Article
Cell Biology
Rola S. Zeidan, Sung Min Han, Christiaan Leeuwenburgh, Rui Xiao
Summary: Iron plays crucial roles in physiological processes and its homeostasis involves a complex network of regulators at systemic, cellular, and molecular levels. Dysregulation of iron homeostasis is often linked to age-related pathologies, highlighting the importance of understanding the interplay between iron balance and aging in order to develop therapeutic strategies for age-related diseases.
AGEING RESEARCH REVIEWS
(2021)
Article
Cardiac & Cardiovascular Systems
Panagiota Pietri, Christodoulos Stefanadis
Summary: Cardiovascular aging and longevity are interconnected through various pathophysiological mechanisms, with factors like cardiometabolic disorders and genetic modulators playing significant roles. Understanding the genetic, molecular, and biochemical pathways of aging may lead to interventions that delay cardiovascular aging, potentially contributing to achieving longevity goals. Research on long-living populations helps translate these mechanisms into clinical data for further study.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Geriatrics & Gerontology
Emerson Santiago, David F. Moreno, Murat Acar
Summary: Aging is a complex phenomenon of functional decay in biological organisms, with the cause(s) still poorly understood. Computational biology offers a unique opportunity to generate models that can help us understand the fundamental nature of aging, identify unaccounted aging factors, and demonstrate the mechanics of aging.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Cell Biology
Lindsay E. Wu, Corrine E. Fiveash, Nicholas L. Bentley, Myung-Jin Kang, Hemna Govindaraju, Jayne A. Barbour, Brendan P. Wilkins, Sarah E. Hancock, Romanthi Madawala, Abhijit Das, Hassina Massudi, Catherine Li, Lynn-Jee Kim, Ashley S. A. Wong, Maria B. Marinova, Ghazal Sultani, Abhirup Das, Neil A. Youngson, David G. Le Couteur, David A. Sinclair, Nigel Turner
Summary: The NAD+-dependent deacylase family of sirtuin enzymes, including SIRT2, play important roles in biological aging, late-life health, and overall lifespan. However, the role of SIRT2 has been less clear. Previous studies showed that transgenic overexpression of SIRT2 can improve health and increase lifespan in a progeria model. In this study, the researchers tested whether SIRT2 overexpression would impact the overall health and lifespan of mice on a nonprogeroid, wild-type background. They found that SIRT2 overexpression did not have an additional impact on health or lifespan in these mice. Biochemical studies also revealed changes in brain metabolites in SIRT2 overexpressing mice, but these changes did not translate into functional differences.
Article
Optics
G. J. Delben, A. L. O. dos Santos, M. G. E. da Luz
Summary: This paper investigates the quantum control of two qubits interacting with a Markovian environment and evolving as an X state. The goal is to make the population or the system concurrence follow a specified trajectory. The research findings indicate that the effects of phase damping can be mitigated by introducing amplitude damping.
Review
Geriatrics & Gerontology
Michael Bene, Adam B. B. Salmon
Summary: A growing number of interventions have been found to extend the lifespan of laboratory animals. However, the extent to which these effects are conserved across species is unclear. This study analyzed published data on longevity interventions in Caenorhabditis and Drosophila, and found limited predictive value for identifying lifespan-extending compounds in mice. These results caution against assuming the translatability of lifespan-extending interventions across species, including humans.
Article
Geriatrics & Gerontology
Tatiana Dandolini Saccon, Ravinder Nagpal, Hariom Yadav, Marcelo Borges Cavalcante, Allancer Divino de Carvalho Nunes, Augusto Schneider, Adam Gesing, Brian Hughes, Matthew Yousefzadeh, Tamar Tchkonia, James L. Kirkland, Laura J. Niedernhofer, Paul D. Robbins, Michal M. Masternak
Summary: The study found that the senolytic drug combination Dasatinib plus Quercetin (D+Q) significantly reduces senescent cell and inflammatory burden in the intestines of aged mice, while also altering specific microbiota signatures. The most prominent changes were observed in the small intestine. This suggests that optimized senolytic regimens may improve health in older subjects by reducing intestinal senescence, inflammation, and microbial dysbiosis.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Cell Biology
Gong-Hua Li, Feifei Han, Fu-Hui Xiao, Kang-Su-Yun Gu, Qiu Shen, Weihong Xu, Wen-Xing Li, Yan-Li Wang, Bin Liang, Jing-Fei Huang, Wenzhong Xiao, Qing-Peng Kong
Summary: This study developed a genome-wide precision metabolic modeling method that successfully characterized metabolic networks of Chinese centenarians, identifying elevated fatty acid oxidation (FAO) as a significant metabolic feature. The findings suggest that elevated FAO may be a novel signature of healthy aging in humans, as it is linked to normal aging decline and age-related diseases.
Article
Multidisciplinary Sciences
Huiying Zhou, Shuhui Li, Jin Liu, Jiaxiao Hu, Si Le, Maomao Li
Summary: Seed aging is the main cause of genetic integrity loss. In this study, the genetic integrity of different rice accessions with varying germination gradients was analyzed using 44 SSR markers. Results showed that the aging resistance of rice accessions ranked from highest to lowest as common wild rice > Xianggu > 9194 > Nipponbare. A germination rate of 60% was identified as the critical value for maintaining genetic integrity. This study provides insights for determining population size and germination rate for rice resource reproduction and regeneration.
SCIENTIFIC REPORTS
(2023)
Article
Microbiology
Greco Hernandez
Summary: The definition and understanding of life have become complex with the development of scientific research. The progress in modern biology has challenged the traditional concept of life, suggesting the possibility of multiple forms of life.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Genetics & Heredity
Angelica Dominguez-de-Barros, Ines Sifaoui, Zuzanna Borecka, Roberto Dorta-Guerra, Jacob Lorenzo-Morales, Rafael Castro-Fuentes, Elizabeth Cordoba-Lanus
Summary: This study found that telomeres shorten with age in Psittacidae species and that short-lived birds accumulate more oxidative stress products but have lower antioxidant capacity compared to long-lived birds. Breeding is also related to telomere shortening, with short-lived birds experiencing increased oxidative damage during breeding while long-lived birds are able to counteract this damage with increased antioxidant capacity.
FRONTIERS IN GENETICS
(2023)
Article
Multidisciplinary Sciences
Wei-Chen Li, Ya Xiao, Xin-Hong Han, Xuan Fan, Xiao-Bing Hei, Yong-Jian Gu
Summary: Multipartite quantum steering is a valuable resource for asymmetric quantum network information tasks, but it is easily affected by decoherence, making it impractical. This study examines the decay of different types of quantum steering in the presence of noise channels. The results provide insights into the survival conditions for each type of steering and reveal the relationship between decoherence strength and state parameters.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Dmitry L. Maslov, Nadezhda V. Zemskaya, Oxana P. Trifonova, Steven Lichtenberg, Elena E. Balashova, Andrey V. Lisitsa, Alexey A. Moskalev, Petr G. Lokhov
Summary: As life expectancy increases and the proportion of older people rises, age-related disorders are becoming more prevalent, posing a major challenge in the field of biomedical research. Analyzing the metabolomic profiles of fruit flies with varying lifespans revealed signatures associated with lifespan extension, particularly in amino acids, phospholipids, and carbohydrate metabolism. This metabolome-level perspective on longevity may offer a molecular measure of organism age for age-related studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Choong-Sil Lee, Seungyeon Kim, Gyuho Hwang, Jaewhan Song
Summary: Research indicates that ubiquitination and deubiquitination play crucial roles in regulating cell death, with DUBs being key players in RCD. By modulating various substrates, DUBs can regulate multiple modes of RCD, highlighting their significance in cell fate determination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Stephan Weissbach, Stanislav Sys, Charlotte Hewel, Hristo Todorov, Susann Schweiger, Jennifer Winter, Markus Pfenninger, Ali Torkamani, Doug Evans, Joachim Burger, Karin Everschor-Sitte, Helen Louise May-Simera, Susanne Gerber
Summary: The study demonstrates systematic heterogeneity in variant calls between different experimental and data analysis setups, and highlights the benefit of reprocessing genomic data with harmonized pipelines for improving concordance.
