Article
Immunology
Kajal Bagri, Rahul Deshmukh
Summary: Vinpocetine may have neuroprotective potential in alleviating cognitive and motor impairments caused by traumatic brain injury. It exerts its effects through antioxidant activity and restoration of brain neurochemical levels under stressed conditions.
INFLAMMOPHARMACOLOGY
(2022)
Article
Immunology
Esber S. Saba, Mona Karout, Leila Nasrallah, Firas Kobeissy, Hala Darwish, Samia J. Khoury
Summary: The study found that TBI leads to an increase in activated microglia, which is negatively correlated with spatial learning and memory abilities 35 days post-injury. The findings could help define therapeutic windows and improve patient outcomes.
CLINICAL IMMUNOLOGY
(2021)
Article
Psychology, Clinical
Vicki Anderson, Stephen J. C. Hearps, Cathy Catroppa, Miriam H. Beauchamp, Nicholas P. Ryan
Summary: This study investigated the different trajectories of social recovery and the influencing factors in children with traumatic brain injury (TBI) through long-term observation. The results showed that social recovery was linked to intact family and parent function, pre-injury adaptive abilities, post-injury cognition, and social participation. Factors related to social impairment included poor pre- and post-injury adaptive abilities, increased behavioral concerns, and deteriorated parent health and family function.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Immunology
Jianqin Xue, Yu Zhang, Junhua Zhang, Zhujun Zhu, Qi Lv, Jianhua Su
Summary: This study revealed the important role of astrocyte-derived CCL7 in promoting microglia-mediated inflammation after TBI, suggesting CCL7 could serve as a potential therapeutic strategy for attenuating TBI by inhibiting microglial activation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Neurosciences
Leilei Mao, Limin Sun, Jingyi Sun, Baoliang Sun, Yanqin Gao, Hong Shi
Summary: The study demonstrates that EP treatment can improve sensorimotor function following TBI, reduce white matter injury, and modulate microglia polarization toward the anti-inflammatory M2 phenotype during the acute phase of TBI recovery, improving the release of inflammatory-related factors.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Review
Physiology
Rodrigo G. Mira, Matias Lira, Waldo Cerpa
Summary: Traumatic brain injury (TBI) is a heterogeneous disorder that causes brain damage due to external forces, leading to CNS damage under various mechanisms. Glial cells such as astrocytes, microglia, and oligodendrocytes play crucial roles in response to TBI, affecting neuronal damage and pathophysiology.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Ping Zheng, Qingke Bai, Jiugeng Feng, Bing Zhao, Jian Duan, Lin Zhao, Ning Liu, Dabin Ren, Shufeng Zou, Wei Chen
Summary: The research showed that the transplantation of neonatal microglia or protease inhibitors-treated adult microglia significantly improved cognitive function and inhibited neuroinflammation in a rat model of traumatic brain injury.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Article
Neurosciences
Chelsea E. Bray, Kristina G. Witcher, Dunni Adekunle-Adegbite, Michelle Ouvina, Mollie Witzel, Emma Hans, Zoe M. Tapp, Jonathan Packer, Ethan Goodman, Fangli Zhao, Titikorn Chunchai, Shane ONeil, Siriporn C. Chattipakorn, John Sheridan, Olga N. Kokiko-Cochran, Candice Askwith, Jonathan P. Godbout
Summary: Traumatic brain injury (TBI) is associated with chronic inflammation and neuropathology, which can be alleviated through turnover of trauma-associated microglia. Microglia turnover improves functional recovery and reduces immune reactivity to challenges. This study highlights the importance of targeting microglia in TBI treatment.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Clinical Neurology
Aria C. Shi, Ursula Rohlwink, Susanna Scafidi, Sujatha Kannan
Summary: Microglia play crucial roles in brain development and recovery after traumatic brain injury, with metabolic alterations influencing their response to injury. Studies have revealed differences in metabolic changes between microglia, astrocytes, and neurons, highlighting the complexity of their interactions in the brain.
FRONTIERS IN NEUROLOGY
(2021)
Article
Immunology
Pengju Wei, Ke Wang, Chen Luo, Yichen Huang, Dilidaer Misilimu, Huimei Wen, Peng Jin, Chuhua Li, Ye Gong, Yanqin Gao
Summary: The study demonstrates that cordycepin can protect neurological function by suppressing neutrophil infiltration, preserving blood-brain barrier integrity, and altering microglia/macrophage polarization after traumatic brain injury.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Biochemistry & Molecular Biology
Tamas Kovacs-Oller, Renata Zempleni, Boglarka Balogh, Gergely Szarka, Balint Fazekas, Adam J. Tengolics, Krisztina Amrein, Endre Czeiter, Istvan Hernadi, Andras Buki, Bela Volgyi
Summary: Traumatic brain injury (TBI) is a major cause of sudden death after head trauma. The retina, as part of the brain, can also be affected by TBI, both in severe and mild-repetitive cases. Our study found that the level of inflammation and cell death in the retina differs between sTBI and rmTBI, indicating different response mechanisms. Therefore, the retina may serve as a model for studying head injuries and developing new diagnostic procedures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Niall J. Bourke, Celia Demarchi, Sara De Simoni, Ravjeet Samra, Maneesh C. Patel, Adam Kuczynski, Quen Mok, Neil Wimalasundera, Fareneh Vargha-Khadem, David J. Sharp
Summary: Long-term outcomes of paediatric traumatic brain injury are difficult to predict. Traumatic brain injury can lead to reductions in brain volume and is associated with cognitive, emotional, and behavioral impairments. This study investigates the impact of brain injury on healthy brain development and shows that volumetric abnormalities are common after moderate/severe traumatic brain injury in both grey and white matter regions.
Article
Neurosciences
Kristina G. Witcher, Chelsea E. Bray, Titikorn Chunchai, Fangli Zhao, Shane M. O'Neil, Alan J. Gordillo, Warren A. Campbell, Daniel B. McKim, Xiaoyu Liu, Julia E. Dziabis, Ning Quan, Daniel S. Eiferman, Andy J. Fischer, Olga N. Kokiko-Cochran, Candice Askwith, Jonathan P. Godbout
Summary: Traumatic brain injury can lead to significant neuropsychiatric problems and neurodegenerative pathologies that last for years. This study showed that microglia play a crucial role in acute and chronic stages of TBI, influencing inflammation and neuropathology development, which in turn affect neuronal homeostasis and behavioral outcomes.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Saef Izzy, Alexander Brown-Whalen, Taha Yahya, Aliyah Sarro-Schwartz, Gina Jin, Joon Yong Chung, Sevda Lule, Liza M. Morsett, Ali Alquraini, Limin Wu, Suzanne E. Hickman, Michael J. Whalen, Joseph El Khoury
Summary: The study found that repetitive closed head injury (rCHI) did not accelerate tau pathology and did not worsen behavioral outcomes in adolescent mice. However, rCHI induced microgliosis in the cortex and hippocampus and astrocytosis in the corpus callosum of P301S mice by 40 days post-injury. There were no significant microgliosis or astrocytosis observed in age-matched WT mice or sham-injured P301S mice after rCHI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Lynde M. Wangler, Chelsea E. Bray, Jonathan M. Packer, Zoe M. Tapp, Amara C. Davis, Shane M. O'Neil, Kara Baetz, Michelle Ouvina, Mollie Witzel, Jonathan P. Godbout
Summary: The neurobiological mechanisms underlying worsened functional outcomes after traumatic brain injury (TBI) in the elderly remain unclear. This study found that aged mice showed more severe cognitive impairment, gliosis, and neuroinflammation after TBI compared to adult mice. Age was associated with enhanced expression of cytokine/chemokine, complement, innate immune, and interferon-associated inflammatory genes in the cortex. Type I interferon (IFN) signaling was significantly enhanced in the aged brain after TBI. Overall, TBI promoted amplified IFN signaling in aged mice, resulting in extended inflammation and gliosis.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Developmental Biology
Shiyu Shu, Zhi Zhang, Dawn Spicer, Ewa Kulikowicz, Ke Hu, Savalan Babapoor-Farrokhran, Sujatha Kannan, Raymond C. Koehler, Courtney L. Robertson
DEVELOPMENTAL NEUROSCIENCE
(2020)
Article
Critical Care Medicine
Zhi Zhang, Samiha Ishrat, Megan O'Bryan, Brandon Klein, Manda Saraswati, Courtney Robertson, Sujatha Kannan
JOURNAL OF NEUROTRAUMA
(2020)
Article
Multidisciplinary Sciences
Anjali Sharma, Rishi Sharma, Zhi Zhang, Kevin Liaw, Siva P. Kambhampati, Joshua E. Porterfield, Ku Chien Lin, Louis B. DeRidder, Sujatha Kannan, Rangaramanujam M. Kannan
Article
Neurosciences
Sarah J. Bertrand, Zhi Zhang, Ruchit Patel, Caroline O'Ferrell, Naresh M. Punjabi, Sapna R. Kudchadkar, Sujatha Kannan
EXPERIMENTAL NEUROLOGY
(2020)
Article
Chemistry, Multidisciplinary
Rishi Sharma, Siva P. Kambhampati, Zhi Zhang, Anjali Sharma, Samuel Chen, Erica I. Duh, Sujatha Kannan, Mark O. M. Tso, Rangaramanujam M. Kannan
JOURNAL OF CONTROLLED RELEASE
(2020)
Article
Biochemistry & Molecular Biology
Zhi Zhang, Hwa Kyung Nam, Spencer Crouch, Nan E. Hatch
Summary: TNAP deficiency plays a crucial role in bone and muscle progenitor cells, impacting bone formation, mineralization, and mitochondrial function. TNAP deficiency also results in decreased trabecular bone volume fraction, trabeculation, and muscle coordination deficiencies similar to hypophosphatasia, highlighting the importance of TNAP in influencing mitochondrial respiration and ATP production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
O. Arteaga Cabeza, Z. Zhang, E. Smith Khoury, R. A. Sheldon, A. Sharma, F. Zhang, B. S. Slusher, R. M. Kannan, S. Kannan, D. M. Ferriero
Summary: This study investigated the therapeutic utility of a GCPII enzyme inhibitor in an experimental neonatal hypoxia-ischemia model, finding potential value in suppressing brain inflammation and reducing brain injury.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Clinical Neurology
Carolyn Tallon, Anjali Sharma, Zhi Zhang, Ajit G. Thomas, Justin Ng, Xiaolei Zhu, Amanda Donoghue, Michael Schulte, Tawnjerae R. Joe, Siva P. Kambhampati, Rishi Sharma, Kevin Liaw, Sujatha Kannan, Rangaramanujam M. Kannan, Barbara S. Slusher
Summary: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by muscle weakness and neuromuscular junction denervation. Glutamate has been identified as an important neurotransmitter for NMJ development and maintenance. Inhibiting elevated GCPII activity in SOD1(G93A) muscle can prolong muscle function and delay NMJ denervation in ALS.
Article
Developmental Biology
Nirnath Sah, Zhi Zhang, Alicia Chime, Amanda Fowler, Antonio Mendez-Trendler, Anjali Sharma, Kannan Rangaramanujam, Barbara Slusher, Sujatha Kannan
Summary: We previously discovered that maternal endotoxin exposure could lead to cerebral palsy and pro-inflammatory microglia in neonatal rabbits. Inhibiting microglial enzyme GCPII has shown neuroprotective effects, and we hypothesized that it could also alter microglial phenotype and normalize microglial processes movement. Our study demonstrated that treating newborn rabbit kits with D-2PMPA, a selective GCPII inhibitor, resulted in significant reversal of microglial process stability, impacting migration, phagocytosis, and inflammatory functions.
DEVELOPMENTAL NEUROSCIENCE
(2023)
Article
Clinical Neurology
Megan B. Faulkner, Mariam Rizk, Zahraa Bazzi, Robert C. Dysko, Zhi Zhang
Summary: The effects of buprenorphine (BPN) on endoplasmic reticulum (ER) stress in children with traumatic brain injury (TBI) are still inconclusive. This study investigated the sex-specific effects of BPN on ER stress, abnormal protein accumulation, and cell loss in a mouse model of pediatric TBI.
NEUROTRAUMA REPORTS
(2023)
Meeting Abstract
Critical Care Medicine
Tejas Athavale, Dhuha Al-Rasool, Mauda Abdullah, Hassan El Ghoul, Krisanu Bandyopadhyay, Zhi Zhang
JOURNAL OF NEUROTRAUMA
(2022)
Article
Immunology
Yesmine Hamood, Mauda Abdullah, Hassan El Ghoul, Nazeh Saad, Robert C. Dysko, Zhi Zhang
Summary: This study investigated the sex-specific effects of Buprenorphine (BPN) on pediatric traumatic brain injury (TBI). The results showed that BPN treatment improved weight loss, motor coordination and strength, and exploration activity in both male and female mice after TBI. BPN also normalized the expression of opioid receptors in astrocytes and reduced neuroinflammation. These findings provide a rationale for assessing potential effects of BPN on chronic pathological progressions after pediatric TBI in both males and females.
BRAIN, BEHAVIOR, & IMMUNITY - HEALTH
(2022)
Meeting Abstract
Critical Care Medicine
Mariam Rizk, Nabeeha Shakil, Zahraa Bazzi, Zhi Zhang
JOURNAL OF NEUROTRAUMA
(2021)
Review
Cell Biology
Mariam Rizk, Justin Vu, Zhi Zhang
Summary: The article discusses the uniqueness of pediatric TBI, the impact of adult hippocampal neurogenesis following pediatric TBI, and current efforts in promoting neuroprotection to facilitate neuroregeneration in developing brains.
NEURAL REGENERATION RESEARCH
(2021)
Meeting Abstract
Critical Care Medicine
Zhi Zhang, Samiha Ishrat, Megan O'Bryan, Brandon Klein, Lena Rammouni, Chloe Grabowski, Manda Saraswati, Courtney Robertson, Sujatha Kannan
JOURNAL OF NEUROTRAUMA
(2019)