Article
Biochemistry & Molecular Biology
You Ji Kim, Kwang Hwan Park, Kyoung-Mi Lee, Yong-Min Chun, Jin Woo Lee
Summary: Ubiquitin-specific protease 7 (USP7) plays a crucial role in regulating self-renewal and differentiation of hBMSCs, especially in the early stages of osteogenic, adipogenic, and chondrogenic differentiation. USP7 acts as an upstream regulator of SOX2 and NANOG, and its deficiency leads to downregulation of these self-renewal regulating proteins. Targeting USP7 could be a potential strategy to preserve the self-renewal capacity of hBMSCs for stem cell therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xueting Xu, Tanveer Ahmed, Lulu Wang, Xintao Cao, Zeyu Zhang, Ming Wang, Yuan Lv, Shahzina Kanwal, Muqddas Tariq, Runxia Lin, Hui Zhang, Yinghua Huang, Hao Peng, Danni Lin, Xue Shi, Didi Geng, Baohua Liu, Xiaofei Zhang, Wen Yi, Yan Qin, Miguel A. Esteban, Baoming Qin
Summary: The study demonstrates the role of mTORC1 in regulating paused pluripotency in mESCs, and reveals a context-dependent function of eIF4F in translating pluripotency genes in SL and 2iL culture conditions.
Article
Cell Biology
Haibin Jiang, Mingxia Du, Yaning Li, Tengfei Zhou, Jia Lei, Hongqing Liang, Zhen Zhong, Rafia S. Al-Lamki, Ming Jiang, Jun Yang
Summary: It has been found that ID1 and ID3 play important roles in the survival and pluripotency of hESCs, regulating the transition between primed and naive-like states through the AKT signaling pathway. TCF3 mediates transcriptional inhibition of MCL1 to promote AKT phosphorylation.
CELL DEATH & DISEASE
(2022)
Article
Biotechnology & Applied Microbiology
Jingjing Hu, Ke Chen, Fangfang Hong, Guosheng Gao, Xiaoyu Dai, Hua Yin
Summary: METTL3 modifies SOCS3 mRNA with m6A to promote the stemness and tumorigenicity of LCSCs.
CANCER GENE THERAPY
(2023)
Article
Developmental Biology
Anish Dattani, Tao Huang, Corin Liddle, Austin Smith, Ge Guo
Summary: Stabilization of human naive pluripotent stem cells and suppression of trophectoderm differentiation require inhibition of Tankyrase. XAV939 prevents trophectoderm induction by reducing YAP activation and stabilizing nuclear angiomotin. Depletion of YAP1 or TAZ in naive pluripotent stem cells allows efficient self-renewal and resistance to trophectoderm differentiation.
Article
Cell & Tissue Engineering
Fuquan Chen, Xiaomin Li, Xiao Feng, Tingting Gao, Weiyu Zhang, Zhi Cheng, Xuan Zhao, Ruiqing Chen, Xinyi Lu
Summary: In this study, lncRNA Lx8-SINE B2 was identified as a novel regulator of ESC proliferation, cell cycle, and metabolism through working with Eno1.
Article
Multidisciplinary Sciences
Pengfei Guo, Nam Hoang, Joseph Sanchez, Elaine H. Zhang, Keshari Rajawasam, Kristiana Trinidad, Hong Sun, Hui Zhang
Summary: The authors demonstrate that the assembly/disassembly of mammalian SWI/SNF complexes is dynamically regulated by a lysine methylation mechanism involving LSD1 demethylase and L3MBTL3 methyl-lysine reader protein. This mechanism targets SET7-methylated lysines in SMARCC1 and SMARCC2 for proteolysis by CRL4 ubiquitin ligase. The study also reveals the critical role of LSD1 and L3MBTL3 in maintaining the pluripotency and self-renewal of embryonic stem cells, as well as regulating proteolysis induced by loss of SWI/SNF subunits.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Xinbao Zhang, Yuting Li, Junxiang Ji, Xin Wang, Meng Zhang, Xiangfen Li, Yan Zhang, Zhenhua Zhu, Shou-Dong Ye, Xiaoxiao Wang
Summary: The study demonstrates that Gadd45 family genes play a role in regulating differentiation of mouse ESCs, with Gadd45g activating the MAPK signaling pathway. Additionally, GADD45G functions as a suppressor in human breast cancers, effectively limiting tumor formation and metastasis.
CELL DEATH DISCOVERY
(2021)
Article
Multidisciplinary Sciences
Noriaki Yamashita, Masahiro Kawahara, Takayuki Imai, Goichi Tatsumi, Ai Asai-Nishishita, Akira Andoh
Summary: A single nucleotide polymorphism in the NUDT15 gene, known as R139C, leads to hematopoietic stem cell exhaustion upon administration of 6-MP. RNA sequencing and GO analysis reveal that changes in DNA damage response and cell cycle processes are the major effects of this mutation on HSCs. Therefore, caution should be exercised in long-term use of 6-MP in patients with NUDT15 R139C due to its potential adverse effects on HSCs.
SCIENTIFIC REPORTS
(2023)
Article
Cell & Tissue Engineering
Se-Ra Park, Seong-Kwan Kim, Soo-Rim Kim, Wook-Joon Yu, Seung-Jin Lee, Hwa-Yong Lee
Summary: Smoking has harmful effects on female fertility by inhibiting the functions of resident endometrial stem cells. Exposure to cigarette smoke extracts significantly suppresses various tissue regeneration-associated functions of endometrial stem cells by activating the SERPINB2 gene. Knockdown of SERPINB2 effectively abolishes the inhibitory effects of cigarette smoke on endometrial stem cell functions.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Developmental Biology
Masaki Kinoshita, Toshihiro Kobayashi, Benjamin Planells, Doris Klisch, Daniel Spindlow, Hideki Masaki, Susanne Bornelov, Giuliano Giuseppe Stirparo, Hitomi Matsunari, Ayuko Uchikura, Ismael Lamas-Toranzo, Jennifer Nichols, Hiromitsu Nakauchi, Hiroshi Nagashima, Ramiro Alberio, Austin Smith
Summary: This study successfully established pluripotent stem cell lines from porcine, ovine, and bovine embryos without using feeder cells or serum factors. The cells showed differentiation in teratomas and in vitro, with global transcriptome analyses revealing commonality in transcription factor expression across the three species. The research also demonstrated the generation of cloned porcine fetuses using genetically modified AFX stem cells through nuclear transfer.
Article
Oncology
Miaoling Tang, Meisongzhu Yang, Geyan Wu, Shuang Mo, Xingui Wu, Shuxia Zhang, Ruyuan Yu, Yameng Hu, Yingru Xu, Ziwen Li, Xinyi Liao, Jun Li, Libing Song
Summary: In liver cancer cells, the upregulation of MFF mediated by the TBX19/PRMT1 complex promotes mitochondrial fission and tumor-initiating capacity, indicating that PRMT1 may be a viable therapeutic target in liver cancer.
Article
Cell Biology
Yasuro Furuichi, Yuki Kawabata, Miho Aoki, Yoshitaka Mita, Nobuharu L. Fujii, Yasuko Manabe
Summary: The study demonstrates that high glucose concentrations impede the proliferation of muscle-specific stem cells and affect cell fate, leading to a decrease in reserve cells. Consequently, hyperglycemia may impact the regenerative capability of skeletal muscle fibers and contribute to sarcopenia.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell & Tissue Engineering
Martin Bergert, Sergio Lembo, Sumana Sharma, Luigi Russo, Danica Milovanovic, Kristjan H. Gretarsson, Mandy Boermel, Pierre A. Neveu, Jamie A. Hackett, Evangelia Petsalaki, Alba Diz-Munoz
Summary: Cell membrane mechanics play a crucial role in the exit from naive pluripotency of mouse embryonic stem cells, with a decrease in membrane-to-cortex attachment identified as an essential cell-intrinsic mechanism for differentiation.
Article
Cell Biology
Warunya Chakritbudsabong, Somjit Chaiwattanarungruengpaisan, Ladawan Sariya, Sirikron Pamonsupornvichit, Joao N. Ferreira, Panithi Sukho, Dulyatad Gronsang, Theerawat Tharasanit, Andras Dinnyes, Sasitorn Rungarunlert
Summary: In addition to the four transcription factors, LIN28 is required for the effective induction of piPSCs and the maintenance of their long-term self-renewal and pluripotency towards the development of all germ layers.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Education & Educational Research
Guohua Zhang, Xiaolian Tu, Nani Ding, Joseph T. F. Lau, Pengcheng Wang, Xue Yang
Summary: This three-wave longitudinal study examined the relationships between college adjustment, self-esteem, and mental health status. The findings suggest that college adjustment and self-esteem have a moderate level of stability and are significantly correlated with mental health status. Furthermore, college adjustment and self-esteem can predict future mental health outcomes. Therefore, interventions targeting self-esteem and college adjustment may have positive effects on long-term mental health.
JOURNAL OF AMERICAN COLLEGE HEALTH
(2023)
Article
Chemistry, Applied
Wangjian Cheng, Jiaqing Mu, Kun Li, Zhanxiong Xie, Pengpeng Zhang, Chongwei An, BaoYun Ye, Jingyu Wang
Summary: Resonance acoustic mixing (RAM) technology is an attractive and safe method for material mixing, which offers high efficiency and uniformity. The study on the preparation of PBX using RAM showed that the mixing process can be divided into three stages: rough cladding, converging into a smooth ball, and flat fluidization. The PBX exhibited good uniformity and rheological behavior.
JOURNAL OF ENERGETIC MATERIALS
(2023)
Correction
Biochemistry & Molecular Biology
Hong Chen, Zhixin Cui, Wenhai Lu, Ping Wang, Jia Wang, Ziyi Zhou, Nan Zhang, Zhuo Wang, Tengfei Lin, Yun Song, Lishun Liu, Xiao Huang, Ping Chen, Genfu Tang, Yong Duan, Binyan Wang, Jianping Li, Yan Zhang, Yong Huo, Hao Zhang, Xiping Xu, Xianhui Qin, Yan Yang
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Neuroimaging
Zhaochu Sun, Ruiliang Wang, Hongquan Dong, Zheng Li, Hua Lu, Youli Hu
Summary: This study demonstrates that a prophylactic intra-arterial injection of 20 mg lidocaine can effectively and safely prevent TCR during endovascular embolization. This finding is significant for the management of TCR.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Automation & Control Systems
Xinquan Zhang, Jianlin Wang
Summary: This paper studies the problem of guaranteed cost control and anti-windup design for a class of switched systems with actuator saturation. The switching strategy and anti-windup compensator are designed to ensure the stability of the closed-loop system and minimize the cost function. Sufficient conditions for the existence of an anti-windup compensator of guaranteed cost are presented using the multiple Lyapunov functions method. Based on these conditions, the minimum upper bound of the cost function is determined by solving an optimization problem under the constraint of linear matrix inequality (LMI). A numerical example is provided to demonstrate the effectiveness of the proposed method.
JOURNAL OF CONTROL AND DECISION
(2023)
Article
Nutrition & Dietetics
Xinyi Wu, Le Cui, Haoquan Wang, Jinhong Xu, Zhaozhao Zhong, Xibei Jia, Jiaqi Wang, Huahua Zhang, Yanteng Shi, Yuhang Tang, Qianhui Yang, Qiongdan Liang, Yujing Zhang, Jing Li, Xiaohong Jiang
Summary: The study compared the effects of consuming sucralose and sucrose on glucose and lipid metabolism in male mice. Results showed that sucralose had a lower impact on glucose and lipid homeostasis compared to sucrose. Sucrose consumption led to increased fat accumulation, hyperlipidaemia, liver steatosis, and glucose intolerance in mice.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Pharmacology & Pharmacy
Yun Qing, Peter F. Thall, Ying Yuan
Summary: A robust Bayesian design is proposed for monitoring a time to event endpoint in a single-arm phase II trial. Simulation results show that the piecewise exponential design has better performance than the exponential inverse gamma model based design, with higher probabilities of correctly stopping the trial early and shorter and less variable trial duration. Compared to the Weibull model based design, the piecewise exponential design does a better job of maintaining small incorrect stopping probabilities when the true median survival time is desirably large.
PHARMACEUTICAL STATISTICS
(2023)
Article
Chemistry, Multidisciplinary
Jie Li, Yan Zhou, Guy Eelen, Qing-tong Zhou, Wen-bo Feng, Viktorija Labroska, Fen-fen Ma, Hui-ping Lu, Mieke Dewerchin, Peter Carmeliet, Ming-wei Wang, De-hua Yang
Summary: The growth of solid tumors relies on tumor vascularization and endothelial cells. Targeting the glycolytic activity of endothelial cells can normalize tumor vessels, reduce metastasis, and improve chemotherapy outcomes.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Chemistry, Multidisciplinary
Xu Chi, Qian Chen, Zhi-An Lan, Xirui Zhang, Xiong Chen, Xinchen Wang
Summary: Conjugated polymers (CPs) have received increasing attention in photocatalysis due to their stability and molecular tunability. In this study, a new efficient cyano (CN) engineering approach was proposed to enhance the photocatalytic performance of CPs. Three CP-based photocatalysts with different CN contents were synthesized to investigate the relationship between CN functionalization and photocatalytic activity. Experimental and theoretical studies revealed that CN functionalization strengthened the donor-acceptor (D-A) interaction, enhanced light absorption, charge separation/transfer efficiency, hydrophilicity of CPs, and facilitated the output of photoinduced electrons from CPs to Pt cocatalyst.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Endocrinology & Metabolism
Wenjing He, Anhua Lin, Chenxiu Wang
Summary: This study found that adipocyte exosomes damage microvascular endothelial cells through the LINC00968/miR-361-5p/TRAF3 signaling pathway in the context of diabetes and obesity, which may serve as a new target for treating microvascular complications caused by diabetes and obesity.
HORMONE AND METABOLIC RESEARCH
(2023)
Proceedings Paper
Engineering, Aerospace
Jiabao Xu, Yan Wu, Qingcheng Zhu, Ping Jin, Jue Wang, Guobiao Cai
Summary: The 3D flow filling process of LOX dome in a liquid oxygen/methane rocket engine was studied, and the volume, flow field pressure, and velocity distributions of liquid oxygen at different times were determined. The flow property of propellant and the injection characteristic time of liquid oxygen were obtained. The results revealed that when the LOX dome was not filled, the flow state of LOX was disorderly and it flowed around the annular wall in the middle dome. However, after the LOX filling was completed, the liquid oxygen flow became stable and the overall velocity distribution became more uniform. There were also varying injection delays in different areas, leading to the inhomogeneity of injection characteristic time and flow rate in the thrust chamber.
13TH ASIA CONFERENCE ON MECHANICAL AND AEROSPACE ENGINEERING, ACMAE 2022
(2023)
Article
Spectroscopy
Zhang Fu, Cao Wei-hua, Cui Xia-hua, Wang Xin-yue, Fu San-ling, Zhang Ya-kun
Summary: Currently, there are few non-destructive testing models for the soluble solids content (SSC) of cherry tomatoes. This study proposes a prediction model based on the spectral characteristics of cherry tomatoes and an improved BP neural network algorithm to solve the problem of rapid non-destructive detection of cherry tomatoes' internal quality.
SPECTROSCOPY AND SPECTRAL ANALYSIS
(2023)
Article
Chemistry, Multidisciplinary
Weitian Zhang, Hongmiao Tian, Tianci Liu, Haoran Liu, Fabo Zhao, Xiangming Li, Chunhui Wang, Xiaoliang Chen, Jinyou Shao
Summary: This study proposes a smart skin system inspired by the active color-changing mechanism of chameleons. By integrating a nanoscale hole array of photonic crystals, carbon nanotube coatings, and liquid crystal elastomers, the smart skin achieves structural color tunability, sensing, and actuation. The system autonomously modulates the color according to the environmental color and successfully demonstrates color scanning from red to green to blue. This research opens up new paths for creating active tunable structural color systems and promotes the development of structural color-based devices and systems.
MATERIALS HORIZONS
(2023)
Article
Electrochemistry
Yuying Li, Jingyi Wang, Zhihong Tian, Feili Lai, Tianxi Liu, Guanjie He
Summary: In this study, VO2/rGO composites with high electrical conductivity were successfully synthesized, and an electrochemically induced phase transition from tunneled VO2/rGO to Zn-3(OH)(2)V2O7 center dot 2H(2)O/rGO with a laminated structure and an enhanced interlayer spacing was demonstrated during the first charge to 1.6 V, showing preferable Zn2+ storage capacity. This work opens a new idea of design strategy to develop high-voltage ZIBs.
BATTERIES & SUPERCAPS
(2023)
Article
Engineering, Environmental
Jiajie Wang, Xiaoxing Wang, Mohammad S. AlQahtani, Sean D. Knecht, Sven G. Bilen, Wei Chu, Chunshan Song
Summary: This study compared CO2 hydrogenation under thermal-catalytic and plasma-catalytic conditions. The results showed significant synergy between plasma and catalyst at low temperatures, leading to increased CO2 conversion. The plasma-catalytic reaction had lower activation energy and promoted CO2 activation.
CHEMICAL ENGINEERING JOURNAL
(2023)