Article
Biochemistry & Molecular Biology
Marta Duran-Guell, Roger Flores-Costa, Mireia Casulleras, Cristina Lopez-Vicario, Esther Titos, Alba Diaz, Jose Alcaraz-Quiles, Raquel Horrillo, Montserrat Costa, Javier Fernandez, Vicente Arroyo, Joan Claria
Summary: Albumin not only reduces leukocyte cytokine production but also has the ability to protect tissues from the damaging actions of inflammatory mediators, particularly in the context of liver injury.
Article
Biochemistry & Molecular Biology
Jinrui Dong, Wei-Wen Lim, Shamini G. Shekeran, Jessie Tan, Sze Yun Lim, Joyce Wei Ting Goh, Benjamin L. George, Sebastian Schafer, Stuart A. Cook, Anissa A. Widjaja
Summary: This study investigated the role of IL11 and gp130 in APAP-induced liver injury using mouse models with conditional knockout of Il11 or gp130 in hepatocytes. The results showed that IL11/gp130 signaling contributes to liver damage and inhibits regeneration in APAP toxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Kartini Kartini, Nina Wati, Rabbindra Gustav, Risa Wahyuni, Yosua Fernaldi Anggada, Risna Hidayani, Antoni Raharjo, Ridho Islamie, Sulistyo Emantoko Dwi Putra
Summary: This study investigated the wound healing effects of P. major leaf extracts, ursolic acid, and oleanolic acid in hyperglycemic rats. The results showed that these substances can improve wound closure and accelerate healing time without causing acute dermal irritation. It was also found that UA and OA may have different mechanisms of action in promoting wound healing in diabetic conditions.
Article
Pharmacology & Pharmacy
Javier M. Anaya-Mancipe, Vanessa M. Queiroz, Rafael F. dos Santos, Rosane N. Castro, Veronica S. Cardoso, Alane B. Vermelho, Marcos L. Dias, Rossana M. S. M. Thire
Summary: This study developed and evaluated a nanostructured PCL electrospun dressing with Plantago major extract for wound healing. The dressing showed high antioxidant capacity and moisture absorption, which are important for skin healing. The extract-controlled release occurred within the first 24 hours, demonstrating its potential for wound healing.
Article
Medicine, General & Internal
Daehee Kim, Byung Seok Moon, Sun Mi Park, Sang Ju Lee, Seo Young Kang, Sanghui Park, Seung Jun Oh, Bom Sahn Kim, Hai-Jeon Yoon
Summary: This study evaluated the feasibility of a TSPO-specific radiotracer in a rat model of paracetamol-induced liver injury. The results showed that [F-18]GE180 enabled visualization of the liver injury through TSPO overexpression, supporting its potential utility as a non-invasive imaging biomarker for the early phase of PLI.
Article
Nanoscience & Nanotechnology
Karine Cappuccio de Castro, Eric Keven Silva, Maria Gabriela Nogueira Campos, Lucia Helena Innocentini Mei
Summary: This study evaluated the effect of crosslinking with maleic anhydride on the properties of electrospun hyaluronic acid/polyvinyl alcohol membranes loaded with Plantago major extract. The crosslinking improved the manufacturing process, reduced fiber diameter, increased decomposition temperature, and improved membrane homogeneity. The results indicated that lower humidity favored membrane stability.
ACS APPLIED NANO MATERIALS
(2022)
Article
Microbiology
Zihan Lin, Yongjun Li, Man Wang, Huan Li, Yihong Wang, Xin Li, Ying Zhang, Di Gong, Lin Fu, Siying Wang, Danfeng Long
Summary: Oxidative stress, inflammatory response, and gut-liver axis dysbiosis are involved in alcoholic liver injury. Previous research suggests that yeast extract (YE) has antioxidant, immune-boosting, and microbiota-regulating properties. This study using a rat model found that both low-dose and high-dose YE can reduce alcohol-induced liver injury and improve gut microbiota disorder. High-dose YE is more effective in metabolic regulation, oxidative stress, and inflammatory responses.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Plant Sciences
Zainul Amiruddin Zakaria, Adibah Sahmat, Azfar Hizami Azmi, Amal Syahirah Nur Zainol, Maizatul Hasyima Omar, Tavamani Balan, Arifah Abdul Kadir, Syahriel Abdullah, Roro Azizah, Lilis Sulistyorini
Summary: The chloroform extract of Bauhinia purpurea leaves has significant antioxidant and hepatoprotective effects. It can treat liver diseases by activating the endogenous enzyme antioxidant defense system.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Alexandre Nuzzo, Shireen Salem, Isabelle Malissin, Abdourahmane Diallo, Nicolas Deye, Antoine Goury, Herve Gourlain, Nicolas Peron, Eric Vicaut, Sebastian Voicu, Bruno Megarbane
Summary: This study aimed to assess the contribution of admission plasma procalcitonin concentration (PCT) in identifying acetaminophen-poisoned patients likely to develop liver injury. The results showed that PCT on admission was associated with liver injury in acetaminophen poisoning, and may be used as a predictive tool to improve clinical decision-making.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2021)
Article
Nutrition & Dietetics
Yizhou Chen, Yanbo Wang, Shenghui Jiang, Jihua Xu, Bin Wang, Xiaohong Sun, Yugang Zhang
Summary: Red-fleshed apple flavonoid extract (RAFE) alleviated carbon tetrachloride-induced liver damage in mice by modulating the abundance and composition of intestinal microorganisms. The study suggests that RAFE has important applications in the treatment of liver damage and regulation of intestinal microbiota imbalance.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Jing Li, Ping Cheng, Shoufeng Li, Pengfei Zhao, Bing Han, Xiaoyuan Ren, Julia Li Zhong, Matthew D. Lloyd, Charareh Pourzand, Arne Holmgren, Jun Lu
Summary: The study found that both the Trx and GSH systems are sensitive to APAP toxicity in vivo, and that the thiol-dependent redox environment is crucial in determining the severity of APAP-induced hepatotoxicity. Dietary selenium and selenoproteins play critical roles in protecting mice from APAP overdose.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Pharmacology & Pharmacy
Ismail Topal, Asli Ozbek Bilgin, Tulin Catakli, Ferda Keskin Cimen, Murat Cankaya, Halis Suleyman
Summary: This study evaluated the effects of pycnogenol (R) on paracetamol-induced liver injury in rats and found that it can reduce liver damage and provide protection.
LATIN AMERICAN JOURNAL OF PHARMACY
(2022)
Review
Biochemistry & Molecular Biology
Qianhui Li, Feng Chen, Fei Wang
Summary: Acute liver failure caused by drug overdose is a significant clinical problem. In addition to the direct toxicity of the drug, inflammation plays a crucial role in the development and severity of the disease. Understanding the involvement of immune cells and their effector molecules is essential for identifying new therapeutic targets.
CELL AND BIOSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Melissa M. Clemens, Stefanie Kennon-McGill, Joel H. Vazquez, Owen W. Stephens, Erich A. Peterson, Donald J. Johann, Felicia D. Allard, Eric U. Yee, Sandra S. McCullough, Laura P. James, Brian N. Finck, Mitchell R. McGill
Summary: This study demonstrates the beneficial effects of exogenous phosphatidic acid in acetaminophen toxicity by activating IL-6 signaling. However, despite the importance of PA in liver repair, exogenous PA did not alter regeneration.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Medicine, Research & Experimental
Muhammad Torequl Islam, Cristina Quispe, Md Amirul Islam, Eunus S. Ali, Sushmita Saha, Umma Hafsa Asha, Milon Mondal, Ahmad Faizal Abdull Razis, Usman Sunusi, Ramla Muhammad Kamal, Manoj Kumar, Javad Sharifi-Rad
Summary: The study demonstrated that nerol exhibited significant hepatoprotective activity against paracetamol-induced liver toxicity in rats. It decreased hepatotoxic markers, improved antioxidant enzyme levels, and maintained normal liver structure. Future research will focus on the mechanisms of action of nerol in Wistar albino rats.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Public, Environmental & Occupational Health
Bee Koon Poh, Shoo Thien Lee, Giin Shang Yeo, Kean Choon Tang, Ab Rahim Noor Afifah, Awal Siti Hanisa, Panam Parikh, Jyh Eiin Wong, Alvin Lai Oon Ng, Poh Bee Koon, Norimah A. Karim, Ruzita A. Talib, Siti Balkis Budin, Alvin Ng Lai Oon, Siti Haslinda Mohd Din, Wong Jyh Eiin, Mohd Ismail Noor, Rahman Jamal, Nor Azmi Kamaruddin, Nik Shanita Safii, Chin Yit Siew, Wee Bee Suan, Nor Aini, Jamil A. Wahab
Meeting Abstract
Cardiac & Cardiovascular Systems
N. F. Aziz, L. Y. N. Si, S. B. Budin, S. Zainalabidin
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2019)
Article
Pharmacology & Pharmacy
Anand Ramalingam, Siti Balkis Budin, Norsyahida Mohd Fauzi, Rebecca H. Ritchie, Satirah Zainalabidin
FRONTIERS IN PHARMACOLOGY
(2019)
Meeting Abstract
Cardiac & Cardiovascular Systems
Anand Ramalingam, Norsyahida Mohd. Fauzi, Siti Balkis Budin, Rebecca Ritchie, Satirah Zainalabidin
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2020)
Article
Pharmacology & Pharmacy
Anand Ramalingam, Norsyahida Mohd Fauzi, Siti Balkis Budin, Satirah Zainalabidin
Summary: This study found that prolonged nicotine administration increases myocardial susceptibility to I/R injury in rats, which is associated with increased mitochondrial permeability transition driven by ROS.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Fatin Farhana Jubaidi, Satirah Zainalabidin, Vanitha Mariappan, Siti Balkis Budin
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Fatin Farhana Jubaidi, Satirah Zainalabidin, Izatus Shima Taib, Zariyantey Abd Hamid, Siti Balkis Budin
Summary: Diabetic cardiomyopathy, a major mortality risk factor among diabetic patients worldwide, is characterized by cardiac structural and functional alterations induced by hyperglycemia-initiated oxidative stress. Flavonoids, the most abundant phytochemicals in plants, have been extensively studied for their therapeutic potential in protecting the heart against diabetes-induced cardiomyopathy through their anti-hyperglycemic, antioxidant, anti-inflammatory, and anti-apoptotic actions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Fatin Farhana Jubaidi, Satirah Zainalabidin, Lai Ying, Nur Liyana Mohammed Yusof, Siti Balkis Budin
Summary: The study demonstrated that H. sabdariffa Linn. polyphenol-rich extract significantly improved vascular function and reduced oxidative stress in diabetic rats, leading to decreased blood pressure, enhanced vasorelaxation, and alleviated oxidative damage.
Article
Multidisciplinary Sciences
Anand Ramalingam, Siti Balkis Budin, Norsyahida Mohd Fauzi, Rebecca H. Ritchie, Satirah Zainalabidin
Summary: This study demonstrates that targeting mitochondrial ROS with mitoTEMPO or resveratrol partially attenuates nicotine-induced cardiac remodeling and dysfunction.
SCIENTIFIC REPORTS
(2021)
Article
Environmental Sciences
Nur Afizah Yusoff, Izatus Shima Taib, Siti Balkis Budin, Mahaneem Mohamed
Summary: The study found that paternal exposure to FNT reduced sperm quality and caused DNA fragmentation in F0 male Sprague Dawley rats, altering the histology and morphometry of the selected organs in the F1 progeny.
Article
Multidisciplinary Sciences
Nur Liyana Mohammed Yusof, Tengku Nurul Tasnim Tengku Affendi, Fatin Farhana Jubaidi, Satirah Zainal Abidin, Siti Balkis Budin
Article
Biology
Norhashima Abd Rashid, Farida Hussan, Asmah Hamid, Nurul Raudzah Adib Ridzuan, Syarifah Aisyah Syed Abd Halim, Nahdia Afiifah Abdul Jalil, Nor Haliza Mohamad Najib, Seong Lin Teoh, Siti Balkis Budin
Article
Multidisciplinary Sciences
Nur Afizah Yusoff, Mahaneem Mohamed, Siti Balkis Budin, Izatus Shima Taib
Article
Biology
Lislivia-Yiang-Nee Si, Anand Ramalingam, Shafreena Shaukat Ali, Amnani Aminuddin, Pei-Yuen Ng, Jalifah Latip, Yusof Kamisah, Siti Balkis Budin, Satirah Zainalabidin
Review
Cardiac & Cardiovascular Systems
Shafreena Shaukat Ali, Wan Amir Nizam Wan Ahmad, Siti Balkis Budin, Satirah Zainalabidin
REVIEWS IN CARDIOVASCULAR MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Mona M. Watany, Marwa M. Elhosary
Summary: Circulating TWEAK and CD163 appear to be promising biomarkers for monitoring myocardial iron overload and predicting iron-induced cardiac decompensation in TDTM patients.
Article
Biochemistry & Molecular Biology
Lixin Xiao, Kang Tang, Ting Fu, Xiaojie Yuan, Samuel Seery, Weilu Zhang, Zhaohua Ji, Zhen He, Yan Yang, Wenhua Zhang, Wenling Jia, Chunhui Liang, Haitao Tang, Fengmei Wang, Yancheng Ye, Lihua Chen, Zhongjun Shao
Summary: This study investigated the characteristics of cytokine/chemokine profiles during chronic hepatitis B virus infection and the effects of nucleotide analogues antiviral therapy on cytokine profiles. The results suggest that specific cytokines and virological markers may serve as potential indicators of different immune statuses in chronic HBV infection, while nucleotide analogues antiviral therapy has limitations in altering cytokine profiles.
Article
Biochemistry & Molecular Biology
Desiree Gutmann, Melanie Dressler, Olaf Eickmeier, Eva Herrmann, Marta Kirwil, Ralf Schubert, Stefan Zielen, Ulrich M. Zissler
Summary: This study found that obese adolescents have increased bronchial inflammation, which may be caused by the pro-inflammatory effects of obesity itself. This finding is important for understanding the relationship between obesity and airway diseases.
Article
Biochemistry & Molecular Biology
Wei Liu, Hui Zeng
Summary: IGF2BP2 enhances the expression of GPX4 through m6A modification, thereby suppressing ferroptosis and attenuating inflammation and pathological changes in ulcerative colitis.
Article
Biochemistry & Molecular Biology
Xiaohua Li, Junping Xu, Xin Lin, Qiong Lin, Tianxing Yu, Lin Chen, Lifang Chen, Xiaoqing Huang, Xueping Zhang, Geng Chen, Liyu Xu
Summary: Macrophages play a significant role in the progression of cryptococcosis. This study investigated the potential involvement of macrophage-derived exosomes in the pathogenesis of cryptococcosis. The study analyzed the changes of microRNAs in macrophage exosomes and explored the effects of highly expressed exo-miRNAs on human endothelial cell permeability, ROS accumulation, and pyroptosis in bronchial epithelioid cells. The results showed that exo-miR-4449 plays a crucial role in the pathogenesis of cryptococcosis and holds promise as a significant biomarker for treatment.
Article
Biochemistry & Molecular Biology
E. Melinda Mahabee-Gittens, Georg E. Matt, Matthew J. Mazzella, John T. Doucette, Parita Ratnani, Ashley L. Merianos
Summary: This study examined the associations between inflammatory markers and pediatric illnesses related to children's exposure to tobacco smoke. The results showed that parent-reported child tobacco smoke exposure was associated with increased levels of C-reactive protein (CRP) in children, while children with bacterial diagnoses had higher levels of IL-8.
Article
Biochemistry & Molecular Biology
Jin-Yu Liang, Hai-Jun Wei, Yi-Yun Tang
Summary: Isthmin is a polypeptide secreted by adipocytes that plays important biological functions in growth and development, angiogenesis, and metabolism. ISM-1, as a regulator of cell proliferation, migration, angiogenesis, and immune microenvironments, plays a crucial role in the occurrence and development of cancer. Furthermore, ISM-1 acts as a regulator of adipocyte glucose uptake and hepatic lipid synthesis.
Article
Biochemistry & Molecular Biology
Abhishek Singh, Baishakhi Mahapatra, Arpita Banerjee, Samer Singh, Sangram Singh, Vikash K. Dubey, Pradeep Das, Rakesh K. Singh
Summary: In Leishmania infection, antigen-activated CD4+ T cells expressing CD200R receptors are the main source of IL-10 production. The expression of CD200R helps T cells acquire the ability to produce IL-10 as a survival strategy in leishmaniasis pathogenesis.
Article
Biochemistry & Molecular Biology
Xun Chen, Chaofeng Wang, Guolong Zhao, Zhong Li, Wentao Zhang, Tao Song, Congming Zhang, Ning Duan
Summary: Failure of bone healing after fracture often results in nonunion, but the underlying mechanism of nonunion pathogenesis is poorly understood. This study reveals that the inflammatory microenvironment in atrophic nonunion inhibits the expression of DNA methyltransferases, resulting in overexpression of CtBP1/2. The increased CtBP1/2 acts as transcriptional corepressors that suppress the expression of six genes involved in bone healing. The disruption of this signaling may represent a new therapeutic strategy to prevent nonunion incidence after bone fracture.
Review
Biochemistry & Molecular Biology
Yuwei Peng, Meng Zhang, Jiangkang Hu
Summary: This review article provides an overview of the pivotal role of non-coding RNAs (ncRNAs) in the activity and pathogenesis of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). These ncRNAs regulate various FLS activities including metastasis, proliferation, and cytokine production. Additionally, the study discusses potential therapeutic approaches involving modulation of ncRNAs to regulate FLS activity.
Review
Biochemistry & Molecular Biology
Milad Khorasani
Summary: This review discusses the role of the cGAS-STING pathway in CRC and highlights the potential therapeutic benefits of targeting this pathway.
Review
Biochemistry & Molecular Biology
Gustavo de Souza Vieira, Talita de Carvalho Kimura, Joao Figueira Scarini, Reydson Alcides de Lima-Souza, Luccas Lavareze, Carolina Emerick, Mayara Trevizol Goncalves, Ingrid Iara Damas, Tayna Figueiredo-Maciel, Raisa Sales de Sa, Iara Goncalves Aquino, Joao Paulo Goncalves de Paiva, Patricia Maria Fernandes, Moises Willian Aparecido Goncalves, Luiz Paulo Kowalski, Albina Altemani, Gary Chris Fillmore, Fernanda Viviane Mariano, Erika Said Abu Egal
Summary: This article provides an in-depth review of the role of hematopoietic cytokines in the tumor microenvironment of head and neck cancers, and summarizes the current clinical trials and findings on the therapeutic application of these cytokines.
Article
Biochemistry & Molecular Biology
Oznur Copur, Havva Yazici, Erhan Canbay, Burak Durmaz, Ebru Canda, Sema Kalkan Ucar, Mahmut Coker, Eser Yildirim Sozmen
Summary: This study explores the oxidative stress, antioxidant parameters, and pro-inflammatory cytokine levels in MPS patients. The results suggest that inflammation plays a role in MPS patients, especially in untreated MPS III and MPS VI patients. The study also highlights potential targets for treatment development.
Article
Biochemistry & Molecular Biology
Saikat Fakir, Nektarios Barabutis
Summary: GHRHAnt have been shown to have protective effects on endothelial cells, opposing interferon-gamma-induced inflammation and barrier disruption.
