Article
Medicine, Research & Experimental
Wei Zhou, Hua Zhang, Lihua Huang, Chuankai Sun, Yuhan Yue, Xiaolei Cao, Hongling Jia, Chunyue Wang, Yunfei Gao
Summary: This study investigated the preventive effects of DSF+Cu2+ on ulcerative colitis in mice and found that DSF and Cu2+ could significantly reverse the symptoms of colitis and inhibit inflammation by multiple mechanisms, including macrophage activation and intestinal barrier protection. The treatment also improved the gut microbiota, highlighting its potential for UC therapy.
Article
Immunology
Ruiqi Guo, Qingyu Meng, Baisen Wang, Fan Li
Summary: In this study, PLD was found to ameliorate DSS-induced colitis by regulating macrophage polarization, indicating its potential as a treatment for colitis. The mechanism behind this effect involves activation of the AMPK pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Kelong Ma, Mengli Chen, Juanjuan Liu, Yuzhu Ge, Tianming Wang, Daqiang Wu, Guiming Yan, Changzhong Wang, Jing Shao
Summary: Sodium houttuyfonate (SH) can decrease fungal burdens, reduce disease activity index score, attenuate colonic damages, lower levels of anti-Saccharomyces cerevisiae antibodies, increase anti-inflammatory factor levels, and eliminate colonized C. albicans by inducing beta-glucan exposure, thus alleviating colitis.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shouna Hu, Yan Ma, Ke Xiong, Yanrong Wang, Yajun Liu, Yongye Sun, Yuexin Yang, Aiguo Ma
Summary: The study showed that vitamin K2 has alleviating effects on ulcerative colitis by regulating intestinal microbiota, reducing inflammation, and improving intestinal barrier function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Lukasz Kopiasz, Katarzyna Dziendzikowska, Joanna Gromadzka-Ostrowska
Summary: This study found that consuming high-molar-mass oat beta-glucans can reduce Crohn's disease by modulating the expression of chemokines and their receptors as well as certain proteins associated with CD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mengfan Luo, Qiaoyue Yuan, Mingzhen Liu, Xingye Song, Yingjie Xu, Tao Zhang, Xiaoqun Zeng, Zhen Wu, Daodong Pan, Yuxing Guo
Summary: This study aimed to develop a novel astaxanthin nanoparticle using gum arabic (GA) and whey protein powder enriched with milk fat globule membranes (MFGM-WPI) as carriers and investigated its effect and alleviation mechanism on colitis in mice. Results showed that MFGM-GA-astaxanthin effectively improved bioaccessibility of astaxanthin, reduced oxidative stress, alleviated colitis symptoms, repaired intestinal barrier function, and restored abnormalities of gut flora. This study provides a promising therapeutic approach for colon diseases using astaxanthin nanoparticles.
Article
Biotechnology & Applied Microbiology
Yong Cao, Yan Lin, Yan Sun, Weiyu Liu, Yichuan Shao, Changqing Zheng
Summary: The study demonstrated that 4-HPR may be a potent anti-UC agent that works by regulating macrophage polarization via PPAR gamma.
Article
Gastroenterology & Hepatology
Julien Kirchgesner, Rishi J. Desai, Maria C. Schneeweiss, Laurent Beaugerie, Sebastian Schneeweiss, Seoyoung C. Kim
Summary: Combination therapy with vedolizumab and thiopurines is associated with a lower risk of treatment failure compared to vedolizumab monotherapy in patients with CD, but the effect is less pronounced in UC.
Article
Gastroenterology & Hepatology
Katia Farias e Silva, Hayandra F. Nanini, Cynthia Machado Cascabulho, Siane L. B. Rosas, Patricia T. Santana, Antonio Jose de Carneiro, Elias Anaissie, Marcio Nucci, Heitor Siffert Pereira de Souza
Summary: The study found that serum BG levels correlated with intestinal inflammation in patients with inflammatory bowel disease, suggesting it may be an important noninvasive approach for detecting mucosal inflammation and monitoring therapeutic responses, particularly in Crohn's disease.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Immunology
Fengkun Guan, Huijuan Luo, Jiazhen Wu, Mengyao Li, Liping Chen, Ning Huang, Guilan Wei, Juan Nie, Baoyi Chen, Ziren Su, Xie Zhang, Yuhong Liu
Summary: Andrographolide sodium bisulfite (ASB) has a protective effect against ulcerative colitis (UC) and liver injury by suppressing macrophage proinflammatory polarization from the gut-liver axis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Immunology
Reza Yarani, Ali Shojaeian, Oana Palasca, Nadezhda T. Doncheva, Lars Juhl Jensen, Jan Gorodkin, Flemming Pociot
Summary: This review discusses the differential regulation of miRNAs in inflammatory bowel disease (IBD) and their potential diagnostic and therapeutic applications. Through literature curation and computational analysis, a consensus set of differentially expressed miRNAs in mucosal tissues was obtained. The role of these miRNAs and their potential targets in IBD are highlighted.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Tatsuki Noguchi, Soichiro Ishihara, Motoi Uchino, Hiroki Ikeuchi, Koji Okabayashi, Kitaro Futami, Shinji Tanaka, Hiroki Ohge, Hisashi Nagahara, Kazuhiro Watanabe, Michio Itabashi, Kinya Okamoto, Yoshiki Okita, Tsunekazu Mizushima, Yusuke Mizuuchi, Kazutaka Yamada, Yoshifumi Shimada, Yu Sato, Hideaki Kimura, Kenichi Takahashi, Koya Hida, Yusuke Kinugasa, Junji Okuda, Koji Daito, Fumikazu Koyama, Hideki Ueno, Takayuki Yamamoto, Tsunekazu Hanai, Atsuo Maemoto, Koji Oba, Yoichi Ajioka, Kenichi Sugihara
Summary: Patients with longstanding inflammatory bowel disease, such as ulcerative colitis and Crohn's disease, are at high risk of developing intestinal cancers. This study found significant differences between intestinal cancers associated with ulcerative colitis and Crohn's disease. Crohn's disease-associated cancers were diagnosed at more advanced stages, detected less frequently by surveillance, and had a poorer prognosis compared to those associated with ulcerative colitis.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Chemistry, Applied
Dominik Rotrekl, Petra Salamunova, Lenka Parakova, Ondrej Bado, Ivan Salon, Frantisek Stepanek, Jaroslav Hanus, Jan Hosek
Summary: The study assessed the usability of yeast glucan particles as carriers for curcumin and the beneficial effect of curcumin in the particles on colitis in rats. The composites showed promising results in reducing colitis symptoms and decreasing pro-inflammatory cytokines, with a greater anti-inflammatory effect compared to pure particles or curcumin alone.
CARBOHYDRATE POLYMERS
(2021)
Review
Immunology
Maorun Zhang, Xiaoping Li, Qi Zhang, Jiahua Yang, Gang Liu
Summary: Colitis-associated colorectal cancer (CAC) is a severe complication of ulcerative colitis (UC), characterized by multiple lesions, worse pathological type, and poor prognosis. Macrophages, as innate immune cells, play a crucial role in both inflammatory response and tumor immunity. Enhanced macrophage infiltration in UC leads to the production of inflammatory cytokines, promoting UC tumorigenesis. Macrophage polarization into M1 has an anti-tumor effect, while M2 polarization promotes tumor growth. Targeting macrophages has shown effectiveness in preventing and treating CAC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mengfan Luo, Qiaoyue Yuan, Mingzhen Liu, Xingye Song, Yingjie Xu, Tao Zhang, Xiaoqun Zeng, Zhen Wu, Daodong Pan, Yuxing Guo
Summary: This study aimed to develop a novel astaxanthin nanoparticle using gum arabic and whey protein powder enriched with milk fat globule membranes as carriers, and investigate its effect and alleviation mechanism on colitis in mice. The study demonstrated that the nanoparticle could improve astaxanthin bioaccessibility and cope with oxidative stress more effectively. In vivo studies showed that the nanoparticle alleviated colitis symptoms, repaired intestinal barrier function, and restored the abnormalities of flora caused by dextran sulfate sodium. This study provides a basis for the therapeutic effect of astaxanthin nanoparticles on colon diseases.