☆ 4.4 Article

The Nail as a Musculoskeletal Appendage - Implications for an Improved Understanding of the Link between Psoriasis and Arthritis

DERMATOLOGY (2009)

Journal

DERMATOLOGY

Volume 218, Issue 2, Pages 97-102

Publisher

KARGER

DOI: 10.1159/000182250

Keywords

Nail disease; Psoriasis; Psoriatic arthritis; Enthesis; Nail anchorage

Categories

Dermatology

Funding

National Institute for Health Research [CL-2007-02-001] Funding Source: researchfish

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Abstract

The nail is considered to be a specialised modification of the skin - an 'epidermal appendage'. However, the phrase 'hanging on by your fingernails' belies a vital aspect of nail micro-anatomy that has been overlooked, namely that the nail is functionally integrated with the musculoskeletal system. The current article reviews how the nail is functionally linked to the distal phalanx and several distal interphalangeal joint structures, including extensor tendon fibres and the collateral ligaments. New histological images exploring this link are provided. The extensor tendon in particular continues from its bony insertion to envelop the nail root, and the collateral ligaments form an integrated network on the sides of the joint, helping to anchor the nail margins. This virtual continuum of connective tissue structures merges with a thick periosteum on the distal phalanx and with the numerous cutaneous ligaments that anchor the fatty pads of the finger pulp to the skin. Copyright (C) 2008 S. Karger AG, Basel

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Letter Rheumatology

Higher risk of short term COVID-19 vaccine adverse events in myositis patients with autoimmune comorbidities: results from the COVAD study

Mrinalini Dey, R. Naveen, Elena Nikiphorou, Parikshit Sen, Sreoshy Saha, James B. Lilleker, Vishwesh Agarwal, Sinan Kardes, Jessica Day, Marcin Milchert, Mrudula Joshi, Tamer Gheita, Babur Salim, Tsvetelina Velikova, Abraham Edgar Gracia-Ramos, Ioannis Parodis, Albert Selva O'Callaghan, Minchul Kim, Tulika Chatterjee, Ai Lyn Tan, Ashima Makol, Arvind Nune, Lorenzo Cavagna, Miguel A. Saavedra, Samuel Katsuyuki Shinjo, Nelly Ziade, Johannes Knitza, Masataka Kuwana, Oliver Distler, Bhupen Barman, Yogesh Preet Singh, Rajiv Ranjan, Avinash Jain, Sapan C. Pandya, Rakesh Kumar Pilania, Aman Sharma, Manesh M. Manoj, Vikas Gupta, Chengappa G. Kavadichanda, Pradeepta Sekhar Patro, Sajal Ajmani, Sanat Phatak, Rudra Prosad Goswami, Abhra Chandra Chowdhury, Ashish Jacob Mathew, Padnamabha Shenoy, Ajay Asranna, Keerthi Talari Bommakanti, Anuj Shukla, Arunkumar R. Pande, Kunal Chandwar, John D. Pauling, Chris Wincup, Dondu Uskudar Cansu, Erick Adrian Zamora Tehozol, Jorge Rojas Serrano, Ignacio Garcia-De La Torre, Nicoletta Del Papa, Gianluca Sambataro, Atzeni Fabiola, Marcello Govoni, Simone Parisi, Elena Bartoloni Bocci, Gian Domenico Sebastiani, Enrico Fusaro, Marco Sebastiani, Luca Quartuccio, Franco Franceschini, Pier Paolo Sainaghi, Giovanni Orsolini, Rossella De Angelis, Maria Giovanna Danielli, Vincenzo Venerito, Lisa S. Traboco, Leonardo Santos Hoff, Suryo Anggoro Kusumo Wibowo, Stylianos Tomaras, Daman Langguth, Vidya Limaye, Merrilee Needham, Nilesh Srivastav, Akira Yoshida, Ran Nakashima, Shinji Sato, Naoki Kimura, Yuko Kaneko, Jesus Loarce-Martos, Sergio Prieto-Gonzalez, Albert Gil-Vila, Raquel Aranega Gonzalez, Hector Chinoy, Vikas Agarwal, Rohit Aggarwal, Latika Gupta

RHEUMATOLOGY (2023)

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Article Rheumatology

Long-term safety of COVID vaccination in individuals with idiopathic inflammatory myopathies: results from the COVAD study

Bohdana Doskaliuk, Naveen Ravichandran, Parikshit Sen, Jessica Day, Mrudula Joshi, Arvind Nune, Elena Nikiphorou, Sreoshy Saha, Ai Lyn Tan, Samuel Katsuyuki Shinjo, Nelly Ziade, Tsvetelina Velikova, Marcin Milchert, Kshitij Jagtap, Ioannis Parodis, Abraham Edgar Gracia-Ramos, Lorenzo Cavagna, Masataka Kuwana, Johannes Knitza, Yi Ming Chen, Ashima Makol, Vishwesh Agarwal, Aarat Patel, John D. Pauling, Chris Wincup, Bhupen Barman, Erick Adrian Zamora Tehozol, Jorge Rojas Serrano, Ignacio Garcia-De La Torre, Iris J. Colunga-Pedraza, Javier Merayo-Chalico, Okwara Celestine Chibuzo, Wanruchada Katchamart, Phonpen Akarawatcharangura Goo, Russka Shumnalieva, Leonardo Santos Hoff, Lina El Kibbi, Hussein Halabi, Binit Vaidya, Syahrul Sazliyana Shaharir, A. T. M. Tanveer Hasan, Dzifa Dey, Carlos Enrique Toro Gutierrez, Carlo V. Caballero-Uribe, James B. Lilleker, Babur Salim, Tamer Gheita, Tulika Chatterjee, Oliver Distler, Miguel A. Saavedra, Hector Chinoy, Vikas Agarwal, Rohit Aggarwal, Latika Gupta

Summary: Limited evidence on long-term COVID-19 vaccine safety in patients with idiopathic inflammatory myopathies (IIMs) contributes to vaccine hesitancy. This study analyzed delayed-onset vaccine adverse events (AEs) in patients with IIMs, other systemic autoimmune and inflammatory disorders (SAIDs), and healthy controls (HCs). The findings showed that vaccination is safe in individuals with IIMs, with AEs and hospitalization rates comparable to SAIDs, and mostly limited to those with autoimmune multimorbidity and active disease. These observations can inform guidelines for identifying high-risk patients in the post-vaccination period.

RHEUMATOLOGY INTERNATIONAL (2023)

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Article Rheumatology

Systemic sclerosis and COVID-19 vaccine safety: short-term insights from the global COVID-19 vaccination in autoimmune disease (COVAD) survey

R. Naveen, Darpan Thakare, Masataka Kuwana, John Pauling, Jessica Day, Mrudula Joshi, Ioannis Parodis, Parikshit Sen, Kshitij Jagtap, Elena Nikiphorou, Sreoshy Saha, Vishwesh Agarwal, Tulika Chatterjee, James Lilleker, Sinan Kardes, Marcin Milchert, Tamer Gheita, Babur Salim, Tsvetelina Velikova, Abraham Edgar Gracia-Ramos, Ai Lyn Tan, Arvind Nune, Lorenzo Cavagna, Miguel Saavedra, Samuel Katsuyuki Shinjo, Nelly Ziade, Johannes Knitza, Oliver Distler, Hector Chinoy, Rohit Aggarwal, Latika Gupta, Vikas Agarwal, Ashima Makol

Summary: The safety profile of COVID-19 vaccines in patients with systemic sclerosis (SSc) was compared with other rheumatic and non-rheumatic autoimmune diseases, as well as healthy controls. The study found that short-term adverse events following vaccination did not differ significantly between the different groups, and background immunosuppression and disease activity did not influence these events.

RHEUMATOLOGY INTERNATIONAL (2023)

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Letter Rheumatology

Flares of autoimmune rheumatic disease following COVID-19 infection: Observations from the COVAD study

Nimrat Kaur Sandhu, Naveen Ravichandraan, Arvind Nune, Jessica Day, Parikshit Sen, Elena Nikiphorou, Ai Lyn Tan, Mrudula Joshi, Sreoshy Saha, Samuel Katsuyuki Shinjo, Kshitij Jagtap, Vishwesh Agarwal, Nelly Ziade, Tsvetelina Velikova, Marcin Milchert, Ioannis Parodis, Abraham Edgar Gracia-Ramos, Lorenzo Cavagna, Masataka Kuwana, Johannes Knitza, Ashima Makol, Aarat Patel, John D. Pauling, Chris Wincup, Bhupen Barman, Erick Adrian Zamora Tehozol, Jorge Rojas Serrano, Ignacio Garcia-De La Torre, Iris J. Colunga-Pedraza, Javier Merayo-Chalico, Celestine Chibuzo Okwara, Wanruchada Katchamart, Phonpen Akawatcharangura Goo, Russka Shumnalieva, Yi-Ming Chen, Leonardo Santos Hoff, Lina El Kibbi, Hussein Halabi, Binit Vaidya, Syahrul Sazliyana Shaharir, A. T. M. Tanveer Hasan, Dzifa Dey, Carlos Enrique Toro Gutierrez, Carlo Vinicio Caballero-Uribe, James B. Lilleker, Babur Salim, Tamer Gheita, Miguel A. Saavedra, Tulika Chatterjee, Oliver Distler, Hector Chinoy, Vikas Agarwal, Rohit Aggarwal, Latika Gupta

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES (2023)

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Article Rheumatology

High fatigue scores in patients with idiopathic inflammatory myopathies: a multigroup comparative study from the COVAD e-survey

Silvia Grignaschi, Minchul Kim, Giovanni Zanframundo, Naveen Ravichandran, James Lilleker, Parikshit Sen, Mrudula Joshi, Vishwesh Agarwal, Sinan Kardes, Jessica Day, Ashima Makol, Marcin Milchert, Tamer Gheita, Babur Salim, Tsvetelina Velikova, Abraham Edgar Gracia-Ramos, Ioannis Parodis, Elena Nikiphorou, Tulika Chatterjee, Ai Lyn Tan, Miguel Saavedra, Samuel Katsuyuki Shinjo, Nelly Ziade, Johannes Knitza, Masataka Kuwana, Arvind Nune, Oliver Distler, Hector Chinoy, Lorenzo Cavagna, Vikas Agarwal, Rohit Aggarwal, Latika Gupta, COVID Study Grp

Summary: Patients with idiopathic inflammatory myopathies (IIMs) exhibit considerable fatigue, similar to other systemic autoimmune diseases (SAIDs) and higher than healthy individuals. Women and Caucasians experience greater fatigue scores.

RHEUMATOLOGY INTERNATIONAL (2023)

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