Article
Multidisciplinary Sciences
Yanlin Zou, Cao Yu, Qian Huang, Xiaorong Tan, Xiaoyan Tan, Xiaolong Zhu, Dongyang Yi, Jingxin Mao
Summary: This study aimed to identify the most effective fraction of Nanocnide lobata in the treatment of burn and scald injuries and determine its bioactive constituents. Chemical identification methods were used to analyze the chemical constituents of Nanocnide lobata extracts, and UPLC-MS analysis revealed the presence of 39 main compounds. The results showed that the petroleum ether extract and volatile oil compounds of Nanocnide lobata might be effective drugs in the treatment of burn and scald injuries by reducing inflammation, promoting wound healing, and reducing scar tissue proliferation.
Review
Health Care Sciences & Services
Jana E. DeJesus, Jake J. Wen, Ravi Radhakrishnan
Summary: Burn injuries can cause persistent inflammatory response, leading to cardiac dysfunction and changes in gene expression. The release of inflammatory mediators and the role of cytokines are the main mechanisms underlying these issues.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Health Care Sciences & Services
Jake J. Wen, Keyan Mobli, Geetha L. Radhakrishnan, Ravi S. Radhakrishnan
Summary: This study identified differentially expressed genes related to the TLR signaling pathway after burn injury and confirmed the important role of burn-induced cytokine cascade in burn-induced heart dysfunction.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Immunology
Chi Zhong, Geao Liang, Peiting Li, Ke Shi, Fuyin Li, Jianda Zhou, Dan Xu
Summary: Hyperpigmentation is a common complication in burn injuries, but the mechanisms behind its occurrence and development are unclear. Recently, it was discovered that postinflammatory hyperpigmentation (PIH) is caused by excessive production of melanin. Inflammatory responses are often seen in patients with hyperpigmentation, but the relationship between PIH and burn injury has not been widely studied. Therefore, we conducted a comprehensive review to explore the connection between melanogenesis, inflammatory mechanisms, and cytokine alterations in burn trauma patients to better understand PIH and guide future research in burn management.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Timothy Olsen, Dennis Caruana, Keely Cheslack-Postava, Austin Szema, Juergen Thieme, Andrew Kiss, Malvika Singh, Gregory Smith, Steven McClain, Timothy Glotch, Michael Esposito, Robert Promisloff, David Ng, Xueyan He, Mikala Egeblad, Richard Kew, Anthony Szema
Summary: This descriptive case series retrospectively analyzed the medical records of war-fighting veterans who reported exposure to airborne hazards while serving in Iraq and Afghanistan. The findings indicate that these veterans experienced new-onset dyspnea and showed evidence of lung damage through pulmonary function testing and lung tissue analysis.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Patrick P. G. Mulder, Marcel Vlig, Anouk Elgersma, Lotte Rozemeijer, Leonore S. Mastenbroek, Esther Middelkoop, Irma Joosten, Hans J. P. M. Koenen, Bouke K. H. L. Boekema
Summary: This study established a human full skin equivalent burn wound model and incorporated human peripheral blood-derived monocytes and T cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Sofina Begum, Samantha Lodge, Drew Hall, Blair Z. Johnson, Sze How Bong, Luke Whiley, Nicola Gray, Vanessa S. Fear, Mark W. Fear, Elaine Holmes, Fiona M. Wood, Jeremy K. Nicholson
Summary: Burn injury in children has long-term effects on metabolism and physiology, leading to increased morbidity and mortality. However, little is known about the metabolic trajectory and specific health outcomes.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Cell Biology
Jie Ding, Yingying Pan, Shammy Raj, Lindy Schaffrick, Jolene Wong, Antoinette Nguyen, Sharada Manchikanti, Larry Unsworth, Peter Kwan, Edward Tredget
Summary: The study found that EXOs from burn patients and healthy individuals can stimulate the proliferation and apoptosis of dermal fibroblasts in vitro. The morphology, density, size, and cytokine levels of EXOs also vary during the stages of wound healing in burn patients. These findings suggest that EXOs may serve as important signals in influencing wound healing after burn injury and further research is needed to understand the mechanisms by which EXOs regulate fibroblasts in healing wounds.
Article
Critical Care Medicine
Marisa E. Luck, Xiaoling Li, Caroline J. Herrnreiter, Mashkoor A. Choudhry
Summary: Ethanol intoxication and burn injury can lead to dysfunction of immune cells in the gastrointestinal system, promoting infections and complications. This study found that both ethanol and burn injury increase the population of regulatory T cells in the small intestine, which have a stronger suppression of effector T cell proliferation.
Article
Critical Care Medicine
Zhao-qi Ren, Bin Du, Hai-jiao Dong, Guang-hua Duan, Ai-cui Du, Yue Wang, Li-xia Zhao, Wen Shao
Summary: Research shows that autologous platelet-rich plasma has significant promoting effects on burn wound healing in rats, significantly reducing wound area and increasing healing rates. It also has a certain analgesic effect on burn pain.
JOURNAL OF BURN CARE & RESEARCH
(2022)
Article
Immunology
Jihye Han, Qingqing Wan, Goo-Young Seo, Kenneth Kim, Sarah El Baghdady, Jee H. Lee, Mitchell Kronenberg, Yun-Cai Liu
Summary: Hypoxia plays an important role in airway inflammation and remodeling in lung diseases. This study focuses on understanding how hypoxic pulmonary epithelium regulates allergic inflammation. The researchers found that the VHL-HIF2 alpha axis mediates the hypoxic response, controlling pulmonary type 2 responses through increasing ADM expression and causing ILC2 activation.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Patricia Hogea, Emanuela Tudorache, Ovidiu Fira-Mladinescu, Monica Marc, Diana Velescu, Diana Manolescu, Felix Bratosin, Ovidiu Rosca, Adelina Mavrea, Cristian Oancea
Summary: This study aimed to explore the potential correlation between cytokine levels in serum and bronchoalveolar lavage fluid (BALF) and their association with lung cancer. The results showed significantly higher levels of cytokines in lung cancer patients compared to those with benign lung diseases, with BALF analysis revealing higher levels than serum analysis. These findings highlight the importance of understanding inflammatory profiles and could contribute to future targeted therapies or diagnostic approaches.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Microbiology
Carolina dos Anjos, Leon G. Leanse, Xiaojing Liu, Hugo V. Miranda, R. Rox Anderson, Tianhong Dai
Summary: The study demonstrated that antimicrobial blue light can effectively kill Vibrio vulnificus, suitable for both in vitro and in vivo treatment, without adverse effects on cell proliferation or apoptosis.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Alessio Filippo Peritore, Ramona D'Amico, Rosalba Siracusa, Marika Cordaro, Roberta Fusco, Enrico Gugliandolo, Tiziana Genovese, Rosalia Crupi, Rosanna Di Paola, Salvatore Cuzzocrea, Daniela Impellizzeri
Summary: The study demonstrated that ultramicronized palmitoylethanolamide (um-PEA) reduced lung damage, inflammation cell infiltration, and cytokine release in LPS-induced acute lung injury (ALI) mice. um-PEA may exert its anti-inflammatory effects possibly through the p38/NF-kappa B pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Toxicology
Yong Ho Kim, Sarah H. Warren, Ingeborg Kooter, Wanda C. Williams, Ingrid J. George, Samuel A. Vance, Michael D. Hays, Mark A. Higuchi, Stephen H. Gavett, David M. DeMarini, Ilona Jaspers, M. Ian Gilmour
Summary: The study found that the adverse health effects of burn pit smoke exposure vary depending on the type of waste and combustion temperature, with burning plastic at high temperatures being the most significant contributor to toxicity outcomes. These findings help better understand the complex chemical and combustion temperature factors that determine the toxicity of burn pit smoke and its potential health risks at military bases.
PARTICLE AND FIBRE TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mona M. Watany, Marwa M. Elhosary
Summary: Circulating TWEAK and CD163 appear to be promising biomarkers for monitoring myocardial iron overload and predicting iron-induced cardiac decompensation in TDTM patients.
Article
Biochemistry & Molecular Biology
Lixin Xiao, Kang Tang, Ting Fu, Xiaojie Yuan, Samuel Seery, Weilu Zhang, Zhaohua Ji, Zhen He, Yan Yang, Wenhua Zhang, Wenling Jia, Chunhui Liang, Haitao Tang, Fengmei Wang, Yancheng Ye, Lihua Chen, Zhongjun Shao
Summary: This study investigated the characteristics of cytokine/chemokine profiles during chronic hepatitis B virus infection and the effects of nucleotide analogues antiviral therapy on cytokine profiles. The results suggest that specific cytokines and virological markers may serve as potential indicators of different immune statuses in chronic HBV infection, while nucleotide analogues antiviral therapy has limitations in altering cytokine profiles.
Article
Biochemistry & Molecular Biology
Desiree Gutmann, Melanie Dressler, Olaf Eickmeier, Eva Herrmann, Marta Kirwil, Ralf Schubert, Stefan Zielen, Ulrich M. Zissler
Summary: This study found that obese adolescents have increased bronchial inflammation, which may be caused by the pro-inflammatory effects of obesity itself. This finding is important for understanding the relationship between obesity and airway diseases.
Article
Biochemistry & Molecular Biology
Wei Liu, Hui Zeng
Summary: IGF2BP2 enhances the expression of GPX4 through m6A modification, thereby suppressing ferroptosis and attenuating inflammation and pathological changes in ulcerative colitis.
Article
Biochemistry & Molecular Biology
Xiaohua Li, Junping Xu, Xin Lin, Qiong Lin, Tianxing Yu, Lin Chen, Lifang Chen, Xiaoqing Huang, Xueping Zhang, Geng Chen, Liyu Xu
Summary: Macrophages play a significant role in the progression of cryptococcosis. This study investigated the potential involvement of macrophage-derived exosomes in the pathogenesis of cryptococcosis. The study analyzed the changes of microRNAs in macrophage exosomes and explored the effects of highly expressed exo-miRNAs on human endothelial cell permeability, ROS accumulation, and pyroptosis in bronchial epithelioid cells. The results showed that exo-miR-4449 plays a crucial role in the pathogenesis of cryptococcosis and holds promise as a significant biomarker for treatment.
Article
Biochemistry & Molecular Biology
E. Melinda Mahabee-Gittens, Georg E. Matt, Matthew J. Mazzella, John T. Doucette, Parita Ratnani, Ashley L. Merianos
Summary: This study examined the associations between inflammatory markers and pediatric illnesses related to children's exposure to tobacco smoke. The results showed that parent-reported child tobacco smoke exposure was associated with increased levels of C-reactive protein (CRP) in children, while children with bacterial diagnoses had higher levels of IL-8.
Article
Biochemistry & Molecular Biology
Jin-Yu Liang, Hai-Jun Wei, Yi-Yun Tang
Summary: Isthmin is a polypeptide secreted by adipocytes that plays important biological functions in growth and development, angiogenesis, and metabolism. ISM-1, as a regulator of cell proliferation, migration, angiogenesis, and immune microenvironments, plays a crucial role in the occurrence and development of cancer. Furthermore, ISM-1 acts as a regulator of adipocyte glucose uptake and hepatic lipid synthesis.
Article
Biochemistry & Molecular Biology
Abhishek Singh, Baishakhi Mahapatra, Arpita Banerjee, Samer Singh, Sangram Singh, Vikash K. Dubey, Pradeep Das, Rakesh K. Singh
Summary: In Leishmania infection, antigen-activated CD4+ T cells expressing CD200R receptors are the main source of IL-10 production. The expression of CD200R helps T cells acquire the ability to produce IL-10 as a survival strategy in leishmaniasis pathogenesis.
Article
Biochemistry & Molecular Biology
Xun Chen, Chaofeng Wang, Guolong Zhao, Zhong Li, Wentao Zhang, Tao Song, Congming Zhang, Ning Duan
Summary: Failure of bone healing after fracture often results in nonunion, but the underlying mechanism of nonunion pathogenesis is poorly understood. This study reveals that the inflammatory microenvironment in atrophic nonunion inhibits the expression of DNA methyltransferases, resulting in overexpression of CtBP1/2. The increased CtBP1/2 acts as transcriptional corepressors that suppress the expression of six genes involved in bone healing. The disruption of this signaling may represent a new therapeutic strategy to prevent nonunion incidence after bone fracture.
Review
Biochemistry & Molecular Biology
Yuwei Peng, Meng Zhang, Jiangkang Hu
Summary: This review article provides an overview of the pivotal role of non-coding RNAs (ncRNAs) in the activity and pathogenesis of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). These ncRNAs regulate various FLS activities including metastasis, proliferation, and cytokine production. Additionally, the study discusses potential therapeutic approaches involving modulation of ncRNAs to regulate FLS activity.
Review
Biochemistry & Molecular Biology
Milad Khorasani
Summary: This review discusses the role of the cGAS-STING pathway in CRC and highlights the potential therapeutic benefits of targeting this pathway.
Review
Biochemistry & Molecular Biology
Gustavo de Souza Vieira, Talita de Carvalho Kimura, Joao Figueira Scarini, Reydson Alcides de Lima-Souza, Luccas Lavareze, Carolina Emerick, Mayara Trevizol Goncalves, Ingrid Iara Damas, Tayna Figueiredo-Maciel, Raisa Sales de Sa, Iara Goncalves Aquino, Joao Paulo Goncalves de Paiva, Patricia Maria Fernandes, Moises Willian Aparecido Goncalves, Luiz Paulo Kowalski, Albina Altemani, Gary Chris Fillmore, Fernanda Viviane Mariano, Erika Said Abu Egal
Summary: This article provides an in-depth review of the role of hematopoietic cytokines in the tumor microenvironment of head and neck cancers, and summarizes the current clinical trials and findings on the therapeutic application of these cytokines.
Article
Biochemistry & Molecular Biology
Oznur Copur, Havva Yazici, Erhan Canbay, Burak Durmaz, Ebru Canda, Sema Kalkan Ucar, Mahmut Coker, Eser Yildirim Sozmen
Summary: This study explores the oxidative stress, antioxidant parameters, and pro-inflammatory cytokine levels in MPS patients. The results suggest that inflammation plays a role in MPS patients, especially in untreated MPS III and MPS VI patients. The study also highlights potential targets for treatment development.
Article
Biochemistry & Molecular Biology
Saikat Fakir, Nektarios Barabutis
Summary: GHRHAnt have been shown to have protective effects on endothelial cells, opposing interferon-gamma-induced inflammation and barrier disruption.
