Article
Cardiac & Cardiovascular Systems
Eman Y. Gohar, Carmen De Miguel, Ijeoma E. Obi, Elizabeth M. Daugherty, Kelly A. Hyndman, Bryan K. Becker, Chunhua Jin, Randee Sedaka, Jermaine G. Johnston, Pengyuan Liu, Joshua S. Speed, Tanecia Mitchell, Alison J. Kriegel, Jennifer S. Pollock, David M. Pollock
Summary: This study found that female rats have a greater ability to adapt to increased dietary salt intake challenges, suggesting that female sex confers a greater ability to maintain Na+ homeostasis. Additionally, the study discovered that the intrarenal endothelin-1 natriuretic pathway is enhanced in women, which may contribute to their better ability to regulate sodium levels.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Medicine, Research & Experimental
Geoffrey J. Culshaw, David Binnie, Neeraj Dhaun, Patrick W. F. Hadoke, Matthew A. Bailey, David J. Webb
Summary: Hypertension is associated with salt-sensitivity, but the mechanism of pressure natriuresis is still unclear. ETA receptor antagonists may promote sodium and water retention by suppressing pressure natriuresis. ETB receptor antagonists increase sodium excretion. However, even highly selective ETA receptor antagonists attenuate pressure natriuresis. ET receptors have different regulatory effects in the kidney.
Review
Biochemistry & Molecular Biology
Peter J. Little, Christopher D. Askew, Suowen Xu, Danielle Kamato
Summary: The endothelium is a single-cell monolayer that lines the entire vasculature, playing roles in barrier function, anticoagulation, vascular aging, endocrine secretion, and inflammation suppression. It produces important factors like nitric oxide and endothelin, with continued research on endothelial dysfunction leading to potential novel cardiovascular therapies.
Article
Physiology
Michaela L. Sundqvist, Jon O. Lundberg, Eddie Weitzberg, Mattias Carlstrom
Summary: The study aimed to investigate potential sex differences in renal nitrate handling during low and high dietary nitrate intake. It was hypothesized that renal clearance and excretion of nitrate are higher in men compared to women. Results showed that women had lower urinary nitrate concentration, amount of nitrate excreted, renal nitrate clearance, and fractional excretion of nitrate compared to men.
Article
Pharmacology & Pharmacy
Bozena Badzynska, Ivana Vaneckova, Janusz Sadowski, Silvie Hojna, Elzbieta Kompanowska-Jezierska
Summary: This study investigated the effects of ETA and ETB receptor blockade on blood pressure, medullary blood flow, and tissue NO in different rat models. The results confirmed the dominant role of ETA receptors in regulating blood pressure and renal hemodynamics in both normotensive and hypertensive rats. Additionally, ETB stimulation was found to preserve medullary perfusion under conditions of endothelin system activation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Elli Zoupa, Nikolaos Pitsikas
Summary: Schizophrenia is a severe psychiatric disorder affecting up to 1% of the worldwide population, and there is a need for novel neuroleptics with higher efficacy and safety. Nitric oxide (NO) appears to be implicated in the pathogenesis of schizophrenia, with NO donors like Sodium nitroprusside (SNP) being proposed as promising compounds for treatment. Further research is needed to assess the potential superiority of these compounds over currently used neuroleptics.
Article
Nutrition & Dietetics
Assaf Buch, Rebecca Goldsmith, Lesley Nitsan, Miri Margaliot, Gabi Shefer, Yonit Marcus, Naftali Stern
Summary: The study indicates that higher potassium excretion is associated with a lower risk of metabolic syndrome, and individuals with higher MS scores tend to have lower potassium excretion. Potassium excretion correlates with all components of MS and can predict the syndrome independently from other variables.
Article
Biochemistry & Molecular Biology
A. M. Ostergaard, M. H. Vrist, J. B. Rosenbaek, J. A. Ejlersen, F. H. Mose, J. N. Bech
Summary: The study investigated the effects of orally administered nitrate on blood pressure, GFR, and urinary sodium excretion. The results showed that there were no differences in blood pressure, GFR, or sodium excretion between the potassium nitrate and placebo groups. The study concluded that healthy subjects may be able to compensate for the effects of nitrate supplementation during steady state conditions.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2023)
Article
Chemistry, Physical
Hojeong Yoon, Seongchul Park, Manho Lim
Summary: The study investigates the use of photoactivation to achieve rapid release of NO for treating sudden cardiac abnormalities. Molsidomine (SIN-10), which releases NO at a slow rate, may be used to alleviate hypertensive crisis.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Review
Medicine, General & Internal
Neveda Murugesan, Damini Saxena, Arundhati Dileep, Muhammad Adrish, Nicola A. Hanania
Summary: Asthma is a heterogeneous disorder with different phenotypes and endotypes. About 10% of individuals have severe asthma, which increases the risk of morbidity and mortality. Fractional exhaled nitric oxide (FeNO) is a cost-effective biomarker used to detect type 2 airway inflammation. FeNO can be measured as an adjunct to diagnostic evaluation and for monitoring airway inflammation in individuals with suspected asthma. However, FeNO may not be a good biomarker to rule out asthma due to its lower sensitivity. It can also be used to predict response to inhaled corticosteroids, adherence, and determine biologic therapy. Higher levels of FeNO are associated with lower lung function and increased risk of future asthma exacerbations, and its predictive value improves when combined with other standard measurements of asthma assessment.
Article
Physiology
Casey G. Turner, Matthew J. Hayat, Caroline Grosch, Arshed A. Quyyumi, Jeffrey S. Otis, Brett J. Wong
Summary: Young non-Hispanic Black adults have reduced microvascular endothelial function compared with non-Hispanic White counterparts. The inhibition of endothelin-1 A receptor (ETAR) contributes to the reduced vasodilation in young non-Hispanic Black adults, independent of superoxide production.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Xiangxiang Zhang, Chao Li, Fukai Liu, Wei Mu, Yongshuo Ren, Boyu Yang, Xiaojun Han
Summary: This study demonstrates a high-throughput, bottom-up approach to assemble spatial programmable prototissues based on the magnetic Archimedes affect and shows their biomedical application for producing nitric oxide for vasodilation.
NATURE COMMUNICATIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Lin Zhang, Chenfei Li, Liting Yang, Gabriel Komla Adzika, Jeremiah Ong'achwa Machuki, Mingjin Shi, Qi Sun, Hong Sun
Summary: The study aimed to investigate the impact of estrogen deficiency during catecholamine stress on vasomotor function, as well as to utilize estrogen replacement therapy to mitigate the adverse effects of stress on aortic vessels. The results showed that estrogen prevented excessive weight gain during stress, while upregulating eNOS activities and decreasing ET-1 expressions to facilitate vasomotor functions. Overall, estrogen treatments during stress preserved vasomotor functions by preventing excessive intima-media thickening and collagen depositions in the aortic vascular walls.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Environmental Sciences
Gaetana Napolitano, Gianluca Fasciolo, Claudio Agnisola, Paola Venditti
Summary: The study found that under sub-lethal nitrite stress, blood nitrite concentration significantly increased in fish and crustaceans, along with increased arginase activity, urea excretion, and blood urea levels. These parameters may serve as markers of sub-lethal nitrite stress in freshwater fish and crustaceans.
Review
Biochemistry & Molecular Biology
Ravneet Singh, Victoria L. Nasci, Ginger Guthrie, Lale A. Ertuglu, Maryam K. Butt, Annet Kirabo, Eman Y. Gohar
Summary: Cardiovascular and renal diseases are increasingly prevalent and age and sex differences play a role in their development and progression. GPER1 has been identified as an important regulator in cardio-renal health, particularly in aging individuals.