Article
Clinical Neurology
Yujun Gao, Xin Guo, Sanwang Wang, Zhengyuan Huang, Baoli Zhang, Jiayu Hong, Yi Zhong, Chao Weng, Haibo Wang, Yunfei Zha, Jie Sun, Lin Lu, Gaohua Wang
Summary: This study aimed to investigate the role of the frontoparietal network (FPN) in the imaging pathophysiology of bipolar disorder (BD). The results showed increased network homogeneity (NH) in the left middle frontal gyrus (MFG) in bipolar mania (BipM) patients, and increased NH in the right inferior parietal lobule (IPL) in remitted bipolar disorder (rBD) patients. Support vector machine analysis demonstrated that NH values in the right IPL could differentiate BipM patients from rBD patients, and support vector regression analysis showed a significant association between predicted and actual symptomatic improvement based on the reduction ratio of the Young's Mania Rating Scale total scores.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Yang Yang, Qian Cui, Fengmei Lu, Yajing Pang, Yuyan Chen, Qin Tang, Di Li, Ting Lei, Zongling He, Shan Hu, Jiaxin Deng, Huafu Chen
Summary: The study revealed abnormal functional connectivity patterns of DMN subsystems in patients with bipolar disorder during major depressive episodes, and these abnormalities were associated with high levels of pessimism, highlighting the importance of pathological mechanisms in this disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Neurosciences
Shaoli Li, Duo Lv, Chao Qian, Jiajun Jiang, Peifen Zhang, Caixi Xi, Lingling Wu, Xingle Gao, Yaoyang Fu, Danhua Zhang, Yiqing Chen, Huimin Huang, Yiyi Zhu, Xiaorong Wang, Jianbo Lai, Shaohua Hu
Summary: Peripheral T-cell subsets may serve as a biomarker to differentiate major depressive disorder (MDD) and bipolar disorder (BD). Significant differences were found in CD3+, CD4+, CD8+ T-cell, and natural killer (NK) cell proportions among patients with MDD, BD mania, and BD depression (BD-D). The random forest model showed good performance in distinguishing BD-D from MDD patients.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qinghe Li, Fanghui Dong, Qun Gai, Kaili Che, Heng Ma, Feng Zhao, Tongpeng Chu, Ning Mao, Peiyuan Wang
Summary: Machine-learning models combined with multisequence MRI neuroimaging features significantly improve the diagnosis of major depressive disorder and accurately predict suicide risk in patients with MDD.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Clinical Neurology
John J. Soderholm, J. Lumikukka Socada, Tom Rosenstrom, Jesper Ekelund, Erkki Isometsa
Summary: The course of illness differs between MDD, BD, and BPD patients. Bipolar depressive patients have an alternating course and the shortest time to first remission. The severity of BPD may predict the duration of remission from depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Yachen Shi, Linhai Zhang, Cancan He, Yingying Yin, Ruize Song, Suzhen Chen, Dandan Fan, Deyu Zhou, Yonggui Yuan, Chunming Xie, Zhijun Zhang
Summary: Neuroimaging features accurately reflect individual sleep disturbance levels and can serve as potential diagnostic biomarkers for major depressive disorder. A classification model based on these features effectively distinguishes MDD patients from normal controls.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Xiao-Li Sun, Li-Na Ma, Zhen-Zhu Chen, Yan-Bing Xiong, Jiao Jia, Yu Wang, Yan Ren
Summary: This study found significant differences in the metabolic phenotypes between bipolar disorder (BD), major depressive disorder (MDD), and healthy controls. Glycerolipid metabolism was significantly involved in both BD and MDD, while pyruvate metabolism was significantly involved in MDD. Pyruvate, choline, and acetate may be potential biomarkers for distinguishing MDD from BD, and pantothenic acid may be a potential biomarker for distinguishing BD from MDD.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Clinical Neurology
Xiaohui Wu, Zhiang Niu, Yuncheng Zhu, Yifan Shi, Hong Qiu, Wenjie Gu, Hongmei Liu, Jie Zhao, Lu Yang, Yun Wang, Tiebang Liu, Yong Xia, Yan Yang, Jun Chen, Yiru Fang
Summary: The study found that using common clinical laboratory tests such as age, DBIL, LDH, FT3, and CRP can effectively distinguish BD from MDD in adolescents. The predictive models showed high accuracy rates, and the external validation also demonstrated good discriminatory ability.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2022)
Article
Health Care Sciences & Services
Antonio Del Casale, Leda Marina Pomes, Luca Bonanni, Federica Fiasche, Clarissa Zocchi, Alessio Padovano, Ottavia De Luca, Gloria Angeletti, Roberto Brugnoli, Paolo Girardi, Robert Preissner, Marina Borro, Giovanna Gentile, Maurizio Pompili, Maurizio Simmaco
Summary: Pharmacogenomics-guided treatment may be effective in the cure of treatment-resistant depression. This study evaluated the clinical changes after PGT in patients with TRD and found that the PGT group showed significant improvements in efficacy index and clinical global impression compared to the control group.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Clinical Neurology
Danielle A. Goldman, Anjali Sankar, Alexandra Rich, Jihoon A. Kim, Brian Pittman, R. Todd Constable, Dustin Scheinost, Hilary P. Blumberg
Summary: This study aimed to identify functional connectivity differences between depressions of bipolar disorder (BD-Dep) and depressions of major depressive disorder (MDD-Dep). The results showed that there were significant differences in functional connectivity patterns between these two groups, suggesting the potential for early diagnosis and treatment strategies.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Petra Steinacker, M. H. D. Rami Al Shweiki, Patrick Oeckl, Heiko Graf, Albert C. Ludolph, Carlos Schonfeldt-Lecuona, Markus Otto
Summary: This study suggests that serum GFAP levels could enhance the differential diagnosis of MDD and could be used to objectively quantify depression severity, with levels increasing with age and MDD severity. The levels of serum GFAP are independent of neurodegeneration.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Medical Laboratory Technology
You-Rim Lee, Jiyeong Lee, Hee-Gyoo Kang
Summary: This study identified a potential serum protein biomarker, tetranectin, for diagnosing and classifying the severity of major depressive disorder (MDD). Further verification and validation studies confirmed the efficacy of tetranectin in qualitative and quantitative analysis, showing fair discrimination performance. Additional research is needed for further verification and validation.
CLINICA CHIMICA ACTA
(2023)
Article
Psychiatry
Dan Lv, Yangpan Ou, Dan Xiao, Huabing Li, Feng Liu, Ping Li, Jingping Zhao, Wenbin Guo
Summary: The study identified disrupted ReHo patterns in MDD patients with SD, and proposed a potential neuroimaging-based diagnostic biomarker through abnormal ReHo values in left postCG and right ITG for high accuracy in discriminating SD in MDD patients, showing promise for diagnostic application.
Article
Clinical Neurology
Alessandro Miola, Leonardo Tondo, Marco Pinna, Martina Contu, Ross J. Baldessarini
Summary: The study compared patients diagnosed with DSM-5 type II bipolar disorder (BD2) and major depressive disorder (MDD). The results showed significant differences between BD2 and MDD patients in terms of symptoms, morbidity, and treatment, which can contribute to better differentiation and treatment planning for the two disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Joseigla Pinto de Oliveira, Karen Jansen, Taiane de Azevedo Cardoso, Thaise Campos Mondin, Luciano Dias de Mattos Souza, Ricardo Azevedo da Silva, Fernanda Pedrotti Moreira
Summary: The study aimed to assess the role of childhood trauma in differentiating MDD and BD, as well as to describe the conversion rate from MDD to BD and its predictors. Findings indicated that predictors of conversion to BD included lower education, substance abuse, younger age of onset, and family history, while childhood trauma was not a significant risk factor for conversion.
PSYCHIATRY RESEARCH
(2021)
Article
Clinical Neurology
Gabriel Tortella, Bernardo Sampaio-Junior, Marina L. Moreno, Adriano H. Moffa, Adriano Fernandes da Silva, Beny Lafer, Paulo Andrade Lotufo, Wagner Gattaz, Lucas Borrione, Rodrigo Machado-Vieira, Stephan Goerigk, Isabela M. Bensenor, Andre R. Brunoni
Summary: The study found that cognitive performance of patients with bipolar depression did not significantly change during transcranial direct current stimulation (tDCS) treatment, and there was no decrease in cognitive function. These results need to be further replicated in larger studies.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2021)
Review
Neurosciences
Christopher R. K. Ching, Derrek P. Hibar, Tiril P. Gurholt, Abraham Nunes, Sophia I. Thomopoulos, Christoph Abe, Ingrid Agartz, Rachel M. Brouwer, Dara M. Cannon, Sonja M. C. de Zwarte, Lisa T. Eyler, Pauline Favre, Tomas Hajek, Unn K. Haukvik, Josselin Houenou, Mikael Landen, Tristram A. Lett, Colm McDonald, Leila Nabulsi, Yash Patel, Melissa E. Pauling, Tomas Paus, Joaquim Radua, Marcio G. Soeiro-de-Souza, Giulia Tronchin, Neeltje E. M. van Haren, Eduard Vieta, Henrik Walter, Ling-Li Zeng, Martin Alda, Jorge Almeida, Dag Alnaes, Silvia Alonso-Lana, Cara Altimus, Michael Bauer, Bernhard T. Baune, Carrie E. Bearden, Marcella Bellani, Francesco Benedetti, Michael Berk, Amy C. Bilderbeck, Hilary P. Blumberg, Erlend Boen, Irene Bollettini, Caterina del Mar Bonnin, Paolo Brambilla, Erick J. Canales-Rodriguez, Xavier Caseras, Orwa Dandash, Udo Dannlowski, Giuseppe Delvecchio, Ana M. Diaz-Zuluaga, Danai Dima, Edouard Duchesnay, Torbjorn Elvsashagen, Scott C. Fears, Sophia Frangou, Janice M. Fullerton, David C. Glahn, Jose M. Goikolea, Melissa J. Green, Dominik Grotegerd, Oliver Gruber, Bartholomeus C. M. Haarman, Chantal Henry, Fleur M. Howells, Victoria Ives-Deliperi, Andreas Jansen, Tilo T. J. Kircher, Christian Knoechel, Bernd Kramer, Beny Lafer, Carlos Lopez-Jaramillo, Rodrigo Machado-Vieira, Bradley J. MacIntosh, Elisa M. T. Melloni, Philip B. Mitchell, Igor Nenadic, Fabiano Nery, Allison C. Nugent, Viola Oertel, Roel A. Ophoff, Miho Ota, Bronwyn J. Overs, Daniel L. Pham, Mary L. Phillips, Julian A. Pineda-Zapata, Sara Poletti, Mircea Polosan, Edith Pomarol-Clotet, Arnaud Pouchon, Yann Quide, Maria M. Rive, Gloria Roberts, Henricus G. Ruhe, Raymond Salvador, Salvador Sarro, Theodore D. Satterthwaite, Aart H. Schene, Kang Sim, Jair C. Soares, Michael Staeblein, Dan J. Stein, Christian K. Tamnes, Georgios V. Thomaidis, Cristian Vargas Upegui, Dick J. Veltman, Michele Wessa, Lars T. Westlye, Heather C. Whalley, Daniel H. Wolf, Mon-Ju Wu, Lakshmi N. Yatham, Carlos A. Zarate, Paul M. Thompson, Ole A. Andreassen
Summary: MRI-derived brain measures have been widely studied in bipolar disorder (BD) and provide insights into the connections between genes, the environment, and behavior. The ENIGMA Bipolar Disorder Working Group is a collaborative effort that aims to generate consensus findings and improve the replicability of studies on BD. Through large-scale neuroimaging studies, the working group has discovered patterns of brain alterations associated with BD, as well as the effects of medications and clinical risk profiles.
HUMAN BRAIN MAPPING
(2022)
Editorial Material
Psychiatry
Rodrigo Machado-Vieira, Joao Quevedo, Lokesh Shahani, Jair C. Soares
BRAZILIAN JOURNAL OF PSYCHIATRY
(2021)
Article
Geriatrics & Gerontology
Z. M. Lobato, A. C. Almeida da Silva, S. M. Lima Ribeiro, M. M. Biella, A. Santos Silva Siqueira, T. Correa de Toledo Ferraz Alves, R. Machado-Vieira, M. K. Borges, R. C. Oude Voshaar, Ivan Aprahamian
Summary: The study aims to evaluate the prevalence of malnutrition in depressed older inpatients and determine which indices of malnutrition predict adverse health outcomes in late-life depression.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Review
Chemistry, Medicinal
Courtney M. Vecera, Gabriel R. Fries, Lokesh R. Shahani, Jair C. Soares, Rodrigo Machado-Vieira
Summary: Studies suggest that the therapeutic efficacy of lithium in treating BD may be related to genetic variations, gene regulation, and stress responses, providing new directions for personalized treatment of BD patients.
Article
Clinical Neurology
M. G. Soeiro-de-Souza, E. Scotti-Muzzi, F. Fernandes, R. T. De Sousa, C. C. Leite, M. C. Otaduy, R. Machado-Vieira
Summary: The study longitudinally assessed H-1-MRS metabolites in the ACC of BDep patients and found higher levels of mI/Cr and Cho/Cr compared to healthy controls at baseline. After treatment, levels of mI/Cr or Cho/Cr in euthymic patients were similar to controls, while non-responders still had elevated Cho/Cr levels. This suggests a critical regulatory effect of lithium on the PI cycle involved in mood regulation.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Antonio L. Teixeira, Trudy Millard Krause, Lopita Ghosh, Lokesh Shahani, Rodrigo Machado-Vieira, Scott D. Lane, Eric Boerwinkle, Jair C. Soares
Summary: This study found that patients with schizophrenia, mood disorders, and anxiety disorders are more likely to test positive for COVID-19 and have a higher risk of mortality compared to a reference group without major psychiatric conditions, after controlling for various demographic and comorbid factors.
Article
Clinical Neurology
Gregory Jones, Carola Rong, Courtney M. Vecera, Christopher Gurguis, Roshan Chudal, Rushaniya Khairova, Edison Leung, Ana C. Ruiz, Lokesh Shahani, Marcus Zanetti, Rafael T. de Sousa, Geraldo Busatto, Jair Soares, Wagner F. Gattaz, Rodrigo Machado-Vieira
Summary: Lithium may play an important role in treating comorbid anxiety in bipolar disorder, both as adjunct and monotherapy. Lower doses of lithium may provide equivalent efficacy and enhance tolerability and compliance.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Biochemistry & Molecular Biology
Gustavo C. Medeiros, Todd D. Gould, William L. Prueitt, Julie Nanavati, Michael F. Grunebaum, Nuri B. Farber, Balwinder Singh, Sudhakar Selvaraj, Rodrigo Machado-Vieira, Eric D. Achtyes, Sagar V. Parikh, Mark A. Frye, Carlos A. Zarate, Fernando S. Goes
Summary: (R,S)-ketamine and (S)-ketamine have rapid and substantial antidepressant effects, but there is no well-accepted method to differentiate responders from non-responders. The association between blood-based biomarkers and response to ketamine was examined in a systematic review/meta-analysis, revealing limited evidence of a consistent relationship.
MOLECULAR PSYCHIATRY
(2022)
Article
Clinical Neurology
Gregory Jones, Robert Suchting, Marcus Zanetti, Edison Leung, Sabrina Correa da Costa, Rafael T. de Sousa, Geraldo Busatto, Jair Soares, Maria C. Otaduy, Wagner F. Gattaz, Rodrigo Machado-Vieira
Summary: The study found that positive adaptations with lithium can be observed throughout the brain after only six weeks of low-therapeutic serum levels of monotherapy. These results remove confounders seen in prior studies and support the extensive evidence for long-term lithium therapy in bipolar disorder, suggesting its potential use in wider demographics.
PSYCHIATRY RESEARCH-NEUROIMAGING
(2022)
Article
Multidisciplinary Sciences
Antonio L. Teixeira, Regina M. Hansen, Joseph S. Wozny, Caroline M. Schaefer, Rodrigo Machado-Vieira, Lokesh Shahani, Scott D. Lane, Jair C. Soares, Trudy M. Krause
Summary: The COVID-19 pandemic has had a significant impact on mental health outcomes, and individuals with COVID-19 are more likely to be diagnosed with new psychiatric disorders.
Article
Multidisciplinary Sciences
Allison C. Nugent, Adam G. Thomas, Margaret Mahoney, Alison Gibbons, Jarrod T. Smith, Antoinette J. Charles, Jacob S. Shaw, Jeffrey D. Stout, Anna M. Namyst, Arshitha Basavaraj, Eric Earl, Travis Riddle, Joseph Snow, Shruti Japee, Adriana J. Pavletic, Stephen Sinclair, Vinai Roopchansingh, Peter A. Bandettini, Joyce Chung
Summary: The NIMH Healthy Research Volunteer Dataset provides a comprehensive collection of data characterizing healthy research volunteers, including various assessments and neuroimaging techniques, which can contribute to a wide range of secondary investigations in both non-clinical and clinical research.
Letter
Biochemistry & Molecular Biology
Gregory Jones, Rodrigo Machado-Vieira
MOLECULAR PSYCHIATRY
(2023)
Meeting Abstract
Neurosciences
Krista Wartchow, Giselli Scaini, Tina Li, Giovana Zunta-Soares, Rodrigo Machado-Vieira, Jair Soares, Joao Quevedo
NEUROPSYCHOPHARMACOLOGY
(2022)
Review
Cell Biology
Gregory H. Jones, Courtney M. Vecera, Omar F. Pinjari, Rodrigo Machado-Vieira
Summary: Bipolar disorder is a heterogeneous and multifactorial disease, where inflammation plays a significant role in affecting various systems. Understanding the role of inflammation in connecting these systems is crucial for identifying promising future targets for therapeutic development and screening.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)