Article
Oncology
Verena Wieser, Irina Tsibulak, Daniel Uwe Reimer, Alain Gustave Zeimet, Heidelinde Fiegl, Hubert Hackl, Christian Marth
Summary: This study investigated the expression of angiogenesis-related genes in ovarian cancer and their association with the response to bevacizumab therapy. The findings suggest that tumoral expression of PDGFA and a high transcriptional angiogenesis score are independent predictors of clinical outcome in ovarian cancer patients.
GYNECOLOGIC ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
David C. Stieg, Yifang Wang, Ling-Zhi Liu, Bing-Hua Jiang
Summary: Recent research has revealed the diverse cellular mechanisms underlying certain types of cancer, leading to more effective treatment options. Ovarian cancer (OC) is particularly challenging to treat, with limited options available, especially for late-stage patients. Dysregulation of miRNAs and ROS in OC plays significant roles in tumorigenesis and affects the therapeutic outcomes through their involvement in angiogenesis regulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Peace Mabeta, Vanessa Steenkamp
Summary: The VEGF/VEGFR axis plays a crucial role in angiogenesis and tumor vascularization. Current therapies targeting VEGF and its receptors have shown limited effectiveness and undesirable off-target effects. Recent studies have identified VEGF splice variants that modulate angiogenesis, and their expression is regulated by cues within the tumor microenvironment. These variants challenge the established norm of VEGF signaling and their aberrant expression has been observed in several cancers, highlighting the need for further research on their role in cancer and their impact on antiangiogenic therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Wen-Bin Wu, Hsuan-Ting Chen, Jun-Jie Lin, Tsung-Hsuan Lai
Summary: The study revealed a negative association between follicular fluid VEGF concentration and ovarian reserve level, as well as oocyte maturation rate in patients undergoing GnRH antagonist IVF protocols. Additionally, a negative correlation was found between follicular fluid VEGF concentration and serum anti-Mullerian hormone (AMH) level. Oocyte maturation rate tended to increase at higher AMH levels.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yutian He, Zhenbo OuYang, Wenwen Liu, Yu Chen, Qiushi Zhang
Summary: Disruptions in alternative splicing regulation play a critical role in the progression of ovarian cancer. This study found that TARDBP, a DNA-binding protein, is significantly upregulated in OC tissue samples, especially in cases of metastasis and poor prognosis. TARDBP regulates the alternative splicing of VEGF, promoting angiogenesis in OC.
Article
Chemistry, Medicinal
Donghwa Kim, Sang Won Choi, Jihee Cho, Jae-Hui Been, Kyoungsun Choi, Wenzhe Jiang, Jaeho Han, Jedo Oh, Changmin Park, Soongyu Choi, Songyi Seo, Koung Li Kim, Wonhee Suh, Sang Kook Lee, Sanghee Kim
Summary: Diabetic retinopathy is a leading cause of blindness associated with excessive angiogenesis. Researchers have developed a novel antiangiogenesis agent by modifying the structure of wondonin marine natural products, resulting in improved bioactivity and selectivity. This compound, 31, shows potential as a lead for developing small-molecule drugs to treat diabetic retinopathy and to uncover new mechanisms of angiogenesis.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Cell Biology
Shu Tan, Xiuwei Chen, Wei Liu
Summary: This study investigated the molecular mechanisms of miR-139-5p/SOX4/TMEM2 axis in angiogenesis and tumorigenesis of ovarian cancer (OC). The expression of miR-139-5p and SOX4 was altered in OC tissues and cells. The study demonstrated that overexpression of miR-139-5p or knockdown of SOX4 inhibited angiogenesis and tumorigenicity of OC. miR-139-5p targeted SOX4 and down-regulated TMEM2 expression to repress VEGF expression and angiogenesis in OC.
CELLULAR SIGNALLING
(2023)
Article
Medicine, Research & Experimental
Ping Li, Hongyan Xin, Lili Lu
Summary: This study demonstrates that MSC-derived EVs transfer miR-424 to down-regulate MYB and inhibit tumorigenesis and angiogenesis of ovarian cancer. The findings suggest a potential prognostic marker and therapeutic target for ovarian cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Oncology
Domenico Ribatti, Antonio Giovanni Solimando, Francesco Pezzella
Summary: Several anti-angiogenic drugs are approved for cancer treatment, but resistance and adverse effects may occur. Combining multiple anti-angiogenic molecules or using them in combination with other treatment regimens is indicated as alternative therapeutic strategies to overcome resistance. Comprehensive omics profiling is crucial for increasing clinical benefits and overcoming resistance to anti-angiogenic therapies.
Article
Immunology
Oladapo O. Yeku, Thapi Dharma Rao, Ian Laster, Artem Kononenko, Terence J. Purdon, Pei Wang, Ziyou Cui, Hong Liu, Renier J. Brentjens, David Spriggs
Summary: The study demonstrates the feasibility and efficacy of MUC16(ecto)-specific BiTEDs in delaying tumor progression and improving survival rates in ovarian cancer, with enhanced effect when combined with anti-VEGF therapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Chemistry, Medicinal
Anurag Mathur, Abha Meena, Suaib Luqman
Summary: Monoterpenoids, a subclass of terpenoids, have been extensively studied for their antitumor properties, including antiproliferative, apoptotic, antiangiogenic, and antimetastatic effects. This review focuses on the effects of specific monoterpenoids on metastasis and relevant signaling pathways. Monoterpenoids exhibit complexity as natural products that regulate metastatic proteins through various signaling pathways. However, limited clinical trials hinder the drug usage of monoterpenoids in preventing cancer metastasis.
PHYTOTHERAPY RESEARCH
(2023)
Article
Oncology
Yunlong Yang, Yihai Cao
Summary: Metastasis, the leading cause of cancer-associated mortality, is still poorly understood. Both blood and lymphatic vasculatures play crucial roles in distal metastasis, with VEGF being a key angiogenic factor. Anti-VEGF drugs have been widely used in clinical treatment of various cancers, but their impact on cancer metastasis and systemic disease is largely unknown.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Oncology
Pauline Wimberger, Mara Julia Gerber, Jacobus Pfisterer, Kati Erdmann, Susanne Fuessel, Theresa Link, Andreas du Bois, Stefan Kommoss, Florian Heitz, Jalid Sehouli, Rainer Kimmig, Nikolaus de Gregorio, Barbara Schmalfeldt, Tjoung-Won Park-Simon, Klaus Baumann, Felix Hilpert, Marcel Grube, Willibald Schroder, Alexander Burges, Antje Belau, Lars Harser, Jan Dominik Kuhlmann
Summary: A study on 413 patients from the ICON7 trial found that the addition of bevacizumab to standard platinum-based chemotherapy significantly improved survival rates in patients with low expression of VEGF-A165b.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Vikas Garg, Lalit Kumar
Summary: Translational research and targeted therapies have significantly impacted the treatment of epithelial ovarian cancer. Recurrent ovarian cancer remains a challenge and requires innovative strategies. Metronomic chemotherapy, which inhibits angiogenesis and activates the immune system, has emerged as a promising approach.
Article
Plant Sciences
Fanru Zhou, Yufan Song, Xia Liu, Chu Zhang, Fan Li, Runan Hu, Yanjing Huang, Wenwen Ma, Kunkun Song, Mingmin Zhang
Summary: Si-Wu-Tang (SWT) significantly improved ovarian function in cyclophosphamide-induced POF mice by enhancing estrogen levels, follicular development, antioxidant defense, and microvascular formation. Additionally, SWT activated Nrf2/HO-1 and STAT3/HIF-1α/VEGF signaling pathways to promote angiogenesis, leading to improved fertility outcomes compared to the model group.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
