Editorial Material
Oncology
Sylvain Peuget, Galina Selivanova
Summary: p53 is a complex cell signaling hub that controls the expression of multiple target genes in response to different stimuli, with the exact code by which p53 integrates these stresses into transcriptional responses still unclear. Regulation of p53 at various levels leads to a wide diversity in p53 complexes on target promoters, providing adaptability to its transcriptional program. Understanding the mechanisms by which p53 selectively directs desired outcomes in cancer cells is crucial as p53-targeted therapies progress, with further investigations needed on cell type- and stimuli-dependent transcriptional outcomes by p53.
Article
Cell Biology
Amy K. Webster, Rojin Chitrakar, Seth M. Taylor, L. Ryan Baugh
Summary: This study investigates the gene expression changes and regulatory strategies in the somatic and germline cells of C. elegans under starvation. The results show that relative expression of germline-enriched genes increases during starvation, while somatic transcription is required for survival. This work reveals the importance of transcriptional regulation during starvation and the different strategies employed by somatic and germline cells.
Article
Cell Biology
Ze Chen, Xiaohua Xie, Na Jiang, Jianhui Li, Lei Shen, Yongjun Zhang
Summary: The study reveals that the overexpression of CCR5 and its ligands is associated with the development of BPD, leading to increased inflammation and decreased alveolarization. Hence, CCR5 may serve as a novel therapeutic target for BPD treatment.
CELL DEATH & DISEASE
(2021)
Article
Geography
Corinna Jentzsch, Juan Masullo
Summary: This research explores the reasons why some communities resist armed groups non-violently while others take up arms to do so, finding that the forms of resistance are linked to prior experiences of collective action, normative commitments, and the role of local political entrepreneurs.
POLITICAL GEOGRAPHY
(2022)
Article
Multidisciplinary Sciences
Claire J. Weaver, Aleena L. Patel, Stanislav Y. Shvartsman, Michael S. Levine, Nicholas Treen
Summary: This study investigates the regulation of transcription factor condensates by ERK signaling in embryos of a simple proto-vertebrate. The authors demonstrate that ERK signaling induces changes in the localization of transcriptional repressor ERF and observe dynamic assembly and dissociation of condensates during interphase. These findings provide insights into the regulation of gene activity and cell signaling.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Ning Ding, Pibao Li, Huiqing Li, Yunlong Lei, Zengzhen Zhang
Summary: The RhoA/ROCK-ezrin/Syk-MyD88/IRAK1 axis plays an important role in the LPS-induced production of pro-inflammatory cytokines in pulmonary alveolar epithelial cells.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Biochemistry & Molecular Biology
Chin-Feng Tsai, Shun-Fa Yang, Chien-Hsien Lo, Hsiao-Ju Chu, Kwo-Chang Ueng
Summary: The study revealed that hypoxia-induced atrial fibrotic response primarily occurs via the ROS/JNK pathway, leading to upregulation of HIF-1 alpha and c-Jun/ATF2 phosphorylation. This mechanism could offer a novel therapeutic strategy against atrial fibrillation by targeting the suppression of ROS/JNK signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Amol K. Bhandage, Antonio Barragan
Summary: Recent findings point to the important role of GABA signaling in the mammalian immune system, impacting functions such as cell migration and cytokine secretion. GABA, originally known as a neurotransmitter, has been identified as a signaling molecule in intercellular and interspecies interactions within the immune system.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biology
Juil Kim, Yuseok Moon
Summary: Kim and Moon discovered that the transcription factor PRDM1 is upregulated in colorectal cancer (CRC) cells in response to ribosomal dysfunction, leading to chemoresistance through the IGF signaling pathway. They also found that PRDM1 promotes cancer cell stemness and survival, providing insights into environmental stress-mediated signaling in CRC.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yubo Sun, Xiangrong Tian, Hao Wu, Xinchang Hao, Baowei Gao, Hongyan Zhang, Juntao Feng, Lirong Han
Summary: GP-1 is a glycoprotein elicitor found in Streptomyces kanasensis zx01 with antiviral activity, and it induces programmed cell death (PCD) in tobacco suspension cells, modulated by hydrogen peroxide (H2O2) and participating in biologically relevant signaling in plant cells.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qiangbo Liu, Yanglin Ding, Yiting Shi, Liang Ma, Yi Wang, Chunpeng Song, Katie A. Wilkins, Julia M. Davies, Heather Knight, Marc R. Knight, Zhizhong Gong, Yan Guo, Shuhua Yang
Summary: The study reveals that the Ca2+-permeable transporter ANNEXIN1 (AtANN1) mediates cold-triggered Ca2+ influx and freezing tolerance in Arabidopsis thaliana. The OST1/SnRK2.6 kinase interacts with and phosphorylates AtANN1, enhancing its Ca2+ transport activity and potentiating Ca2+ signaling in response to cold stress. This cascade linking OST1-AtANN1 leads to cold-induced Ca2+ signal generation, activating the cold response and enhancing freezing tolerance in Arabidopsis.
Article
Genetics & Heredity
Kelsey A. A. Herrmann, Yizhou Liu, Arnau Llobet-Rosell, Colleen N. N. McLaughlin, Lukas J. J. Neukomm, Jaeda C. C. Coutinho-Budd, Heather T. T. Broihier
Summary: This study reveals divergent signaling requirements for dSARM in glial phagocytosis and axon degeneration. The results demonstrate that the NAD(+) hydrolase activity of dSARM is essential for both functions, while SAM domain-mediated multimerization is only important for axon degeneration. In addition, dSARM functions in a genetic pathway with MAP3K Ask1 during development.
Article
Plant Sciences
Tianli Tu, Shuangshuang Zheng, Panrong Ren, Xianwen Meng, Jiuhai Zhao, Qian Chen, Chuanyou Li
Summary: The research demonstrates that arsenate inhibits primary root elongation by regulating the transcription of local auxin biosynthesis genes in Arabidopsis root tips. Furthermore, arsenate activates cytokinin signaling and stabilizes ARR1 protein to promote the transcription of ASA1 and ASB1 genes.
Article
Biochemistry & Molecular Biology
Koki Watanabe, Daiki Asano, Hiroko Ushikubo, Akane Morita, Asami Mori, Kenji Sakamoto, Kunio Ishii, Tsutomu Nakahara
Summary: Metformin can protect against NMDA-induced retinal neurotoxicity by activating the AMPK and MEK/ERK signaling pathways in rats. This neuroprotective effect may be partially due to inhibitory effects on inflammatory responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Uriel N. Morzan, Gonzalo Diaz Miron, Luca Grisanti, Mariano C. Gonzalez Lebrero, Gabriele S. Kaminski Schierle, Ali Hassanali
Summary: Peptides associated with neurodegenerative diseases have been found to exhibit intrinsic visible fluorescence, even without aromatic residues. This has sparked interest from researchers and motivated the search for strategies to control the optical properties of new biophotonic materials.
JOURNAL OF PHYSICAL CHEMISTRY B
(2022)
Article
Pharmacology & Pharmacy
Maria Paraskevi Kotini, Maarja Andaloussi Mae, Heinz-Georg Belting, Christer Betsholtz, Markus Affolter
VASCULAR PHARMACOLOGY
(2019)
Article
Multidisciplinary Sciences
Zeynep Kabakci, Simon Kappeli, Claudio Cantu, Lasse D. Jensen, Christiane Konig, Janine Toggweiler, Christian Gentili, Giovanni Ribaudo, Giuseppe Zagotto, Konrad Basler, Lorenzo A. Pinna, Giorgio Cozza, Stefano Ferrari
SCIENTIFIC REPORTS
(2019)
Article
Cell Biology
Leila Shokri, Sachi Inukai, Antonina Hafner, Kathryn Weinand, Korneel Hens, Anastasia Vedenko, Stephen S. Gisselbrecht, Riccardo Dainese, Johannes Bischof, Edy Furger, Jean-Daniel Feuz, Konrad Basler, Bart Deplancke, Martha L. Bulyk
Article
Biology
Valerie S. Salazar, Luciane P. Capelo, Claudio Cantu, Dario Zimmerli, Nehal Gosalia, Steven Pregizer, Karen Cox, Satoshi Ohte, Marina Feigenson, Laura Gamer, Jeffry S. Nyman, David J. Carey, Aris Economides, Konrad Basler, Vicki Rosen
Article
Multidisciplinary Sciences
Luis Zurkirchen, Sandra Varum, Sonja Giger, Annika Klug, Jessica Hausel, Raphael Bossart, Martina Zemke, Claudio Cantu, Zeynep Kalender Atak, Nicola Zamboni, Konrad Basler, Lukas Sommer
NATURE COMMUNICATIONS
(2019)
Review
Developmental Biology
Gustavo Aguilar, M. Alessandra Vigano, Markus Affolter, Shinya Matsuda
WILEY INTERDISCIPLINARY REVIEWS-DEVELOPMENTAL BIOLOGY
(2019)
Article
Multidisciplinary Sciences
Fabien Cannac, Chao Qi, Julia Falschlunger, George Hausmann, Konrad Basler, Volodymyr M. Korkhov
Article
Biology
Antonio Galeone, Joshua M. Adams, Shinya Matsuda, Maximiliano F. Presa, Ashutosh Pandey, Seung Yeop Han, Yuriko Tachida, Hiroto Hirayama, Thomas Vaccari, Tadashi Suzuki, Cathleen M. Lutz, Markus Affolter, Aamir Zuberi, Hamed Jafar-Nejad
Article
Multidisciplinary Sciences
Yannick Mesrouze, Gustavo Aguilar, Fedir Bokhovchuk, Typhaine Martin, Clara Delaunay, Frederic Villard, Marco Meyerhofer, Catherine Zimmermann, Patrizia Fontana, Roman Wille, Thomas Vorherr, Dirk Erdmann, Pascal Furet, Clemens Scheufler, Tobias Schmelzle, Markus Affolter, Patrick Chene
SCIENTIFIC REPORTS
(2020)
Article
Cell Biology
Zhenguo Yang, Shuilong Wu, Federica Fontana, Yanyu Li, Wei Xiao, Zhangdai Gao, Alice Krudewig, Markus Affolter, Heinz-Georg Belting, Salim Abdelilah-Seyfried, Jingjing Zhang
Summary: The research reveals a non-canonical role of claudin-5 in zebrafish vasculogenesis, where it regulates adhesive forces between arterial endothelial cells, limiting cell motility and affecting lumen formation in the artery.
JOURNAL OF CELL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Michael David Bruegger, Tomas Valenta, Hassan Fazilaty, George Hausmann, Konrad Basler
Article
Chemistry, Medicinal
Maria P. Kotini, Felix Bachmann, Jochen Spickermann, Paul M. McSheehy, Markus Affolter
Summary: Derazantinib (DZB), an inhibitor of fibroblast growth factor receptors and vascular endothelial growth factor receptors, may have a potential dual role as an anti-angiogenic treatment. The study demonstrated in a zebrafish embryo model that DZB interferes with various angiogenic processes linked to FGF and VEGF signaling.
Article
Developmental Biology
M. Alessandra Vigano, Clara-Maria Ell, Manuela M. M. Kustermann, Gustavo Aguilar, Shinya Matsuda, Ning Zhao, Timothy J. Stasevich, Markus Affolter, George Pyrowolakis
Summary: Protein interactions play a crucial role in cellular development and function, and the development of specific protein binders has created a new toolbox for direct protein manipulation. Single short tags have been shown to efficiently bind and manipulate proteins of interest in living cells, opening up new possibilities for studying dynamic cellular processes.
Article
Biology
Erich Brunner, Ryohei Yagi, Marc Debrunner, Dezirae Beck-Schneider, Alexa Burger, Eliane Escher, Christian Mosimann, George Hausmann, Konrad Basler
LIFE SCIENCE ALLIANCE
(2019)
Review
Immunology
Gustavo Aguilar, Shinya Matsuda, M. Alessandra Vigano, Markus Affolter