Article
Biochemistry & Molecular Biology
Vlad Tocan, Junya Hayase, Sachiko Kamakura, Akira Kohda, Shouichi Ohga, Motoyuki Kohjima, Hideki Sumimoto
Summary: The tight junction protein Par3 coordinates with the small GTPase Cdc42 to target atypical protein kinase C (aPKC) for hepatocyte polarization, apical membrane development, and regulation of the lateral maintainer Lgl, essential for establishing polarity and lumen formation in liver cells.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Developmental Biology
Juan Lu, Wei Dong, Yan Tao, Yang Hong
Summary: Dig, an essential polarity protein and tumor suppressor, contains a positively charged polybasic domain that binds to phosphoinositides on the plasma membrane, contributing significantly to its localization and function in polarity and tumorigenesis. This electrostatic targeting of Dig is controlled by potential phosphorylation-dependent regulation and interactions with other polarity proteins, highlighting the importance of electrostatic PM targeting in regulating cell polarity.
Article
Biochemistry & Molecular Biology
Mariana Osswald, Andre Barros-Carvalho, Ana M. Carmo, Nicolas Loyer, Patricia C. Gracio, Claudio E. Sunkel, Catarina C. F. Homem, Jens Januschke, Eurico Morais-de-Sa
Summary: Research reveals that aPKC protein in Drosophila plays a crucial role in maintaining epithelial structure, and its dysregulation leads to the formation of epithelial gaps, which are caused by increased epithelial constriction rather than the loss of apical-basal polarity. By manipulating constriction, the incidence of epithelial gaps can be modulated. The study also traces the origin of large epithelial gaps to tissue rupture next to dividing cells. Excessive tissue stress can break the epithelial barrier during proliferation.
Review
Neurosciences
Lili Zhang, Xiangyun Wei
Summary: This review article summarizes the importance of Par3, Par6, and aPKC in cell polarization and their diverse functions in various neurodevelopmental processes, as well as their involvement in neuropsychiatric and neurodegenerative disorders. The versatile functions of Par complexes rely on their fundamental roles in cell polarity in different cellular contexts. The review also discusses the correlation between cell polarization and subcellular polarization in neurons.
JOURNAL OF NEUROSCIENCE
(2022)
Editorial Material
Biochemistry & Molecular Biology
Chris T. Ho, Stephanie L. Gupton
Summary: The shape of a neuron undergoes significant changes in development. A recent study reveals the existence of a novel septin cytoskeleton network that plays a critical role in establishing proper neuronal morphology.
Article
Dermatology
Mika Watanabe, Hideyuki Kosumi, Shin-Ichi Osada, Shota Takashima, Yunan Wang, Wataru Nishie, Tsukasa Oikawa, Tomonori Hirose, Hiroshi Shimizu, Ken Natsuga
Summary: COL17 is crucial for maintaining epidermal cell polarity, as its deficiency can lead to asymmetric cell division and affect the health of epidermal cells.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Developmental Biology
Teresa Bonello, Mario Aguilar-Aragon, Alexander Tournier, Barry J. Thompson, Joseph P. Campanale
Summary: Adherens junctions play a crucial role in maintaining apical-basal polarization in epithelial cells by providing a diffusion barrier that restricts the spread of polarity determinants along the membrane for precise domain size control. Movement of adherens junctions in response to mechanical forces enables spontaneous adjustment of apical versus basolateral domain size as an emergent property of the polarising system.
CELLS & DEVELOPMENT
(2021)
Article
Biology
Yoshiaki Miyake, Masanori Obana, Ayaha Yamamoto, Shunsuke Noda, Koki Tanaka, Hibiki Sakai, Narihito Tatsumoto, Chihiro Makino, Soshi Kanemoto, Go Shioi, Shota Tanaka, Makiko Maeda, Yoshiaki Okada, Kazunori Imaizumi, Katsuhiko Asanuma, Yasushi Fujio
Summary: Upregulation of OASIS in podocytes contributes to podocyte and/or tubular injury through decreased PRKCi expression and is a critical event for the disturbance of kidney homeostasis.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Le T. M. Le, Srdja Drakulic, Jens R. Nyengaard, Monika M. Golas, Bjoern Sander
Summary: The tripartite partition defect (PAR) polarity complex is a major regulator of cellular polarity, consisting of PAR3, atypical protein kinase C (aPKC), and PAR6 proteins. This study characterized PAR3 and the aPKC-PAR6 complex using single-particle electron microscopy (EM), providing a basis for further high-resolution studies of PAR proteins and complex formation.
MOLECULAR BIOTECHNOLOGY
(2022)
Article
Cell Biology
Shinuo Weng, Robert J. Huebner, John B. Wallingford
Summary: Convergent extension is an evolutionarily conserved cell movement that elongates organ systems. Studies have shown that cell crawling and junction contraction are two distinct cellular mechanisms, and integrating these two modes via mechano-reciprocity can enhance the effectiveness of CE.
Article
Neurosciences
Shigeru Tanaka, Naoto Shimada, Hiroko Shiraki, Tatsuhiro Miyagi, Kana Harada, Izumi Hide, Norio Sakai
Summary: During neuronal development, GPR3 plays a crucial role in neurite outgrowth and neuronal differentiation by mediating multiple signaling pathways including PKA, ERKs, and PI3K. Additionally, GPR3 activation accelerates polarity formation by influencing downstream signaling pathways such as Akt and GRK2, ultimately promoting neurite outgrowth and polarity establishment in differentiated neurons.
MOLECULAR AND CELLULAR NEUROSCIENCE
(2022)
Article
Biology
Kenji Matsuzawa, Hayato Ohga, Kenta Shigetomi, Tomohiro Shiiya, Masanori Hirashima, Junichi Ikenouchi
Summary: The study demonstrates that MAGI proteins regulate apical constriction of epithelial cells by modulating the distribution of Par polarity proteins, thereby maintaining steady state intercellular tension throughout the epithelial cell sheet.
COMMUNICATIONS BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Tirtha Das Banerjee, Suriya Narayanan Murugesan, Heidi Connahs, Antonia Monteiro
Summary: In this study, the localization and function of Armadillo/beta-catenin dependent and independent Wnt signaling in eyespot and band development in Bicyclus anynana were explored. Armadillo (Arm) protein localization, expression analysis of all eight Wnt ligand and four frizzled receptor transcripts, and CRISPR-Cas9 experiments were used to investigate the role of specific ligands and receptors. The results reveal the essential role of distinct Wnt signaling pathways in eyespot and band patterning in butterflies, suggesting their interaction to control active domains.
Article
Neurosciences
Fereshteh Khodaei, S. H. Sadati, Mahyar Doost, Reza Lashgari
Summary: This study investigates the distribution of local field potentials (LFPs) and current source density (CSD) in the primary visual cortex (V1) by presenting different stimulus properties in the visual field area of Macaque monkeys, and reveals the crucial role of stimulus properties in determining the flow.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Carlos Wilson, Alfredo Caceres
Summary: This article reviews the role of epigenetic mechanisms in regulating axonal specificity, growth, and guidance, as well as the importance of splicing in axonal growth. Exploring the connection between epigenetics and axonal growth raises new questions and perspectives for understanding the development of axons in physiological and pathological contexts.
Editorial Material
Multidisciplinary Sciences
Andrew Bradbury, Andreas Plueckthun
Article
Biology
Raphael Thuret, Helene Auger, Nancy Papalopulu
Article
Developmental Biology
Tulay Gulsen, Irene Hadjicosti, Yueshi Li, Xinyun Zhang, Paul R. Whitley, Andrew D. Chalmers
DEVELOPMENTAL BIOLOGY
(2016)
Article
Biology
Nick E. Phillips, Cerys S. Manning, Tom Pettini, Veronica Biga, Elli Marinopoulou, Peter Stanley, James Boyd, James Bagnall, Pawel Paszek, David G. Spiller, Michael R. H. White, Marc Goodfellow, Tobias Galla, Magnus Rattray, Nancy Papalopulu
Article
Multidisciplinary Sciences
Lena D'Hooghe, Andrew D. Chalmers, Sam Heywood, Paul Whitley
Article
Endocrinology & Metabolism
Benjamin Sharpe, Dhafer A. Alghezi, Claire Cattermole, Mark Beresford, Rebecca Bowen, John Mitchard, Andrew D. Chalmers
Article
Biochemical Research Methods
Nick E. Phillips, Cerys Manning, Nancy Papalopulu, Magnus Rattray
PLOS COMPUTATIONAL BIOLOGY
(2017)
Article
Developmental Biology
Eamon Dubaissi, Karine Rousseau, Robert Lea, Ximena Soto, Siddarth Nardeosingh, Axel Schweickert, Enrique Amaya, David J. Thornton, Nancy Papalopulu
Article
Cell Biology
Laura A. Jones, Cecile Villemant, Toby Starborg, Anna Salter, Georgina Goddard, Peter Ruane, Philip G. Woodman, Nancy Papalopulu, Sarah Woolner, Victoria J. Allan
JOURNAL OF CELL BIOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Hua Tian, John S. Fletcher, Raphael Thuret, Alex Henderson, Nancy Papalopulu, John C. Vickerman, Nicholas P. Lockyer
JOURNAL OF LIPID RESEARCH
(2014)
Correction
Multidisciplinary Sciences
Gail Doughton, Jun Wei, Nicolas Tapon, Melanie J. Welham, Andrew D. Chalmers
Article
Multidisciplinary Sciences
Cerys S. Manning, Veronica Biga, James Boyd, Jochen Kursawe, Bodvar Ymisson, David G. Spiller, Christopher M. Sanderson, Tobias Galla, Magnus Rattray, Nancy Papalopulu
NATURE COMMUNICATIONS
(2019)
Article
Biochemistry & Molecular Biology
Ximena Soto, Veronica Biga, Jochen Kursawe, Robert Lea, Parnian Doostdar, Riba Thomas, Nancy Papalopulu
Article
Multidisciplinary Sciences
Thomas G. Minchington, Sam Griffiths-Jones, Nancy Papalopulu
SCIENTIFIC REPORTS
(2020)
Article
Biochemical Research Methods
Luisa Cutillo, Alexis Boukouvalas, Elli Marinopoulou, Nancy Papalopulu, Magnus Rattray
BMC BIOINFORMATICS
(2020)