Article
Fisheries
Ricardo Perez-Velasco, Marlenne Manzano-Sarabia, Miguel Angel Hurtado-Oliva
Summary: Salinity changes in the oceans due to climate change affect the biology and immune responses of oysters like C. corteziensis. High salinity stress conditions pose a greater challenge to the oysters compared to low salinity stress conditions, potentially increasing vulnerability to other environmental stressors and diseases.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Laura Pastor, Elisabeth Vera, Jose M. Marin, David Sanz-Rubio
Summary: Lung diseases are a common cause of death globally, with chronic airway inflammation and abnormal tissue repair playing a role in their pathogenesis. Extracellular vesicles play a key role in the development of LD, serving as potential therapeutic targets and biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Muhammad Waqas Sadiq, Olaf Holz, Birthe D. Ellinghusen, Cornelia Faulenbach, Meike Mueller, Philipp Badorrek, Ulf G. Eriksson, Markus Friden, Stina Stomilovic, Anders J. Lundqvist, Jens M. Hohlfeld
Summary: This study evaluated the lung pharmacokinetics of commonly prescribed drugs by sampling different lung compartments after inhalation and oral administration. The results showed that inhalation of salbutamol resulted in significantly higher lung concentrations compared to plasma, with salmeterol and fluticasone showing even higher concentration ratios. The study concluded that combining data from multiple individuals and techniques sampling different lung compartments enabled the generation of pharmacokinetic profiles for evaluating lung targeting after inhaled and oral drug delivery.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Review
Biology
Mariaenrica Tine, Davide Biondini, Marco Damin, Umberto Semenzato, Erica Bazzan, Graziella Turato
Summary: Lung cancer is the leading cause of cancer death worldwide, mainly due to delayed diagnosis in advanced stages. Recent advancements in targeted therapies and immunotherapies have emerged for specific genetic or immunological lung cancer patients. The identification and characterization of tumors rely on bioptic samples, but less invasive procedures are becoming more common. Extracellular vesicles (EV), released by various cells, have shown potential as diagnostic markers. This review summarizes the promising findings on lung-cancer-related EV, discussing their role as potential biomarkers and their impact on lung cancer pathogenesis.
Article
Immunology
Pernilla Darlington, Jonas Melin, Natalia Rivera, Johan Grunewald, Anders Eklund, Susanna Kullberg
Summary: Peripheral blood lymphopenia is associated with a more severe disease phenotype in sarcoidosis patients, and it is correlated with specific human leukocyte antigen (HLA) alleles. The decrease in lymphocytes may not be due to their migration to other organs but could be influenced by the presence of HLA-DRB1*07 allele.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2023)
Article
Infectious Diseases
S. Ruiz, D. Concordet, T. Lanot, B. Georges, P. Goudy, S. Baklouti, C. Mane, E. Losha, H. Vinour, D. Rousset, M. Lavit, V Minville, J-M Conil, P. Gandia
Summary: The study evaluated hydroxychloroquine concentrations in the lung epithelial lining fluid in critically ill COVID-19 patients. Results showed that lung exposure may be higher than plasma concentrations, indicating that low plasma concentrations should not lead to increased drug dosage.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Article
Microbiology
Jennifer M. Baker, Kevin J. Hinkle, Roderick A. McDonald, Christopher A. Brown, Nicole R. Falkowski, Gary B. Huffnagle, Robert P. Dickson
Summary: An ecological-based analytical approach can distinguish signal from noise in low-biomass microbiome studies, with whole lung tissue identified as the preferred specimen type for murine lung microbiome studies. It is crucial to consider potential source communities, including negative control specimens and contiguous biological sites, during sequencing, analysis, and reporting for biological interpretation of low-biomass microbiome studies.
Article
Microbiology
Antonio F. Caballero-Bermejo, Ignacio Darnaude-Ximenez, Myriam Aguilar-Perez, Alicia Gomez-Lopez, Aranzazu Sancho-Lopez, Cristina Lopez Garcia-Gallo, Gema Diaz Nuevo, Elena Diago-Sempere, Belen Ruiz-Antoran, Cristina Avendano-Sola, Piedad Ussetti-Gil
Summary: This study investigated the pharmacokinetics of Isavuconazole (ISA) in lung transplant recipients and found that ISA achieves adequate concentrations in the lung with a tolerable safety profile.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Tsutomu Ishihara, Ken-ichiro Tanaka, Ayaka Takafuji, Keita Miura, Tohru Mizushima
Summary: In this study, the researchers explored the potential use of benziodarone as a therapeutic agent against diseases caused by overproduction of reactive oxygen species (ROS). They screened a library of approved drugs and found that benziodarone reduced superoxide anions produced by leukemia cells without causing cytotoxicity. Further investigation revealed that benziodarone inhibited NADPH oxidases in the plasma membrane and showed preventive effects on murine lung injury caused by lipopolysaccharide (LPS), demonstrating its ROS-reducing activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Celia Maria Curieses Andres, Jose Manuel Perez de la Lastra, Celia Andres Juan, Francisco J. Plou, Eduardo Perez-Lebena
Summary: This article mainly discusses the dual role of superoxide anion and reactive oxygen species (ROS) at the physiological and pathological levels, as well as the involvement of superoxide anion in cell signaling, diseases, and cell death. It focuses on the generation pathways of superoxide anion, the oxidation mechanism of biomolecules, and the role of superoxide dismutase in living organisms. It also explores the toxicity of superoxide and derived radicals in the oxidative death of microbial pathogens, and how they are utilized by the innate immune system to lyse microorganisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Matt S. Zinter, A. Birgitta Versluys, Caroline A. Lindemans, Madeline Y. Mayday, Gustavo Reyes, Sara Sunshine, Marilynn Chan, Elizabeth K. Fiorino, Maria Cancio, Sabine Prevaes, Marina Sirota, Michael A. Matthay, Sandhya Kharbanda, Christopher C. Dvorak, Jaap J. Boelens, Joseph L. DeRisi
Summary: This study reveals the association between the metatranscriptomes of bronchoalveolar lavage (BAL) and pretransplant lung function in pediatric allogeneic hematopoietic cell transplantation (HCT). Abnormal pulmonary function and dysregulated microbial composition and gene expression in BAL are associated with post-HCT mortality. These findings highlight the potential importance of microbiome depletion and epithelial gene expression in the development of pre-HCT lung dysfunction.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
B. Hammer, C. Bal, M. Gysan, S. Zehetmayer, S. Geleff, A. Zech, M. Kramer, S. Ayazseven, M. Idzko, B. Mosleh, M. A. Hoda, D. Gompelmann
Summary: The proportion of PD-1+ T cells in bronchoalveolar lavage (BAL) differed among patients with lung cancer, asthma, and interstitial lung disease (ILD). PD-1+ CD4+ and PD-1+ CD8+ T cells in BAL samples from these patients were determined via flow cytometry and compared. The proportion of PD-1+ CD4+ and PD-1+ CD8+ T cells was highest in ILD patients, followed by lung cancer patients, and lowest in asthma patients. ILD patients showed a significantly different proportion of PD-1+ CD3+ CD4+ BAL cells compared to asthma patients. The proportion of PD-1+ CD4+ and PD-1+ CD8+ T cells in the BAL of lung cancer patients did not differ significantly from patients with benign lung diseases. Further research is needed to evaluate the role of the PD-1/PD-L1 pathway in ILD patients.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Stephanie Puukila, Mark D. Lawrence, Carmine G. De Pasquale, Andrew D. Bersten, Shailesh Bihari, James McEvoy-May, Ashley Nemec-Bakk, Dani-Louise Dixon
Summary: This study found that the number of M2 macrophages in the lungs of chronic heart failure (CHF) patients increased, which may be related to pulmonary fibrotic remodeling and increased severity of dyspnea.
Letter
Respiratory System
S. D. Pouwels, Janette K. Burgess, Erik Verschuuren, Dirk-Jan Slebos
Summary: The study assessed the cellular composition of lung lining fluid at different locations within the lung post-lung transplantation. Neutrophils and lymphocytes decrease in more distal regions, while macrophages increase. This information can help determine the best sampling technique and location for measuring specific factors and biomarkers in lung lining fluid.
RESPIRATORY RESEARCH
(2021)
Article
Pediatrics
Julie Renwick, Emma Reece, Jamie Walsh, Ross Walsh, Thara Persaud, Cathal O'Leary, Seamas C. Donnelly, Peter Greally
Summary: This study aimed to investigate signals of dysfunctional neutrophil responses in early life in CF patients and their association with lung damage in later childhood. Results showed that specific protein concentrations in early life were correlated with later lung damage scores, providing important clues for early prediction of disease progression.
FRONTIERS IN PEDIATRICS
(2021)
Article
Cardiac & Cardiovascular Systems
Timoteo Marchini, Dennis Wolf, Nathaly Anto Michel, Maximilian Mauler, Bianca Dufner, Natalie Hoppe, Jessica Beckert, Markus Jaeckel, Natalia Magnani, Daniel Duerschmied, Deborah Tasat, Silvia Alvarez, Jochen Reinoehl, Constantin von zur Muhlen, Marco Idzko, Christoph Bode, Ingo Hilgendorf, Pablo Evelson, Andreas Zirlik
BASIC RESEARCH IN CARDIOLOGY
(2016)
Article
Engineering, Biomedical
Deborah R. Tasat, Marcos E. Bruno, Mariela Domingo, Pablo Gurman, Orlando Auciello, Maria L. Paparella, Pablo Evelson, Maria B. Guglielmotti, Daniel G. Olmedo
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2017)
Article
Pathology
Deborah R. Tasat, Mariela G. Domingo, Marcos E. Bruno, Maria B. Guglielmotti, Daniel G. Olmedo
TOXICOLOGIC PATHOLOGY
(2017)
Article
Environmental Sciences
Agustina I. Tesone, Romina M. Lasagni Vitar, Julia Tau, Guillermo A. Maglione, Susana Llesuy, Deborah R. Tasat, Alejandro Berra
ENVIRONMENTAL RESEARCH
(2018)
Article
Environmental Sciences
Melisa L. Kurtz, Francisco Astort, Christian Lezon, Sebastian A. Ferraro, Guillermo A. Maglione, Nadia S. Orona, Silvia M. Friedman, Patricia M. Boyer, Deborah R. Tasat
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2018)
Article
Cardiac & Cardiovascular Systems
N. S. Orona, F. Astort, G. A. Maglione, J. S. Yakisich, D. R. Tasat
CARDIOVASCULAR TOXICOLOGY
(2019)
Article
Environmental Sciences
Guillermo A. Maglione, Melisa L. Kurtz, Nadia S. Orona, Francisco Astort, Ivan Tavera Busso, Patricia M. Mandalunis, Alejandro Berra, Deborah R. Tasat
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Sebastian Ariel Ferraro, Mariela Gisele Domingo, Analia Etcheverrito, Daniel Gustavo Olmedo, Deborah Ruth Tasat
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2020)
Article
Environmental Sciences
Nadia S. Orona, Francisco Astort, Guillermo A. Maglione, Sebastian A. Ferraro, Maximiliano Martin, Celina Morales, Patricia M. Mandalunis, Fernando Brites, Deborah R. Tasat
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2020)
Article
Environmental Sciences
Guillermo Alberto Maglione, Melisa Lidia Kurtz, Nadia Soledad Orona, Francisco Astort, Fernando Brites, Celina Morales, Alejandro Berra, Deborah Ruth Tasat
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2020)
Article
Environmental Sciences
Maria de los A. Gutierrez, Monica A. Palmieri, Daniela S. Giuliani, Jorge E. Colman Lerner, Guillermo Maglione, Dario Andrinolo, Deborah R. Tasat
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2020)
Article
Engineering, Biomedical
Mariela Gisele Domingo, Melisa Kurtz, Guillermo Maglione, Maximiliano Martin, Fernando Brites, Deborah Ruth Tasat, Daniel Gustavo Olmedo
Summary: This study evaluated the biological response of lung, liver, and kidneys to acute exposure to titanium dioxide. The results showed increased titanium concentration in the plasma and target organs after one month of exposure. Histopathological analysis revealed the presence of particles, but no structural changes were observed. Oxidative metabolism in the lung, liver, and kidneys showed alterations, with decreased antioxidant enzyme activity in the liver. Determination of serum biochemical markers and analysis of oxidative metabolism were not early bioindicators of tissue damage.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Orlando Auciello, Sandra Renou, Karam Kang, Deborah Tasat, Daniel Olmedo
Summary: The tissue response and biocompatibility of UNCD-coated titanium micro-implants were evaluated in a murine model. The histological evaluation showed good tissue integration and no inflammatory response. Although the osseointegration percentage was similar between the UNCD-coated and control groups, the tribological properties of UNCD make it a superior implant coating material.
Article
Biochemistry & Molecular Biology
Monica A. Palmieri, Deborah R. Tasat, Beatriz L. Molinari
CELLULAR AND MOLECULAR BIOLOGY
(2018)
Article
Multidisciplinary Sciences
Neyliane F. G. Dos Santos, Rafael F. Silva, Marcela M. P. L. Pinto, Edvane B. Da Silva, Deborah R. Tasat, Ademir Amaral
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2017)
Article
Fisheries
Ratiporn Thongsoi, Siriluk Maskaew, Panumas Puechpon, Benjaporn Noppradit, Napassawan Inaek, Prapaporn Utarabhand, Phanthipha Runsaeng
Summary: In this study, a PPAE gene called FmPPAE1 was cloned and analyzed in banana shrimp. FmPPAE1 plays a vital role in regulating the proPO system, exhibits antibacterial properties, and contributes to the suppression of bacterial proliferation.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Jishuang Tan, Paizelaiti Sahaer, Huan Li, Wei Han, Hongyan Sun
Summary: Circular RNAs (circRNA) are involved in gene expression and affect cellular processes such as transcription, splicing, and translation by interacting with microRNA and RNA binding proteins. A study identified circDNAJB6 as a circular RNA abundant in chicken macrophages after bacterial infection, and found that circDNAJB6 exacerbates cellular injury and interacts with multiple miRNAs and target genes, potentially impacting autophagy and MAPK signaling pathways.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Rodrigo Guabiraba, Damaris Ribeiro Rodrigues, Paul T. Manna, Melanie Chollot, Vincent Saint-Martin, Sascha Trapp, Marisa Oliveira, Clare E. Bryant, Brian J. Ferguson
Summary: The innate immune response relies on the ability of host cells to detect and respond to microbial nucleic acids. Toll-like receptors (TLRs) play a crucial role in this process by distinguishing self from non-self. This study focused on TLR21, an avian TLR that recognizes bacterial DNA motifs. The findings suggest that avian TLR21 shares similar activation mechanisms to mammalian TLR9, highlighting the conservation of nucleic acid sensing mechanisms across species.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Safieh Zeinali, Kate Sutton, Lonneke Vervelde
Summary: Chickens have a unique immune structure characterized by the absence of draining lymph nodes and the presence of well-developed mucosa-associated lymphoid tissue. The structure and development of chicken lymphoid tissues in the intestine, particularly Peyer's patches, have been poorly studied. However, the use of CSF1R-eGFP reporter transgenic chickens has allowed for the visualization and investigation of the development and distribution of these tissues. This research provides insights that could benefit mucosal vaccination strategies and the development of targeted vaccine delivery systems.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Retraction
Fisheries
G. -g. Li, Z. -z. Guo, X. -f. Ma, N. Cao, S. -n. Geng, Y. -q. Zheng, M. -j. Meng, H. -h. Lin, G. Han, G. -j. Du
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Jinyue Yang, Peng Zhou, Wanrong Wu, Qingxiang Zhang, Dong Chen, Rui Luo
Summary: This study cloned and characterized the full-length sequence of duck MRE11 (duMRE11) for the first time, and found that this protein plays an important role in the innate immune response of ducks.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Mengjiao Guo, Jiaqi Zhang, Mingtao Li, Xiaorong Zhang, Yantao Wu
Summary: rNLRC3 negatively regulates the NF -KB signaling pathway induced by P. multocida in rabbits by inhibiting the activation of NF -KB, reducing the expression of inflammatory cytokines, and interacting with rTRAF4 and rTRAF6. The NACHT-LRR domain is the functional domain of rNLRC3. These findings provide insights into the important role of rNLRC3 in combating P. multocida infection.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Yinan Li, Xingye Lian, Wenwen Yang, Jinyuan Leng, Jiejie Sun, Yu Liu, Siqi Fan, Lingling Wang, Linsheng Song
Summary: The DM9-containing protein CgDM9CP-7 plays an important role in the innate immune response of molluscs. It is constitutively expressed in various tissues and is up-regulated in haemocytes after stimulation by Vibrio splendidus and lipopolysaccharide (LPS). CgDM9CP-7 binds to various pathogens and exhibits antimicrobial activity, while also regulating the expression of CgMyD88 and CgIL-17.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Xiuwen Bao, Haoran Song, Liying He, Yong Li, Shuqi Niu, Jinlin Guo
Summary: This study focuses on the interaction between Hepialus xiaojinensis larvae and Ophiocordyceps sinensis during the infection process. The results show that the infected third instar larvae enhance antioxidant defense ability, while the infected fourth instar larvae reduce this ability and allocate more energy to growth and development.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)