Ethyl pyruvate improves white matter remodeling in rats after traumatic brain injury

Distinct patterns of structural damage underlie working memory and reasoning deficits after traumatic brain injury

(2020) Amy E Jolly et al.   BRAIN

Strategic white matter injury associated with long‐term information processing speed deficits in mild traumatic brain injury

(2020) Lijun Bai et al.   HUMAN BRAIN MAPPING

Investigating Brain Network Changes and Their Association With Cognitive Recovery After Traumatic Brain Injury: A Longitudinal Analysis

(2020) Nádia Moreira da Silva et al.   Frontiers in Neurology

Ethyl Pyruvate Increases Post-Ischemic Levels of Mitochondrial Energy Metabolites: A 13C-Labeled Cerebral Microdialysis Study

(2020) Kevin H. Nygaard et al.   Metabolites

Microglia/macrophage polarization: Fantasy or evidence of functional diversity?

(2020) Xiaoming Hu   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

HMGB1-RAGE Signaling Plays a Role in Organic Dust-Induced Microglial Activation and Neuroinflammation

(2019) Nyzil Massey et al.   TOXICOLOGICAL SCIENCES

Anti-Inflammatory and Neuroprotective Effects of DIPOPA (N,N-Diisopropyl-2-Oxopropanamide), an Ethyl Pyruvate Bioisoster, in the Postischemic Brain

(2019) Hye-Kyung Lee et al.   Neurotherapeutics

TGFα preserves oligodendrocyte lineage cells and improves white matter integrity after cerebral ischemia

(2019) Xuejiao Dai et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Ganaxolone enhances microglial clearance activity and promotes remyelination in focal demyelination in the corpus callosum of ovariectomized rats

(2019) Abdeslam Mouihate et al.   CNS Neuroscience & Therapeutics

Inhibition of Neuronal Nitric Oxide Synthase by Ethyl Pyruvate in Schwann Cells Protects Against Peripheral Nerve Degeneration

(2019) Hyung-Joo Chung et al.   NEUROCHEMICAL RESEARCH

Minocycline reduces intracerebral hemorrhage–induced white matter injury in piglets

(2019) Heng Yang et al.   CNS Neuroscience & Therapeutics

Hyperbaric oxygen preconditioning attenuates brain injury after intracerebral hemorrhage by regulating microglia polarization in rats

(2019) Ming Wang et al.   CNS Neuroscience & Therapeutics

Heterogeneity of microglia and their differential roles in white matter pathology

(2019) Janice Lee et al.   CNS Neuroscience & Therapeutics

Rosiglitazone polarizes microglia and protects against pilocarpine‐induced status epilepticus

(2019) Jing Peng et al.   CNS Neuroscience & Therapeutics

Macrophages reprogram after ischemic stroke and promote efferocytosis and inflammation resolution in the mouse brain

(2019) Wenting Zhang et al.   CNS Neuroscience & Therapeutics

Melatonin protects against ischemic stroke by modulating microglia/macrophage polarization toward anti‐inflammatory phenotype through STAT3 pathway

(2019) Zong‐Jian Liu et al.   CNS Neuroscience & Therapeutics

Ethyl pyruvate enhances spontaneous remyelination by targeting microglia phagocytosis

(2019) Yan He et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Spatiotemporal analysis of impaired microglia process movement at sites of secondary neurodegeneration post-stroke

(2018) Murielle G Kluge et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Triggering receptor expressed on myeloid cells-2 expression in the brain is required for maximal phagocytic activity and improved neurological outcomes following experimental stroke

(2018) Kota Kurisu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Ethyl Pyruvate Attenuates Early Brain Injury Following Subarachnoid Hemorrhage in the Endovascular Perforation Rabbit Model Possibly Via Anti-inflammation and Inhibition of JNK Signaling Pathway

(2017) Tao Lv et al.   NEUROCHEMICAL RESEARCH

Metabolic fate of glucose in rats with traumatic brain injury and pyruvate or glucose treatments: A NMR spectroscopy study

(2017) Katsunori Shijo et al.   NEUROCHEMISTRY INTERNATIONAL

Anti-inflammatory and anti-excitoxic effects of diethyl oxopropanamide, an ethyl pyruvate bioisoster, exert robust neuroprotective effects in the postischemic brain

(2017) Hye-Kyung Lee et al.   Scientific Reports

The effect of ethyl pyruvate and N-acetylcysteine on ischemia-reperfusion injury in an experimental model of ischemic stroke

(2016) Suha Turkmen et al.   AMERICAN JOURNAL OF EMERGENCY MEDICINE

Pyruvate treatment attenuates cerebral metabolic depression and neuronal loss after experimental traumatic brain injury

(2016) Nobuhiro Moro et al.   BRAIN RESEARCH

A novel effect of ethyl pyruvate in Schwann cell de-differentiation and proliferation during Wallerian degeneration

(2015) Byung Sun Park et al.   Animal Cells and Systems

Demyelination as a rational therapeutic target for ischemic or traumatic brain injury

(2015) Hong Shi et al.   EXPERIMENTAL NEUROLOGY

HDAC inhibition prevents white matter injury by modulating microglia/macrophage polarization through the GSK3β/PTEN/Akt axis

(2015) Guohua Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ethyl Pyruvate Protects against Blood-Brain Barrier Damage and Improves Long-term Neurological Outcomes in a Rat Model of Traumatic Brain Injury

(2014) Hong Shi et al.   CNS Neuroscience & Therapeutics

Microglial and macrophage polarization—new prospects for brain repair

(2014) Xiaoming Hu et al.   Nature Reviews Neurology

Oxidative Stress and Proinflammatory Cytokines Contribute to Demyelination and Axonal Damage in a Cerebellar Culture Model of Neuroinflammation

(2013) Alessandra di Penta et al.   PLoS One

Moderate and severe traumatic brain injury in adults

(2008) Andrew IR Maas et al.   LANCET NEUROLOGY