Journal
CURRENT PROTEIN & PEPTIDE SCIENCE
Volume 10, Issue 2, Pages 128-132Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138920309787847608
Keywords
Allostery; chaperonin; elastic network model; myosin; normal mode analysis; polymerase
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Funding
- National Institutes of Health [1R01GM067851-01]
- NIH
- NHLBI
- BRB
- University at Buffalo
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [ZIAHL001050] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM067851] Funding Source: NIH RePORTER
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Allostery forms the basis of intra-molecular communications in various enzymes, however the underlying conformational changes are largely elusive. Recently, we have proposed to employ an elastic model based normal mode analysis to investigate the allosteric transitions in several molecular nanomachines (including myosin II, DNA polymerase and chaperonin GroEL). After combining with bioinformatics analysis of the evolutionary sequence variations, we have been able to identify the highly conserved and robust modes of collective motions that are capable of transmitting molecular signals over long distances.
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