Article
Medicine, General & Internal
Yoonhee Kim, Kyeongil Min, Myung Woo Park, Hyun Iee Shin, Du Hwan Kim
Summary: We report a case of a 27-year-old survivor of a crowd crush incident in Itaewon, Seoul, Korea, who developed left sciatic neuropathy and right common peroneal neuropathy with multifocal rhabdomyolysis. The patient presented with severe pain, paraparesis, and paresthesia in her lower extremities. Imaging and neurography revealed nerve injuries and muscle changes indicative of rhabdomyolysis. After three months of rehabilitation and conservative treatment, the patient showed improvement in muscle strength and regained independent mobility. This case highlights the occurrence of multifocal neuropathy and rhabdomyolysis in a crowd crush incident.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Aaron Yeoh, Ramsey Cheung, Aijaz Ahmed, Amit S. Chitnis, Albert Do, Robert J. Wong
Summary: This study evaluated the ASCVD risk and statin use in patients with MAFLD. The results showed that over 46% of MAFLD patients had intermediate or high 10-year ASCVD risk, but the utilization rate of statins was only 48.3%, indicating underutilization of statins in this population.
AMERICAN JOURNAL OF MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Rhonda M. Cooper-DeHoff, Mikko Niemi, Laura B. Ramsey, Jasmine A. Luzum, E. Katriina Tarkiainen, Robert J. Straka, Li Gong, Sony Tuteja, Russell A. Wilke, Mia Wadelius, Eric A. Larson, Dan M. Roden, Teri E. Klein, Sook Wah Yee, Ronald M. Krauss, Richard M. Turner, Latha Palaniappan, Andrea Gaedigk, Kathleen M. Giacomini, Kelly E. Caudle, Deepak Voora
Summary: Statins are commonly prescribed medications that reduce cholesterol and prevent cardiovascular disease. However, statin-associated musculoskeletal symptoms can affect patient adherence and long-term effectiveness. Genetic variations in SLCO1B1, ABCG2, and CYP2C9 genes have been identified to impact the metabolism and adverse events of statins. This study summarizes the literature supporting these associations and provides therapeutic recommendations based on genotypes to improve the safety, adherence, and effectiveness of statin therapy.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Obstetrics & Gynecology
Margaret Olutayo Alese, Jagidesa Moodley, Thajasvarie Naicker
Summary: Preeclampsia is a multisystemic disorder with high morbidity and mortality rates among maternal and perinatal populations, especially in middle and low-income countries. Liver biomarkers show potential in predicting the occurrence and outcome of preeclampsia, offering specific predictors for the severe condition resulting from liver dysfunction in the disease.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Review
Medicine, General & Internal
Beatrice A. Golomb, Jun Hee Han, Peter H. Langsjoen, Eero Dinkeloo, Alice E. Zemljic-Harpf
Summary: Despite the favorable observational associations and theoretical benefits, the past associations of statins to non-COVID-19 infection outcomes were not supported in meta-analysis of RCTs, suggesting potential disparities due to healthy-user/tolerator effects and indication bias. The drop in cholesterol levels in less severely affected individuals and the impaired mitochondrial function caused by statins may contribute to apparent favorable statin associations and increased risks in patients with existing mitochondrial compromise. The high rates of rhabdomyolysis in hospitalized COVID-19 patients highlight the need to consider both risks and benefits of statins. Advocacy for statins in COVID-19 should be suspended until clear evidence of RCT benefits with attention to risk modifiers.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Lan Shen, Lin Qiu, Li Wang, Hengye Huang, Dong Liu, Ying Xiao, Yi Liu, Jingjin Jin, Xiulan Liu, Dao Wen Wang, Ben He, Ning Zhou
Summary: The study found that the use of statins can reduce the risk of in-hospital mortality in COVID-19 patients, especially among patients with coronary heart disease, indicating that the continued use of statins may be beneficial for COVID-19 patients.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
David Ray Chang, Hung-Chieh Yeh, I-Wen Ting, Chen-Yuan Lin, Han-Chun Huang, Hsiu-Yin Chiang, Shih-Ni Chang, Hsiu-Chen Tsai, Yen-Chun Lo, Chiung-Tzu Hsiao, Pei-Lun Chu, Chin-Chi Kuo
Summary: The study found that for each doubling increase in uPCR, uACR, and uNAP, the adjusted hazard ratios for all-cause mortality increased. The increase in uNAP was also associated with the risk of all-cause mortality. Patients with severe proteinuria but normal albuminuria had the highest risk of all-cause mortality.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Pietro Manuel Ferraro, Viola D'Ambrosio, Andrea Di Paolantonio, Valeria Guglielmino, Paolo Calabresi, Mario Sabatelli, Marco Luigetti
Summary: This study reports the prevalence of kidney involvement and kidney function over time in ATTRv patients with different transthyretin gene mutations. The results show that kidney involvement is common in ATTRv patients, with abnormal UPE appearing to be a common feature of the disease. No single predictor was associated with either eGFR values or its slope over time.
Article
Medicine, General & Internal
Wen-Fang Chiang, Jenq-Shyong Chan, Po-Jen Hsiao, Shih-Hua Lin
Summary: Statin treatment for hypercholesterolemia can cause reversible rhabdomyolysis and acute kidney injury. This case highlights the importance of considering hypothyroidism, which can present with concomitant myopathy and kidney injury, in patients with persistent symptoms after discontinuation of statin therapy.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Mara Sophie Vell, Rohit Loomba, Arunkumar Krishnan, Kirk J. Wangensteen, Jonel Trebicka, Kate Townsend Creasy, Christian Trautwein, Eleonora Scorletti, Katharina Sophie Seeling, Leonida Hehl, Miriam Daphne Rendel, Inuk Zandvakili, Tang Li, Jinbo Chen, Marijana Vujkovic, Saleh Alqahtani, Daniel James Rader, Kai Markus Schneider, Carolin Victoria Schneider
Summary: This cohort study suggests that regular statin use is associated with a reduction in liver disease, particularly hepatocellular carcinoma (HCC) and liver-related deaths. The protective effect of statins is time and dose dependent and is particularly beneficial for men, individuals with diabetes, and those with a high Fibrosis-4 index at baseline.
Article
Endocrinology & Metabolism
Robin Dagher, Rami Massie, Benoit J. Gentil
Summary: Mutations in the HADHB gene cause Mitochondrial Trifunctional Protein (MTP) deficiency, leading to the inability to metabolize long-chain fatty acids in affected patients. Different clinical manifestations are associated with this deficiency, with the pathophysiology of sensorimotor neuropathy remaining relatively unknown.
MOLECULAR GENETICS AND METABOLISM
(2021)
Article
Oncology
Yuma Shibutani, Shinya Suzuki, Atsunobu Sagara, Tomohiro Enokida, Susumu Okano, Takao Fujisawa, Fumiaki Sato, Tetsuro Yumoto, Motohiko Sano, Toshikatsu Kawasaki, Makoto Tahara
Summary: This retrospective study evaluated the association between lenvatinib-induced proteinuria and renal function in patients with thyroid cancer. The results showed that the degree of proteinuria was not associated with renal function. Therefore, treatment with lenvatinib should be continued with attention to renal function, regardless of the degree of proteinuria.
FRONTIERS IN ONCOLOGY
(2023)
Article
Pharmacology & Pharmacy
Tingting Zhao, Minyi Li, Qian Xiang, Beifeng Lie, Deqi Chen, Weiming Wang, Xuling Li, Tiancheng Xu, Xi Zhang, Yuntong Li, Ruixue Dong, Xinwen Du, Yilin Wang, Junzheng Yang, Bao He, Quan Zhu, Tingting Duan, Zhenghai Li, Youhua Xu
Summary: In this study, both in vitro and in vivo experiments were conducted to investigate the mechanism of action of Yishen Huashi (YSHS) in diabetic nephropathy (DN). The results showed that YSHS significantly reduced levels of HbA1c and mALB, preserved the integrity of the glomerular filtration barrier, reduced oxidative stress damage, and enhanced communication between glomerular endothelial cells and podocytes. The PI3K/AKT/mTOR signaling pathway was found to play a crucial role in the effects of YSHS on DN.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Jordan S. S. Langford, Eric Tokita, Cecilia Martindale, Leah Millsap, James Hemp, Laura A. A. Pace, Melissa M. M. Cortez
Summary: This study investigated individuals with idiopathic autonomic neuropathy and unexplained gastrointestinal symptoms using wireless motility capsule testing. The results showed abnormal transit times in the foregut and midgut, while contractility abnormalities were more prominent in the hindgut. There was also neuroanatomical overlap between autonomic reflex abnormalities and WMC-based transit and/or contractility abnormalities.
FRONTIERS IN NEUROLOGY
(2022)
Review
Pediatrics
Xin-Ying Yang, Tong-Li Han, Jun-Lan Lv
Summary: Through analysis of seven patients, we found that when GBS meets RML, the most prominent characteristics were male dominance, multiple factors causing limb weakness, pain and respiratory failure, more severe limb weakness and respiratory muscle paralysis compared to GBS alone, and an increased probability of mechanical ventilation. Neuroelectrophysiological studies revealed axonal lesions. Close monitoring and timely intervention are crucial in remedying potentially fatal complications. With plasma exchange, peritoneal dialysis and supportive treatment, the long-term outcome of most patients was satisfactory.
FRONTIERS IN PEDIATRICS
(2022)