Article
Obstetrics & Gynecology
Alan Penzias, Ricardo Azziz, Kristin Bendikson, Tommaso Falcone, Karl Hansen, Micah Hill, William Hurd, Sangita Jindal, Suleena Kalra, Jennifer Mersereau, Robert Rebar, Richard Reindollar, Chevis N. Shannon, Anne Steiner, Dale Stovall, Cigdem Tanrikut, Hugh Taylor, Belinda Yauger
Summary: This document provides the latest recommendations for the evaluation of potential sperm, oocyte, and embryo donors as well as their recipients, incorporating recent information about optimal screening and testing for sexually transmitted infections, genetic diseases, and psychological assessments. The revised document incorporates recent information from US agencies and organizations, which are essential for programs offering gamete and embryo donation services.
FERTILITY AND STERILITY
(2021)
Article
Fisheries
Charles Brighton Ndandala, Mingshu Dai, Umar Farouk Mustapha, Xiaomeng Li, Jinlei Liu, Hai Huang, Guangli Li, Huapu Chen
Summary: The GH-IGFs axis is essential in regulating physiological functions in teleost fish. Nutritional status and fasting/refeeding have significant effects on the expression of IGF genes. IGFs play crucial roles in growth, reproduction, and other physiological functions in teleost fish.
AQUACULTURE REPORTS
(2022)
Article
Reproductive Biology
Anamaria-Cristina Herta, Nazli Akin, Katy Billooye, Laura Saucedo-Cuevas, Francesca Lolicato, Ingrid Segers, Ellen Anckaert, Johan Smitz
Summary: The study shows that oocytes from cultured mouse follicles can overcome complete denudation, restoring functional transzonal projections, with no significant differences in meiotic and developmental competence compared to those from intact cultured follicles. These findings provide good premises for developing successful strategies to rescue human oocyte competence in in vitro culture approaches.
BIOLOGY OF REPRODUCTION
(2021)
Article
Immunology
Antonia E. Gallman, Finn D. Wolfreys, David N. Nguyen, Moriah Sandy, Ying Xu, Jinping An, Zhongmei Li, Alexander Marson, Erick Lu, Jason G. Cyster
Summary: The study reveals that P2RY8 and GGG negatively regulate the trafficking of B and T cells to the bone marrow, with Ggt5 and Abcc1 playing crucial roles in GGG catabolism and transportation.
SCIENCE IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Julian Hirt, Christof Manuel Schoenenberger, Hannah Ewald, Daeria O. Lawson, Davide Papola, Ramon Rohner, Katja Suter, Shanshan Lin, Federico Germini, Linan Zeng, Ali Shahabinezhad, Saifur Rahman Chowdhury, Ya Gao, Arunima Bhattacharjee, Joo Pedro Lima, Ana Marusic, Ivan Buljan, Arnav Agarwal, Gordon H. Guyatt, Matthias Briel, Stefan Schandelmaier
Summary: Improving methodological quality is important in the health research community, but finding appropriate methods guidance can be challenging. The Library of Guidance for Health Scientists (LIGHTS) is a new searchable database that aims to help researchers find relevant methods guidance.
Article
Medicine, General & Internal
Julian Hirt, Christof Manuel Schoenenberger, Hannah Ewald, Daeria O. Lawson, Davide Papola, Ramon Rohner, Katja Suter, Shanshan Lin, Federico Germini, Linan Zeng, Ali Shahabinezhad, Saifur Rahman Chowdhury, Ya Gao, Arunima Bhattacharjee, Joo Pedro Lima, Ana Marusic, Ivan Buljan, Arnav Agarwal, Gordon H. Guyatt, Matthias Briel, Stefan Schandelmaier
Summary: The Library of Guidance for Health Scientists (LIGHTS) is a searchable database aimed at providing information on methods guidance for health researchers. The project team continuously indexes eligible guidance documents to increase access to and use of methods guidance.
Article
Anatomy & Morphology
Muhan Hu, Ekta Tiwary, Jeevan K. Prasain, Michael Miller, Rosa Serra
Summary: The C. elegans TGFss pathway regulates various pathways to modulate PG metabolism and sperm guidance. DAF-3 likely functions in the nervous system and possibly the germline to affect sperm guidance. Results suggest that reduced PGF levels in daf-1 mutants contribute to sperm guidance defects.
DEVELOPMENTAL DYNAMICS
(2021)
Review
Cell Biology
Reza K. Oqani, Seongjun So, Yeonmi Lee, Jung Jae Ko, Eunju Kang
Summary: Infertility is a growing concern globally, and the development of alternative methods such as the generation of artificial oocytes from different stem cell sources offers new hope. This article provides an overview of the mechanisms involved in the in vitro generation of functional oocytes, and discusses its potential in medical applications.
Article
Obstetrics & Gynecology
Jennifer K. Blakemore, James A. Grifo, Shannon M. DeVore, Brooke Hodes-Wertz, Alan S. Berkeley
Summary: This study evaluated the outcomes of patients undergoing planned oocyte cryopreservation, finding that 38.1% of patients took action with their cryopreserved oocytes, while 58.9% did not use them. Further research with larger cohorts and epidemiological comparisons to current egg freezing patients are needed.
FERTILITY AND STERILITY
(2021)
Article
Obstetrics & Gynecology
Ana Cobo, Juan Antonio Garcia-Velasco, Jose Remohi, Antonio Pellicer
Summary: The oocyte vitrification technique has been widely used in the field of fertility preservation, benefiting women at risk of losing ovarian function. Age is a critical factor affecting reproductive prognosis, and elective fertility preservation patients should make decisions before the age of 35. Diseases and surgeries such as cystectomy before oocyte retrieval can impact reproductive outcomes.
FERTILITY AND STERILITY
(2021)
Article
Agriculture, Dairy & Animal Science
Jana Rychtarova, Alena Langerova, Helena Fulka, Pasqualino Loi, Michal Benc, Josef Fulka
Summary: The long-term storage of biological material is crucial for various fields, and a simple approach for evaluating sperm DNA damage level has been proposed to address the issue of limited frozen biological material quantities.
Review
Medicine, General & Internal
Eric Han, David B. Seifer
Summary: Oocyte cryopreservation (OC) is a process of stimulating ovarian follicles, retrieving follicular fluid, isolating and vitrifying mature oocytes. It has been increasingly used as an option for future biologic children for patients undergoing gonadotoxic therapies. Planned OC, also known as elective OC, is growing in popularity to overcome age-related fertility decline. This review discusses medically indicated and planned OC, focusing on the physiology, technique, timing, financial considerations, and outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Jiyeon Leem, Guang-Yu Bai, Jae-Sung Kim, Jeong Su Oh
Summary: This study revealed that increased WIP1 during in vitro postovulatory aging reduces the capacity of oocytes to respond to and repair DNA damage. As oocytes aged in vitro, they lost their ability to respond to DNA double-strand breaks, which was associated with higher expression of WIP1. The inhibition of WIP1 was found to restore DNA repair capacity in aged oocytes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Obstetrics & Gynecology
Sarah Druckenmiller Cascante, Alan S. Berkeley, Frederick Licciardi, Caroline McCaffrey, James A. Grifo
Summary: This review provides an update on planned oocyte cryopreservation, a fertility preservation method that allows women to delay childbearing while still having the option of having a biological child. Despite increased usage, many women who have undergone oocyte cryopreservation have not yet used their frozen eggs, and more research is needed to determine the optimal age and number of eggs to freeze.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Multidisciplinary Sciences
Pil-Soo Jeong, Hae-Jun Yang, Se-Been Jeon, Min-Ah Gwon, Min Ju Kim, Hyo-Gu Kang, Sanghoon Lee, Young-Ho Park, Bong-Seok Song, Sun-Uk Kim, Deog-Bon Koo, Bo-Woong Sim
Summary: This study examined the role of luteolin in the maturation of mammalian oocytes. The results showed that supplementation of luteolin during in vitro maturation improved the developmental competence of oocytes. Furthermore, luteolin reduced oxidative stress and mitochondria-mediated apoptosis in oocytes, leading to improved maturation.
Article
Endocrinology & Metabolism
Madeleine J. Cox, Melissa C. Edwards, Valentina Rodriguez Paris, Ali Aflatounian, William L. Ledger, Robert B. Gilchrist, Vasantha Padmanabhan, David J. Handelsman, Kirsty A. Walters
Article
Biochemistry & Molecular Biology
William A. Stocker, Kelly L. Walton, Dulama Richani, Karen L. Chan, Kiri H. Beilby, Bethany J. Finger, Mark P. Green, Robert B. Gilchrist, Craig A. Harrison
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Editorial Material
Obstetrics & Gynecology
Richard A. Anderson, Robert B. Gilchrist
FERTILITY AND STERILITY
(2020)
Article
Endocrinology & Metabolism
Ali Aflatounian, Melissa C. Edwards, Valentina Rodriguez Paris, Michael J. Bertoldo, Reena Desai, Robert B. Gilchrist, William L. Ledger, David J. Handelsman, Kirsty A. Walters
JOURNAL OF ENDOCRINOLOGY
(2020)
Review
Obstetrics & Gynecology
Dulama Richani, Kylie R. Dunning, Jeremy G. Thompson, Robert B. Gilchrist
Summary: Metabolism is crucial for oocyte quality, with glucose being essential for COC maturation and energy production. Mitochondria are the main ATP source in oocytes, while cumulus cells play a vital role in maintaining ATP levels. New insights in oocyte lipid metabolism and innovative strategies in IVM have shown positive effects on oocyte competence.
HUMAN REPRODUCTION UPDATE
(2021)
Editorial Material
Endocrinology & Metabolism
Michael J. Bertoldo, Johan Smitz, Lindsay E. Wu, Hoi Chang Lee, Teresa K. Woodruff, Robert B. Gilchrist
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2020)
Article
Endocrinology & Metabolism
Irene E. Sucquart, Ruchi Nagarkar, Melissa C. Edwards, Valentina Rodriguez Paris, Ali Aflatounian, Michael J. Bertoldo, Rebecca E. Campbell, Robert B. Gilchrist, Denovan P. Begg, David J. Handelsman, Vasantha Padmanabhan, Richard A. Anderson, Kirsty A. Walters
Summary: PCOS is a prevalent endocrine condition with a range of endocrine, reproductive, and metabolic abnormalities; Androgen actions play a key role in PCOS pathogenesis; NK3R antagonism may be beneficial in treating adverse metabolic features associated with PCOS and support the development of novel therapeutic strategies.
Editorial Material
Genetics & Heredity
Michel De Vos, Michael Grynberg, Tuong M. Ho, Ye Yuan, David F. Albertini, Robert B. Gilchrist
Summary: This review aims to help professionals understand the appropriate use of IVM, supporting its clinical potential and safety, and exploring the current and future role of IVM in human ART.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Genetics & Heredity
Nazli Akin, Dulama Richani, Xiuhua Liao, Yiqing Zhao, Anamaria-Cristina Herta, Katy Billooye, William A. Stocker, David G. Mottershead, Craig A. Harrison, Johan Smitz, Ellen Anckaert, Robert B. Gilchrist
Summary: This study assessed the effect of adding novel TGF-beta superfamily proteins, cumulin and super-GDF beta, to the culture media in a biphasic IVM system. The results showed that cumulin and super-GDF9 significantly improved oocyte developmental competence in standard IVM, but had no effect in CAPA-IVM.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Endocrinology & Metabolism
Ali Aflatounian, Valentina Rodriguez Paris, Dulama Richani, Melissa C. Edwards, Blake J. Cochran, William L. Ledger, Robert B. Gilchrist, Michael J. Bertoldo, Lindsay E. Wu, Kirsty A. Walters
Summary: PCOS is characterized by reproductive and endocrine abnormalities, with metabolic dysregulation. Recent study found that treating obese, pre-diabetic women with NMN could improve skeletal muscle insulin sensitivity. The research on DHT-induced PCOS mouse model showed that NMN treatment could normalize NAD levels in muscle, leading to the improvement of metabolic dysfunction and insulin sensitivity.
MOLECULAR METABOLISM
(2022)
Article
Obstetrics & Gynecology
Robert B. Gilchrist, Johan Smitz
Summary: Oocyte in vitro maturation (IVM) is a minimally invasive technique involving the collection and culture of immature oocytes to maturity outside the body. It is now classified as nonexperimental and is primarily indicated for patients with a high antral follicle count and for fertility preservation in cancer patients. Significant advances in IVM culture methods have been made based on animal studies and a simplified patient treatment protocol, leading to its routine practice in specialized centers worldwide.
FERTILITY AND STERILITY
(2023)
Article
Endocrinology & Metabolism
Valentina Rodriguez Paris, Melissa C. Edwards, Ali Aflatounian, Michael J. Bertoldo, William L. Ledger, David J. Handelsman, Robert B. Gilchrist, Kirsty A. Walters
Summary: PCOS is a common disorder with unclear etiology and pathogenesis, managed based on symptoms. A PCOS mouse model showed that irregular cycles, anovulation, and weight gain are early features, while adiposity, impaired glucose tolerance, and dyslipidemia are later characteristics. These findings support early diagnosis with body weight criteria.
JOURNAL OF THE ENDOCRINE SOCIETY
(2021)
Review
Developmental Biology
Amy Winship, Jacqueline Donoghue, Brendan J. Houston, Jacinta H. Martin, Tessa Lord, Alaknanda Adwal, Macarena Gonzalez, Elodie Desroziers, Gulfam Ahmad, Dulama Richani, Elizabeth G. Bromfield
REPRODUCTION FERTILITY AND DEVELOPMENT
(2020)
