piRNAs and PIWI proteins: regulators of gene expression in development and stem cells

Identification of piRNA Binding Sites Reveals the Argonaute Regulatory Landscape of the C. elegans Germline

(2018) En-Zhi Shen et al.   CELL

A Sex Chromosome piRNA Promotes Robust Dosage Compensation and Sex Determination in C. elegans

(2018) Wen Tang et al.   DEVELOPMENTAL CELL

A Neuronal piRNA Pathway Inhibits Axon Regeneration in C. elegans

(2018) Kyung Won Kim et al.   NEURON

The piRNA targeting rules and the resistance to piRNA silencing in endogenous genes

(2018) Donglei Zhang et al.   SCIENCE

PIWI family emerging as a decisive factor of cell fate: An overview

(2017) Murugavel Ponnusamy et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Expression of Piwi protein MIWI2 defines a distinct population of multiciliated cells

(2017) Gregory A. Wasserman et al.   JOURNAL OF CLINICAL INVESTIGATION

piRNA-mediated regulation of transposon alternative splicing in the soma and germ line

(2017) Felipe Karam Teixeira et al.   NATURE

Characterization of the piRNA pathway during development of the sea anemone Nematostella vectensis

(2017) Daniela Praher et al.   RNA Biology

Translational repression of the Drosophila nanos mRNA involves the RNA helicase Belle and RNA coating by Me31B and Trailer hitch

(2017) Michael Götze et al.   RNA

piRNA Biogenesis in Drosophila melanogaster

(2017) Xiawei Huang et al.   TRENDS IN GENETICS

piRNAs and Aubergine cooperate with Wispy poly(A) polymerase to stabilize mRNAs in the germ plasm

(2017) Jérémy Dufourt et al.   Nature Communications

The emergence of piRNAs against transposon invasion to preserve mammalian genome integrity

(2017) Christina Ernst et al.   Nature Communications

Piwi Is Required to Limit Exhaustion of Aging Somatic Stem Cells

(2017) Pedro Sousa-Victor et al.   Cell Reports

Pan-arthropod analysis reveals somatic piRNAs as an ancestral defence against transposable elements

(2017) Samuel H. Lewis et al.   Nature Ecology & Evolution

Inheritance of a Nuclear PIWI from Pluripotent Stem Cells by Somatic Descendants Ensures Differentiation by Silencing Transposons in Planarian

(2016) Norito Shibata et al.   DEVELOPMENTAL CELL

Oncogenic transformation ofDrosophilasomatic cells induces a functional piRNA pathway

(2016) Delphine Fagegaltier et al.   GENES & DEVELOPMENT

Sequence-dependent but not sequence-specific piRNA adhesion traps mRNAs to the germ plasm

(2016) Anastassios Vourekas et al.   NATURE

Piwi maintains germline stem cells and oogenesis in Drosophila through negative regulation of Polycomb group proteins

(2016) Jamy C Peng et al.   NATURE GENETICS

Transcriptomic Variation during Spermiogenesis in Mouse Germ Cells

(2016) Haiyang Zuo et al.   PLoS One

XenopusPiwi proteins interact with a broad proportion of the oocyte transcriptome

(2016) James A. Toombs et al.   RNA

A somatic piRNA pathway in the Drosophila fat body ensures metabolic homeostasis and normal lifespan

(2016) Brian C. Jones et al.   Nature Communications

Specific patterns of PIWI-interacting small noncoding RNA expression in dysplastic liver nodules and hepatocellular carcinoma

(2016) Francesca Rizzo et al.   Oncotarget

c-Fos Repression by Piwi Regulates Drosophila Ovarian Germline Formation and Tissue Morphogenesis

(2016) Jonathon D. Klein et al.   PLoS Genetics

Transposon Dysregulation Modulates dWnt4 Signaling to Control Germline Stem Cell Differentiation in Drosophila

(2016) Maitreyi Upadhyay et al.   PLoS Genetics

In vivo mapping of a dynamic ribonucleoprotein granule interactome in early Drosophila embryos

(2016) Jimiao Zheng et al.   FEBS Open Bio

MIWI and piRNA-mediated cleavage of messenger RNAs in mouse testes

(2015) Peng Zhang et al.   CELL RESEARCH

piRNAs and piRNA-Dependent siRNAs Protect Conserved and Essential C. elegans Genes from Misrouting into the RNAi Pathway

(2015) Carolyn M. Phillips et al.   DEVELOPMENTAL CELL

piRNA-directed cleavage of meiotic transcripts regulates spermatogenesis

(2015) Wee Siong Sho Goh et al.   GENES & DEVELOPMENT

Independent and coordinate trafficking of single Drosophila germ plasm mRNAs

(2015) Shawn C. Little et al.   NATURE CELL BIOLOGY

piRNA-guided slicing specifies transcripts for Zucchini-dependent, phased piRNA biogenesis

(2015) F. Mohn et al.   SCIENCE

piRNA-guided transposon cleavage initiates Zucchini-dependent, phased piRNA production

(2015) B. W. Han et al.   SCIENCE

Piwi Is a Key Regulator of Both Somatic and Germline Stem Cells in the Drosophila Testis

(2015) Jacob Gonzalez et al.   Cell Reports

Aubergine iCLIP Reveals piRNA-Dependent Decay of mRNAs Involved in Germ Cell Development in the Early Embryo

(2015) Bridlin Barckmann et al.   Cell Reports

Discovery and Characterization of piRNAs in the Human Fetal Ovary

(2015) Zev Williams et al.   Cell Reports

Distinct mechanisms underlie oral vs aboral regeneration in the cnidarian Hydractinia echinata

(2015) Brian Bradshaw et al.   eLife

piRNAs from Pig Testis Provide Evidence for a Conserved Role of the Piwi Pathway in Post-Transcriptional Gene Regulation in Mammals

(2015) Daniel Gebert et al.   PLoS One

Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis

(2014) Lan-Tao Gou et al.   CELL RESEARCH

PIWI homologs mediate Histone H4 mRNA localization to planarian chromatoid bodies

(2014) L. Rouhana et al.   DEVELOPMENT

Reduced pachytene piRNAs and translation underlie spermiogenic arrest in Maelstrom mutant mice

(2014) J. Castaneda et al.   EMBO JOURNAL

PRDE-1 is a nuclear factor essential for the biogenesis of Ruby motif-dependent piRNAs in C. elegans

(2014) E.-M. Weick et al.   GENES & DEVELOPMENT

Retrotransposons and pseudogenes regulate mRNAs and lncRNAs via the piRNA pathway in the germline

(2014) Toshiaki Watanabe et al.   GENOME RESEARCH

Timed regulation of P-element-induced wimpy testis-interacting RNA expression during rat liver regeneration

(2014) Francesca Rizzo et al.   HEPATOLOGY

A single female-specific piRNA is the primary determiner of sex in the silkworm

(2014) Takashi Kiuchi et al.   NATURE

PIWI proteins and PIWI-interacting RNAs in the soma

(2014) Robert J. Ross et al.   NATURE

Global effects of the CSR-1 RNA interference pathway on the transcriptional landscape

(2014) Germano Cecere et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Piwi Is Required in Multiple Cell Types to Control Germline Stem Cell Lineage Development in the Drosophila Ovary

(2014) Xing Ma et al.   PLoS One

Small RNA profiling and characterization of piRNA clusters in the adult testes of the common marmoset, a model primate

(2014) Takamasa Hirano et al.   RNA

An atlas of chromatoid body components

(2014) O. Meikar et al.   RNA

Drosophila piwi Mutants Exhibit Germline Stem Cell Tumors that Are Sustained by Elevated Dpp Signaling

(2013) Zhigang Jin et al.   CURRENT BIOLOGY

Analysis of Hydra PIWI proteins and piRNAs uncover early evolutionary origins of the piRNA pathway

(2013) Robyn S.M. Lim et al.   DEVELOPMENTAL BIOLOGY

The C. elegans CSR-1 Argonaute Pathway Counteracts Epigenetic Silencing to Promote Germline Gene Expression

(2013) Meetu Seth et al.   DEVELOPMENTAL CELL

Protection of Germline Gene Expression by the C. elegans Argonaute CSR-1

(2013) Christopher J. Wedeles et al.   DEVELOPMENTAL CELL

piRNA-Triggered MIWI Ubiquitination and Removal by APC/C in Late Spermatogenesis

(2013) Shuang Zhao et al.   DEVELOPMENTAL CELL

An Ancient Transcription Factor Initiates the Burst of piRNA Production during Early Meiosis in Mouse Testes

(2013) Xin Zhiguo Li et al.   MOLECULAR CELL

The Genetic Makeup of the Drosophila piRNA Pathway

(2013) Dominik Handler et al.   MOLECULAR CELL

A Transcriptome-wide RNAi Screen in the Drosophila Ovary Reveals Factors of the Germline piRNA Pathway

(2013) Benjamin Czech et al.   MOLECULAR CELL

Spatio-temporal requirements for transposable element piRNA-mediated silencing during Drosophila oogenesis

(2013) Jérémy Dufourt et al.   NUCLEIC ACIDS RESEARCH

Piwi Genes Are Dispensable for Normal Hematopoiesis in Mice

(2013) Mona J. Nolde et al.   PLoS One

Deficiency of MIWI2 (Piwil4) Induces Mouse Erythroleukemia Cell Differentiation, but Has No Effect on Hematopoiesis In Vivo

(2013) James E. Jacobs et al.   PLoS One

PIWI proteins and PIWI-interacting RNAs function in Hydra somatic stem cells

(2013) C. E. Juliano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transposition-Driven Genomic Heterogeneity in the Drosophila Brain

(2013) P. N. Perrat et al.   SCIENCE

C. elegans piRNAs Mediate the Genome-wide Surveillance of Germline Transcripts

(2012) Heng-Chi Lee et al.   CELL

A Role for Neuronal piRNAs in the Epigenetic Control of Memory-Related Synaptic Plasticity

(2012) Priyamvada Rajasethupathy et al.   CELL

piRNAs Can Trigger a Multigenerational Epigenetic Memory in the Germline of C. elegans

(2012) Alyson Ashe et al.   CELL

piRNAs Initiate an Epigenetic Memory of Nonself RNA in the C. elegans Germline

(2012) Masaki Shirayama et al.   CELL

piRNA biogenesis during adult spermatogenesis in mice is independent of the ping-pong mechanism

(2012) Ergin Beyret et al.   CELL RESEARCH

Repeated, Long-Term Cycling of Putative Stem Cells between Niches in a Basal Chordate

(2012) Yuval Rinkevich et al.   DEVELOPMENTAL CELL

Small RNA pathways in Schmidtea mediterranea

(2012) Alissa M. Resch et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Mili and Miwi target RNA repertoire reveals piRNA biogenesis and function of Miwi in spermiogenesis

(2012) Anastassios Vourekas et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Deep sequencing reveals unique small RNA repertoire that is regulated during head regeneration in Hydra magnipapillata

(2012) Srikar Krishna et al.   NUCLEIC ACIDS RESEARCH

Function, Targets, and Evolution of Caenorhabditis elegans piRNAs

(2012) M. P. Bagijn et al.   SCIENCE

The history and enduring contributions of planarians to the study of animal regeneration

(2012) Sarah A. Elliott et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Uniting Germline and Stem Cells: The Function of Piwi Proteins and the piRNA Pathway in Diverse Organisms

(2011) Celina Juliano et al.   Annual Review of Genetics

piRNA Production Requires Heterochromatin Formation in Drosophila

(2011) Prashanth Rangan et al.   CURRENT BIOLOGY

A late phase of germ plasm accumulation during Drosophila oogenesis requires Lost and Rumpelstiltskin

(2011) Kristina S. Sinsimer et al.   DEVELOPMENT

PAPI, a novel TUDOR-domain protein, complexes with AGO3, ME31B and TRAL in the nuage to silence transposition

(2011) L. Liu et al.   DEVELOPMENT

The endonuclease activity of Mili fuels piRNA amplification that silences LINE1 elements

(2011) Serena De Fazio et al.   NATURE

Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing

(2011) Michael Reuter et al.   NATURE

Widespread expression of piRNA-like molecules in somatic tissues

(2011) Zheng Yan et al.   NUCLEIC ACIDS RESEARCH

Separation of stem cell maintenance and transposon silencing functions of Piwi protein

(2011) M. S. Klenov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of piRNAs in the central nervous system

(2011) E. J. Lee et al.   RNA

Piwi positive cells that line the vasculature epithelium, underlie whole body regeneration in a basal chordate

(2010) Yuval Rinkevich et al.   DEVELOPMENTAL BIOLOGY

Aubergine is a component of a nanos mRNA localization complex

(2010) Agata N. Becalska et al.   DEVELOPMENTAL BIOLOGY

Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo

(2010) Christel Rouget et al.   NATURE

Transposable element insertions have strongly affected human evolution

(2010) R. J. Britten   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biogenesis pathways of piRNAs loaded onto AGO3 in the Drosophila testis

(2010) A. Nagao et al.   RNA

Ectopic Expression of Germline Genes Drives Malignant Brain Tumor Growth in Drosophila

(2010) A. Janic et al.   SCIENCE

Collapse of Germline piRNAs in the Absence of Argonaute3 Reveals Somatic piRNAs in Flies

(2009) Chengjian Li et al.   CELL

mRNA Localization: Gene Expression in the Spatial Dimension

(2009) Kelsey C. Martin et al.   CELL

A Broadly Conserved Pathway Generates 3′UTR-Directed Primary piRNAs

(2009) Nicolas Robine et al.   CURRENT BIOLOGY

Transposable elements in gene regulation and in the evolution of vertebrate genomes

(2009) Guillaume Bourque   CURRENT OPINION IN GENETICS & DEVELOPMENT

The TDRD9-MIWI2 Complex Is Essential for piRNA-Mediated Retrotransposon Silencing in the Mouse Male Germline

(2009) Masanobu Shoji et al.   DEVELOPMENTAL CELL

A regulatory circuit for piwi by the large Maf gene traffic jam in Drosophila

(2009) Kuniaki Saito et al.   NATURE

Peculiarities of piRNA-mediated post-transcriptional silencing of Stellate repeats in testes of Drosophila melanogaster

(2009) Roman N. Kotelnikov et al.   NUCLEIC ACIDS RESEARCH

PAP- and GLD-2-type poly(A) polymerases are required sequentially in cytoplasmic polyadenylation and oogenesis in Drosophila

(2008) P. Benoit et al.   DEVELOPMENT

MILI, a PIWI-interacting RNA-binding Protein, Is Required for Germ Line Stem Cell Self-renewal and Appears to Positively Regulate Translation

(2008) Yingdee Unhavaithaya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Isolation of new polar granule components in Drosophila reveals P body and ER associated proteins

(2008) Travis Thomson et al.   MECHANISMS OF DEVELOPMENT

Transposable elements and the evolution of regulatory networks

(2008) Cédric Feschotte   NATURE REVIEWS GENETICS

The PIWI proteins SMEDWI-2 and SMEDWI-3 are required for stem cell function and piRNA expression in planarians

(2008) D. Palakodeti et al.   RNA