Article
Engineering, Environmental
Dapeng Wang, Wenli Ruan, Lili Fan, Huifen Xu, Qian Song, Heng Diao, Rui He, Ying Jin, Aihua Zhang
Summary: This study investigates the effect of arsenite exposure on HSCs activation and ECM deposition, and reveals that inactivation of Mig-6 function through hypermethylation of its promoter region leads to hyperphosphorylation of EGFR/ERK signaling, thus mediating arsenite-induced HSCs activation.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Multidisciplinary Sciences
Jung-Yoon Yoo, Tae Hoon Kim, Jung-Ho Shin, Ryan M. Marquardt, Ulrich Muller, Asgerally T. Fazleabas, Steven L. Young, Bruce A. Lessey, Ho-Geun Yoon, Jae-Wook Jeong
Summary: Progesterone-induced MIG-6 reduction in the endometrium is associated with endometriosis-related infertility, and Erbb2 is identified as the key mediator of Mig-6 loss in this context.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Yuki Katayama, Tadaaki Yamada, Keiko Tanimura, Shinsaku Tokuda, Kenji Morimoto, Soichi Hirai, Yohei Matsui, Ryota Nakamura, Masaki Ishida, Hayato Kawachi, Kazue Yoneda, Kazutaka Hosoya, Takahiro Tsuji, Hiroaki Ozasa, Akihiro Yoshimura, Masahiro Iwasaku, Young Hak Kim, Mano Horinaka, Toshiyuki Sakai, Takahiro Utsumi, Shinsuke Shiotsu, Takayuki Takeda, Ryohei Katayama, Koichi Takayama
Summary: In this study, it was found that epidermal growth factor receptor (EGFR) signaling is involved in adaptive resistance to lorlatinib in ALK-rearranged NSCLC. EGFR inhibition enhanced ALK inhibition-induced apoptosis and halted the proliferation of ALK-rearranged lung cancer cells. Combination therapy with EGFR inhibitor and lorlatinib significantly suppressed tumor regrowth after cessation of treatment. This study provides new insights into tumor evolution and the development of combined therapeutic strategies for ALK-rearranged lung cancer.
NPJ PRECISION ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jin-Soo Park, RyeonJin Cho, Eun-Young Kang, Yeon-Mok Oh
Summary: Research suggests that the protein Slit2 may be beneficial in treating emphysema by promoting regeneration of lung cells. Studies in mice show that Slit2 can increase cell proliferation and migration, leading to alveolar regeneration in a mouse model of emphysema. This signaling pathway could potentially be a target for developing new treatments for emphysema.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Review
Cell Biology
Colin E. Evans
Summary: Inflammatory lung injury is characterized by cell death, leukocyte infiltration, and disruption of nutrient and oxygen transport. Pulmonary hypoxia is a characteristic feature of inflammatory lung conditions. Hypoxia-inducible transcription factors HIF-1 and HIF-2 control the vascular response to hypoxia. HIF signaling regulates inflammatory lung injury and repair in different cell types.
Article
Cell Biology
Xiaochen Li, Xiaopei Cao, Hanqiu Zhao, Mingzhou Guo, Xiaoyu Fang, Ke Li, Lu Qin, Yuanzhou He, Xiansheng Liu
Summary: Hypoxia activates the Notch4-ERK/JNK/P38 MAPK signaling pathway to promote the proliferation, migration, and anti-apoptotic effects of LUAD cells. Notch4 plays a key role in the growth and metastasis of LUAD. Inhibitors of ERK, JNK, and P38 can partially reverse the effects of Notch4.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, General & Internal
Po-Li Wei, Jang-Chun Lin, Chin-Sheng Hung, Precious Takondwa Makondi, Uyanga Batzorig, Tung-Cheng Chang, Chien-Yu Huang, Yu-Jia Chang
Summary: HD6 plays a tumor-suppressive role in colorectal cancer by regulating cell proliferation, migration, invasion, and cell cycle progression through the modulation of cyclins, CDKs, serpine-1, and EGFR signaling pathways.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Sara Fukushima, Hiroki Nishi, Mikako Kumano, Daisuke Yamanaka, Naoyuki Kataoka, Fumihiko Hakuno, Shin-Ichiro Takahashi
Summary: Amino acids act as metabolic regulatory signals, directly controlling G6Pase mRNA levels through transcriptional regulation independent of hormone signaling pathways. Amino acid starvation affects the urea cycle, while supplementation of ornithine can fully rescue G6Pase mRNA transcription.
Article
Biochemistry & Molecular Biology
Dongming Lv, Shirong Ding, Li Zhong, Jian Tu, Hongbo Li, Hao Yao, Yutong Zou, Ziliang Zeng, Yan Liao, Xuesi Wan, Lili Wen, Xianbiao Xie
Summary: This study discovered that FTO may serve as a novel therapeutic target for osteosarcoma by promoting tumor growth and metastasis through reducing DACT1 expression and activating the Wnt signaling pathway. The research on the drug entacapone confirmed that the m(6)A-mediated FTO/DACT1 axis could be targeted for osteosarcoma treatment.
Article
Surgery
David S. Wheeler, Keizo Misumi, Natalie M. Walker, Ragini Vittal, Michael P. Combs, Yoshiro Aoki, Russell R. Braeuer, Vibha N. Lama
Summary: Histopathologic examination of lungs afflicted by chronic lung allograft dysfunction consistently shows both mononuclear cell inflammation and mesenchymal cell fibroproliferation, with interleukin 6 (IL-6) potentially playing a critical role in mediating the communication between these cells and contributing to the pathogenesis of CLAD.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Oncology
Li-Hsin Cheng, Chung-Chi Hsu, Hung-Wen Tsai, Wen-Ying Liao, Pei-Ming Yang, Tai-Yan Liao, Hsiao-Yen Hsieh, Tze-Sian Chan, Kelvin K. Tsai
Summary: Small cell lung cancer (SCLC) is a highly aggressive and deadly tumor. The upregulation of neurogenesis-associated protein ASPM-I1 is found in SCLC cells and is associated with poor patient prognosis. ASPM-I1 plays a crucial role in maintaining SCLC stemness and tumorigenesis through the regulation of multiple pathways and the Wnt signaling pathway.
Article
Plant Sciences
Yu-Hsuan Cheng, Mickael Durand, Virginie Brehaut, Fu-Chiun Hsu, Zsolt Kelemen, Yves Texier, Anne Krapp, Yi-Fang Tsay
Summary: NLP6 and NLP7 act as activators in nitrate signaling and repressors under ammonium conditions to regulate different genes. Nuclear localization and nucleocytosolic shuttling of NLP6 and NLP7 are independent of each other. NLP6 and NLP7 play a more dominant role in the response to high nitrate.
Article
Mathematical & Computational Biology
Soutick Saha, Hye-ran Moon, Bumsoo Han, Andrew Mugler
Summary: Cell signaling networks are complex and difficult to characterize completely. Mathematical modeling provides clues, but extracting falsifiable predictions is challenging. This study uses an inverse approach, focusing on deducing minimal signaling networks from experimental data to explain antagonistic responses.
NPJ SYSTEMS BIOLOGY AND APPLICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Akihisa Kato, Serina Ng, Amalraj Thangasamy, Haiyong Han, Wendi Zhou, Stephane Raeppel, Michael Fallon, Sushovan Guha, Sudhakar Ammanamanchi
Summary: High expression of the RON tyrosine kinase receptor has been identified as a predictor of poor prognosis in pancreatic cancer. RON directly regulates HIF-1 alpha, a key driver of genes involved in cancer cell invasion and metastasis. Inhibition of RON could be a potential novel therapeutic target for cancers, including triple-negative breast cancer.
MOLECULAR CARCINOGENESIS
(2021)
Article
Medical Laboratory Technology
Yufeng Wu, Zhensheng Liu, Dongfang Tang, Hongliang Liu, Sheng Luo, Thomas E. Stinchcombe, Carolyn Glass, Li Su, Lijuan Lin, David C. Christiani, Qiming Wang, Qingyi Wei
Summary: The study identified two independent SNPs (HBEGF rs4150236G>A and ITPR3 rs116454384C>T) significantly associated with overall survival in non-small cell lung cancer (NSCLC) patients, with genetic scores also correlating with better survival and disease-specific survival.
TRANSLATIONAL RESEARCH
(2021)
Review
Cell Biology
Ziye Rong, Peipei Tu, Peiqi Xu, Yan Sun, Fangfang Yu, Na Tu, Lixia Guo, Yanan Yang
Summary: Mitochondria are essential organelles in eukaryotic cells that provide energy through oxidative phosphorylation. Mitochondrial DNA is prone to damage by DNA damaging agents, which can lead to dysfunction and contribute to various human diseases. Understanding mtDNA repair mechanisms is crucial for developing therapeutic strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Leah Hawkins Bressler, Marc A. Fritz, San-Pin Wu, Lingwen Yuan, Suzanna Kafer, Tianyuan Wang, Francesco J. DeMayo, Steven L. Young
Summary: The study found reduced proliferation and angiogenesis markers, increased inflammation, and altered ER expression patterns in women with suboptimal endometrial thickening after clomiphene treatment. The results suggest potential mechanisms underlying the lower pregnancy rates associated with suboptimal endometrial thickening in these women.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Peipei Tu, Bin Huang, Minggang Li, Yaofang Zhang, Shixiang Bao, Na Tu, Yanan Yang, Jingtao Lu
Summary: Type 2 diabetes (T2D) is a complex systemic disease that might benefit from treatment with exendin-4, as shown in this study on C57BL/6 J mice. The study investigated epigenetic alterations in pancreatic tissues of diabetic mice and demonstrated an improvement in T2D progression with exendin-4 treatment through modulation of histone acetylation and methylation patterns. Understanding these epigenetic changes may lead to novel therapeutic approaches for T2D.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Oncology
Maya Hassane, Zahraa Rahal, Nareg Karaoghlanian, Jiexin Zhang, Ansam Sinjab, Justin W. Wong, Wei Lu, Paul Scheet, J. Jack Lee, Maria Gabriela Raso, Luisa M. Solis, Junya Fujimoto, Hassan Chami, Alan L. Shihadeh, Humam Kadara
CANCER PREVENTION RESEARCH
(2022)
Article
Developmental Biology
Manoj K. Madhavan, Francesco J. DeMayo, John P. Lydon, Niraj R. Joshi, Asgerally T. Fazleabas, Ripla Arora
Summary: The uterine luminal epithelium folds characteristically in mammals, including humans, horses and rodents. However, the precise function of these folds remains unknown. This study reveals dynamic changes in the 3D uterine folding pattern during early pregnancy and suggests that the folds and chambers are two distinct structures with specific roles in implantation and post-implantation morphogenesis.
Article
Developmental Biology
Mackenzie J. Dickson, Yeong Seok Oh, Artiom Gruzdev, Rong Li, Nuria Balaguer, Andrew M. Kelleher, Thomas E. Spencer, San-Pin Wu, Francesco J. DeMayo
Summary: Approximately 75% of unsuccessful pregnancies are caused by implantation failure. This study developed a mouse strain with a decidual-specific iCre recombinase and confirmed its activity and tissue specificity during pregnancy. This research provides a valuable tool for investigating genetic networks and cellular dynamics associated with decidualization and infertility.
Article
Endocrinology & Metabolism
Sylvia C. Hewitt, San-pin Wu, Tianyuan Wang, Madhumita Ray, Marja Brolinson, Steven L. Young, Thomas E. Spencer, Alan DeCherney, Francesco J. DeMayo
Summary: This study investigates the molecular processes underlying estrogen responses and their effects on endometrial health. By analyzing the ESR1 cistromes and transcriptomes of endometrial biopsies and organoids, the study identifies candidate ESR1 target genes and reveals differences in the distribution and regulation of ESR1 binding sites between different stages of the menstrual cycle. The findings provide valuable resources for understanding how estrogen affects endometrial function and health.
Review
Immunology
Chen Chen, Aibao Chen, Yanan Yang
Summary: Vector-borne diseases pose major health threats globally, and γδT cells play a crucial role in regulating host-pathogen interactions and disease progression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Yan Li, Lihong Fan, Jianming Zheng, Xiu Nie, Yu Sun, Qin Feng, Shenyi Lian, Wenqi Bai, Weijing Cai, Yanan Yang, Bo Su, Yanfeng Xi, Dongmei Lin
Summary: This study systematically investigated the pre-screening methods and characterized the genetic and clinical features of Lynch syndrome (LS) colorectal cancers (CRCs) in Asia. The results demonstrated that MMR IHC and MSI testing were effective methods for LS pre-screening and identified previously unreported pathogenic germline variants of MMR genes in LS patients.
CANCER BIOLOGY & MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Sylvia C. Hewitt, Artiom Gruzdev, Cynthia J. Willson, San-Pin Wu, John P. Lydon, Niels Galjart, Francesco J. DeMayo
Summary: Receptors for estrogen and progesterone interact via Cohesin/CTCF loop extrusion at enhancers distal from regulated genes. Loss-of- function CTCF mutation indicates its importance in uterine homeostasis. Deleting Ctcf gene in female reproductive tissues of mice resulted in reduced uterine glands and hypoplastic uteri with decreased endometrial stroma. Ctcf deletion also altered the expression of progesterone-responsive genes, including Ihh, Fst, and Errfi1. Our findings highlight the key role of uterine Ctcf in progesterone-dependent expression and optimal post-pubertal uterine development.
Article
Multidisciplinary Sciences
Rong Li, Tianyuan Wang, Ryan M. Marquardt, John P. Lydon, San-Pin Wu, Francesco J. DeMayo
Summary: Estrogen and progesterone regulate uterine biology through their receptors ERα and PR, respectively. This study identifies TRIM28 as a protein that interacts with ERα and PR to regulate uterine function. TRIM28 deficiency disrupts PR and ERα chromatin binding, resulting in the inability of the uterus to support early pregnancy.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Ming Zhao, Timothy P. P. DiPeri, Maria Gabriela Raso, Xiaofeng Zheng, Yasmeen Qamar Rizvi, Kurt W. W. Evans, Fei Yang, Argun Akcakanat, Marco Roberto Estecio, Debu Tripathy, Ecaterina E. E. Dumbrava, Senthil Damodaran, Funda Meric-Bernstam
Summary: Research shows that increasing TROP2 expression can enhance the activity of TROP2 antibody drug conjugates (ADCs). In certain breast cancers, downregulating the transcription factor ZEB1 can increase the expression of E-cad and TROP2, making cancer cells more sensitive to TROP2 ADCs such as sacituzumab govitecan (SG). The demethylating agent decitabine decreases DNA methyltransferase expression and TROP2 promoter methylation, leading to increased TROP2 expression. Treatment with decitabine and overexpression of TROP2 significantly enhance the antitumor activity of SG.
Article
Biochemistry & Molecular Biology
Sylvia C. Hewitt, Artiom Gruzdev, Cynthia J. Willson, San-Pin Wu, John P. Lydon, Niels Galjart, Francesco J. DeMayo
Summary: Receptors for estrogen and progesterone interact through Cohesin/CTCF loop extrusion at enhancers distal from regulated genes. Loss-of-function CTCF mutation in endometrial tumors indicates its importance in uterine homeostasis. Our study reveals that uterine Ctcf plays a key role in progesterone-dependent expression of uterine genes underlying optimal post-pubertal uterine development.
Article
Multidisciplinary Sciences
San-Pin Wu, Tianyuan Wang, Zheng-Chen Yao, Mary C. Peavey, Xilong Li, Lecong Zhou, Irina V. Larina, Francesco J. DeMayo
Summary: PGR plays a pivotal role in directing the molecular program for uterine remodeling and pregnancy support. Mutant PGR can lead to dysfunction of the myometrium, affecting fertility and pregnancy adaptation.
Article
Oncology
Yung-Hung Luo, Han Liu, Jason A. Wampfler, Henry D. Tazelaar, Yalun Li, Tobias Peikert, Dan Liu, Konstantinos Leventakos, Yuh-Min Chen, Yanan Yang, Shih-Hwa Chiou, Ping Yang
Summary: This study demonstrates that osimertinib as a second or subsequent line of treatment in patients previously treated with EGFR-TKIs without identification of T790M mutation showed a lower risk of death compared to those who received first-line or second-generation TKIs without subsequent osimertinib. Patients with EGFR mutations and PD-L1 expression >= 50% had a higher risk of treatment failure with osimertinib and worse overall survival. These results suggest that osimertinib as a second-line or subsequent treatment may be a potential alternative for patients without identification of T790M, while high PD-L1 expression is associated with poor outcomes in patients receiving osimertinib.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)