Article
Oncology
Qizhi Qin, Mario Gomez-Salazar, Robert J. Tower, Leslie Chang, Carol D. Morris, Edward F. McCarthy, Kang Ting, Xinli Zhang, Aaron W. James
Summary: The study reveals that NELL1, a secreted glycoprotein, plays a crucial role in sarcoma progression and prognosis by modulating cell invasion potential. Deletion of NELL1 significantly reduces metastasis and disease progression in osteosarcoma, both in human and mouse models. Further analysis shows that NELL1 loss alters the expression of matricellular proteins associated with cell signaling.
Article
Multidisciplinary Sciences
Andy Chan, Sophia Ma, Bret J. Pearson, Danny Chan
Summary: The extracellular matrix plays a crucial role in the maintenance, regeneration, and differentiation of stem cells within their niche. By studying the collagen gene family in the freshwater planarian Schmidtea mediterranea, researchers have identified a key gene, col4-1, which influences the proliferation of neoblasts. Furthermore, evidence suggests that an interaction between type IV collagen, the discoidin domain receptor, and neuregulin-7 regulate the balance of symmetric and asymmetric division of neoblasts through the NRG-7/EGFR pathway.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Xuezhou Zhang, Jing Liu, Xuecheng Yang, Wei Jiao, Chengquan Shen, Xinzhao Zhao, Yonghua Wang
Summary: This study constructed and validated a prognostic prediction model for bladder cancer based on differentially expressed ECM-related genes (ERGs), and identified COL6A1 as a potential biomarker for predicting malignant progression, prognosis, and efficacy of immunotherapy in bladder cancer.
Article
Oncology
Xuejian Li, Huifei Wang, Aran Jia, Yuanyuan Cao, Liuqing Yang, Zanhui Jia
Summary: The present study aimed to explore the significance and molecular mechanisms of galectin-1 (LGALS1) in ovarian cancer (OC). The results demonstrated that LGALS1 mRNA expression was markedly increased in OC and associated with advanced tumor, lymphatic metastasis and residual lesions. The enrichment analysis revealed that the upregulated differentially expressed genes were primarily associated with the metastasis of cancer cells. The study highlighted that LGALS1 may regulate cell adhesion and participate in the development of OC, making it a potential therapeutic target.
Review
Biochemistry & Molecular Biology
Kena Song, Zhangqing Yu, Xiangyang Zu, Guoqiang Li, Zhigang Hu, Yun Xue
Summary: Collagens play a significant role in cancer progression as the main component of the extracellular matrix (ECM). The interaction between collagens and tumor cells is complex, involving biochemical and mechanical signals. The remodeling of collagens during cancer development promotes tumor progression. Collagens have potential value in cancer diagnosis and prognosis, with fragments in serum reported as biomarkers. However, more research and drug development are needed to better understand the mechanisms and improve cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Zhenlin Wang, Zunyun Wang, Xianyu Hu, Qijun Han, Ke Chen, Gang Pang
Summary: This study established an extracellular matrix prognostic model for gastric cancer patients through comparing activated signaling pathways and LASSO regression analysis, which can help evaluate patients' risk of death and response to immunotherapy.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Mihaela Chivu-Economescu, Laura G. Necula, Lilia Matei, Denisa Dragu, Coralia Bleotu, Andrei Sorop, Vlad Herlea, Simona Dima, Irinel Popescu, Carmen C. Diaconu
Summary: In this study, through bioinformatics assessment and gene analysis, we identified nine candidate biomarker genes associated with gastric cancer progression and prognosis. The high expression of these genes is correlated with poor overall survival and immune infiltrate, making them potential new therapeutic targets for gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Kassandra Lopez, Seigmund Wai Tsuen Lai, Edwin De Jesus Lopez Gonzalez, Raul G. Davila, Sarah C. Shuck
Summary: Extracellular vesicles (EVs) are versatile membrane-derived particles released from cells and found in various biological matrices and the extracellular space. Different types of EVs, including apoptotic bodies, exosomes, and microvesicles, differ in their size, origin, membrane protein expression, and cargo contents. EVs act as shuttles for proteins, DNA, RNA, and other molecules between cells, influencing cell physiology. In the tumor microenvironment (TME), EVs play a crucial role in tumor growth and progression by facilitating communication among fibroblasts, macrophages, and tumor cells. Therefore, it is important to develop robust techniques for EV isolation and characterization to understand their association with diseases accurately.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Oncology
Jin Zhang, Jieya Liu, Hongying Zhang, Jiao Wang, Hui Hua, Yangfu Jiang
Summary: Collagens, as the main components of extracellular matrix in the tumor microenvironment, play crucial roles in tumor progression. Both fibrillar and nonfibrillar collagens are involved, with the nonfibrillar network-forming collagens, such as type IV and type VIII collagens, frequently overexpressed in human cancers, promoting tumor cell proliferation, adhesion, invasion, metastasis, and angiogenesis.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Review
Cell Biology
Zoi Piperigkou, Kyriaki Tzaferi, George Makrokanis, Konstantina Cheli, Nikos K. Karamanos
Summary: Proteoglycans, as a major component of the extracellular matrix, play a crucial role in cancer progression. Recent studies have shown that proteoglycans interact with microRNAs, affecting cell-cell and cell-matrix communication and thus regulating cancer cell biogenesis and expression. Understanding the regulatory mechanisms of proteoglycans is of great significance for cancer diagnosis and treatment.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Oncology
George Noid, Garrett Godfrey, William Hall, Jainil Shah, Eric Paulson, Paul Knechtges, Beth Erickson, X. Allen Li
Summary: This study found a correlation between extracellular volume fraction (ECVf) calculated from dual-energy CT data and treatment response measured by changes in CA19-9 levels in pancreatic cancer patients undergoing chemoradiation therapy. The ECVf could be used to predict treatment response after neoadjuvant chemoradiation therapy for pancreatic cancer.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Review
Oncology
Carole Luthold, Tarek Hallal, David P. Labbe, Francois Bordeleau
Summary: Prostate cancer affects a large number of men worldwide. Understanding the mechanisms of disease progression and therapy resistance is crucial for developing effective treatments. Alterations in the extracellular matrix, particularly stiffening, play a role in prostate cancer progression. This review examines the association between extracellular matrix stiffening and disease progression and castration resistance in prostate cancer.
Review
Oncology
Ruoxi Xu, Peng Yin, Jifu Wei, Qiang Ding
Summary: The significance of matrix stiffness in cancer development, particularly in breast cancer, has been explored. Increased matrix stiffness alters cellular activity and promotes the growth of breast cancer. Studies have shown that increased matrix stiffness is closely linked to breast cancer progression.
FRONTIERS IN ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Stephan Niland, Andrea Ximena Riscanevo, Johannes Andreas Eble
Summary: This review examines the current knowledge of the interplay of various MMPs in the context of cancer on the protein, subcellular, and cellular level, with a focus on MMP-14. It highlights the importance of a deeper understanding of functional mechanisms for the development of new prognostic and predictive markers, as well as targeted therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Dominika Czaplinska, Renata Ialchina, Henriette Berg Andersen, Jiayi Yao, Arnaud Stigliani, Johs Dannesboe, Mette Flinck, Xiaoming Chen, Jakub Mitrega, Sebastian Peter Gnosa, Oksana Dmytriyeva, Frauke Alves, Joanna Napp, Albin Sandelin, Stine Falsig Pedersen
Summary: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with limited treatment options and increasing prevalence worldwide. This study reveals a complex interplay between tumor acidosis, extracellular matrix composition, and genotype in PDAC development. The findings may provide guidance for future acidosis-targeted therapies.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Cell Biology
Jan Van Deun, Quentin Roux, Sarah Deville, Thibaut Van Acker, Pekka Rappu, Ilkka Miinalainen, Jyrki Heino, Frank Vanhaecke, Bruno G. De Geest, Olivier De Wever, An Hendrix
Article
Engineering, Biomedical
Flavia Castro, Marta L. Pinto, Catarina L. Pereira, Karine Serre, Mario A. Barbosa, Karim Vermaelen, Fatima Gartner, Raquel M. Goncalves, Olivier De Wever, Maria J. Oliveira
Review
Oncology
Jonas Steenbrugge, Emiel A. De Jaeghere, Evelyne Meyer, Hannelore Denys, Olivier De Wever
Summary: Tumor-derived secretory factors influence splenic hematopoietic and stromal cells to promote tumor metastasis. While animal models provide valuable insights, translating these findings to clinical practice poses specific challenges.
Article
Oncology
Philippe Giron, Carolien Eggermont, Amir Noeparast, Hugo Vandenplas, Erik Teugels, Ramses Forsyth, Olivier De Wever, Pedro Aza-Blanc, Gustavo J. Gutierrez, Jacques De Greve
Summary: The study identifies USP13 as a protein that can increase the sensitivity of lung cancer cells with EGFR mutations to targeted therapy, potentially improving treatment efficacy.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Chemistry, Medicinal
Ivones Hernandez-Balmaseda, Idania Rodeiro Guerra, Ken Declerck, Jose Alfredo Herrera Isidron, Claudina Perez-Novo, Guy Van Camp, Olivier De Wever, Kethia Gonzalez, Mayrel Labrada, Adriana Carr, Geovanni Dantas-Cassali, Diego Carlos dos Reis, Livan Delgado-Roche, Roberto Rafael Nunez, Rene Delgado-Hernandez, Miguel David Fernandez, Miriam T. Paz-Lopes, Wim Vanden Berghe
Summary: In vitro and in vivo studies demonstrated the antitumor effects of TTE on colon tumor cell lines and a murine colorectal cancer model, including suppression of cell growth, migration, and angiogenesis, as well as promotion of antitumor immunogenic cell death. Transcription profiling and pathway analysis revealed that TTE triggers specific gene expression and autophagy stress pathways, leading to its antitumor effects.
Article
Biochemical Research Methods
Edward Geeurickx, Lien Lippens, Pekka Rappu, Bruno G. De Geest, Olivier De Wever, An Hendrix
Summary: This study presents a protocol for using recombinant EV as a biological reference material to evaluate EV application performance, map technical variability, and promote inter-laboratory studies, which can be completed in about 4-5 days.
Article
Multidisciplinary Sciences
Valerie De Meulenaere, Benedicte Descamps, Olivier De Wever, Christian Vanhove, Karel Deblaere
Review
Biochemistry & Molecular Biology
Emily De Lombaerde, Olivier De Wever, Bruno G. De Geest
Summary: Direct intratumoral injection allows for local immune activation, leading to decreased systemic toxicity, improved efficacy, and abscopal effects. The approval of the first intratumoral oncolytic virotherapy, talimogene laherparepvec (T-VEC), has sparked interest in studying other immunotherapeutic approaches.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Neurosciences
Ana Rita Pombo Antunes, Isabelle Scheyltjens, Francesca Lodi, Julie Messiaen, Asier Antoranz, Johnny Duerinck, Daliya Kancheva, Liesbet Martens, Karen De Vlaminck, Hannah Van Hove, Signe Schmidt Kjolner Hansen, Francesca Maria Bosisio, Koen Van der Borght, Steven De Vleeschouwer, Raf Sciot, Luc Bouwens, Michiel Verfaillie, Niels Vandamme, Roosmarijn E. Vandenbroucke, Olivier De Wever, Yvan Saeys, Martin Guilliams, Conny Gysemans, Bart Neyns, Frederik De Smet, Diether Lambrechts, Jo A. Van Ginderachter, Kiavash Movahedi
Summary: By utilizing single-cell RNA sequencing and CITE-seq, this study reveals the complexity of the immune landscape in glioblastomas, including conserved populations of dendritic cells and macrophages. The results indicate that microglia-derived tumor-associated macrophages dominate in newly diagnosed tumors, but are replaced by monocyte-derived TAMs in recurrences.
NATURE NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Catalina Lodillinsky, Laetitia Fuhrmann, Marie Irondelle, Olena Pylypenko, Xiao-Yan Li, Helene Bonsang-Kitzis, Fabien Reyal, Sophie Vacher, Claire Calmel, Olivier De Wever, Ivan Bieche, Marie-Lise Lacombe, Ana Maria Eijan, Anne Houdusse, Anne Vincent-Salomon, Stephen J. Weiss, Philippe Chavrier, Mathieu Boissan
Summary: The study reveals that NME1 plays a crucial role in the in situ-to-invasive transition of breast cancer, showing a negative correlation with MT1-MMP and impacting the invasive potential of breast cancer cells.
Article
Chemistry, Multidisciplinary
Yentl Van Rymenant, Muhammet Tanc, Roos Van Elzen, An Bracke, Olivier De Wever, Koen Augustyns, Anne-Marie Lambeir, Mark Kockx, Ingrid De Meester, Pieter Van Der Veken
Summary: Fibroblast activation protein (FAP) is a proline-selective protease highly expressed in the tumor microenvironment, and selective activity-based probes have been developed to detect FAP with subnanomolar affinity and selectivity. These probes are suitable for biological studies and have been tested for in situ FAP activity staining in patient-derived cryosections of urothelial tumors.
FRONTIERS IN CHEMISTRY
(2021)
Article
Oncology
Jonas Steenbrugge, Niels Vander Elst, Kristel Demeyere, Olivier De Wever, Niek N. Sanders, Wim van den Broeck, Eric Ciamporcero, Timothy Perera, Evelyne Meyer
Summary: c-MET plays a crucial role in cancer progression, and OMO-1, a potent c-MET inhibitor, shows promising therapeutic efficacy in TNBC. OMO-1 not only reduces tumor progression dose dependently but also enhances the effects of cisplatin, providing potential benefits for TNBC patients, even in cases of non-c-MET addicted tumors.
Article
Materials Science, Biomaterials
Aranit Harizaj, Benedicte Descamps, Christophe Mangodt, Stephan Stremersch, Arianna Stoppa, Lieve Balcaen, Toon Brans, Hilde De Rooster, Nausikaa Devriendt, Juan C. Fraire, Eduardo Bolea-Fernandez, Olivier De Wever, Wouter Willaert, Frank Vanhaecke, Christian V. Stevens, Stefaan C. De Smedt, Bart Roman, Christian Vanhove, Ine Lentacker, Kevin Braeckmans
Summary: Longitudinal in vivo monitoring of transplanted cells is crucial for cancer research and treatment assessment. MRI offers high spatial resolution and soft-tissue contrast, but suffers from low sensitivity, requiring high concentrations of contrast agents. Photoporation provides an attractive alternative for efficient delivery of contrast agents into the cytosol, avoiding the quenching effect and improving MR signal intensity.
BIOMATERIALS SCIENCE
(2021)
Article
Oncology
Emiel A. De Jaeghere, Frederiek Laloo, Lien Lippens, Mieke Van Bockstal, Kathia De Man, Eline Naert, Jo Van Dorpe, Koen Van de Vijver, Philippe Tummers, Amin Makar, Pieter J. L. De Visschere, Olivier De Wever, Frederic Amant, Hannelore G. Denys, Katrien Vandecasteele
GYNECOLOGIC ONCOLOGY
(2020)
Article
Biochemical Research Methods
Bert Dhondt, Nicolaas Lumen, Olivier De Wever, An Hendrix
