Article
Cardiac & Cardiovascular Systems
Shiyun Wang, Zixuan Deng, Hong Zhang, Rong Zhang, Dandan Yan, Xiaojiao Zheng, Weiping Jia, Cheng Hu
Summary: Hp genotype affects the association between DDAH 1 rs233109 and diabetic macroangiopathy in Chinese patients with type 2 diabetes.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Samsul Arefin, Lars Lofgren, Peter Stenvinkel, Anna B. Granqvist, Karolina Kublickiene
Summary: We investigated the changes in plasma amino acid (AA) metabolism in patients with chronic kidney disease (CKD) and their relationship with endothelial and vascular smooth muscle function. The study found that CKD patients had altered levels of AAs and their metabolites, which were associated with abnormal vascular maintenance. These findings suggest that targeting AA metabolism could be a potential treatment option for CKD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pediatrics
Chien-Ning Hsu, You-Lin Tain
Summary: This review summarizes the levels of circulating and urinary ADMA in children and adolescents with kidney disease, as well as its pathophysiological role in the kidneys. Additionally, various analytical methods for measuring ADMA and the issues that need to be addressed before clinical implementation are discussed.
Article
Medicine, Research & Experimental
Yichen Zhao, Xiaoye Ma, Yuchen Zhou, Junchao Xie, Xueyuan Liu, Yanxin Zhao
Summary: Dimethylarginine dimethylamino hydrolase-1 (DDAH-1) plays a protective role in ischemic stroke by regulating ADMA levels and preventing tight junction protein degradation, thus protecting the blood-brain barrier. Supplementation of L-arginine helps restore DDAH-1 function.
LABORATORY INVESTIGATION
(2021)
Review
Pediatrics
Michalina Jezierska, Joanna Stefanowicz
Summary: Asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) play important roles in various processes in the body, particularly in adult chronic kidney disease. Higher ADMA concentrations are associated with hypertension and higher mortality, while SDMA reflects glomerular filtration rate well. However, there is a lack of data on dimethylarginines in renal diseases in children.
Article
Biochemistry & Molecular Biology
You-Lin Tain, Hung-Wei Yang, Chih-Yao Hou, Guo-Ping Chang-Chien, Sufan Lin, Chien-Ning Hsu
Summary: This study investigated the use of Cu/ZIF-8 nanoparticles to deliver GSNO and effectively reduce hypertension and improve kidney function in a pediatric CKD model. The nanoparticles enhanced endogenous NO generation, reduced renal oxidative stress, and downregulated the renin-angiotensin system. This research has the potential to improve the treatment of pediatric CKD.
Article
Pharmacology & Pharmacy
Meiting Wu, Ting Li, Ge Li, Bingxuan Niu, Tian Wu, Li Yan, Shiming Wang, Shuangyi He, Chuyi Huang, Weiqiang Tong, Niansheng Li, Junlin Jiang
Summary: This study reveals the underlying mechanisms of ADMA in diabetic cardiomyopathy, specifically focusing on the role of EndMT. It is found that ADMA induces EndMT in cardiac microvascular endothelial cells (HCMECs) under high glucose conditions, while over-expression of DDAH1 protects against EndMT. Additionally, the study identifies the involvement of LncRNA DANCR in the regulation of the FoxO1/DDAH1/ADMA pathway and EndMT. These findings provide new insights into the pathogenesis of diabetic cardiomyopathy and suggest potential therapeutic targets.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sakkarai Mohamed Asha Parveen, Sirisha Natani, K. K. Sruthi, Priyanka Khilar, Ramesh Ummanni
Summary: This study found that DDAH1 overexpression in prostate cancer cells is positively regulated by HIF-1 alpha and Nrf2. Under hypoxia, HIF-1 alpha activates DDAH1 expression by binding to the HRE in the promoter region, while in the absence of HIF-1 alpha, Nrf2 promotes DDAH1 expression through AREs.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
You-Lin Tain, Chih-Yao Hou, Guo-Ping Chang-Chien, Sufan Lin, Chien-Ning Hsu
Summary: This study aimed to investigate the protective effects of sodium thiosulfate (STS) in a rat model of maternal CKD-induced hypertension. The results showed that STS treatment could enhance H2S and NO signaling pathways, alter gut microbiota, and protect offspring from maternal CKD-primed hypertension. This suggests that early-life interventions targeting reactive sulfur species (RSS) have potential preventive and therapeutic benefits for CKD-induced hypertension.
Article
Biophysics
Yongning Gao, Jingyu Zhang, Hui Chen, Zhu Wang, Jingjing Hou, Lihua Wang
Summary: The study reveals the relationship between DMA and platelet function in chronic kidney disease, demonstrating that DMA can enhance platelet activation, potentially through the activation of PKC delta.
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
(2021)
Article
Cell Biology
Ying Fan, Qiang Gao, Jia-Xin Guan, Lei Liu, Ming Hong, Li Jun, Li Wang, Hai-Feng Ding, Li-Hong Jiang, Bo-Yu Hou, Mei Li, Zhi-Qiang Song, De-Qin Sun, Chao-Qi Yan, Lan Ma
Summary: Cerebrovascular endothelial dysfunction is involved in leukoaraiosis progression. The DDAH2 gene polymorphism is associated with higher plasma asymmetric dimethylarginine levels in patients with leukoaraiosis. GG genotype of DDAH2 (-449 G/C) is more common in patients with leukoaraiosis and is correlated with higher levels of asymmetric dimethylarginine.
NEURAL REGENERATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Sakkarai Mohamed Asha Parveen, Karthik Reddy Kami Reddy, Ramesh Ummanni
Summary: The expression of Dimethylarginine dimethylaminohydrolase-1 (DDAH1) is frequently increased in various cancers, including prostate cancer, and it enhances nitric oxide (NO) production by metabolising endogenous NO synthase (NOS) inhibitors. DDAH1 protects prostate cancer cells from cell death and promotes survival. This study reveals the role of DDAH1 in the antioxidant defense system and its role in promoting cell survival.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Shan Huang, Zexing Li, Zewen Wu, Chang Liu, Minghang Yu, Mingjie Wen, Liyun Zhang, Xi Wang
Summary: The study reveals that DDAH2 regulates the RLR-mediated antiviral response by inhibiting the MAVS pathway in mitochondria, promoting mitochondrial fission and blocking innate immune responses. TBK1 inhibits DDAH2 through phosphorylation, leading to a reciprocal inhibitory loop between the DDAH2-NO cascade and the RLR signaling pathway.
Article
Medicine, General & Internal
Chun-Fan Chen, Chiu-Yang Lee, Fu-An Chen, Chih-Yu Yang, Tz-Heng Chen, Shuo-Ming Ou, Kuo-Hua Lee, Ching-Po Li, Chia-Hao Chan, Pui-Ching Lee, Yung-Tai Chen, Tsung-Lun Lee, Yang Ho, Fan-Yu Chen, Hao-Wei Ma, Jinn-Yang Chen, Ann Charis Tan, Szu-Yuan Li, Chih-Ching Lin
Summary: The study demonstrates that FIR therapy can reduce the incremental changes in plasma ADMA concentration, which may be associated with the improvement of AVF prognosis in patients with advanced DKD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Agriculture, Dairy & Animal Science
Simona Grelova, Martina Karasova, Csilla Tothova, Terezia Kiskova, Darina Baranova, Branislav Lukac, Maria Fialkovicova, Alena Michalova, Lukas Kunay, Miroslav Svoboda
Summary: This study investigates the relationship between SDMA, FGF 23, and traditional indicators of kidney function in cats with CKD. The results suggest that FGF 23 levels are higher in CKD patients compared to healthy cats, but there is no evident correlation between FGF 23 and other markers. On the other hand, phosphate shows a strong correlation with SDMA, urea, and creatinine, indicating its potential as an independent factor in CKD progression.
Article
Infectious Diseases
Lisa Pilgram, Lukas Eberwein, Bjoern-Erik O. Jensen, Carolin E. M. Jakob, Felix C. Koehler, Martin Hower, Jan T. Kielstein, Melanie Stecher, Bernd Hohenstein, Fabian Prasser, Timm Westhoff, Susana M. Nunes de Miranda, Maria J. G. T. Vehreschild, Julia Lanznaster, Sebastian Dolff
Summary: This multicentre cohort study aimed to evaluate the situation of CKD5D patients during the COVID-19 pandemic and investigate the association between dialysis dependency and mortality. The results showed that dialysis dependency was not related to mortality, but the mortality rate of CKD patients was high.
Article
Transplantation
Graziella D'Arrigo, Francesca Mallamaci, Patrizia Pizzini, Daniela Leonardis, Giovanni Tripepi, Carmine Zoccali
Summary: This longitudinal study investigated the relationship between repeated measurements of CKD-MBD biomarkers and renal outcomes in CKD patients. The results suggested that serum PTH, calcium, phosphate, FGF23, and 1,25-dihydroxyvitamin D were independently associated with the progression to kidney failure.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Alda Huqi, Carmine Zoccali, Robert P. Giugliano, Raffaele De Caterina
EUROPEAN HEART JOURNAL
(2023)
Review
Urology & Nephrology
Roberto Minutolo, Luca De Nicola, Francesca Mallamaci, Carmine Zoccali
Summary: Low salt diets and diuretics are the key components for controlling blood pressure in chronic kidney disease patients. Loop diuretics are generally preferred to thiazides in patients with advanced CKD, but this review suggests that thiazides, particularly chlorthalidone, may still be useful in improving hypertension control in these patients. However, careful attention should be paid to potential side effects such as hyponatremia, hypokalemia, volume depletion, and acute kidney injury. Further well-powered randomized trials are needed to confidently recommend the use of these drugs in advanced CKD.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Transplantation
Carmine Zoccali, Giovanni Tripepi, Luca Neri, Matteo Savoia, Maria Eva Baro Salvador, Pedro Ponce, Jeffrey Hymes, Frank Maddux, Francesca Mallamaci, Stefano Stuard
Summary: A reduction in dialysate temperature was found to be associated with a decrease in the risk of IDH in HD patients, but had no impact on all-cause mortality.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Transplantation
Beatriz Martin-Carro, Juan F. Navarro-Gonzalez, Alberto Ortiz, Carmine Zoccali, Jurgen Floege, Manuel A. Ferreira, Jose L. Gorriz-Teruel, Natalia Carrillo-Lopez, Sara Panizo, Francesco Locatelli, Markus Ketteler, Gerard M. London, Manuel Naves-Diaz, Cristina Alonso-Montes, Jorge B. Cannata-Andia, Jose L. Fernandez-Martin
Summary: This study found that diabetic patients on haemodialysis have a higher risk of mortality, and high serum parathyroid hormone (PTH) levels are particularly associated with increased mortality risk in diabetic patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Urology & Nephrology
Carmine Zoccali, Francesca Mallamaci, Raffaele De Caterina
Summary: In chronic kidney disease patients, hypofiltration can lead to drug accumulation, while hyperfiltration can cause increased renal excretion of drugs. This review focuses on whether hyperfiltration affects drug clearance and if dose adjustment is needed.
CLINICAL KIDNEY JOURNAL
(2023)
Review
Urology & Nephrology
Carmine Zoccali, Patrick B. Mark, Pantelis Sarafidis, Rajiv Agarwal, Marcin Adamczak, Rodrigo Bueno de Oliveira, Ziad A. Massy, Peter Kotanko, Charles J. Ferro, Christoph Wanner, Michel Burnier, Raymond Vanholder, Francesca Mallamaci, Andrzej Wiecek
Summary: Patients with CKD are at high risk of CVD, so it's important to identify and monitor cardiovascular complications and hypertension. Biomarkers like troponins and ECG have limited use in diagnosing cardiac ischemia in these patients. However, techniques like stress echocardiography, myocardial perfusion scintigraphy, and stress testing can help detect coronary disease in patients with CKD.
NATURE REVIEWS NEPHROLOGY
(2023)
Article
Transplantation
Claudia Torino, Francesca Mallamaci, Pantelis Sarafidis, Aikaterini Papagianni, Robert Ekart, Radovan Hojs, Marian Klinger, Krzysztof Letachowicz, Danilo Fliser, Sarah Seiler-Mussler, Fabio Lizzi, Kostas Siamopoulos, Olga Balafa, Evangelia Ntounousi, Itzchak Slotki, Linda Shavit, Aristeidis Stavroulopoulos, Ziad A. Massy, Alexandre Seidowsky, Yuri Battaglia, Alberto Martinez-Castelao, Gustavo Villalobos, Enrico Fiaccadori, Giuseppe Regolisti, Thierry Hannedouche, Thomas Bachelet, Kitty J. Jager, Friedo W. Dekker, Rocco Tripepi, Giovanni Tripepi, Luna Gargani, Rosa Sicari, Eugenio Picano, Gerard Michel London, Carmine Zoccali
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Transplantation
Pedro Barrera-Baena, Minerva Rodriguez-Garcia, Enrique Rodriguez-Rubio, Lucia Gonzalez-Llorente, Alberto Ortiz, Carmine Zoccali, Francesco Locatelli, Juergen Floege, Martine Cohen-Solal, Manuel Anibal Ferreira, Markus Ketteler, Gerard Michel London, Jose Luis Gorriz-Teruel, Emilio Sanchez-Alvarez, Miguel Angel Hevia-Suarez, Jesus Maria Fernandez-Gomez, Beatriz Martin-Carro, Carlos Gomez-Alonso, Cristina Alonso-Montes, Jorge Benito Cannata-Andia, Jose Luis Fernandez-Martin
Summary: This study analyzed the association between biochemical parameters of CKD-MBD and bone fragility fractures in hemodialysis patients, and found that hyperphosphatemia is independently and consistently associated with an increased risk of bone fractures.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Editorial Material
Transplantation
Carmine Zoccali, Fabio Manfredini, Mehmet Kanbay, Francesca Mallamaci
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Urology & Nephrology
Carmine Zoccali, Francesca Mallamaci
Summary: The traditional peer review process in medicine is facing a crisis due to issues such as publication delays, potential bias, and a lack of transparency. In response, innovative models like Peer Community In Research Reports (PCI RR) provide a rapid, transparent, and collaborative evaluation process for scientific research. The success of the PCI RR model relies on the engagement and support of researchers, publishers, and other stakeholders.
JOURNAL OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Carmine Zoccali, Francesca Mallamaci
Summary: The landscape of medical congresses is currently facing a crisis due to various factors such as the COVID-19 pandemic, declining attendance, concerns about content quality, and ethical issues related to the pharmaceutical industry. To address these challenges, potential solutions have been identified, including hybrid events, tiered registration fees, collaboration with sponsors, leveraging technology, and improving content quality and transparency.
JOURNAL OF NEPHROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Belinda Spoto, Ernesto Di Betta, Patrizia Pizzini, S. Lonardi, F. Mallamaci, G. Tripepi, Mehmet Kanbay, Giovanni Cancarini, Carmine Zoccali
Summary: This study compared individuals with metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO) and found no significant differences in circulating levels of cytokines and adipokines, as well as the expression of inflammatory genes in adipose tissue. The results suggest that metabolically healthy obese individuals have similar inflammation profiles to metabolically unhealthy obese individuals.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Review
Urology & Nephrology
Anna Pisano, Carmine Zoccali, Davide Bolignano, Graziella D'Arrigo, Francesca Mallamaci
Summary: The study aimed to define the clinical penetrance of sleep apnoea in patients with chronic kidney disease and end-stage kidney disease, revealing a high prevalence of sleep apnoea in both non-dialysis CKD and ESKD patients. This highlights the importance of using objective diagnostic tools to identify sleep apnoea in kidney disease patients.
CLINICAL KIDNEY JOURNAL
(2023)