Article
Virology
Maria Carolina Dos Santos Guedes, Wlisses Henrique Veloso Carvalho-Silva, Jose Leandro Andrade-Santos, Maria Carolina Accioly Brelaz-de-Castro, Fabricio Oliveira Souto, Rafael Lima Guimaraes
Summary: The mechanisms causing impaired immunological recovery in HIV-positive patients receiving antiretroviral therapy (ART) have not been fully understood yet. A study was conducted on 44 ART-treated HIV-positive patients to analyze T-lymphocytes immunophenotyping and cytokines levels. The patients were classified as immunological non-responders (INR) and immunological responders (IR) based on their CD4+ T cell levels. The study found that thymic exhaustion and increased immune activation are two significant mechanisms contributing to the impaired immune recovery in ART-treated HIV patients.
Review
Oncology
Isabelle Poizot-Martin, Sylvie Bregigeon, Romain Palich, Anne-Genevieve Marcelin, Marc-Antoine Valantin, Caroline Solas, Marianne Veyri, Jean-Philippe Spano, Alain Makinson
Summary: Kaposi sarcoma-immune reconstitution inflammatory syndrome (KS-IRIS) is a common disease among people living with HIV, despite the improvement of KS with antiretroviral therapy (ART), the occurrence of KS-IRIS still exists and is associated with significant morbidity and mortality.
Review
Biology
Vania Maria Sabadoto Brienze, Julio Cesar Andre, Elisabete Liso, Irina Vlasova-St. Louis
Summary: IRIS is an exaggerated immune reaction that occurs in immunocompromised patients with late-stage HIV infection who have started ART, caused by virtually any opportunistic pathogen. Recent research focuses on identifying risk factors for Cryptococcal IRIS and understanding C-IRIS immunopathogenesis, with new findings in blood and cerebrospinal fluid potentially useful in predicting and diagnosing CM-IRIS. Current therapeutic regimens and novel treatment approaches for combating CM-IRIS are also discussed, along with the utility of biomarkers for clinical monitoring and adjusting treatment modalities in AIDS patients co-infected with Cryptococcus who have initiated ART.
Article
Materials Science, Biomaterials
Yi Wang, Shourong Liu, Wenhui Zhang, Liping Zheng, Er Li, Mingli Zhu, Dingyan Yan, Jinchuan Shi, Jianfeng Bao, Jianhua Yu
Summary: This study aimed to develop and evaluate a model to predict immune reconstitution in HIV/AIDS patients after antiretroviral therapy (ART). A total of 502 HIV/AIDS patients were randomized into training and evaluation groups. The model, consisting of white blood cells, baseline CD4+ T-cell counts, ratio of effector regulatory T cells to resting regulatory T cells, and low-density lipoprotein cholesterol, showed excellent discrimination and calibration, indicating its ability to predict poor immune reconstitution. The simple-to-use nomogram has practical clinical value in the management of HIV/AIDS patients after ART.
Article
Microbiology
Polidy Pean, Yoann Madec, Eric Nerrienet, Laurence Borand, Didier Laureillard, Marcelo Fernandez, Olivier Marcy, Daniel Scott-Algara, CAMELIA Study Team
Summary: The aim of this study was to evaluate the reconstitution of NK cells in HIV-infected patients with TB-IRIS compared to those without IRIS. The results showed that NK cell reconstitution appeared to be better in TB-IRIS subjects. However, the development of IRIS does not appear to affect the NK cell reconstitution in HIV and TB-infected individuals.
Article
Immunology
Ran Tao, Xiaorong Peng, Xiang Liu, Junwei Su, Guanjing Lang, Ying Huang, Yafei Zhang, Biao Zhu
Summary: Cryptococcal meningitis (CM) is a common opportunistic infection in HIV patients. This study reports two cases of CM-associated immune reconstitution inflammatory syndrome (IRIS) treated with lenalidomide, which resulted in rapid clinical remission and improved cognitive function. The study also suggests that lenalidomide may improve cognitive function by regulating intracranial inflammation through multiple pathways, not just by TNF-α blocking.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Immunology
Luxin Pei, Kiyoshi F. Fukutani, Rafael Tiburcio, Adam Rupert, Eric W. Dahlstrom, Frances Galindo, Elizabeth Laidlaw, Andrea Lisco, Maura Manion, Bruno B. Andrade, Irini Sereti
Summary: The study identified metabolic disturbances in IRIS before and during the event, linking oxidative stress, tryptophan pathway, and lipid signaling with IRIS development. Metabolic pathways of lipids and amino acids were significantly associated with inflammatory biomarkers like IL-12p70 and IL-8 during the IRIS event, suggesting the impact of cellular metabolism on immune cell activation and vice versa.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Caian L. Vinhaes, Virginia Sheikh, Deivide Oliveira-de-Souza, Jing Wang, Adam Rupert, Gregg Roby, Maria B. Arriaga, Kiyoshi F. Fukutani, Fred Sawe, Doug Shaffer, Jintanat Ananworanich, Nittaya Phanuphak, Bruno B. Andrade, Irini Sereti
Summary: The study found that systemic inflammatory profiles in people with severe immunosuppression can predict the development of immune reconstitution inflammatory syndrome (IRIS). By developing a composite score incorporating various biomarkers, including interleukin-6, IL-10, IL-27, sCD14, interferon-gamma, tumor necrosis factor-alpha, hyaluronic acid, D-dimer, body mass index, and hemoglobin, accurate predictions of IRIS occurrence and death risk can be made.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
You Ge, Ying Zhou, Yahong Liu, Jing Lu, Tao Qiu, Ling-En Shi, Zhi Zhang, Haiyang Hu, Pingmin Wei, Gengfeng Fu
Summary: This study analyzed longitudinal samples from 1557 male patients receiving cART and found that both heterosexual and MSM patients showed an increasing trend in CD4(+) T cell counts after treatment. However, heterosexual patients had a lower CD4(+) T cell recovery rate compared to MSM patients. Heterosexuality was identified as an independent risk factor for immunological non-responders and was associated with lower probability of achieving conventional and optimal immune recovery.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Immunology
Joseph M. Rocco, Elizabeth Laidlaw, Frances Galindo, Megan Anderson, Adam Rupert, Jeanette Higgins, Ornella Sortino, Ana M. Ortega-Villa, Virginia Sheikh, Gregg Roby, Safia Kuriakose, Andrea Lisco, Maura Manion, Irini Sereti
Summary: Severe mycobacterial IRIS in HIV can cause secondary HLH driven by pathologic IFN gamma production and T-cell activation, leading to worse outcomes. Increased ferritin, anemia, CXCL9, and sCD25 associate with this phenotype and may be used for risk stratification and treatment optimization.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Cell Biology
Makiko Watanabe, Mladen Jergovic, Lisa Davidson, Bonnie J. LaFleur, Yvonne Castaneda, Carmine Martinez, Megan J. Smithey, Raymond P. Stowe, Elias K. Haddad, Janko Nikolich-Zugich
Summary: HIV-positive patients on successful ART treatment do not show clinical signs of AIDS, but have a shorter lifespan and exhibit chronic diseases associated with advanced age. This study investigated immune system aging in HIV-positive subjects and found that aging by a decade did not significantly impact immune system changes. However, differences were observed in immune control of human cytomegalovirus and sustained inflammation in older HIV-positive patients treated successfully.
Review
Biology
Caian L. Vinhaes, Mariana Araujo-Pereira, Rafael Tiburcio, Juan M. Cubillos-Angulo, Fernanda O. Demitto, Kevan M. Akrami, Bruno B. Andrade
Summary: Antiretroviral therapy (ART) has greatly improved the care of people living with HIV, but can lead to immune reconstitution inflammatory syndrome (IRIS), causing significant morbidity and mortality. There are still gaps in understanding IRIS pathogenesis and optimizing therapeutic strategies.
Article
Immunology
Joseph M. Rocco, Elizabeth Laidlaw, Frances Galindo, Megan Anderson, Ornella Sortino, Safia Kuriakose, Andrea Lisco, Maura Manion, Irini Sereti
Summary: People with HIV and mycobacterial infections may develop immune reconstitution inflammatory syndrome (IRIS) after starting antiretroviral therapy. The pathophysiology of mycobacterial-IRIS overlaps with primary hemophagocytic lymphohistiocytosis (pHLH). By evaluating protein-altering variants in genes associated with HLH, it was found that 23.2% of IRIS patients had these variants, compared to only 3.8% of those without IRIS. These findings suggest a possible genetic component in the risk of mycobacterial IRIS in people with HIV and mycobacterial infections.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Medicine, Research & Experimental
Mohsen Sheykhhasan, Aidin Foroutan, Hamed Manoochehri, Saeideh Gholamzadeh Khoei, Naresh Poondla, Massoud Saidijam
Summary: HIV/AIDS remains a major global public health issue, with gene therapy showing promising results in combating HIV infection. Traditional treatment methods have limitations and side effects, making gene therapy an effective alternative.
Review
Immunology
Yannick Foerster, Lukas Sollfrank, Laura Rechtien, Thomas Harrer, Carola Berking, Michael Sticherling
Summary: This article describes three patients with bullous pemphigoid and concomitant HIV-1 infection. The patients received modern combined antiretroviral therapy and additional treatment based on the severity of their condition. All patients experienced significant improvement in their skin lesions.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Infectious Diseases
Amine Benadji, Xavier Duval, Kostas Danis, Bruno Hoen, Bernard Page, Guillaume Beraud, Veronique Vernet-Garnier, Christophe Strady, Nathalie Brieu, Laurence Maulin, Carine Roy, Marie-Cecile Pioy, Jacques Gaillat, Emmanuelle Varon, Sarah Tubiana
Summary: This study found that both host factors and pneumococcal serotypes have an impact on 30-day mortality in invasive pneumococcal disease patients, emphasizing the need for a targeted vaccination strategy for high-risk populations.
Letter
Infectious Diseases
Chloe Dimeglio, Fabrice Herin, Guillaume Martin-Blondel, Marcel Miedouge, Jacques Izopet
JOURNAL OF INFECTION
(2022)
Article
Infectious Diseases
Florence Ader, Maude Bouscambert-Duchamp, Maya Hites, Nathan Peiffer-Smadja, Julien Poissy, Drifa Belhadi, Alpha Diallo, Minh-Patrick Le, Gilles Peytavin, Therese Staub, Richard Greil, Jeremie Guedj, Jose-Artur Paiva, Dominique Costagliola, Yazdan Yazdanpanah, Charles Burdet, France Mentre
Summary: A study conducted in COVID-19 patients admitted to hospital and requiring oxygen support found that remdesivir did not show significant clinical benefits compared to standard care alone.
LANCET INFECTIOUS DISEASES
(2022)
Article
Immunology
Paul Dalla-Pozza, Maxime Hentzien, Clotilde Allavena, Anne Doe de Maindreville, Kevin Bouiller, Marc-Antoine Valantin, Emmanuel Lafont, Olivia Zaegel-Faucher, Antoine Cheret, Guillaume Martin-Blondel, Laurent Cotte, Firouze Bani-Sadr
Summary: This study highlights that factors other than low CD4(+) cell count and high HIV viral load may be associated with the occurrence of PML in people with HIV. Further studies are warranted to investigate in greater detail the immunologic characteristics of people with HIV who develop PML despite immune-virological control.
Letter
Hematology
Guillaume Moulis, Johanne Germain, Manuela Rueter, Margaux Lafaurie, Myriam Aroichane, Thibault Comont, Matthieu Mahevas, Jean-Francois Viallard, Stephane Cheze, Mikael Ebbo, Sylvain Audia, Soraya Leclerc-Teffahi, Agnes Sommet, Odile Beyne-Rauzy, Marc Michel, Bertrand Godeau, Maryse Lapeyre-Mestre
AMERICAN JOURNAL OF HEMATOLOGY
(2022)
Article
Clinical Neurology
Rebecca Lajaunie, Ilaria Mainardi, Jacques Gasnault, Vanessa Rousseau, Andrea G. Tarantino, Agnes Sommet, Paola Cinque, Guillaume Martin-Blondel
Summary: This study analyzed PML patients who received treatment with recombinant human IL-7 and found that their survival rate was not affected by underlying conditions, but was associated with an increase in blood lymphocytes and CD4(+) T cells, as well as a decrease in JC virus replication in the cerebrospinal fluid. The study suggests that rhIL-7 may contribute to improved survival in PML patients.
ANNALS OF NEUROLOGY
(2022)
Letter
Immunology
Chloe Dimeglio, Fabrice Herin, Isabelle Da-Silva, Marion Porcheron, Guillaume Martin-Blondel, Sabine Chapuy-Regaud, Jacques Izopet
CLINICAL INFECTIOUS DISEASES
(2022)
Letter
Infectious Diseases
Chloe Dimeglio, Marion Migueres, Sabine Chapuy-Regaud, Isabelle Da-Silva, Isabelle Jougla, Claire Pradere, Marion Porcheron, Guillaume Martin-Blondel, Catherine Lougarre, Fabrice Herin, Jacques Izopet
JOURNAL OF INFECTION
(2022)
Letter
Infectious Diseases
Guillaume Martin-Blondel, Anne-Genevieve Marcelin, Cathia Soulie, Sofia Kaisaridi, Clovis Lusivika-Nzinga, Celine Dorival, Laura Nailler, Anais Boston, Clea Melenotte, Geraldine Gaube, Christophe Choquet, Roland Liblau, Fabrice Carrat, Youri Yordanov
JOURNAL OF INFECTION
(2022)
Letter
Public, Environmental & Occupational Health
Laurie Windels, Veronique Naneix-Laroche, Christophe Pasquier, Pierre Delobel, Perrine Parize, Guillaume Martin-Blondel
JOURNAL OF TRAVEL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Remi Planes, Miriam Pinilla, Karin Santoni, Audrey Hessel, Charlotte Passemar, Kenneth Lay, Perrine Paillette, Ana-Luiza Chaves Valadao, Kim Samirah Robinson, Paul Bastard, Nathaniel Lam, Ricardo Fadrique, Ida Rossi, David Pericat, Salimata Bagayoko, Stephen Adonai Leon-Icaza, Yoann Rombouts, Eric Perouzel, Michele Tiraby, Qian Zhang, Pietro Cicuta, Emmanuelle Jouanguy, Olivier Neyrolles, Clare E. Bryant, Andres R. Floto, Caroline Goujon, Franklin Zhong Lei, Guillaume Martin-Blondel, Stein Silva, Jean-Laurent Casanova, Celine Cougoule, Bruno Reversade, Julien Marcoux, Emmanuel Ravet, Etienne Meunier
Summary: The activation of inflammasomes plays a crucial role in regulating the infection of SARS-CoV-2. Lung epithelial cells serve as the primary entry site of the virus and express the inflammasome-forming sensor NLRP1. The cleavage of NLRP1 by coronavirus 3CL proteases leads to inflammasome assembly, cell death, and reduced production of viral particles. Additionally, these proteases also inactivate the executioner protein Gasdermin D, promoting an alternative form of cell death called pyroptosis. Analysis of pyroptosis markers in COVID-19 patients suggests that GSDME/caspase-3 could potentially serve as markers of disease severity.
Article
Immunology
Alexandra Serris, Amani Ouedrani, Fabrice Uhel, Marianne Gazzano, Vincent Bedarida, Claire Rouzaud, Marie-Elisabeth Bougnoux, Jean-Herle Raphalen, Sylvain Poiree, Olivier Lambotte, Guillaume Martin-Blondel, Fanny Lanternier
Summary: Invasive fungal diseases (IFD) continue to be a major cause of morbidity and mortality, necessitating the development of new treatment approaches. Recent data suggest that checkpoint inhibitors (ICI) may have a beneficial effect. This report presents a case of a diabetic patient with refractory IFD following SARSCoV-2 infection, who was treated with ICI and interferon-gamma in combination with antifungal therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Multidisciplinary Sciences
Reinhard Hohlfeld, Roland S. Liblau
Summary: The clinical variability of multiple sclerosis aligns with the diversity of four previously unidentified autoantigens.
Article
Infectious Diseases
Guillaume Beraud, Sarah Tubiana, Marie-Line Erpelding, Vincent Le Moing, Catherine Chirouze, Isabelle Gorenne, Pauline Manchon, Pierre Tattevin, Veronique Vernet, Emmanuelle Varon, Bruno Hoen, Xavier Duval
Summary: The study described patients with coexisting infective endocarditis and bacterial meningitis, finding that the main presentation was meningitis, with most common pathogens being Streptococcus pneumoniae and Staphylococcus aureus. The results of this study are important for the identification and treatment of patients with dual infections.
INFECTIOUS DISEASES AND THERAPY
(2022)
Article
Ophthalmology
Emmanuelle Loubsens, Raphael Adam, Alexa Debard, Lisa Barioulet, Fanny Varenne, Pierre Fournie, Thomas Sales de Gauzy, Priscille Olle, Guillaume Martin-Blondel, Vincent Soler
Summary: This study reviewed the management, treatment, and outcomes of patients with necrotizing herpetic retinitis (NHR) and proposed an algorithm for first-line management of NHR. The visual prognosis of NHR patients was poor and prompt investigation of immune status and presence of factors justifying intravitreal antiviral injections is necessary.
INTERNATIONAL OPHTHALMOLOGY
(2023)