Article
Multidisciplinary Sciences
Hyung Jin Hahn, Sang Gyu Kwak, Dong-Kyu Kim, Jong-Yeup Kim
Summary: Research indicates that individuals with Behcet disease are more likely to develop psoriasis, with higher risk seen in male BD patients and older individuals. Additionally, Behcet disease patients are also more prone to developing psoriatic arthritis.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Weize Gao, Zhan Wang, Wenshuai Li, Yongxin Li, Mingjun Liu
Summary: This review systematically demonstrates the research progress of psoriasis-related biomarkers and elaborates their related mechanisms in the pathological development of psoriasis and psoriatic arthritis. In addition, we summarize the development of biologic therapies for psoriasis and psoriatic arthritis in order to drive the broader discussion of psoriasis as an autoimmune-mediated inflammatory skin disease.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Rheumatology
Telma Thrastardottir, Elana Meer, Arna Hauksdottir, Bjorn Gudbjornsson, Sigurdur Yngvi Kristinsson, Alexis Ogdie, Thorvardur Jon Love
Summary: This study found a strong site-specific association between pharyngeal culture samples and an increased risk of PsA and psoriasis, regardless of the pathogen.
Article
Medicine, General & Internal
Jie Zhu, Zhicheng Wang, Lu Tao, Ling Han, Qiong Huang, Xu Fang, Ke Yang, Guiqin Huang, Zhizhong Zheng, Nikhil Yawalkar, Zhenghua Zhang, Kexiang Yan
Summary: This study provides evidence for an association between MTHFR polymorphism and the risk of PsA, as well as the efficacy and hepatotoxicity of low-dose MTX in the Chinese population.
FRONTIERS IN MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Irmina Olejniczak-Staruch, Magdalena Ciazynska, Dorota Sobolewska-Sztychny, Joanna Narbutt, Malgorzata Skibinska, Aleksandra Lesiak
Summary: Numerous scientific studies have shown significant skin and gut dysbiosis in patients with psoriasis, with changes in abundance of specific bacterial taxa. Treatments for psoriasis have been found to significantly influence skin and gut microbiome, with orally administered probiotics having a positive impact on the course of the disease. Further research is needed to understand the influence of microbiome on the development of inflammatory skin diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Public, Environmental & Occupational Health
Holly R. Harris, Karen Moreno Nascimento Korkes, Tricia Li, Marina Kvaskoff, Eunyoung Cho, Luiz Fernando Carvalho, Abrar A. Qureshi, Mauricio Abrao, Stacey A. Missmer
Summary: A bidirectional association between endometriosis and psoriasis with PsA was found in this study. Psoriasis with concomitant PsA was associated with a higher risk of laparoscopically confirmed endometriosis, while the diagnosis of endometriosis was suggestive of subsequent risk of psoriasis with PsA.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Rheumatology
Philip J. Mease, Mei Liu, Sabrina Rebello, Robert R. McLean, Blessing Dube, Meghan Glynn, Peter Hur, Alexis Ogdie
Summary: Patients with PsA who have nail psoriasis demonstrated worse disease activity, quality of life, and work productivity compared to those without nail involvement, highlighting the importance of identifying and managing nail disease in PsA patients.
JOURNAL OF RHEUMATOLOGY
(2021)
Review
Medicine, General & Internal
Fei Qi, Yaqi Tan, Amin Yao, Xutong Yang, Yanling He
Summary: Psoriatic disease is a spectrum of diseases affecting both skin and musculoskeletal features, with a considerable number of patients progressing from cutaneous psoriasis to psoriatic arthritis. The use of proteomics technologies provides a unique opportunity to explore potential biomarkers for psoriatic arthritis.
FRONTIERS IN MEDICINE
(2021)
Article
Immunology
Guillaume Larid, Adriana Delwail, Thomas Dalle, Philippe Vasseur, Christine Silvain, Jean-Francois Jegou, Franck Morel, Jean-Claude Lecron, Elisabeth Gervais
Summary: Psoriatic arthritis (PsA) and cutaneous psoriasis (PsO) exhibit distinct cytokine production profiles, which are influenced by clinical phenotype and metabolic syndrome.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Judith Haschka, David Simon, Sara Bayat, Zora Messner, Eleni Kampylafka, Filippo Fagni, Susanna Skalicky, Matthias Hackl, Heinrich Resch, Jochen Zwerina, Arnd Kleyer, Alexander Cavallaro, Michael Sticherling, Goerg Schett, Roland Kocijan, Juergen Rech
Summary: This study aimed to identify circulating miRNA signatures associated with psoriasis (PsO) and psoriatic arthritis (PsA) patients. The results show significant differences in miRNA signatures between PsA and PsO patients compared to controls, with five miRNAs being involved in bone and cartilage metabolism, suggesting a link between psoriatic inflammation and bone/cartilage changes.
Review
Medicine, General & Internal
Mihaela Agache, Claudiu C. Popescu, Luminita Enache, Bianca M. Dumitrescu, Catalin Codreanu
Summary: Ultrasonography is advantageous for assessing psoriatic arthritis (PsA) due to its ability to evaluate multiple targets, including joints, entheses, and tendons, as well as skin and nails. However, the use of nail ultrasound in medical practice is limited due to the requirement for probes with a higher frequency. This article narratively evaluates recent studies on the value of nail ultrasound in diagnosing and monitoring PsA.
Article
Rheumatology
Timothy S. H. Kwok, Mitchell Sutton, Daniel Pereira, Richard J. Cook, Vinod Chandran, Nigil Haroon, Robert D. Inman, Dafna D. Gladman
Summary: Isolated axial PsA and AS with psoriasis are relatively uncommon. HLA-B*27 positivity is associated with isolated axial PsA and may predict the development of peripheral disease. Isolated axial PsA is associated with better functional status. Isolated axial PsA appears clinically distinct from isolated axial AS with psoriasis.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Review
Medicine, General & Internal
Stephen R. Pennington, Oliver FitzGerald
Summary: Although having skin/nail psoriasis is an important risk factor for developing psoriatic arthritis (PsA), it alone is not sufficient to identify which patients with psoriasis will develop PsA. Further molecular assessment of psoriasis patients may help refine the profile of those at risk of developing PsA, leading to the design of disease prevention studies and new treatment approaches.
FRONTIERS IN MEDICINE
(2021)
Article
Immunology
Valentina Natoli, Amandine Charras, Sigrun R. Hofmann, Sarah Northey, Susanne Russ, Felix Schulze, Liza Mccann, Susanne Abraham, Christian M. Hedrich
Summary: This study investigated disease-associated DNA methylation patterns in CD4(+) T-cells from psoriasis and psoriatic arthritis (PsA) patients. The DNA methylation profiles in CD4(+) T-cells can distinguish between skin psoriasis and PsA, and may be used to quantify disease activity and guide individualized treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zi-Tong Chen, Rong-Fen Chen, Xiao-Long Li, Qiao Wang, Wei-Wei Ren, Dan-Dan Shan, Yu-Jing Zhao, Li-Ping Sun, Hui-Xiong Xu, Yu-Ling Shi, Le-Hang Guo
Summary: Objective is to identify patients in the subclinical psoriatic arthritis (Sub-PsA) phase by ultrasound (US) and provide a solution to screen them.
EUROPEAN RADIOLOGY
(2023)
Article
Dermatology
K. A. Bain, E. McDonald, F. Moffat, M. Tutino, M. Castelino, A. Barton, J. Cavanagh, U. Z. Ijaz, S. Siebert, I. B. McInnes, A. Astrand, S. Holmes, S. W. F. Milling
BRITISH JOURNAL OF DERMATOLOGY
(2020)
Article
Rheumatology
Darren Plant, Anne Barton
Article
Rheumatology
James M. Gwinnutt, Kimme L. Hyrich, Mark Lunt, Anne Barton, Suzanne M. M. Verstappen
Article
Genetics & Heredity
Stephanie F. Ling, Nisha Nair, Suzanne M. M. Verstappen, Anne Barton, Hans-Dieter Zucht, Petra Budde, Peter Schulz-Knappe, Darren Plant
PHARMACOGENOMICS JOURNAL
(2020)
Article
Rheumatology
Anne Barton, Meghna Jani, Christine Bundy, James Bluett, Stephen McDonald, Brian Keevil, Faraz Dastagir, Melissa Aris, Ian Bruce, Pauline Ho, Eoghan McCarthy, Ellen Bruce, Ben Parker, Kimme Hyrich, Rachel Gorodkin
Summary: This study successfully reduced self-reported non-adherence to MTX from 24.7% to 7.4% through a series of interventions. Key factors for improvement included motivational interviewing and consistency in information delivery.
Article
Rheumatology
Sizheng Steven Zhao, Eftychia Bellou, Suzanne M. M. Verstappen, Michael J. Cook, Jamie C. Sergeant, Richard B. Warren, Anne Barton, John Bowes
Summary: Observational and genetic evidence suggest that BMI and glycemic control are associated with increased risk of psoriatic disease, while psoriatic disease is associated with increased risk of coronary artery disease.
Review
Genetics & Heredity
Philippa D. K. Curry, Andrew P. Morris, Anne Barton, James Bluett
Summary: Psoriatic arthritis is a chronic musculoskeletal disease that affects a significant proportion of psoriasis patients. The response to targeted therapies, such as TNF inhibitors, varies among patients. Researchers have been investigating potential genetic biomarkers for predicting drug response. Although several genetic variants have been reported to correlate with TNF inhibitor response, further validation and implementation into clinical practice are needed.
PHARMACOGENOMICS JOURNAL
(2023)
Article
Rheumatology
Ryan M. Hum, Pauline Ho, Nisha Nair, Meghna Jani, Ann W. Morgan, John D. Isaacs, Anthony G. Wilson, Kimme L. Hyrich, Darren Plant, Anne Barton
Summary: This study suggests that higher levels of TNF-a inhibitor serum drug levels (SDLs) are associated with good treatment response in fully adherent patients. Interventions to improve SDLs, such as encouraging adherence, may improve treatment response. The identified SDL cut-offs for adalimumab and certolizumab may be useful in clinical practice.
Review
Biochemistry & Molecular Biology
Robert Gurke, Annika Bendes, John Bowes, Michaela Koehm, Richard M. Twyman, Anne Barton, Dirk Elewaut, Carl Goodyear, Lisa Hahnefeld, Rainer Hillenbrand, Ewan Hunter, Mark Ibberson, Vassilios Ioannidis, Sabine Kugler, Rik J. Lories, Eduard Resch, Stefan Rueping, Klaus Scholich, Jochen M. Schwenk, James C. Waddington, Phil Whitfield, Gerd Geisslinger, Oliver FitzGerald, Frank Behrens, Stephen R. Pennington
Summary: The definitive diagnosis and early treatment of immune-mediated inflammatory diseases (IMIDs) are challenging due to variable clinical manifestations. Psoriatic arthritis (PsA) is an example of such a disease. The detection of molecular biomarkers offers hope for the early diagnosis and treatment of PsA, but specific biomarkers are not yet available. By analyzing multi-omics data and integrating them with clinical assessment, it is possible to develop molecular profiles that improve the diagnosis and treatment outcomes of PsA patients.
Letter
Rheumatology
Sizheng Steven Zhao, Anne Barton, John Bowes
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Biochemical Research Methods
Elena Vigorito, Anne Barton, Costantino Pitzalis, Myles J. Lewis, Chris Wallace
Summary: In this study, a Bayesian beta-binomial mixture model (BBmix) is proposed for calling genotypes using RNA-Seq data, which can model specific biases in RNA-Seq. The benchmarking results show that BBmix generally outperforms competitors in genotype calling, with an increase of up to 1.4% in the accuracy of heterozygous calls. BBmix can be easily incorporated into standard genotype calling pipelines and the model parameters are generally transferable within datasets, making it possible to call genotypes in a large number of samples with less than 1 hour of learning.
Letter
Rheumatology
Philippa D. K. Curry, Hector Chinoy, Meghna Jani, Darren Plant, Kimmie L. Hyrich, Ann W. Morgan, A. G. Wilson, John D. Isaacs, Andrew P. Morris, Anne Barton, James Bluett
JOURNAL OF RHEUMATOLOGY
(2023)
Letter
Rheumatology
Chuan Fu Yap, Nisha Nair, Annick de Vries, Floris C. Loeff, Ann W. Morgan, John D. Isaacs, Anthony G. Wilson, Kimme L. Hyrich, Anne Barton, Darren Plant
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Stephanie F. Ling, Chuan Fu Yap, Nisha Nair, James Bluett, Ann W. Morgan, John D. Isaacs, Anthony G. Wilson, Kimme L. Hyrich, Anne Barton, Darren Plant
Summary: This study aimed to identify proteomic biomarkers associated with clinical outcome measures in patients with rheumatoid arthritis (RA) starting biologic disease-modifying antirheumatic drugs (bDMARDs). Through SWATH-MS analysis of serum samples from RA patients before and after 3 months of treatment, ten proteins were found to be significantly associated with clinical outcome measures, and one of them was validated in an independent cohort.
Article
Rheumatology
Katriona Goldmann, Athina Spiliopoulou, Andrii Iakovliev, Darren Plant, Nisha Nair, Cankut Cubuk, Paul McKeigue, Michael R. Barnes, Anne Barton, Costantino Pitzalis, Myles J. Lewis
Summary: This study conducted expression quantitative trait locus (eQTL) analysis using RNA-Sequencing to explore the link between genetic variants and gene expression in rheumatoid arthritis (RA) patients. The analysis identified 898 eQTL genes in synovium and blood, with 232 genes in common. A specific eQTL at HLA-DPB2 was found to be associated with clinical severity and the lympho-myeloid pathotype.
ANNALS OF THE RHEUMATIC DISEASES
(2023)