期刊
CURRENT PROTEIN & PEPTIDE SCIENCE
卷 10, 期 2, 页码 128-132出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138920309787847608
关键词
Allostery; chaperonin; elastic network model; myosin; normal mode analysis; polymerase
资金
- National Institutes of Health [1R01GM067851-01]
- NIH
- NHLBI
- BRB
- University at Buffalo
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [ZIAHL001050] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM067851] Funding Source: NIH RePORTER
Allostery forms the basis of intra-molecular communications in various enzymes, however the underlying conformational changes are largely elusive. Recently, we have proposed to employ an elastic model based normal mode analysis to investigate the allosteric transitions in several molecular nanomachines (including myosin II, DNA polymerase and chaperonin GroEL). After combining with bioinformatics analysis of the evolutionary sequence variations, we have been able to identify the highly conserved and robust modes of collective motions that are capable of transmitting molecular signals over long distances.
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