Cell Surface Mechanics Gate Embryonic Stem Cell Differentiation

The stiffness of living tissues and its implications for tissue engineering

(2020) Carlos F. Guimarães et al.   Nature Reviews Materials

Membrane-proximal F-actin restricts local membrane protrusions and directs cell migration

(2020) Anjali Bisaria et al.   SCIENCE

Defined conditions for propagation and manipulation of mouse embryonic stem cells

(2019) Carla Mulas et al.   DEVELOPMENT

Hydraulic control of mammalian embryo size and cell fate

(2019) Chii Jou Chan et al.   NATURE

The Strength of Mechanical Forces Determines the Differentiation of Alveolar Epithelial Cells

(2018) Jiao Li et al.   DEVELOPMENTAL CELL

In pursuit of the mechanics that shape cell surfaces

(2018) Alba Diz-Muñoz et al.   Nature Physics

Tracing the transitions from pluripotency to germ cell fate with CRISPR screening

(2018) Jamie A. Hackett et al.   Nature Communications

Ezrin enhances line tension along transcellular tunnel edges via NMIIa driven actomyosin cable formation

(2017) Caroline Stefani et al.   Nature Communications

Importance of environmental stiffness for megakaryocyte differentiation and proplatelet formation

(2016) A. Aguilar et al.   BLOOD

Steering cell migration by alternating blebs and actin-rich protrusions

(2016) Alba Diz-Muñoz et al.   BMC BIOLOGY

Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation

(2016) Laralynne Przybyla et al.   Cell Stem Cell

Asymmetric division of contractile domains couples cell positioning and fate specification

(2016) Jean-Léon Maître et al.   NATURE

Genetic Exploration of the Exit from Self-Renewal Using Haploid Embryonic Stem Cells

(2014) Martin Leeb et al.   Cell Stem Cell

Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells

(2014) Medha M. Pathak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exit from Pluripotency Is Gated by Intracellular Redistribution of the bHLH Transcription Factor Tfe3

(2013) Joerg Betschinger et al.   CELL

The self-renewal of mouse embryonic stem cells is regulated by cell–substratum adhesion and cell spreading

(2013) Patricia Murray et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Naive pluripotency is associated with global DNA hypomethylation

(2013) Harry G Leitch et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Plasma membrane tension orchestrates membrane trafficking, cytoskeletal remodeling, and biochemical signaling during phagocytosis

(2013) T. A. Masters et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synergistic Mechanisms of DNA Demethylation during Transition to Ground-State Pluripotency

(2013) Jamie A. Hackett et al.   Stem Cell Reports

Membrane Tension Maintains Cell Polarity by Confining Signals to the Leading Edge during Neutrophil Migration

(2012) Andrew R. Houk et al.   CELL

Extracellular-matrix tethering regulates stem-cell fate

(2012) Britta Trappmann et al.   NATURE MATERIALS

Constitutively active ezrin increases membrane tension, slows migration, and impedes endothelial transmigration of lymphocytes in vivo in mice

(2011) Y. Liu et al.   BLOOD

Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation

(2011) Jason Wray et al.   NATURE CELL BIOLOGY

Temporary increase in plasma membrane tension coordinates the activation of exocytosis and contraction during cell spreading

(2011) N. C. Gauthier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organizing the cell cortex: the role of ERM proteins

(2010) Richard G. Fehon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Soft Substrates Promote Homogeneous Self-Renewal of Embryonic Stem Cells via Downregulating Cell-Matrix Tractions

(2010) Farhan Chowdhury et al.   PLoS One

Control of Directed Cell Migration In Vivo by Membrane-to-Cortex Attachment

(2010) Alba Diz-Muñoz et al.   PLOS BIOLOGY

Hematopoietic Stem Cell Development Is Dependent on Blood Flow

(2009) Trista E. North et al.   CELL

Plasma Membrane Area Increases with Spread Area by Exocytosis of a GPI-anchored Protein Compartment

(2009) Nils C. Gauthier et al.   MOLECULAR BIOLOGY OF THE CELL

Material properties of the cell dictate stress-induced spreading and differentiation in embryonic stem cells

(2009) Farhan Chowdhury et al.   NATURE MATERIALS

Identification and characterization of subpopulations in undifferentiated ES cell culture

(2008) Y. Toyooka et al.   DEVELOPMENT