Article
Chemistry, Multidisciplinary
Eleni-Anna Argyri, Stylianos-Panagiotis Piromalis, Antonios Koutelidakis, Dimitrios Kafetzopoulos, Andreas S. Petsas, Dimitrios Skalkos, Constantina Nasopoulou, Charalampia Dimou, Haralabos C. Karantonis
Summary: The study found that adding olive paste and additional ingredients can enhance the antioxidant properties of cookies, enriched cookies not only performed well in sensory acceptability, but also had higher unsaturated fat, total phenolics, and antioxidant activities than regular cookies.
APPLIED SCIENCES-BASEL
(2021)
Article
Psychology, Biological
M. Catherine Prater, Alexis R. Scheurell, Chad M. Paton, Jamie A. Cooper
Summary: It is suggested that the type of dietary fat consumed regularly can affect appetite and weight management. This study aimed to evaluate the effects of a diet enriched with cottonseed oil (polyunsaturated fat-rich) or olive oil (monounsaturated fat-rich) on appetite responses in adults with high cholesterol. The results showed that cottonseed oil had a greater effect on appetite suppression compared to olive oil, indicating its potential benefits for weight maintenance.
PHYSIOLOGY & BEHAVIOR
(2023)
Review
Nutrition & Dietetics
Miguel A. Martinez-Gonzalez, Carmen Sayon-Orea, Vanessa Bullon-Vela, Maira Bes-Rastrollo, Fernando Rodriguez-Artalejo, Maria Jose Yusta-Boyo, Marta Garcia-Solano
Summary: A systematic review and meta-analysis of multiple studies found that consumption of olive oil is associated with a reduced risk of cardiovascular disease, type 2 diabetes, and all-cause mortality, but not with cancer risk.
CLINICAL NUTRITION
(2022)
Article
Pharmacology & Pharmacy
Samantha J. Snow, Andres R. Henriquez, Jenifer I. Fenton, Travis Goeden, Anna Fisher, Beena Vallanat, Michelle Angrish, Judy E. Richards, Mette C. Schladweiler, Wan-Yun Cheng, Charles E. Wood, Haiyan Tong, Urmila P. Kodavanti
Summary: This study found that diets enriched with coconut oil, fish oil, or olive oil can modify ozone-induced metabolic changes in a diet-specific manner. Different types of dietary oils have different impacts on metabolic responses, potentially leading to alterations in peripheral energy homeostasis.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Margarita R. Ramis, Fiorella Sarubbo, David Moranta, Silvia Tejada, Jeronia Llado, Antoni Miralles, Susana Esteban
Summary: Long-term intake of a diet rich in polyphenols has been shown to improve memory and learning, restore brain neurotransmitters and important proteins levels, and have a positive impact on brain health.
Article
Food Science & Technology
Veronica Conti, Chiara Piccini, Marco Romi, Patrizia Salusti, Giampiero Cai, Claudio Cantini
Summary: The aim of this research was to evaluate the levels of antioxidants and polyphenols in pasta enriched with either carrot or olive leaf flours after simulating gastrointestinal digestion. The results showed that the enriched pasta had higher antioxidant power and polyphenol content, and this effect was maintained throughout the digestion process.
Article
Biochemistry & Molecular Biology
Dongwei Wang, Yani Deng, Lei Zhao, Kai Wang, Dongmei Wu, Zhuoyan Hu, Xuwei Liu
Summary: This study aimed to explore the potential of GABA and fermented litchi juice enriched with GABA (FLJ) in protecting against obesity in a high-fat diet mouse model. Supplementation of GABA and FLJ showed an anti-obesogenic effect by reducing body weight gain, fat accumulation, and oxidative damage, and improving serum lipid profile and hepatic function. Sequencing of fecal samples indicated that GABA and FLJ intervention had different regulatory effects on gut microbiota dysbiosis induced by the high-fat diet.
Article
Biochemistry & Molecular Biology
Anna Starzynska-Janiszewska, Carmen Fernandez-Fernandez, Beatriz Martin-Garcia, Vito Verardo, Ana Maria Gomez-Caravaca
Summary: This study examined the use of solid state fermentations to extract phenolic compounds from olive leaves and found that fermentation using mycelium of Aspergillus awamori, Aspergillus niger, and Aspergillus oryzae was effective in increasing the content of hydroxytyrosol and elenolic acid derivatives.
Article
Neurosciences
Jifu Xin, Yuhong He, Kai Guo, Dayong Yang
Summary: Oxygen-induced retinopathy (OIR) is a type of retinal disease that leads to vision loss, and its treatment has not been entirely satisfactory. This study explores the changes in the expression of BDNF, CNTF, and FGF-2 in OIR mice and finds that their expression is significantly increased in OIR mice.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Marta Gronksa-Peski, J. Tiago Goncalves, Jean M. Hebert
Summary: Research shows that an enriched environment promotes adult neurogenesis by increasing the function of fibroblast growth factor receptor (FGFR) within neurogenic cells. Activation of FGFR by an enriched environment signals through FGFR substrate (FRS) to induce stem cell proliferation and via FRS and phospholipase C gamma to increase the number of adult-born neurons.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Jesus Roman Martinez Alvarez, Ana Belen Lopez Jaen, Monica Cavia-Saiz, Pilar Muniz, Victoria Valls-Belles
Summary: The study aimed to determine the effects of olive oil enriched with lycopene on oxidative stress biomarkers in hypercholesterolemic subjects. The results showed that consumption of oil enriched with lycopene led to an increase in plasma antioxidant capacity and a decrease in biomarkers of oxidative stress and inflammatory markers related to atherosclerosis risk.
Article
Nutrition & Dietetics
Diana C. Mantilla-Escalante, Maria-Carmen Lopez De las Hazas, M. Carmen Crespo, Roberto Martin-Hernandez, Joao Tome-Carneiro, Lorena Del Pozo-Acebo, Jordi Salas-Salvado, Monica Bullo, Alberto Davalos
Summary: This study aimed to characterize the modulation of exosomal lncRNAs, mRNAs and miRNAs after a 1-year adherence to different diets. Results showed that Mediterranean diets enriched with nuts or extra-virgin olive oil significantly altered exosomal RNA content compared to a low-fat diet, with implications on metabolic pathways. Further investigation into the impact of exosomal RNAs from dietary interventions is warranted.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Chemistry, Multidisciplinary
Xin Min, Xiao-Hui Deng, Huilin Lao, Zi-Cong Wu, Yi Chen, Yuelian Luo, Haoyang Wu, Junbo Wang, Qing-Ling Fu, Hao Xiong
Summary: In this study, mesenchymal stem cell-derived small extracellular vesicles (MSC-sEVs) were used as nanoscale vehicles to deliver brain-derived neurotrophic factor (BDNF) for the treatment of noise-induced hearing loss (NIHL). The results showed that BDNF-loaded sEVs efficiently increased the expression of BDNF protein in the cochlea, and significantly attenuated cochlear hair cell loss and NIHL in mice. Transcriptomic analysis also revealed the involvement of various mRNAs and miRNAs in the protective actions of BDNF-sEVs against oxidative stress.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Food Science & Technology
Umile Gianfranco Spizzirri, Paolino Caputo, Cesare Oliviero Rossi, Pasquale Crupi, Marilena Muraglia, Vittoria Rago, Rocco Malivindi, Maria Lisa Clodoveo, Donatella Restuccia, Francesca Aiello
Summary: Olive mill wastewater was used to synthesize an antioxidant macromolecule, which can be used as a functional ingredient in the preparation of functional puddings. The wastewater showed strong antioxidant properties and was successfully used to synthesize a polymeric conjugate with good toxicity characteristics and antioxidant performance. In comparison with non-functional counterparts, the wastewater exhibited better consistency and antioxidant features in the functional food.
Article
Agriculture, Dairy & Animal Science
Sara Sechi, Silvia Carta, Fabio Correddu, Alessandro Di Cerbo, Anna Nudda, Raffaella Cocco
Summary: This study investigated the effects of different diets on the biochemical parameters and fatty acid profile of dogs' blood. It was found that adding antioxidant compounds to the diet can improve the health of the animals. Fish-based diet showed better fatty acid profile compared to chicken-based diet. However, regardless of the basal diet, diets combined with antioxidants improved the fatty acid profile.
Article
Cell Biology
Maria Serena Paladini, Davide Marangon, Andrea C. Rossetti, Alice Guidi, Giusy T. Coppolino, Camilla Negri, Vittoria Spero, Maria Pia Abbracchio, Davide Lecca, Raffaella Molteni
Summary: Prenatal stress exposure can have severe consequences on offspring's brain development and long-term repercussions in adulthood. It can also increase the severity of EAE symptoms and alter the maturation of spinal cord oligodendrocytes.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Alessandra Berry, Monica Mazzelli, Chiara Musillo, Marco Andrea Riva, Annamaria Cattaneo, Francesca Cirulli
Summary: Prenatal stress can interact with adult metabolic challenges to induce an inflammatory phenotype, affecting the same metabolic and neuroendocrine effectors engaged by prenatal stress and providing mechanistic insight into the comorbidity between mood and metabolic disorders.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Michaela Schmidt, Andrea Carlo Rossetti, Christiane Brandwein, Marco Andrea Riva, Peter Gass, Peter Elsner, Jana Hesse-Macabata, Uta-Christina Hipler, Stefan Smesny, Berko Milleit
Summary: In this study, BDNF knockout mice exhibited cognitive deficits and there was a quadratic association between PLA2 activity and performance in behavioral tests. Similar to findings in schizophrenia patients, BDNF deficiency and female sex were associated with elevated plasma PLA2 levels. PLA2 activity was also significantly correlated with body and adrenal weight, highlighting a possible connection with steroidogenesis.
Review
Pharmacology & Pharmacy
Andrea de Bartolomeis, Annarita Barone, Veronica Begni, Marco Andrea Riva
Summary: Antipsychotics are the main treatment for schizophrenia and have also been used to treat mood disorders. While their mechanism of action is well recognized, their intracellular mechanisms are still not completely understood.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Toxicology
Camila Reck Rampelotto, Viviane Goncalves Pereira, Larissa da Silva Silveira, Aline Rossato, Alencar Kolinski Machado, Michele Rorato Sagrillo, Andre Gundel, Marilise Escobar Burger, Scheila Rezende Schaffazick, Cristiane de Bona da Silva
Summary: The study developed FA-loaded nanocapsule suspensions prepared with ethylcellulose and evaluated their in vitro release profile, mucoadhesion, cytotoxicity, and protective effect against oxidative damage. Results showed that the nanocapsules had controlled release of FA, mucoadhesive properties, non-toxicity to cells, and protective effects against oxidative conditions. This nanocarrier formulation shows promise for further preclinical investigations in oxidative mechanism-related diseases.
TOXICOLOGY IN VITRO
(2022)
Review
Clinical Neurology
Nadia Cattane, Anthony C. Vernon, Alessandra Borsini, Catia C. Scassellati, Dominique M. Endres, Lucile A. Capuron, Ryad Tamouza, Michael Eriksen Benros, Juan C. Leza, Carmine M. Pariante, Marco A. Riva, Annamaria Cattaneo, Neuropsychopharmacology(ECNP)ImmunoNeuroPsychiatryThematicWorking Grp
Summary: Animal models are valuable tools for studying the pathogenesis and treatment of mental disorders. They allow investigation of behavioral, physiological, and neuroanatomical alterations relevant to these disorders in controlled conditions. Stress and infection-related exposures are common environmental risk factors that can trigger or unmask psychopathological phenotypes in animals. This review focuses on different stress paradigms and immune challenges and examines the subsequent alterations in various biological and behavioral domains at different stages of animals' lives. Animal models provide insights into the pathophysiology of human mental illnesses and offer potential for discovering novel drug targets.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
Vittoria Spero, Maria Serena Paladini, Paola Brivio, Marco Andrea Riva, Francesca Calabrese, Raffaella Molteni
Summary: Stressful events can trigger a strong antioxidant response, which can be affected by genetic factors and previous adverse experiences. The antipsychotic drug lurasidone can restore this impaired antioxidant response in specific brain regions.
PSYCHOPHARMACOLOGY
(2022)
Article
Psychiatry
Emily J. Jaehne, Jessica N. Kent, Emily J. Antolasic, Bradley J. Wright, Jereme G. Spiers, Kerstin C. Creutzberg, Federico De Rosa, Marco A. Riva, Caryl E. Sortwell, Timothy J. Collier, Maarten van den Buuse
Summary: The BDNF Val66Met polymorphism, associated with reduced activity-dependent BDNF release and increased risk for anxiety disorders and PTSD, was found to impair fear memory in rats. This impairment was not dependent on animal sex or observed during adolescence, and there were no genotype differences in other types of memory.
TRANSLATIONAL PSYCHIATRY
(2022)
Review
Clinical Neurology
Maria Grazia Di Benedetto, Catia Scassellati, Nadia Cattane, Marco Andrea Riva, Annamaria Cattaneo
Summary: This article conducted a systematic review on the relationship between childhood trauma and early life stress with psychiatric disorders, supporting the significant role of the neurotrophic factor BDNF in mediating this relationship.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Behavioral Sciences
Anne Stephanie Mallien, Laura Becker, Natascha Pfeiffer, Federica Terraneo, Melissa Hahn, Anthonieke Middelman, Rupert Palme, Kerstin Camile Creutzberg, Veronica Begni, Marco Andrea Riva, Damiana Leo, Heidrun Potschka, Fabio Fumagalli, Judith R. Homberg, Peter Gass
Summary: In preclinical psychiatry research, the study focused on the severity assessment of a genetically modified rat strain with DAT gene deficiency, showing alterations in behavior patterns and coping difficulties due to the high extracellular dopamine levels. The study aimed to provide evidence for a relative severity assessment for the rat model based on scientific evidence and proposed classifying the rats as moderate according to the criteria of the EU directive 2010/63.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Clinical Neurology
Paola Brivio, Maria Teresa Gallo, Piotr Gruca, Magdalena Lason, Ewa Litwa, Fabio Fumagalli, Mariusz Papp, Francesca Calabrese
Summary: Stress has a major impact on psychiatric disorders and individuals vary in their susceptibility and response to stress. This study investigated the neural activation and behavioral changes in rats exposed to chronic mild stress (CMS) and subsequently faced with a new acute challenge. The findings suggest that the ventral hippocampus plays a crucial role in both chronic and acute stress response, and targeting this brain region may be a potential therapeutic strategy to enhance stress resilience.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Developmental Biology
Emily J. Jaehne, Jessica N. Kent, Nikki Lam, Lina Schonfeld, Jereme G. Spiers, Veronica Begni, Federico De Rosa, Marco A. Riva, Maarten van den Buuse
Summary: Exercise has been shown to be beneficial in reducing symptoms of affective disorders and increasing BDNF expression. This study found that rats that had access to running wheels during adolescence exhibited higher levels of anxiety and depression-like behaviors in adulthood, regardless of their BDNF Val66Met genotype.
DEVELOPMENTAL PSYCHOBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Paola Brivio, Maria Teresa Gallo, Piotr Gruca, Magdalena Lason, Ewa Litwa, Fabio Fumagalli, Mariusz Papp, Francesca Calabrese
Summary: Despite the availability of several antidepressant treatments, they are not effective for all patients. Recently, N-acetylcysteine (NAC) has been explored as a potential adjunctive therapy for psychiatric disorders due to its antioxidant properties. Preclinical studies have shown that NAC can enhance neuroplastic mechanisms and improve resilience, particularly through the modulation of Nr4a1 expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Behavioral Sciences
Rodrigo Orso, Kerstin Camile Creutzberg, Francisco Sindermann Lumertz, Erika Kestering-Ferreira, Bruna Alvim Stocchero, Mariana Kude Perrone, Veronica Begni, Rodrigo Grassi-Oliveira, Marco Andrea Riva, Thiago Wendt Viola
Summary: Exposure to stress during early development may lead to altered neurobiological functions. This may be due to the disruption of glial density and morphology, as observed in rodent studies. However, the effects on different glial cells appear to vary. Our meta-analysis shows that prenatal and early life stress can increase microglia density and decrease oligodendrocyte density in offspring. Additional findings include an increase in microglia soma size with early life stress. These effects are influenced by factors such as stress protocol, sex, age, and tissue type. The results highlight the importance of glial cell alterations in stress-induced dysfunctions throughout development.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Eva Falvo, Silvia Giatti, Silvia Diviccaro, Lucia Cioffi, Monika Herian, Paola Brivio, Francesca Calabrese, Donatella Caruso, Roberto Cosimo Melcangi
Summary: Patients affected by diabetes mellitus (DM) have an increased risk of cognitive deficits, dementia, and Alzheimer's disease, but the mechanisms underlying diabetic encephalopathy are not fully understood. In this study, male animal models of DM showed cognitive impairment due to neuroinflammation, oxidative stress, mitochondrial dysfunction, and aberrant synaptogenesis. No observations in female rats have been reported on these aspects before, so the impact of type 1 DM on memory abilities, neuroinflammation, synaptogenesis, and mitochondrial functionality was explored in a female rat model. The findings suggest that T1DM has specific effects on different brain areas, with aberrant synaptogenesis and neuroinflammation observed in the hippocampus but not in the cerebral cortex.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Xinyu Wang, Jun Huang, Huan Li, Yanlong Li, Shuang Cai, Bangxin Xue, Zhekun Zhu, Xiangzhou Zeng, Xiangfang Zeng
Summary: Embryo development plays a crucial role in pregnancy outcome and lifelong health. A high throughput screening cell model was established to select nutrients that can enhance embryonic development. Resveratrol was identified as a potential candidate for promoting embryo development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
ViVi Tang Kang Wee, Hitoshi Shirakawa, Sung-Ling Yeh, Chiu-Li Yeh
Summary: This study investigated the effects of fermented rice bran (FRB) on modulating intestinal aryl hydrocarbon receptor (AhR) expression, innate lymphoid cell (ILC)3 populations, the fecal microbiota distribution, and their associations with dextran sodium sulfate (DSS)-induced acute colitis. The results showed that FRB supplementation can improve gut health, alleviate colitis symptoms, and have anti-colitis effects by enhancing ILC3 and AhR functions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang
Summary: The study demonstrates that rutin can ameliorate kidney damage caused by PFOA exposure by improving oxidative stress and regulating lipid metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ya-Jie Ding, Xue-Ning Li, Zhe Xiao, Chen-Yang Li, Li-Hong Jia
Summary: This study investigates the impact of maternal vitamin D levels during pregnancy on infantile eczema. The findings suggest that lower prenatal maternal vitamin D levels increase the risk of eczema in infants aged 0-1 year. Furthermore, the study indicates that infants with eczema have lower expression of the Foxp3 gene in cord blood and decreased placental FOXP3 protein expression. These results suggest that vitamin D may affect the development of infantile eczema through the regulation of gene and protein expression in cord blood and placenta.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shujing Liu, Shiyu Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, Chunlu Fang, Yuan Wei, Fu Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li
Summary: Long-term consumption of a high-fat diet disrupts energy balance and leads to weight gain. The fat mass and obesity-associated (FTO) gene is involved in high-fat diet-induced obesity. The hypothalamus plays a crucial role in regulating energy balance, and high-fat diet-induced hypothalamic leptin resistance contributes to obesity. The study reveals that FTO is associated with hypothalamic leptin resistance and provides new insight into its role in obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xiaoling Chen, Jun He, Yuheng Luo, Ping Zheng, Bing Yu, Daiwen Chen, Zhiqing Huang
Summary: This study found that oleanolic acid promotes the transformation of fast muscle fibers to slow muscle fibers through the TGR5-mediated CaN/NFATc1 signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao Hu
Summary: Long-term alternate-day fasting can ameliorate obesity-induced anxiety-like behavior and hippocampal damage, but it can cause anxiety in normal-weight mice. Short-term alternate-day fasting does not produce adverse emotional reactions in normal-weight mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jannis Ulke, Christian Schwedler, Janine Krueger, Vanessa Stein, Peter Geserick, Andre Kleinridders, Kai Kappert
Summary: This study characterized the glycosylation pattern of PTPRJ in the liver and found that high-fat diet-induced obesity altered the glycosylation pattern of PTPRJ. These findings provide new insights into the role of glycosylation in metabolic disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Marii Mochizuki, Yasuyuki Suzuki, Erika Takemasa, Akiko Yano, Matome Imai, Masaki Mogi
Summary: This study evaluated the feasibility and efficacy of leucine supplementation in offsetting immune dysfunction in sarcopenia. The results showed that leucine supplementation not only improved muscle mass and restored mitochondrial respiratory function, but also reduced inflammation levels. These findings are important for the rational design and optimization of leucine supplementation in patients with sarcopenia and autoimmune diseases.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Zhan Su, Jun Fang, Bin Yao, Gang Liu
Summary: Osteoporosis is a serious skeletal disorder that can be prevented and treated by polyphenols, which have antioxidant and anti-allergy properties. Polyphenols affect bone metabolism and density by inhibiting oxidative stress and exhibiting antibacterial effects. This article provides an overview of the preventive and therapeutic effects of polyphenols on osteoporosis and discusses the mechanisms involved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal high-fat diet can affect the structure and function of offspring's pancreas, leading to weight gain, glucose metabolism disorders, and insulin secretion defects. The study found that this may be related to DNA methylation of specific genes in the pancreas.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Hanaa Mousa, Aisha Al Saei, Rozaimi Mohamad Razali, Susu M. Zughaier
Summary: Vitamin D deficiency and dyslipidemia have significant implications for human health. This study investigates the proteomic profiles of individuals with and without these conditions, revealing decreased HDL-associated apolipoproteins and increased acute-phase proteins. Pathway analysis highlights inflammatory and cancer pathways associated with vitamin D deficiency and dyslipidemia.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qi-Lan Jiang, Tao Li, Qin Xu, Yang Zeng, Wei Wang, Bo-Tao Zhang, Qing-Ping Yao, Rui Jiang, Jun Jiang
Summary: Environmental factors, especially dietary habits, play a significant role in the susceptibility and progression of cardiovascular diseases through epigenetic modification. This study found that a methyl donor diet can attenuate balloon injury-induced intimal hyperplasia in rat carotid arteries, potentially by influencing the composition and function of the extracellular matrix.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Jiayi Cai, Yajie Qiao, Lingbin Chen, Youguang Lu, Dali Zheng
Summary: The Notch signaling pathway plays a regulatory role in normal biological processes such as cellular differentiation, apoptosis, and stem cell self-renewal. Dysregulation of this pathway is associated with various types of cancer. Natural products targeting the Notch pathway have shown potential as chemopreventive and anti-cancer agents, providing a feasible solution to fight against cancer by either alone or in combination with current therapeutic agents.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)