Review
Medicine, Research & Experimental
Alvin C. Powers
Summary: Type 1 diabetes is a result of autoimmune response requiring lifelong insulin therapy. Although there is considerable heterogeneity in genetics, pathology, and clinical course of T1D, there are still knowledge gaps and opportunities for improving understanding of its pathogenesis. Emerging therapies are being developed to treat or prevent T1D.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Federico Boscari, Angelo Avogaro
Summary: This article discusses innovative management approaches for type 1 diabetes, covering advancements in both technological and biological aspects, including new insulin formulations and devices, insulin pumps, continuous glucose monitoring systems, and artificial pancreas, emphasizing the importance of biological approaches for replacing insulin.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2021)
Article
Medicine, General & Internal
Mercedes J. Burnside, Dana M. Lewis, Hamish R. Crocket, Renee A. Meier, Jonathan A. Williman, Olivia J. Sanders, Craig A. Jefferies, Ann M. Faherty, Ryan G. Paul, Claire S. Lever, Sarah K. J. Price, Carla M. Frewen, Shirley D. Jones, Tim C. Gunn, Christina Lampey, Benjamin J. Wheeler, Martin de Bock
Summary: In patients with type 1 diabetes, the use of an open-source AID system resulted in a significantly higher percentage of time in the target glucose range compared to a sensor-augmented insulin pump.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
Malgorzata Buksinska-Lisik, Przemyslaw Jerzy Kwasiborski, Robert Ryczek, Wojciech Lisik, Artur Mamcarz
Summary: This study evaluated the association between blood pressure indices provided by ABPM and the prevalence of CAD in pancreas transplant candidates. The results showed that 24-hour blood pressure and daytime blood pressure were significantly associated with the prevalence of CAD. ABPM can be used as a valuable tool to identify pancreas recipients most susceptible to CAD.
Article
Gastroenterology & Hepatology
Bor-Shiuan Shyr, Bor-Uei Shyr, Shih-Chin Chen, Che-Chuan Loong, Yi-Ming Shyr, Shin-E Wang
Summary: After pancreas transplantation, outcomes for T2DM patients are comparable to those of T1DM patients in terms of surgical risks, immunological and endocrine outcomes, and graft survival rates.
HEPATOBILIARY SURGERY AND NUTRITION
(2021)
Article
Public, Environmental & Occupational Health
Lasse Bjerg, Soffia Gudbjornsdottir, Stefan Franzen, Bendix Carstensen, Daniel R. Witte, Marit E. Jorgensen, Ann-Marie Svensson
Summary: This study revealed that the duration of diabetes-related complications is a key factor affecting mortality in individuals with type 1 diabetes, particularly with the highest mortality rate associated with cardiovascular disease in the initial period after diagnosis. After the diagnosis of diabetic kidney disease, the all-cause mortality rate also increases, but stabilizes after a few years.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Medicine, General & Internal
Steven J. Russell, Roy W. Beck, Edward R. Damiano, Firas H. El-Khatib, Katrina J. Ruedy, Zoey Li, Courtney A. Balliro, Peter Calhoun, R. Paul Wadwa, Bruce Buckingham, Keren Zhou, Mark Daniels, Philip Raskin, Perrin C. White, Jane Lynch, Jeremy Pettus, Irl B. Hirsch, Robin Goland, John B. Buse, Davida Kruger, Nelly Mauras, Andrew Muir, Janet B. McGill, Fran Cogen, Jill Weissberg-Benchell, Jordan S. Sherwood, Luz E. Castellanos, Mallory A. Hillard, Marwa Tuffaha, Melissa S. Putman, Mollie Y. Sands, Gregory Forlenza, Robert Slover, Laurel H. Messer, Erin Cobry, Viral N. Shah, Sarit Polsky, Rayhan Lal, Laya Ekhlaspour, Michael S. Hughes, Marina Basina, Betul Hatipoglu, Leann Olansky, Amrit Bhangoo, Nikta Forghani, Himala Kashmiri, Francoise Sutton, Abha Choudhary, Jimmy Penn, Rabab Jafri, Maria Rayas, Elia Escaname, Catherine Kerr, Ruby Favela-Preza, Schafer Boeder, Subbulaxmi Trikudanathan, Kristen M. Williams, Natasha Leibel, M. Sue Kirkman, Kate Bergamo, Klara R. Klein, Jean M. Dostou, Sriram Machineni, Laura A. Young, Jamie C. Diner, Arti Bhan, J. Kimberly Jones, Matthew Benson, Keisha Bird, Kimberly Englert, Andrea Cedeno, Joe Permuy, Kristina Cossen, Eric Felner, Maamoun Salam, Julie M. Silverstein, Samantha Adamson, Seema Meighan, Andrew Dauber
Summary: In this 13-week, randomized trial, the use of a bionic pancreas was shown to be more effective in reducing glycated hemoglobin levels compared to standard care.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Multidisciplinary Sciences
Colin M. Dayan, Rachel E. J. Besser, Richard A. Oram, William Hagopian, Manu Vatish, Owen Bendor-Samuel, Matthew D. Snape, John A. Todd
Summary: Recent studies have shown that monitoring pancreatic islet autoantibodies and genetic risk assessment can identify most children who will develop T1D, with immunotherapy and primary prevention methods showing success in delaying disease progression. By shifting focus towards early diagnosis and b cell preservation, a future without daily insulin injections for children with T1D is anticipated.
Article
Multidisciplinary Sciences
Frederike Lunkenheimer, Alexander J. J. Eckert, Dorte Hilgard, Daniel Koeth, Bernhard Kulzer, Ursula Lueck, Blanca Luedecke, Antonia Mueller, Harald Baumeister, Reinhard W. W. Holl
Summary: Mental comorbidities in patients with type 1 diabetes mellitus (T1D) are common and have a negative impact on diabetes outcomes. Patients with comorbid PTSD, especially younger patients, have higher HbA1c levels, more hospital admissions, and higher rates of DKA. Patients with comorbid PTSD in adulthood have fewer hospital admissions but longer hospital stays.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, Research & Experimental
Lingling Jia, Jiahong Li, Ming Zhang, He Liu, Zhengnan Ren, Xiao Liang Dong, Xiaohua Pan, Ju Qiu, Li-Long Pan, Jia Sun
Summary: This study investigated the protective role of cathelicidin-related antimicrobial peptide (CRAMP) and its mechanisms in enteric pathogen-accelerated type 1 diabetes (T1D). The findings showed that CRAMP plays a crucial role in gut barrier protection, immune modulation, and microbial regulation, and it can inhibit gut immune dysregulation, gut dysbiosis, and migration of T cells to the pancreas.
Article
Immunology
Leslie Wilson, Tiffany Kwok, Yanlei Ma, Jenise Wong, Martin Ho, Yelena Ionova, Maureen McGrath, Monica M. Mueller, Stephen E. Gitelman, Telba Irony
Summary: This study investigated the preferences of 90 type 1 diabetes patients for the risks and benefits of pancreatic islet cell transplantation (ICT) therapy through a discrete choice instrument. The results showed that patients had the strongest preference for avoiding serious complications, while also strongly desiring insulin independence and clinical treatment success.
Review
Endocrinology & Metabolism
Munachiso Nwokolo, Roman Hovorka
Summary: Diabetes technologies, such as CSII pumps and CGM, have significantly improved diabetes care by enhancing glycemic control and reducing diabetes distress. Closed-loop systems, including hybrid and fully closed-loop systems, have demonstrated safety and efficacy in research settings. However, the clinical adoption of closed-loop therapy is still in its early stages, with challenges in equitable access and regulatory navigation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Per G. Hagelqvist, Andreas Andersen, Kaisar B. Maytham, Christine R. Andreasen, Susanne Engberg, Tommi B. Lindhardt, Jens Faber, Jens J. Holst, Julie L. Forman, Ulrik Pedersen-Bjergaard, Filip K. Knop, Tina Vilsboll
Summary: This study aims to compare the effects of exercise-related hypoglycemia and hypoglycemia induced at rest on cardiac repolarisation in patients with type 1 diabetes. The results showed that both scenarios caused prolonged QTc interval and Tpe interval during hypoglycemia, accompanied by increased plasma adrenaline and decreased plasma potassium. During the recovery phase, the hypoglycemia induced at rest group had a longer QTc interval compared to the exercise-related hypoglycemia group. This indicates that both scenarios may increase the risk of ventricular arrhythmias in patients.
DIABETES OBESITY & METABOLISM
(2023)
Article
Multidisciplinary Sciences
Andrzej S. Januszewski, Yoon Hi Cho, Mugdha V. Joglekar, Ryan J. Farr, Emma S. Scott, Wilson K. M. Wong, Luke M. Carroll, Yik W. Loh, Paul Z. Benitez-Aguirre, Anthony C. Keech, David N. O'Neal, Maria E. Craig, Anandwardhan A. Hardikar, Kim C. Donaghue, Alicia J. Jenkins
Summary: The study compared plasma C-peptide levels in individuals with and without diabetes, finding greater beta-cell function loss in younger-onset Type 1 diabetes. Adults with diabetes had persistent insulin secretion, while those with childhood-onset diabetes and longer duration possibly had regenerative secretion.Relationships between C-peptide levels and circulating miRs were observed, suggesting the need for further clinical and basic science studies.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Antonio J. Amor, Aida Casas, Adriana Pane, Sabina Ruiz, Enrique Montagud-Marrahi, Alicia Molina-Andujar, Montserrat Ruiz, Rosa Mayordomo, Mireia Musquera, Joana Ferrer-Fabrega, Constantino Fondevila, Fritz Diekmann, Pedro Ventura-Aguiar, Enric Esmatjes
Summary: The study evaluated weight trajectories after pancreas transplantation in T1D individuals and found a significant weight loss at 6 months post-transplant, followed by a gradual increase. Participants from 2010-2015 showed higher weight gain, surpassing the control group. Weight gain was associated with glucose-related biochemical markers, but the risk of graft failure/dysfunction was not significant after adjusting for age, sex, and other variables.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)