Review
Immunology
Yanzhi Jiang, Jianxin Lin, Haiyun Zheng, Ping Zhu
Summary: This review examines the role of purinergic signaling in ischemia-reperfusion injury and rejection after heart transplantation, as well as its clinical applications and prospects.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Ana Isabel Alvarez-Mercado, Carlos Rojano-Alfonso, Marc Mico-Carnero, Albert Caballeria-Casals, Carmen Peralta, Arani Casillas-Ramirez
Summary: Visceral obesity is closely related to metabolic syndrome and diabetes, contributing to a higher risk of post-surgical complications in liver surgery. Metabolic diseases like NAFLD and diabetes exacerbate hepatic I/R injury, leading to poorer outcomes after liver surgery. Autophagy plays a crucial role in these conditions and may serve as an effective therapeutic target to improve postoperative results for patients with metabolic diseases undergoing liver surgery.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Immunology
Tong Wu, Cheng Zhang, Tianfeng Shao, Jianzhong Chen, Diyu Chen
Summary: Ischemia-reperfusion injury (IRI) is a crucial factor in liver transplantation, and the activation of hepatic macrophages, especially NLRP3 inflammasome, plays a significant role in the progression of IRI. The NLRP3 inflammasome pathway in hepatic macrophages is highly expressed and may lead to liver IRI, making it a potential therapeutic target.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Maximilian J. Roesel, Nirmal S. Sharma, Andreas Schroeter, Tomohisa Matsunaga, Yao Xiao, Hao Zhou, Stefan G. Tullius
Summary: Transplant centers use older donors to meet the demand for lung transplantation, but this is associated with a higher rate of lung ischemia reperfusion injury. Understanding and improving the condition of older lungs is critical to optimize transplant outcomes. Ex vivo lung perfusion can recondition ischemic lungs through ex-vivo perfusing and ventilation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Fernando Lucas-Ruiz, Alejandro Penin-Franch, Jose Antonio Pons, Pablo Ramirez, Pablo Pelegrin, Santiago Cuevas, Alberto Baroja-Mazo
Summary: The NLRP3 inflammasome and pyroptosis play important roles in liver transplantation, affecting the progression of liver disease and treatment outcomes. Studying this pathway may lead to new strategies for the future treatment of LT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Marc Mico-Carnero, Arani Casillas-Ramirez, Alfredo Sanchez-Gonzalez, Carlos Rojano-Alfonso, Carmen Peralta
Summary: This study investigated the role of Neuregulin-1 (NRG1) in liver transplantation from brain death donors (DBD). The results showed that NRG1 and p21-activated kinase 1 (PAK1) levels increased in both steatotic and non-steatotic grafts from DBDs. The protective effects of NRG1 and PAK1 were associated with increased levels of VEGFA and IGF1, respectively. However, exogenous NRG1 was not an appropriate strategy for liver grafts from DBD.
Review
Immunology
Christof Kaltenmeier, Hamza O. Yazdani, Sanah Handu, Brandon Popp, David Geller, Samer Tohme
Summary: The innate immune system, particularly neutrophils and Neutrophil Extracellular Traps (NETs), plays a crucial role in liver ischemia and reperfusion injury (IRI) by promoting inflammation, tissue damage, and tumor progression. Understanding the role of innate immune cells and targeting neutrophils and NETs can contribute to the prevention and treatment of IRI.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Nora Jahn, Ulrich Sack, Sebastian Stehr, Maria Theresa Voeelker, Sven Laudi, Daniel Seehofer, Selim Atay, Panagiota Zgoura, Richard Viebahn, Andreas Boldt, Hans-Michael Hau
Summary: Peripheral blood innate immune cells and clinical factors can be used to predict early renal graft injury (eRGI) after kidney transplantation. Monocyte and NK cell levels on postoperative day 7 are highly predictive for eRGI. Patient age, body mass index, cardiovascular disease, donor age, donor source, and cold ischemia time are also associated with eRGI.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Gastroenterology & Hepatology
Isabel M. A. Bruggenwirth, Otto B. van Leeuwen, Robert J. Porte, Paulo N. Martins
Summary: The transplant community is facing challenges due to the shortage of suitable liver donor organs and the increasing number of unused livers with deteriorating quality. Ex situ machine perfusion provides additional data for assessing liver graft viability and predicting postoperative risks.
LIVER TRANSPLANTATION
(2022)
Review
Cell Biology
Albert Caballeria-Casals, Marc Mico-Carnero, Carlos Rojano-Alfonso, Cristina Maroto-Serrat, Arani Casillas-Ramirez, Ana I. Alvarez-Mercado, Jordi Gracia-Sancho, Carmen Peralta
Summary: This study discusses the role of FGF15/19 in liver surgeries, indicating that it can protect the liver from damage and promote regeneration, and has potential beneficial or harmful effects.
Review
Biochemistry & Molecular Biology
Huixia Liu, Yujuan Li, Jing Xiong
Summary: The kidney maintains a relatively stable level of oxygen partial pressure through a complex interplay of various factors. Hypoxia is a key factor in the pathogenesis of acute kidney injury and chronic kidney disease, as well as in the development of renal cancer.
Review
Biochemistry & Molecular Biology
Ruta Zulpaite, Povilas Miknevicius, Bettina Leber, Kestutis Strupas, Philipp Stiegler, Peter Schemmer
Summary: Solid organ transplantation faces challenges such as organ shortage, extended criteria donor organs, and immune regulation issues with a lack of accurate biomarkers for predicting dysfunction and rejection. Tryptophan and its metabolites are of interest in this field, offering therapeutic and prognostic potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Ihor Krasivskyi, Ilija Djordjevic, Mahmoud Tayeh, Kaveh Eghbalzadeh, Borko Ivanov, Soi Avgeridou, Stephen Gerfer, Christopher Gaisendrees, Laura Suhr, Anton Sabashnikov, Christian Joerg Rustenbach, Navid Mader, Fabian Doerr, Thorsten Wahlers
Summary: Acute mesenteric ischemia (AMI) is associated with poor clinical outcomes after cardiac surgery. This study aimed to analyze the impact of AMI on short-term outcomes and relevant risk factors for in-hospital mortality after cardiac surgery. It also investigated the role of opioids and lactic acid in the detection and prevention of AMI. The study found that higher levels of lactic acid and treatment with opioids were independent predictors of mesenteric ischemia, while peripheral vascular disease, dialysis, and septic shock were relevant predictors of in-hospital mortality.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Ulrich Wirth, Tianxiao Jiang, Josefine Schardey, Katharina Kratz, Mingming Li, Malte Schirren, Florian Kuehn, Alexandr Bazhin, Jens Werner, Markus Guba, Christian Schulz, Joachim Andrassy
Summary: Liver transplantation as a treatment for end-stage liver diseases is associated with risks of immunological factors, infectious complications, and biliary complications. Gut dysbiosis and repeated antibiotic therapies can affect the gut microbiome, while biliary interventions can colonize the biliary tract with multi-drug resistant germs. The role of microbiome research in liver transplantation, particularly in biliary complications and infections, is still not well understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Zhiyong Guo, Jinghong Xu, Shanzhou Huang, Meixian Yin, Qiang Zhao, Weiqiang Ju, Dongping Wang, Ningxin Gao, Changjun Huang, Lu Yang, Maogen Chen, Zhiheng Zhang, Zebin Zhu, Linhe Wang, Caihui Zhu, Yixi Zhang, Yunhua Tang, Haitian Chen, Kunpeng Liu, Yuting Lu, Yi Ma, Anbin Hu, Yinghua Chen, Xiaofeng Zhu, Xiaoshun He
Summary: Ischemia-free liver transplantation can avoid graft ischemia-reperfusion injury and has the potential to improve transplant outcomes and organ utilization.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
