MicroRNAs in the pathogenesis of myelodysplastic syndromes and myeloid leukaemia

Characterization of human plasma-derived exosomal RNAs by deep sequencing

(2013) Xiaoyi Huang et al.   BMC GENOMICS

MicroRNA-Antagonism Regulates Breast Cancer Stemness and Metastasis via TET-Family-Dependent Chromatin Remodeling

(2013) Su Jung Song et al.   CELL

miR-22 in tumorigenesis

(2013) Su Jung Song et al.   CELL CYCLE

The Oncogenic MicroRNA miR-22 Targets the TET2 Tumor Suppressor to Promote Hematopoietic Stem Cell Self-Renewal and Transformation

(2013) Su Jung Song et al.   Cell Stem Cell

Identification of maternal serum microRNAs as novel non-invasive biomarkers for prenatal detection of fetal congenital heart defects

(2013) Shasha Zhu et al.   CLINICA CHIMICA ACTA

MicroRNAs and other non-coding RNAs as targets for anticancer drug development

(2013) Hui Ling et al.   NATURE REVIEWS DRUG DISCOVERY

A Myc–microRNA network promotes exit from quiescence by suppressing the interferon response and cell-cycle arrest genes

(2013) Damon Polioudakis et al.   NUCLEIC ACIDS RESEARCH

An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells

(2013) D. Rohle et al.   SCIENCE

Effects ofTET2mutations on DNA methylation in chronic myelomonocytic leukemia

(2012) Jumpei Yamazaki et al.   Epigenetics

Expression analysis of mir-17-5p, mir-20a and let-7a microRNAs and their target proteins in CD34+ bone marrow cells of patients with myelodysplastic syndromes

(2012) Diamantina Vasilatou et al.   LEUKEMIA RESEARCH

BCR-ABL/GATA1/miR-138 mini circuitry contributes to the leukemogenesis of chronic myeloid leukemia

(2012) C Xu et al.   ONCOGENE

miR-34 – a microRNA replacement therapy is headed to the clinic

(2012) Andreas G. Bader   Frontiers in Genetics

Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies

(2011) Z. Li et al.   BLOOD

Identification of a risk dependent microRNA expression signature in myelodysplastic syndromes

(2011) Lubomir Sokol et al.   BRITISH JOURNAL OF HAEMATOLOGY

TET2 Inactivation Results in Pleiotropic Hematopoietic Abnormalities in Mouse and Is a Recurrent Event during Human Lymphomagenesis

(2011) Cyril Quivoron et al.   CANCER CELL

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation

(2011) Kelly Moran-Crusio et al.   CANCER CELL

Hypomethylating Agents in the Treatment of Myelodysplastic Syndromes and Myeloid Leukemia

(2011) Anna Szmigielska-Kaplon et al.   CURRENT CANCER DRUG TARGETS

Epigenetic regulation of miRNA genes in acute leukemia

(2011) X Agirre et al.   LEUKEMIA

Decreased TET2 gene expression during chronic myeloid leukemia progression

(2011) F. Albano et al.   LEUKEMIA RESEARCH

MicroRNA-193a represses c-kit expression and functions as a methylation-silenced tumor suppressor in acute myeloid leukemia

(2011) X-N Gao et al.   ONCOGENE

Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations

(2010) D. T. Starczynowski et al.   BLOOD

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

(2010) Maria E. Figueroa et al.   CANCER CELL

Distinctive microRNA expression profiles in CD34+ bone marrow cells from patients with myelodysplastic syndrome

(2010) Michaela Dostalova Merkerova et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Epigenetic Changes in the Myelodysplastic Syndrome

(2010) Jean-Pierre Issa   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

IDH1andIDH2Gene Mutations Identify Novel Molecular Subsets Within De Novo Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study

(2010) Guido Marcucci et al.   JOURNAL OF CLINICAL ONCOLOGY

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

(2010) Myunggon Ko et al.   NATURE

Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia

(2010) Marc H. G. P. Raaijmakers et al.   NATURE

miR-22 Forms a Regulatory Loop in PTEN/AKT Pathway and Modulates Signaling Kinetics

(2010) Nadav Bar et al.   PLoS One

Silencing of hsa-miR-124 by EVI1 in cell lines and patients with acute myeloid leukemia

(2010) I. Vazquez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia

(2010) Shuangli Mi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization

(2009) R. Popovic et al.   BLOOD

MicroRNA and leukemia: Tiny molecule, great function

(2009) Haifeng Zhao et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Significant inverse correlation of microRNA-150/MYB and microRNA-222/p27 in myelodysplastic syndrome

(2009) Kais Hussein et al.   LEUKEMIA RESEARCH

MicroRNAs: key regulators of stem cells

(2009) Vamsi K. Gangaraju et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mutation inTET2in Myeloid Cancers

(2009) François Delhommeau et al.   NEW ENGLAND JOURNAL OF MEDICINE

MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia

(2008) R. Garzon et al.   BLOOD

MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemia

(2008) M. Jongen-Lavrencic et al.   BLOOD

Aberrant DNA methylation is a dominant mechanism in MDS progression to AML

(2008) Y. Jiang et al.   BLOOD

Genetic and Epigenetic Silencing of MicroRNA-203 Enhances ABL1 and BCR-ABL1 Oncogene Expression

(2008) María J. Bueno et al.   CANCER CELL

Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases

(2008) Xi Chen et al.   CELL RESEARCH

Prognostic Significance of, and Gene and MicroRNA Expression Signatures Associated With,CEBPAMutations in Cytogenetically Normal Acute Myeloid Leukemia With High-Risk Molecular Features: A Cancer and Leukemia Group B Study

(2008) Guido Marcucci et al.   JOURNAL OF CLINICAL ONCOLOGY

A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia

(2008) Maria Chiara Di Bernardo et al.   NATURE GENETICS

Serum MicroRNAs Are Promising Novel Biomarkers

(2008) Shlomit Gilad et al.   PLoS One

Distinct microRNA expression profiles in acute myeloid leukemia with common translocations

(2008) Z. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating microRNAs as stable blood-based markers for cancer detection

(2008) P. S. Mitchell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA