Article
Reproductive Biology
Tiantuan Jiang, Keying Wen, Alian Liao, Yixian Wang, Yafei Jiao, Jinming Guo, Yaosheng Chen, Zuyong He, Peiqing Cong
Summary: In this study, the researchers successfully edited the BMP15 gene by injecting CRISPR ctRNP into porcine oocytes, revealing the role of BMP15 in the in vitro maturation of oocytes. Editing BMP15 resulted in reduced BMP15 protein expression, leading to the attenuation of SMAD1/5/8 signaling activation and impaired cumulus expansion in porcine cumulus cell-oocyte complexes (COCs).
Review
Obstetrics & Gynecology
Shogo Imanaka, Hiroshi Shigetomi, Hiroshi Kobayashi
Summary: This review summarizes the molecular mechanisms of glucose metabolism during oocyte maturation, focusing on the role of pyruvate dehydrogenase (PDH) and the metabolic balance between aerobic glycolysis and the TCA cycle/OXPHOS. The understanding of the PDK-PDH axis is crucial for developing novel therapeutic strategies to improve oocyte quality.
REPRODUCTIVE SCIENCES
(2022)
Article
Developmental Biology
Yafei Jiao, Tiantuan Jiang, Qiyuan Lin, Jinming Guo, Chang Bei, Peiqing Cong, Delin Mo, Xiaohong Liu, Yaosheng Chen, Zuyong He
Summary: This study found that the absence of BMP15 protein in biallelic-BMP15-edited pigs can lead to premature activation of follicles and hinder follicular development, resulting in infertility. This research expands our understanding of the role of BMP15 in nonrodent polyovulatory mammals.
Article
Agriculture, Dairy & Animal Science
Riho Morikawa, Jibak Lee, Takashi Miyano
Summary: GDF9 promotes the growth of OCCs while BMP15 enhances LHCGR mRNA expression in cumulus cells, affecting oocyte maturation.
JOURNAL OF REPRODUCTION AND DEVELOPMENT
(2021)
Article
Chemistry, Multidisciplinary
Hui Li, Liji You, Yufeng Tian, Jing Guo, Xianbao Fang, Chenmin Zhou, Lanying Shi, You-Qiang Su
Article
Biochemistry & Molecular Biology
Xiaolin Chen, Chengxiu Hu, Xing Fan, Yiying Wang, Qiannan Li, You-Qiang Su, Dai-Min Zhang, QianLu Yang, Anthony G. Passerini, ChongXiu Sun
Summary: mTOR inhibitors induce PKC-dependent endothelial MLC phosphorylation, contraction, and hyperpermeability that promote pneumonitis.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Cell Biology
Hongdao Zhang, Fengjuan Zhang, Qinghua Chen, Mingzhe Li, Xiaolong Lv, Yali Xiao, Zhaozhen Zhang, Li Hou, Yana Lai, Ying Zhang, Aihua Zhang, Shiqi Gao, Heling Fu, Wen Xiao, Jianli Zhou, Feiyang Diao, Aimin Shi, You-Qiang Su, Wentao Zeng, Ligang Wu, Jianmin Li
Summary: Piwi-interacting RNAs (piRNAs) are crucial for germ cell development in golden hamsters, with defects leading to disrupted reproductive function and embryonic arrest. The findings highlight the essential role of piRNAs in mammalian oogenesis and the potential for using golden hamsters as a model species for piRNA studies.
NATURE CELL BIOLOGY
(2021)
Article
Cell Biology
Hong Yin, Teng Zhang, Hao Wang, Xin Hu, Xuan Hou, Xianbao Fang, Yaoxue Yin, Hui Li, Lanying Shi, You-Qiang Su
Summary: The research reveals that EML1 plays a crucial role in controlling oocyte meiotic progression in mice, and its loss leads to abnormal oocytes unable to progress to the second meiotic division.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Shiwen Ni, Teng Zhang, Chenmin Zhou, Min Long, Xuan Hou, Liji You, Hui Li, Lanying Shi, You-Qiang Su
Summary: The formation of IMPDH cytoophidium in mouse ovaries affects oocyte meiosis and development competence, and treatment with IMPDH inhibitor in vitro shows similar effects.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Reproductive Biology
You-Qiang Su, Yaoxue Yin, Jing Guo, Xuhong Gong, Yufeng Tian, Lanying Shi
Summary: The coordinated development of germline and somatic compartments in a follicle is crucial for the formation of a functional oocyte. The bi-directional communication between the oocyte and granulosa cells plays a vital role in supporting the development and function of both compartments. MTOR, a serine/threonine kinase, is emerging as a major regulator of oocyte and follicle development, controlling various aspects of their development and function.
BIOLOGY OF REPRODUCTION
(2022)
Article
Cell Biology
Xiaoli Wei, Lanping Zheng, Yingpu Tian, Haibin Wang, Youqiang Su, Gensheng Feng, Chao Wang, Zhongxian Lu
Summary: In this study, the crucial roles of the tyrosine phosphatase SHP2 in modulating the proliferation and apoptosis of ovarian granulosa cells (GCs) were identified. SHP2 deficiency promoted GC proliferation and inhibited GC apoptosis, while SHP2 overexpression had the opposite effects. Furthermore, SHP2 was found to balance follicular development by suppressing PI3K/AKT signaling. This study provides a potential therapeutic target for the clinical treatment of follicle developmental dysfunction.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2022)
Article
Cell Biology
Feifei Yuan, Xiaoqiong Hao, Yanying Cui, Fuxin Huang, Xiao Zhang, Yanli Sun, Tiantian Hao, Zhijuan Wang, Wei Xia, Youqiang Su, Meijia Zhang
Summary: Germ cell division and differentiation require close contact and interaction with somatic cells. LH-EGFR signaling activates sphingosine kinases (SphK) in somatic cells, leading to the production of S1P. S1P acts as a functional transmitter of LH-EGFR signaling, inducing meiotic maturation in somatic cells and improving developmental competence in oocytes.
CELL DEATH & DISEASE
(2022)
Article
Biology
Zhijuan Wang, Hongwei Wei, Zhanying Wu, Xiaodan Zhang, Yanli Sun, Longwei Gao, Wenqing Zhang, You-Qiang Su, Meijia Zhang
Summary: This study reveals the molecular mechanism of the movement of mouse spermatozoa out of the isthmic reservoir in preparation for fertilization. It involves the expression of TGFB1, NPPC, and TGF-beta signaling in cumulus cells and ampullary epithelial cells. Oocyte-dependent and cumulus cell-derived TGFB1 plays a critical role in promoting sperm migration in the oviduct and subsequent fertilization.
COMMUNICATIONS BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Hui Li, Hailian Zhao, Chunhui Yang, Ruibao Su, Min Long, Jinliang Liu, Lanying Shi, Yuanchao Xue, You-Qiang Su
Summary: Mammalian oogenesis relies on stored mRNAs for successful development, but how their fate is determined remains unclear. RNA-binding proteins (RBPs) are important regulators, but the full complement in oocytes is unknown. This study identified 1396 RBPs in mouse oocytes and found LSM14B to be an important RBP specific to oocytes, essential for oogenesis and proper translation of its bound mRNAs.
Article
Agriculture, Dairy & Animal Science
Yuta Matsuno, Natsumi Maruyama, Wataru Fujii, Kunihiko Naito, Koji Sugiura
ANIMAL SCIENCE JOURNAL
(2020)
Article
Medicine, Research & Experimental
Hong Yin, Xuan Hou, Teng Zhang, Lanying Shi, You-Qiang Su
JOURNAL OF BIOMEDICAL RESEARCH
(2020)
Article
Oncology
Jiqiang Wang, Zhihui Liu, Qianru Sun, Shuang Xia, Jing Cui, Lan Yang, Liyou An, Jiaxin Zhang, Lei Su, Youqiang Su, Fuliang Du
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2019)
Article
Agriculture, Dairy & Animal Science
Asuka Onuma, Yoshie A. Fujioka, Wataru Fujii, Koji Sugiura, Kunihiko Naito
JOURNAL OF REPRODUCTION AND DEVELOPMENT
(2019)
Article
Biology
Arisa Ikeda, Wataru Fujii, Koji Sugiura, Kunihiko Naito
COMMUNICATIONS BIOLOGY
(2019)
