How does protein misfolding in the endoplasmic reticulum affect lipid metabolism in the liver?

GTP-Dependent Membrane Fusion

(2013) James A. McNew et al.   Annual Review of Cell and Developmental Biology

The role of phospholipids in the biological activity and structure of the endoplasmic reticulum

(2013) Thomas A. Lagace et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

C/EBP Homologous Protein (CHOP) Contributes to Suppression of Metabolic Genes during Endoplasmic Reticulum Stress in the Liver

(2013) Madhusudana R. Chikka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATF4 Protein Deficiency Protects against High Fructose-induced Hypertriglyceridemia in Mice

(2013) Guozhi Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disorders of Protein Misfolding: Alpha-1-Antitrypsin Deficiency as Prototype

(2013) Gary A. Silverman et al.   JOURNAL OF PEDIATRICS

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

(2013) Wafa B’chir et al.   NUCLEIC ACIDS RESEARCH

Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains

(2013) R. Volmer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apolipoprotein B Secretory Regulation by Degradation

(2012) Sven-Olof Olofsson et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Intracellular Trafficking and Secretion of VLDL

(2012) Samata Tiwari et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The degradation of apolipoprotein B100: Multiple opportunities to regulate VLDL triglyceride production by different proteolytic pathways

(2012) Edward A. Fisher   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The Role of Endoplasmic Reticulum in Hepatic Lipid Homeostasis and Stress Signaling

(2012) Suneng Fu et al.   Cell Metabolism

IRE1α-XBP1s Induces PDI Expression to Increase MTP Activity for Hepatic VLDL Assembly and Lipid Homeostasis

(2012) Shiyu Wang et al.   Cell Metabolism

Silencing of Lipid Metabolism Genes through IRE1α-Mediated mRNA Decay Lowers Plasma Lipids in Mice

(2012) Jae-Seon So et al.   Cell Metabolism

Determinants of VLDL-triglycerides production

(2012) Søren Nielsen et al.   CURRENT OPINION IN LIPIDOLOGY

Proteasome Dysfunction Mediates Obesity-Induced Endoplasmic Reticulum Stress and Insulin Resistance in the Liver

(2012) T. Otoda et al.   DIABETES

Endoplasmic reticulum polymers impair luminal protein mobility and sensitize to cellular stress in alpha1-antitrypsin deficiency

(2012) Adriana Ordóñez et al.   HEPATOLOGY

Endoplasmic reticulum stress induces hepatic steatosis via increased expression of the hepatic very low-density lipoprotein receptor

(2012) Hyunsun Jo et al.   HEPATOLOGY

Lipolysis Response to Endoplasmic Reticulum Stress in Adipose Cells

(2012) Jingna Deng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The impact of the unfolded protein response on human disease

(2012) Shiyu Wang et al.   JOURNAL OF CELL BIOLOGY

Acyl-CoA:diacylglycerol acyltransferase: Molecular biology, biochemistry and biotechnology

(2012) Qin Liu et al.   PROGRESS IN LIPID RESEARCH

Pathophysiology of hypertriglyceridemia

(2011) H.C. Hassing et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis

(2011) Kezhong Zhang et al.   EMBO JOURNAL

Hepatic autophagy mediates endoplasmic reticulum stress-induced degradation of misfolded apolipoprotein B

(2011) Wei Qiu et al.   HEPATOLOGY

Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice

(2011) Chunbin Zhang et al.   HEPATOLOGY

A Thematic Review Series: Lipid droplet storage and metabolism: from yeast to man: Fig. 1.

(2011) Karen Reue   JOURNAL OF LIPID RESEARCH

Regulation of glucose homeostasis through a XBP-1–FoxO1 interaction

(2011) Yingjiang Zhou et al.   NATURE MEDICINE

The transcription factor cyclic AMP–responsive element–binding protein H regulates triglyceride metabolism

(2011) Jung Hoon Lee et al.   NATURE MEDICINE

Apolipoprotein B100 biogenesis: a complex array of intracellular mechanisms regulating folding, stability, and lipoprotein assemblyThis paper is one of a selection of papers published in this special issue entitled “Canadian Society of Biochemistry, Molecular & Cellular Biology 52nd Annual Meeting — Protein Folding: Principles and Diseases” and has undergone the Journal's usual peer review process.

(2010) Angela C. Rutledge et al.   Biochemistry and Cell Biology

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

The regulatory subunits of PI3K, p85α and p85β, interact with XBP-1 and increase its nuclear translocation

(2010) Sang Won Park et al.   NATURE MEDICINE

IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates

(2009) Dan Han et al.   CELL

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

(2009) Julie Hollien et al.   JOURNAL OF CELL BIOLOGY

GRP78 expression inhibits insulin and ER stress–induced SREBP-1c activation and reduces hepatic steatosis in mice

(2009) Hélène L. Kammoun et al.   JOURNAL OF CLINICAL INVESTIGATION

Glucosamine-induced endoplasmic reticulum stress attenuates apolipoprotein B100 synthesis via PERK signaling

(2009) Wei Qiu et al.   JOURNAL OF LIPID RESEARCH

Lipid-Induced ER Stress: Synergistic Effects of Sterols and Saturated Fatty Acids

(2009) Ludovic Pineau et al.   TRAFFIC

Switch-like Control of SREBP-2 Transport Triggered by Small Changes in ER Cholesterol: A Delicate Balance

(2008) Arun Radhakrishnan et al.   Cell Metabolism

Triglyceride containing lipid droplets and lipid droplet-associated proteins

(2008) Sven-Olof Olofsson et al.   CURRENT OPINION IN LIPIDOLOGY

UPR Pathways Combine to Prevent Hepatic Steatosis Caused by ER Stress-Mediated Suppression of Transcriptional Master Regulators

(2008) D. Thomas Rutkowski et al.   DEVELOPMENTAL CELL

Thematic Review Series: Glycerolipids.Mammalian glycerol-3-phosphate acyltransferases: new genes for an old activity

(2008) Ruth E. Gimeno et al.   JOURNAL OF LIPID RESEARCH

Membrane phospholipid synthesis and endoplasmic reticulum function

(2008) Paolo Fagone et al.   JOURNAL OF LIPID RESEARCH

Regulation of Hepatic Lipogenesis by the Transcription Factor XBP1

(2008) A.-H. Lee et al.   SCIENCE