Article
Oncology
Conrad Falkenberg, Thomas Dirschka, Georgia Gilbert, Eggert Stockfleth, Bernhard Homey, Lutz Schmitz
Summary: The study compared epidermal AKs from organ transplant recipients and immunocompetent control group, and found that AKs with marked basal proliferation (PRO III) and acantholysis (AK I) were more common in transplant recipients. Acantholytic AKs were significantly associated with advanced basal proliferation. Therefore, AKs with marked basal proliferation and acantholysis may represent histological high-risk factors for the progression into iSCC.
Article
Dermatology
D. Y. Lee, B. R. Kim, S. Yang, M. Kim, T. Y. Yoon, S. W. Youn
Summary: This study quantitatively assessed histopathological findings of actinic keratosis (AK) and identified bowenoid type, epidermal thickening, and higher proportion of keratinocytic atypia as significant factors associated with progression to invasive squamous cell carcinoma (SCC). Multivariate analysis revealed that the proportion of keratinocytic atypia was the only independent predisposing factor for SCC progression.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Dermatology
Anke S. Lonsdorf, Aric Keller, Julia Hartmann, Alexander H. Enk, Patrick Gholam
Summary: This study evaluated the efficacy and tolerability of low-irradiance photodynamic therapy combined with Er:YAG pretreatment compared to conventional photodynamic therapy in the treatment of actinic keratoses in organ transplant recipients. The results showed that low-irradiance photodynamic therapy combined with Er:YAG pretreatment achieved a significantly superior lesion response rate without negatively impacting pain or cosmetic outcome.
ACTA DERMATO-VENEREOLOGICA
(2022)
Article
Dermatology
Zeeshaan-Ul Hasan, Ikhlaaq Ahmed, Rubeta N. Matin, Victoria Homer, John T. Lear, Ferina Ismail, Tristan Whitmarsh, Adele C. Green, Jason Thomson, Alan Milligan, Sarah Hogan, Vanessa Van-de-Velde, Liza Mitchell-Worsford, Jonathan Kentley, Claire Gaunt, Yolande Jefferson-Hulme, Sarah J. Bowden, Piers Gaunt, Keith Wheatley, Charlotte M. Proby, Catherine A. Harwood
Summary: This study aimed to evaluate the feasibility, activity, and evaluation outcomes of topical chemoprevention of cSCC in OTRs, and the results support further investigation of 5-FU-based treatments in future phase III trials.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Dermatology
Yoon-Seob Kim, Sun Shin, Seung-Hyun Jung, Young Min Park, Gyeong Sin Park, Sug Hyung Lee, Yeun-Jun Chung
Summary: The mechanism of progression from actinic keratosis (AK) and cutaneous squamous cell carcinoma (SCC) in situ (SCCIS) to SCC is unclear. This study found driver gene mutations in these lesions, indicating their precancerous nature. The genomic progression of these lesions to SCC showed common trunks and unique branches, with AK tissues tending to have lower mutation/burden than SCC tissues but harboring driver mutations.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Oncology
Valeria Righi, Camilla Reggiani, Elisabetta Tarentini, Adele Mucci, Alessia Paganelli, Anna Maria Cesinaro, Ema Mataca, Shaniko Kaleci, Barbara Ferrari, Marco Meleti, Cristina Magnoni
Summary: The study assessed the metabolomic fingerprints of AK I, AK II, AK III and SCC, finding that AK I are metabolically active lesions with profiles similar to high-grade AKs and SCC. The negative association of AKs with parakeratosis and positive association with hypertrophy suggest a similar behavior between AKs and SCCs. The findings support the notion that all AKs should be treated independently, as they may be associated with SCC.
Article
Dermatology
Chryssoula Papageorgiou, Aimilios Lallas, Sofia Magdalini Manoli, Caterina Longo, Michela Lai, Konstantinos Liopyris, Konstantinos Lallas, Elizabeth Lazaridou, Zoe Apalla
Summary: The aim of this study was to investigate the clinical and dermatoscopic criteria that could suggest early invasion and serve as potent predictors to discriminate early SCC from AK. The main positive dermatoscopic predictors of early SCC were dotted/glomerular vessels, hairpin vessels, and white structureless areas, whereas background erythema represented a negative SCC predictor.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Dermatology
Rachel E. Christensen, Dirk M. Elston, Brandon Worley, McKenzie A. Dirr, Noor Anvery, Bianca Y. Kang, Soon Bahrami, Robert T. Brodell, Lorenzo Cerroni, Carly Elston, Tammie Ferringer, M. Yadira Hurley, Kyle Garton, Joyce Siong See Lee, Yeqiang Liu, John C. Maize, Jennifer M. McNiff, Ronald P. Rapini, Omar P. Sangueza, Christopher R. Shea, Cheng Zhou, Murad Alam
Summary: This article presents consensus recommendations on the diagnostic criteria, nomenclature, and reporting guidelines for actinic keratosis (AK) and cutaneous squamous cell carcinoma (cSCC), based on a literature review and a multiround Delphi process involving international expert dermatopathologists. Consensus was reached on key dermatopathologic features, cellular differentiation grading in cSCC, the utility of immunohistochemistry for cSCC diagnosis, and pathologic features to be reported for cSCC and AK. However, not all questions achieved consensus.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Vidhi Patel, Madhusudhan R. Sanaka, Yi Qin, John McMichael, James Bena, Claire Beveridge, John Barron, Siva Raja, Jamak Modaresi Esfeh, Prashanthi N. Thota
Summary: This retrospective cohort study demonstrates that immunosuppressant use is associated with neoplastic progression in Barrett's esophagus (BE) patients, while solid organ transplantation (SOT) is not. Therefore, close surveillance of BE patients on chronic immunosuppressants needs to be considered.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Dermatology
Yoon-Seob Kim, Seung-Hyun Jung, Young Min Park, Gyeong Sin Park, Hei Sung Kim, Lee-So Maeng, Yeun-Jun Chung
Summary: This study investigates the genomic alterations between actinic keratosis (AK) and cutaneous squamous cell carcinoma (cSCC), and identifies TP53 and NOTCH1 as common driver mutations in cSCC. The study also reveals that cSCC has a higher abundance of somatic mutations and copy number alterations (CNAs) compared to AK/CIS, and that ultraviolet is the main cause of these mutations in both AK/CIS and cSCC.
EXPERIMENTAL DERMATOLOGY
(2023)
Review
Virology
Roni Bitterman, Deepali Kumar
Summary: Solid organ transplantation comes with an increased risk of respiratory viral infections, especially problematic for lung transplant recipients. While influenza has treatment options, other respiratory viruses present treatment challenges. Novel antivirals, immunologic treatments, and vaccines are hoped for in the coming years to address this evolving area of concern.
Article
Dermatology
Jennifer R. Dusendang, Ekama Carlson, David S. Lee, Sangeeta Marwaha, Shabnam Madani, Stacey E. Alexeeff, Allison Webber, Nelson B. Goes, Lisa J. Herrinton
Summary: This study aimed to evaluate the risk of cutaneous squamous cell carcinoma (cSCC) in solid organ transplant recipients (SOTRs) using immunosuppressive medications. The results showed that the annual incidence of cSCC was higher in SOTRs compared to persons without transplantation. Lung transplant and the use of voriconazole were associated with an increased risk of cSCC, while belatacept and other immunosuppressive medications were not.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Oncology
Robert P. Carroll, Michael Boyer, Val Gebski, Bronwyn Hockley, Julie K. Johnston, Svjetlana Kireta, Hsiang Tan, Anne Taylor, Kate Wyburn, John RZalcberg
Summary: Maintaining baseline immunosuppression before treatment with an immune checkpoint inhibitor in kidney transplant recipients might not affect expected efficacy and might reduce the risk of allograft rejection mediated by immune checkpoint inhibitors.
Article
Oncology
Eric A. Engels, Gregory Haber, Allyson Hart, Charles F. Lynch, Jie Li, Karen S. Pawlish, Baozhen Qiao, Kelly J. Yu, Ruth M. Pfeiffer
Summary: A previous cancer diagnosis is a negative factor in evaluating patients for solid organ transplantation. Statistical cure models were used to analyze cancer patients in the US general population. Patients with high cure probabilities at transplantation showed better outcomes, while those with low cure probabilities had increased cancer-specific mortality after transplantation.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Mengmeng Ji, Amanda J. Vinson, Su-Hsin Chang, Massini Merzkani, Krista L. Lentine, Yasar Caliskan, Kristin Progar, Nicole Nesselhauf, Casey Dubrawka, Tarek Alhamad
Summary: This study evaluated kidney use and transplant outcomes from deceased donors with active or resolved COVID-19, showing a decreasing likelihood of nonuse over time and no worse outcomes within 2 years post-transplant.