Marine Seagrass Extract of Thalassia testudinum Suppresses Colorectal Tumor Growth, Motility and Angiogenesis by Autophagic Stress and Immunogenic Cell Death Pathways

Chrysoeriol ameliorates TPA-induced acute skin inflammation in mice and inhibits NF-κB and STAT3 pathways

(2020) Jia-Ying Wu et al.   PHYTOMEDICINE

A new perspective in cancer immunotherapy: PD-1 on myeloid cells takes center stage in orchestrating immune checkpoint blockade

(2020) Christopher E. Rudd   Science Immunology

Targeted deletion of PD-1 in myeloid cells induces antitumor immunity

(2020) Laura Strauss et al.   Science Immunology

Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019

(2020) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Co-Regulation of Immune Checkpoint PD-L1 with Interferon-Gamma Signaling is Associated with a Survival Benefit in Renal Cell Cancer

(2020) Jörg Hänze et al.   Targeted Oncology

Polyphenol-Mediated Autophagy in Cancer: Evidence of In Vitro and In Vivo Studies

(2020) Monica Benvenuto et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Roles of IFN-γ in tumor progression and regression: a review

(2020) Dragica Jorgovanovic et al.   Biomarker Research

Polyphenolic Fraction Obtained From Thalassia testudinum Marine Plant and Thalassiolin B Exert Cytotoxic Effects in Colorectal Cancer Cells and Arrest Tumor Progression in a Xenograft Mouse Model

(2020) Livan Delgado-Roche et al.   Frontiers in Pharmacology

Apigenin Increases SHIP-1 Expression, Promotes Tumoricidal Macrophages and Anti-Tumor Immune Responses in Murine Pancreatic Cancer

(2020) Krystal Villalobos-Ayala et al.   Cancers

Identification of Dietary Phytochemicals Capable of Enhancing the Autophagy Flux in HeLa and Caco-2 Human Cell Lines

(2020) Kohta Ohnishi et al.   Antioxidants

Luteolin suppresses colorectal cancer cell metastasis via regulation of the miR‑384/pleiotrophin axis

(2019) Yuanyuan Yao et al.   ONCOLOGY REPORTS

Apigenin-mediated Alterations in Viability and Senescence of SW480 Colorectal Cancer Cells Persist in The Presence of L-thyroxine

(2019) Bagheri Zohreh et al.   Anti-Cancer Agents in Medicinal Chemistry

Marine-Derived Anticancer Agents: Clinical Benefits, Innovative Mechanisms, and New Targets

(2019) Renato B. Pereira et al.   Marine Drugs

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

Marine Natural Products: A Source of Novel Anticancer Drugs

(2019) Shaden A. M. Khalifa et al.   Marine Drugs

Apigenin, A Plant Flavone Playing Noble Roles in Cancer Prevention Via Modulation of Key Cell Signaling Networks

(2019) Deepti Singh et al.   Recent Patents on Anti-Cancer Drug Discovery

Anti-angiogenic effects of mangiferin and mechanism of action in metastatic melanoma

(2019) René Delgado-Hernández et al.   MELANOMA RESEARCH

HDACi Delivery Reprograms Tumor-Infiltrating Myeloid Cells to Eliminate Antigen-Loss Variants

(2018) Andrew Nguyen et al.   Cell Reports

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Assessment of the cytotoxic potential of an aqueous-ethanolic extract from Thalassia testudinum angiosperm marine grown in the Caribbean Sea

(2018) Idania Rodeiro et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

From Marine Origin to Therapeutics: The Antitumor Potential of Marine Algae-Derived Compounds

(2018) Celso Alves et al.   Frontiers in Pharmacology

Turn Back the TIMe: Targeting Tumor Infiltrating Myeloid Cells to Revert Cancer Progression

(2018) Robin Maximilian Awad et al.   Frontiers in Immunology

Autophagy-dependent cell death

(2018) Donna Denton et al.   CELL DEATH AND DIFFERENTIATION

Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12

(2018) Christopher S. Garris et al.   IMMUNITY

Capsaicin-induced TRIB3 upregulation promotes apoptosis in cancer cells

(2018) Rong-Jaan Lin et al.   Cancer Management and Research

Luteolin inhibits colorectal cancer cell epithelial-to-mesenchymal transition by suppressing CREB1 expression revealed by comparative proteomics study

(2017) Yuan Liu et al.   Journal of Proteomics

TRRUST v2: an expanded reference database of human and mouse transcriptional regulatory interactions

(2017) Heonjong Han et al.   NUCLEIC ACIDS RESEARCH

Emodin induces apoptosis of lung cancer cells through ER stress and the TRIB3/NF-κB pathway

(2017) Jin Su et al.   ONCOLOGY REPORTS

Epithelial Mesenchymal Transition in Cancer Progression: Prev entive Phytochemicals

(2017) Soorya P. Illam et al.   Recent Patents on Anti-Cancer Drug Discovery

A Critical Review on Polyphenols and Health Benefits of Black Soybeans

(2017) et al.   Nutrients

Phytochemicals Approach for Developing Cancer Immunotherapeutics

(2017) Shu-Yi Yin et al.   Frontiers in Pharmacology

Dual Faces of IFN  in Cancer Progression: A Role of PD-L1 Induction in the Determination of Pro- and Antitumor Immunity

(2016) M. Mandai et al.   CLINICAL CANCER RESEARCH

From mice to men: Murine models of colorectal cancer for use in translational research

(2016) Jonathan P. Evans et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Molecular targets of luteolin in cancer

(2016) Muobarak J. Tuorkey   EUROPEAN JOURNAL OF CANCER PREVENTION

Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer

(2016) Yaqing Zhang et al.   GUT

Secondary metabolites of seagrasses (Alismatales and Potamogetonales; Alismatidae): Chemical diversity, bioactivity, and ecological function

(2016) Christian Zidorn   PHYTOCHEMISTRY

Downregulation of NEDD9 by apigenin suppresses migration, invasion, and metastasis of colorectal cancer cells

(2016) Jin Dai et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Effects of Pleiotrophin on endothelial and inflammatory cells: Pro-angiogenic and anti-inflammatory properties and potential role for vascular bio-prosthesis endothelialization

(2015) Daniela Palmieri et al.   Advances in Medical Sciences

Chemical constituents of Trichosanthes kirilowii and their cytotoxic activities

(2015) Chau Van Minh et al.   ARCHIVES OF PHARMACAL RESEARCH

Polyphenols in whole rice grain: Genetic diversity and health benefits

(2015) Yafang Shao et al.   FOOD CHEMISTRY

Comparative study of anti-angiogenic activities of luteolin, lectin and lupeol biomolecules

(2015) Rashmi K. Ambasta et al.   Journal of Translational Medicine

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Anti-inflammatory/antioxidant use in long-term maintenance cancer therapy: a new therapeutic approach to disease progression and recurrence

(2014) Sarah Crawford   Therapeutic Advances in Medical Oncology

Proteogenomic Analysis Reveals Unanticipated Adaptations of Colorectal Tumor Cells to Deficiencies in DNA Mismatch Repair

(2013) P. J. Halvey et al.   CANCER RESEARCH

Apigenin up-regulates transgelin and inhibits invasion and migration of colorectal cancer through decreased phosphorylation of AKT

(2013) Li Chunhua et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Frondoside A Suppressive Effects on Lung Cancer Survival, Tumor Growth, Angiogenesis, Invasion, and Metastasis

(2013) Samir Attoub et al.   PLoS One

Strange attractors: DAMPs and autophagy link tumor cell death and immunity

(2013) W Hou et al.   Cell Death & Disease

Antinociception Produced by Thalassia Testudinum Extract BM-21 is Mediated by the Inhibition of Acid Sensing Ionic Channels by the Phenolic Compound Thalassiolin B

(2011) Anoland Garateix et al.   Molecular Pain

Anticancer Drugs from Marine Flora: An Overview

(2011) N. Sithranga Boopathy et al.   Journal of Oncology

Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols

(2010) Wipob Suttana et al.   Molecular Cancer

Potential hepatoprotective effects of new Cuban natural products in rat hepatocytes culture

(2008) I. Rodeiro et al.   TOXICOLOGY IN VITRO