang, Yu Fu, Takaki Miyata, Sakiko Matsumoto, Tomoyasu Shinoda, Kyoko Itoh, Akihiro Harada, Shinji Hirotsune, Mingyue Jin
Summary: This study reveals the functional cooperation between aSyn and tau during brain development. Deletion of aSyn and tau alters the balance between progenitor cell proliferation and neurogenesis, resulting in an overproduction of early born neurons. Furthermore, there is a reduction in neural progenitor cells in the aSyn-/-tau-/- cortex, leading to diminished gliogenesis. Additionally, expansion and maturation of macroglial cells are suppressed in the aSyn-/-tau-/- postnatal brain, resulting in reduced brain size and cortical thickness.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Neurosciences
Solene Clavreul, Laura Dumas, Karine Loulier
Summary: In the mammalian brain, astrocytes form a diverse population with variations in morphology, molecular makeup, function, and location. Recent studies have shed light on the development and maturation of astrocytes in the cerebral cortex, providing a better understanding of their diversity. However, the origins of this diversity are still unclear, and further research using advanced tools and techniques is underway.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Immunology
Amadi Ogonda Ihunwo, Jessica Perego, Gianvito Martino, Elisa Vicenzi, Paola Panina-Bordignon
Summary: Neural stem cells play a crucial role in the brain, being able to self-renew and differentiate into neurons. They are regulated by signals from the local and distant environment. Zika virus and severe acute respiratory syndrome coronavirus 2 may cause damage to neural stem cells and the brain.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Yuhualei Pan, Dan Tian, Huan Wang, Yushang Zhao, Chengjie Zhang, Song Wang, Dan Xie, Dong Zhang, Yanbing Zhu, Yongbo Zhang
Summary: The research revealed that perforin-mediated neurotoxicity plays a critical role in the ischemic brain, indicating that targeting perforin-mediated neurotoxicity in brain-resident microglia and invading perforin(+)CD45(+) immune cells may be a potential strategy for the treatment of ischemic stroke.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biology
Yuanyuan Huang, Wuxiang Sun, Fujia Gao, Haoran Ma, Tao Yuan, Zixuan Liu, Huiyu Liu, Jiewei Hu, Jing Bai, Xin Zhang, Ruimin Wang
Summary: This study aimed to explore the role of brain-derived estrogen (BDE2) in hippocampal neurogenesis with aging in female rats. The results showed that cell differentiation declined over middle age, while the differentiation of astrocytes and microglia markedly increased. Female forebrain neuronal aromatase knockout (FBN-ARO-KO) rats exhibited declined neurogenesis and cognitive impairment compared to WT controls. The study suggests that BDE2 plays a key role in maintaining hippocampal neurogenesis and cognitive function.
Review
Cell Biology
Werend Boesmans, Amelia Nash, Kinga R. Tasnady, Wendy Yang, Lincon A. Stamp, Marlene M. Hao
Summary: Enteric glia are support cells of the enteric nervous system that play a vital role in regulating gut functions and maintaining homeostasis. Their plasticity and heterogeneity make them neural precursors with the potential for neurogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kaoru Tominaga, Eiji Sakashita, Katsumi Kasashima, Kenji Kuroiwa, Yasumitsu Nagao, Naoki Iwamori, Hitoshi Endo
Summary: Epigenetic factors play a crucial role in establishing functional organ systems during development, including brain development. However, the precise mechanism of epigenetic regulation in brain development and neurogenesis remains largely unknown. In this study, the researchers discovered the critical role of the Tip60 protein in brain development and the maintenance and function of neural stem/progenitor cells (NSCs). Tip60 deficiency led to multiple abnormalities in brain development, including microcephaly, reduced proliferation of developing brain cells, and impaired neural differentiation and migration. The study also revealed that Tip60 is involved in the transition from neurogenesis to gliogenesis during brain development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Fiorenza Stagni, Renata Bartesaghi
Summary: Down syndrome is a genetic disorder caused by triplication of Chromosome 21, leading to intellectual impairment and potential development of Alzheimer's disease. Research on DS suggests that pharmacological interventions during the embryonic period can have significant benefits for brain development and cognitive abilities. This review provides a comprehensive summary of the neurogenesis and dendritic changes in DS throughout different stages of life, aiming to identify potential therapeutic targets and explore the possibility of fetal therapy for individuals with DS.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Cell Biology
Raphaela Almeida Chiareli, Gustavo Almeida Carvalho, Bruno Lemes Marques, Lennia Soares Mota, Onesia Cristina Oliveira-Lima, Rodrigo Mello Gomes, Alexander Birbrair, Renato Santiago Gomez, Fabricio Simao, Friederike Klempin, Marcel Leist, Mauro Cunha Xavier Pinto
Summary: Astrocytes play a crucial role in providing trophic and metabolic support for neurons, and they can transform into reactive astrocytes during injuries and infections to release signaling molecules for cerebral defense. Understanding the signaling pathways of reactive astrocytes can help control neuroinflammation and identify new targets for neurorepair.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Chiara Galante, Nicolas Marichal, Franciele Franco Scarante, Litsa Maria Ghayad, Youran Shi, Carol Schuurmans, Benedikt Berninger, Sophie Peron
Summary: The proneural transcription factor Ascl1 is involved in neural fate decisions. It has been widely used to reprogram non-neuronal cells into neurons in vitro. However, this study found that, in vivo, Ascl1 only had very low efficiency in inducing neuronal reprogramming of glial cells in the postnatal mouse cerebral cortex. Instead, Ascl1 selectively enhanced the proliferation of oligodendrocyte progenitor cells (OPCs).
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Cell Biology
Zhenmeiyu Li, Guoping Liu, Lin Yang, Mengge Sun, Zhuangzhi Zhang, Zhejun Xu, Yanjing Gao, Xin Jiang, Zihao Su, Xiaosu Li, Zhengang Yang
Summary: The human cerebral cortex is responsible for our exceptional cognitive abilities. The remarkable increase in the size of the human cerebral cortex is mainly due to longer neurogenic period facilitated by increased cortical radial glial cells expressing BMP7. BMP7 promotes neurogenesis, inhibits gliogenesis, and mutually inhibits SHH signaling, which promotes cortical gliogenesis.
Article
Neurosciences
Dimitrinka Atanasova, Nikolai Lazarov, Dimo S. Stoyanov, Radoslav H. Spassov, Anton B. Tonchev, Jana Tchekalarova
Summary: Agomelatine has anti-inflammatory and antidepressant effects, which can restore abnormal neuroglia activity in the model and partially restore suppressed neurogenesis.
Review
Biochemistry & Molecular Biology
Sarah Larrigan, Sujay Shah, Alex Fernandes, Pierre Mattar
Summary: During brain development, the genome is repeatedly reconfigured to aid neuronal and glial differentiation, with a range of chromatin remodeling complexes facilitating the process. The non-redundancy of these complexes suggests a need for a variety of remodelers with different specificities and activities in neurodevelopment. The nucleosome remodeling and deacetylase (NuRD) complex plays a key role in the biochemistry, genetics, and functions of neural progenitors and neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Qianliang Li, Nadia N. Aalling, Benjamin Foerstera, Ali Ertuerk, Maiken Nedergaard, Kjeld Mollgard, Anna L. R. Xavier
FLUIDS AND BARRIERS OF THE CNS
(2020)
Article
Cell Biology
Xiaowei Wang, Nanhong Lou, Allison Eberhardt, Yujia Yang, Peter Kusk, Qiwu Xu, Benjamin Forstera, Sisi Peng, Meng Shi, Antonio Ladron-de-Guevara, Christine Delle, Bjorn Sigurdsson, Anna L. R. Xavier, Ali Erturk, Richard T. Libby, Lu Chen, Alexander S. Thrane, Maiken Nedergaard
SCIENCE TRANSLATIONAL MEDICINE
(2020)
Article
Multidisciplinary Sciences
Michael Giannetto, Maosheng Xia, Frederik Filip Staeger, Tanner Metcalfe, Hanna S. Vinitsky, Juliana A. M. L. Dang, Anna L. R. Xavier, Benjamin T. Kress, Maiken Nedergaard, Lauren M. Hablitz
SCIENTIFIC REPORTS
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Evan Hunter Stanton, Niklas Daniel Ake Persson, Ryszard Stefan Gomolka, Tuomas Lilius, Bjorn Sigurosson, Hedok Lee, Anna Lenice Ribeiro Xavier, Helene Benveniste, Maiken Nedergaard, Yuki Mori
Summary: The study developed a novel DCE-MRI protocol and compared CSF transport in mice under different anesthesia states, revealing that CSF influx in the glymphatic system is influenced by anesthesia and has distinct efflux pathways. Dynamic contrast MR provided new insights into CSF clearance pathways.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Clinical Neurology
Chiara Pavan, Anna L. R. Xavier, Marta Ramos, Jane Fisher, Marios Kritsilis, Adam Linder, Peter Bentzer, Maiken Nedergaard, Iben Lundgaard
Summary: In this study, it was found that NETs disrupt the transport of cerebrospinal fluid through the glymphatic system in pneumococcal meningitis, leading to the formation of cerebral edema. Treatment with DNase can restore glymphatic transport and reduce the increased brain weight in rats, while first-line antibiotic treatment does not have the same effect on restoring fluid dynamics. Therefore, the glymphatic system and NETs may be potential new treatment targets in pneumococcal meningitis.
ANNALS OF NEUROLOGY
(2021)
Article
Otorhinolaryngology
Andressa Silva de Freitas, Izabella C. Santos, Cristina Furia, Rodrigo Dornelas, Ana Catarina Alves e Silva, Fernando Luiz Dias, Gil F. Salles
Summary: This study evaluated late and asymptomatic patients after open partial horizontal laryngectomy (OPHL) and found that dysphagia is common in these patients. Older age, lower preoperative serum albumin levels, greater postoperative weight loss, and diabetes are associated with a higher risk of severe dysphagia in the late period after OPHL.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Otorhinolaryngology
Andressa Silva de Freitas, Guilherme Maia Zica, Mariana Salles, Ana Catarina Alves E Silva, Thiago Huaytalla Silva, Fernando Luiz Dias, Izabella Costa Santos
Summary: The study investigated and compared the relationship between self-reported quality of life and objective assessments of swallowing function in patients undergoing SCL CHEP. The findings showed that swallowing function is crucial for quality of life, with residue potentially being more important than aspiration.
INTERNATIONAL ARCHIVES OF OTORHINOLARYNGOLOGY
(2022)
Article
Psychiatry
Natalia Bezerra Mota, Juliana Pimenta, Maria Tavares, Leonardo Palmeira, Alexandre Andrade Loch, Cecilia Hedin-Pereira, Elisa C. Dias
Summary: Brazil is a continental country with rich ethnic, cultural, and religious diversity, but also faces significant socioeconomic inequality. To improve mental health diagnosis and rehabilitation, Brazil has established a network for psychosocial care, including mental health clinics and community services tailored to each specific area and attentive to regional culture and infrastructure. Additionally, new digital technologies, especially computational speech analysis, can contribute to unbiased assessments, reducing stigma and enabling more effective diagnosis of mental diseases.
PSYCHIATRY RESEARCH
(2022)
Article
Oncology
Giovanni Succo, Andy Bertolin, Izabela Costa Santos, Martina Tascone, Marco Lionello, Marco Fantini, Andressa Silva de Freitas, Ilaria Bertotto, Andrea Elio Sprio, Giuseppe Sanguineti, Fernando Luiz Dias, Giuseppe Rizzotto, Erika Crosetti
Summary: A study of 134 cases of T4a laryngeal cancer treated with OPHL+/- PORT was conducted, showing that OPHL can be a viable option in selected pT4a LC patients who refuse total laryngectomy.
Review
Cell Biology
Bruna L. M. Marcelino, Brendha L. dos Santos, Jhulimar G. Doerl, Samantha F. Cavalcante, Sara N. Maia, Nivia M. R. Arrais, Andrea Zin, Selma M. B. Jeronimo, Claudio Queiroz, Cecilia Hedin-Pereira, Eduardo B. Sequerra
Summary: An outbreak of microcephalic patients in Brazil was caused by Zika virus (ZIKV) infection, which reduces neuron numbers and causes neuronal death. Studies on human, molecular, cell, and animal models help understand the natural history and pathology of ZIKV in the embryonic central nervous system (CNS). Infection timing and the mechanism of viral spread through the CNS explain the diversity of phenotypes found in congenital ZIKV syndrome (CZVS).
DISEASE MODELS & MECHANISMS
(2023)
Article
Medicine, General & Internal
Andressa Silva de Freitas, Guilherme Maia Zica, Emilson Queiroz Freitas, Ana Catarina Alves E Silva, Fernando Luiz Dias, Izabella Costa Santos
Summary: This study investigated the correlation between food residues and their anatomical location, and the presence of laryngotracheal penetration and aspiration in patients after supracricoid laryngectomy with cricohyoidoepiglotopexy reconstruction. The results showed that there were food residues in different anatomical regions, and residues on the base of the tongue and posterior pharyngeal wall were associated with laryngotracheal penetration, while residues in the upper esophageal sphincter were associated with aspiration.
EINSTEIN-SAO PAULO
(2022)
Article
Biology
F. S. Erthal, A. F. Bastos, C. Vaccariello, A. T. S. Madeira, T. S. Santos, J. B. Stariolo, L. Oliveira, M. G. Pereira, K. C. Calaza, C. Hedin-Pereira, E. Volchan
Summary: Gender equity is still far from being achieved in most academic institutions worldwide, with women facing multiple obstacles in scientific leadership. Implicit bias and stereotype threat are seen as major driving forces behind gender disparities. Cultural stereotypes negatively impacting attitudes and judgments towards women and other social groups contribute to the lack of visibility in the scientific community.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2021)
Article
Medicine, General & Internal
Andressa Silva de Freitas, Guilherme Maia Zica, Ana Catarina Alves e Silva, Fernando Luiz Dias, Emilson Queiroz Freitas, Izabella Costa Santos
Summary: The study found that in patients who underwent supracricoid laryngectomy without complaints of swallowing issues, elderly individuals over the age of 60 are more likely to experience laryngotracheal aspiration compared to those under 60 years old.
EINSTEIN-SAO PAULO
(2021)
Article
Medicine, General & Internal
Guilherme Maia Zica, Andressa Silva de Freitas, Ana Catarina Alves e Silva, Fernando Luiz Dias, Izabella Costa Santos, Emilson Queiroz Freitas, Hilton Augusto Koch
EINSTEIN-SAO PAULO
(2020)
Letter
Audiology & Speech-Language Pathology
Andressa Silva Freitas, Guilherme Maia Zica, Christiane Lopes de Albuquerque