Article
Health Care Sciences & Services
Chiao-Yun Lin, Ren-Chin Wu, Lan-Yan Yang, Shih-Ming Jung, Shir-Hwa Ueng, Yun-Hsin Tang, Huei-Jean Huang, Hsiu-Jung Tung, Cheng-Tao Lin, Hsuan-Yu Chen, Angel Chao, Chyong-Huey Lai
Summary: Diagnostic agreement among pathologists for endometrial hyperplasia is poor. This study identified miR-30a-3p, miR-141, miR-200a, miR-200b, and complete PTEN loss as useful tissue biomarkers for predicting endometrial cancer risk in patients with simple or complex hyperplasia without atypia.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Oncology
Yuan Zhang, Li Li, Xiao-Ping Ke, Ping Liu
Summary: This study identified a prognostic immunometabolic signature, SCGB2A1, for endometrial cancer (EC). The results indicate that PTEN mutation and SCGB2A1 expression are associated with immune infiltration, gene expression, and prognosis in EC patients.
TRANSLATIONAL CANCER RESEARCH
(2023)
Article
Cell Biology
Fu-Shu Li, Pei-Pei Li, Ling Li, Yan Deng, Ying Hu, Bai-Cheng He
Summary: The inhibitory effects of PTEN on BMP9's osteogenic potential may be partially mediated through decreasing the expression of Wnt10b via the disturbance of interaction between CREB and BMP/Smad signaling.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Fengjie Zhu, Zhe Ren
Summary: This study found that Icariin can target the miR-205-5p/PTEN axis to suppress the malignant cell phenotype and inhibit the growth of lung cancer.
Article
Oncology
Tiezhong Yi, Yicun Song, Lingling Zuo, Siyun Wang, Jintian Miao
Summary: Researches have found that LINC00470 is upregulated in endometrial cancer and correlates with patient prognosis. LINC00470 promotes the invasiveness, migration, and angiogenesis of endometrial cancer cells, and facilitates tumor formation and metastasis in vivo, effects that can be reversed by upregulating PTEN. Furthermore, LINC00470 stimulates PTEN methylation through MYC-induced recruitment of DNMT3a, exacerbating the progression of endometrial cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Genetics & Heredity
Stetson Thacker, Charis Eng
Summary: PTEN gene is strongly associated with autism spectrum disorder, and animal models with PTEN mutations provide insight into the neurobiology and pathogenesis of autism. The study identified differential protein expression in P40, predominantly related to PTEN function and neurological processes, with ASD risk genes identified as major regulatory hubs in the affected pathways.
NPJ GENOMIC MEDICINE
(2021)
Article
Medicine, Research & Experimental
Lingyan Zhang, Zibin Bu, Juan Shen, Liping Shang, Yuanyuan Chen, Ping Zhang, Yan Wang
Summary: The study revealed that miR-221 acts as an oncogene in T-ALL, and its downregulation inhibits the development of ALL by targeting PTEN. Therefore, miR-221 may serve as a potential novel therapeutic target for ALL.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Medicine, General & Internal
Giovanni Innella, Elena Bonora, Iria Neri, Annalucia Virdi, Alba Guglielmo, Laura Maria Pradella, Claudio Ceccarelli, Laura Benedetta Amato, Anna Lanzoni, Sara Miccoli, Giuseppe Gasparre, Roberta Zuntini, Daniela Turchetti
Summary: Germline PTEN pathogenic variants cause PTEN Hamartoma Tumor Syndrome (PHTS), characterized by hamartomas, developmental anomalies, and increased cancer risk. Mucocutaneous features are crucial for diagnosing PHTS patients, with molecular analyses providing insights into the pathogenic processes induced by PTEN alterations.
FRONTIERS IN MEDICINE
(2021)
Article
Oncology
Gang Wu, Weiyuan Huang, Junnv Xu, Wenzhu Li, Yu Wu, Qianyu Yang, Kun Liu, Mingyue Zhu, Priya S. Balasubramanian, Mengsen Li
Summary: In patients with nasopharyngeal carcinoma, PTEN negative status is associated with later TNM stage, later clinical-stage, shorter progression-free survival (PFS), and worse prognosis. K-trans and K-ep derived from DCE-MRI, with reliable capability, may serve as potential imaging markers correlated with PTEN expression for noninvasive prediction. Combining radiological and clinical features can enhance the classification performance of PTEN expression.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Cell Biology
Jing Zhao, Linlin Yin, Lin Jiang, Li Hou, Ling He, Chunyan Zhang
Summary: The study revealed the essential role of PTEN nuclear translocation in neuronal injury following oxygen-glucose deprivation in rat cortical neurons. The mechanism may involve modulation of cell signaling pathways and apoptosis-related proteins. Preventing PTEN nuclear translocation could be a potential strategy for preventing brain injury following hypoxia-ischemia.
Article
Medicine, Research & Experimental
Youmei Zi, Yingzi Zhang, Yanwei Wu, Lina Zhang, Ru Yang, Yan Huang
Summary: MicroRNA-25-3p has been shown to be upregulated in multiple myeloma tissues and cell lines, and this upregulation is associated with poor prognostic markers. The miR-25-3p regulates the PI3K/AKT signaling pathway by targeting the tumor suppressor PTEN, leading to promotion of cancer progression in multiple myeloma.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Cell Biology
Fumitaka Obayashi, Atsuko Hamada, Sachiko Yamasaki, Taku Kanda, Shigeaki Toratani, Tetsuji Okamoto
Summary: This study presents a case of a Japanese woman diagnosed with Cowden syndrome (CS) who had multiple oral polyps, breast cancer, and thyroid cancer. Genetic analysis revealed novel mutations in the PTEN gene, a tumor suppressor gene known to be associated with CS. Further investigation using induced pluripotent stem cells (iPSCs) derived from the patient's blood cells confirmed reduced expression of PTEN transcript, potentially indicating PTENo as the cause for the disease.
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
(2022)
Article
Oncology
Di Wu, Hong-Qiang Yu, Hao-Jun Xiong, Yu-Jun Zhang, Xiao-Tong Lin, Jie Zhang, Wu Wu, Teng Wang, Xiao-Yu Liu, Chuan-Ming Xie
Summary: The study revealed that elevated expression of the sodium pump alpha 3 subunit is associated with colorectal cancer metastasis. Through mechanisms involving decreased p53 expression and activated mTOR pathway, the alpha 3 subunit promotes migration of colorectal cancer cells. Additionally, a positive correlation between alpha 3 subunit expression and mTOR activity was observed in an aggressive colorectal cancer subtype.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yeqian Zhang, Fengrong Yu, Bo Ni, Qing Li, Seong-Woo Bae, Jong-Ho Choi, Han-Kwang Yang, Seong-Ho Kong, Chunchao Zhu
Summary: The study revealed that DDX18 is overexpressed in gastric cancer tissues and is closely related to tumor characteristics, clinical data, and prognosis. DDX18 promotes cell proliferation, migration, and invasion while inhibiting apoptosis. DDX18 enhances the maturation of microRNA-21 by interacting with Drosha, thereby affecting the PTEN-AKT signaling pathway.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Garima Akhil Chandrakar, Arvind Bhake, Sunita Vagha
Summary: This study aims to investigate the immunoexpression of PTEN and its correlation with various clinicopathologic parameters in lesion of atypical endometrial hyperplasia and endometrioid endometrial carcinoma type-1. It will be conducted as a cross-sectional study with a sample size of 20 cases each in two groups. PTEN immunoexpression will be examined using immunohistochemical method and compared with other clinicopathologic parameters using statistical analysis.
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
(2023)
Article
Pharmacology & Pharmacy
M. Joerger, D. Hess, A. Delmonte, E. Gallerani, A. Fasolo, L. Gianni, S. Cresta, P. Barbieri, S. Pace, C. Sessa
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2015)
Review
Pharmacology & Pharmacy
Alice Pasini, Angelo Delmonte, Anna Tesei, Daniele Calistri, Emanuele Giordano
Article
Oncology
Chiara Catania, Edoardo Botteri, Massimo Barberis, Fabio Conforti, Francesca Toffalorio, Filippo De Marinis, Sabrina Boselli, Cristina Noberasco, Angelo Delmonte, Gianluca Spitaleri, Lorenzo Spaggiari, Nicole Rotmensz, Antonio Passaro, Barbara Bazolli, Marina Alfieri, Michela Manzotti, Caterina Fumagalli, Alessandra Milani, Tommaso De Pas
Article
Oncology
M. Joerger, D. Hess, A. Delmonte, E. Gallerani, P. Barbieri, S. Pace, C. Sessa
INVESTIGATIONAL NEW DRUGS
(2015)
Article
Oncology
Rita Chiari, Giulio Metro, Daniela Iacono, Guido Bellezza, Alberto Rebonato, Alessandra Dubini, Isabella Sperduti, Chiara Bennati, Luca Paglialunga, Marco Angelo Burgio, Sara Baglivo, Raffaele Giusti, Vincenzo Minotti, Angelo Delmonte, Lucio Crino
Article
Oncology
Andrea Casadei Gardini, Elisa Chiadini, Luca Faloppi, Giorgia Marisi, Angelo Delmonte, Mario Scartozzi, Cristian Loretelli, Alessandro Lucchesi, Devil Oboldi, Alessandra Dubini, Giovanni Luca Frassineti, Paola Ulivi
Article
Oncology
Matteo Canale, Elisabetta Petracci, Angelo Delmonte, Elisa Chiadini, Claudio Dazzi, Maximilian Papi, Laura Capelli, Claudia Casanova, Nicoletta De Luigi, Marita Mariotti, Alessandro Gamboni, Rita Chiari, Chiara Bennati, Daniele Calistri, Vienna Ludovini, Lucio Crino, Dino Amadori, Paola Ulivi
CLINICAL CANCER RESEARCH
(2017)
Article
Oncology
Paola Ulivi, Elisa Chiadini, Claudio Dazzi, Alessandra Dubini, Matteo Costantini, Laura Medri, Maurizio Puccetti, Laura Capelli, Daniele Calistri, Alberto Verlicchi, Alessandro Gamboni, Maximilian Papi, Marita Mariotti, Nicoletta De Luigi, Emanuela Scarpi, Sara Bravaccini, Gian Michele Turolla, Dino Amadori, Lucio Crino, Angelo Delmonte
CLINICAL LUNG CANCER
(2016)
Meeting Abstract
Oncology
Todd M. Bauer, Martin Schuler, Rossana Berardi, Wan-Teck Lim, Robin Van Geel, Maja De Jonge, Analia Azaro, Maya Gottfried, Ji-Youn Han, Dae Ho Lee, Mira Wollner, David Hong, Arndt Voge, Angelo Delmonte, Alexander Krohn, Yong Zhang, Matthew Squires, Monica Giovannini, Mikhail Akimov, Dong-Wan Kim
JOURNAL OF THORACIC ONCOLOGY
(2016)
Article
Oncology
Elisa Gobbini, Domenico Galetta, Marcello Tiseo, Paolo Graziano, Antonio Rossi, Emilio Bria, Massimo Di Maio, Giulio Rossi, Vanesa Gregorc, Ferdinando Riccardi, Vieri Scotti, Anna Ceribelli, Lucio Buffoni, Angelo Delmonte, Tindara Franchina, Maria Rita Migliorino, Diego Cortinovis, Salvatore Pisconti, Paola Bordi, Annamaria Catino, Evaristo Maiello, Francesca Arizio, Silvia Novello
Article
Oncology
Mara A. Bonelli, Graziana Digiacomo, Claudia Fumarola, Roberta Alfieri, Federico Quainia, Angela Falco, Denise Madeddu, Silvia La Monica, Daniele Cretella, Andrea Ravelli, Paola Ulivi, Michela Tebaldi, Daniele Calistri, Angelo Delmonte, Luca Ampollini, Paolo Carbognani, Marcello Tiseo, Andrea Cavazzoni, Pier Giorgio Petronini
Article
Biochemistry & Molecular Biology
Paola Ulivi, Angelo Delmonte, Elisa Chiadini, Daniele Calistri, Maximilian Papi, Marita Mariotti, Alberto Verlicchi, Angela Ragazzini, Laura Capelli, Alessandro Gamboni, Maurizio Puccetti, Alessandra Dubini, Marco Angelo Burgio, Claudia Casanova, Lucio Crino, Dino Amadori, Claudio Dazzi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2015)
Editorial Material
Oncology
Francesca Toffalorio, Gianluca Spitaleri, Chiara Catania, Laura Dal Zotto, Cristina Noberasco, Angelo Delmonte, Mariacarmela Santarpia, Fabio Vecchio, Veronica Brunelli, Cristiano Rampinelli, Amassimo Barberis, Caterina Fumagalli, Massimo Zucchetti, Monique Zangarini, Tullia Diena, Romano Danesi, Filippo De Braud, Tommaso De Pas
Article
Oncology
C. Catania, D. Radice, G. Spitaleri, L. Adamoli, C. Noberasco, A. Delmonte, F. Vecchio, F. de Braud, F. Toffalorio, A. Goldhirsch, T. De Pas
Article
Infectious Diseases
Manlio Monti, Danila Diano, Francesco Allegrini, Angelo Delmonte, Valentina Fausti, Paola Cravero, Giulia Marcantognini, Giovanni Luca Frassineti
BMC INFECTIOUS DISEASES
(2017)