Article
Neurosciences
Satoshi Kawauchi, Takao Yasuhara, Kyohei Kin, Satoru Yabuno, Chiaki Sugahara, Takayuki Nagase, Kakeru Hosomoto, Yosuke Okazaki, Yousuke Tomita, Michiari Umakoshi, Tatsuya Sasaki, Masahiro Kameda, Cesario Borlongan, Isao Date
Summary: This study investigates the regenerative mechanisms of SB623 cells in rats with experimental acute ischemic stroke. The results show that both encapsulated and non-encapsulated SB623 cells have therapeutic effects, improving neurological severity score and reducing infarction area. Encapsulated SB623 cells demonstrate enhanced neurogenesis and increased viability.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Review
Cell Biology
Cyril Bouland, Pierre Philippart, Didier Dequanter, Florent Corrillon, Isabelle Loeb, Dominique Bron, Laurence Lagneaux, Nathalie Meuleman
Summary: Bone regeneration is a complex process relying on interactions between osteogenesis and angiogenesis. Tissue engineering provides strategies with regenerative cell sources, growth factors, and mechanical stimulation. Vascularization is crucial for bone formation and function, with studies showing synergy between mesenchymal stromal cells (MSCs) and endothelial progenitor cells (EPCs) in promoting regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Kitti Thiankhaw, Nipon Chattipakorn, Siripron C. Chattipakorn
Summary: MCAO and cerebral I/R injury can lead to microvascular injury, blood-brain barrier dysfunction, inflammation, oxidative stress, and neuronal death, resulting in brain infarction. HBOT has shown positive effects on neurological outcomes after these injuries, but conflicting data exists on its impact on functional recovery. Studies have been conducted to evaluate the potential benefits of HBOT, both in vivo and clinically, in the context of stroke outcomes.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Stefania Crippa, Anastasia Conti, Valentina Vavassori, Samuele Ferrari, Stefano Beretta, Silvia Rivis, Roberto Bosotti, Serena Scala, Stefania Pirroni, Raisa Jofra-Hernandez, Ludovica Santi, Luca Basso-Ricci, Ivan Merelli, Pietro Genovese, Alessandro Aiuti, Luigi Naldini, Raffaella Di Micco, Maria Ester Bernardo
Summary: Mesenchymal stromal cells (MSCs) have been shown to play a supportive role in the expansion and engraftment of hematopoietic stem and progenitor cells (HSPCs). In this study, we developed a co-culture system using bone marrow (BM)-MSCs to improve the transplantation outcome of CRISPR-Cas9 gene-edited (GE) human HSPCs. We found that BM-MSCs can produce hematopoietic supportive and anti-inflammatory factors that enhance the expansion and clonogenic potential of GE-HSPCs in vitro, leading to improved engraftment and early phase hematological reconstitution in transplanted mice. This study suggests a potential clinical application of BM-MSCs in promoting successful transplantation of GE-HSPCs.
Article
Polymer Science
Zhe Xing, Xiaofeng Jiang, Qingzong Si, Anna Finne-Wistrand, Bin Liu, Ying Xue, Kamal Mustafa
Summary: In a rat calvarial defect model, adding endothelial cells (ECs) to a culture of bone marrow stromal cells (BMSCs) has been reported to enhance bone formation significantly. This study aimed to further investigate the ossification process of newly formed osteoid and host response to poly(L-lactide-co-1,5-dioxepan-2-one) [poly(LLA-co-DXO)] scaffolds. The results showed increased expression of endochondral ossification-related genes in the CO group, along with the formation of cartilage-like tissue in the scaffold pores and the observation of multinucleated giant cells (MNGCs) surrounding the scaffold fragments.
Review
Cell Biology
Xinyu Li, Qing Fan, Xueqiang Peng, Shuo Yang, Shibo Wei, Jingang Liu, Liang Yang, Hangyu Li
Summary: MSCs in the tumour microenvironment play a crucial role in promoting tumour development. Utilizing exosomes as communicators offers potential for improving outcomes and developing targeted treatment.
CELL DEATH DISCOVERY
(2022)
Review
Cell Biology
Stefania Crippa, Ludovica Santi, Margherita Berti, Giada De Ponti, Maria Ester Bernardo
Summary: The human organism requires the production of approximately 1 trillion new blood cells per day through hematopoiesis in the bone marrow, regulated by the BM microenvironment and HSPCs. The BM niche, defined by interactions between HSPCs and non-hematopoietic cells, controls HSPC maintenance and orchestrates hematopoiesis according to the body's needs. Mesenchymal stromal cells (MSCs) play a key role in the BM niche by regulating HSPC homeostasis and impacting the outcome of hematopoietic stem cell transplantation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biology
Zheting Liao, Yu Jin, Yuhao Chu, Hansen Wu, Xiaoyu Li, Zhonghao Deng, Shuhao Feng, Nachun Chen, Ziheng Luo, Xiaoyong Zheng, Liangxiao Bao, Yongqing Xu, Hongbo Tan, Liang Zhao
Summary: A study using single-cell RNA sequencing explored the transcriptomic landscape of alcohol-induced osteonecrosis of the femoral head (ONFH). The study revealed the relevance of stromal and endothelial cells to the pathogenesis of the disease and provided resources for developing cell type-specific therapeutic strategies.
COMMUNICATIONS BIOLOGY
(2022)
Article
Materials Science, Biomaterials
Ziyan Wang, Feixue Mi, Jinchen Li, Dandan Chen, Minmin Lin, Xinyu Wang, Siying Wu, Changfeng Wu, Chao Liu
Summary: Bone marrow stromal cells (BMSCs) have great potential in bone defect repair. By using semiconducting polymer dots (Pdots) as markers, we successfully selected BMSCs and evaluated their therapeutic efficacy in a bone defect model.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Hannah L. L. Smith, Juliet C. C. Gray, Stephen A. A. Beers, Janos M. M. Kanczler
Summary: Osteosarcoma, a bone cancer typically found in adolescents, is closely related to the conversion of bone marrow during adolescence. This study compared the differentiation potential of bone marrow cells from different regions with osteosarcoma cell lines. The results showed distinct differences in the differentiation abilities of hematopoietic and adipocyte-rich bone marrow, which correlated with specific characteristics of the osteosarcoma cell lines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Sijie Li, Wenbo Zhao, Guiyou Liu, Changhong Ren, Ran Meng, Yuan Wang, Haiqing Song, Qingfeng Ma, Yuchuan Ding, Xunming Ji
Summary: Chronic remote ischemic conditioning (RIC) appears to be well-tolerated and associated with a low annual risk of ischemic stroke and cardio-cerebrovascular events in patients with symptomatic internal carotid artery or middle cerebral artery occlusion with impaired hemodynamics.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Review
Cell & Tissue Engineering
Mauro Krampera, Katarina Le Blanc
Summary: MSCs have shown exceptional safety in clinical trials, but reliable potency assays to predict their immunosuppressive efficacy are still lacking. They are approved for certain diseases in Japan and Europe, but not in the United States. Researchers discuss potential mechanisms of action, experimental models, and approaches for identifying MSC effects in vivo.
Article
Biochemistry & Molecular Biology
Chun-Wei Wu, Jia-Jin Chen, Chou-Ching K. Lin, Chien-An Chen, Chun-Ie Wu, Ing-Shiou Hwang, Tsung-Hsun Hsieh, Bor-Shing Lin, Chih-Wei Peng
Summary: This study investigated the changes in brain tissue optical properties using frequency-domain near-infrared spectroscopy (FD-NIRS) and established the relationship between cerebral hemodynamics and infarct variation in a middle cerebral artery occlusion (MCAO) model. The results suggest that FD-NIRS parameters may be associated with the severity of the infarction and subsequent pathologies in MCAO.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Jing Li, Yongfeng Chen
Summary: This study found that RRPs can help promote hematopoietic recovery in mice with aplastic anemia and facilitate the recovery of hematopoietic tissue. The study also revealed the hematopoietic regulatory mechanisms of RRPs, providing a laboratory basis for clinical research on RRPs.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Cell & Tissue Engineering
Krzysztof Dabkowski, Anna Labedz-Maslowska, Barbara Dolegowska, Krzysztof Safranow, Marta Budkowska, Ewa Zuba-Surma, Teresa Starzynska
Summary: A growing body of research suggests that bone marrow-derived stem cells (BMSCs) may play a role in tissue repair in the pancreas, but their specific involvement in acute and chronic pancreatitis is not well understood.
STEM CELLS INTERNATIONAL
(2022)
