The use of microfluidics in hemostasis

Sources of Variability in Platelet Accumulation on Type 1 Fibrillar Collagen in Microfluidic Flow Assays

(2013) Keith B. Neeves et al.   PLoS One

Atherosclerotic geometries exacerbate pathological thrombus formation poststenosis in a von Willebrand factor-dependent manner

(2013) Erik Westein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High Content Evaluation of Shear Dependent Platelet Function in a Microfluidic Flow Assay

(2012) Ryan R. Hansen et al.   ANNALS OF BIOMEDICAL ENGINEERING

Thrombus Growth and Embolism on Tissue Factor-Bearing Collagen Surfaces Under Flow

(2012) Thomas V. Colace et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Blood Clots Are Rapidly Assembled Hemodynamic Sensors

(2012) Ryan W. Muthard et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Evaluation of a novel flow chamber system to assess clot formation in factor VIII-deficient mouse and anti-factor IXa-treated human blood

(2012) S. Ogawa et al.   HAEMOPHILIA

Microfluidic system for simultaneous optical measurement of platelet aggregation at multiple shear rates in whole blood

(2012) Melissa Li et al.   LAB ON A CHIP

Monitoringin vitrothrombus formation with novel microfluidic devices

(2012) Erik Westein et al.   PLATELETS

In vitro microvessels for the study of angiogenesis and thrombosis

(2012) Y. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shear-Activated Nanotherapeutics for Drug Targeting to Obstructed Blood Vessels

(2012) N. Korin et al.   SCIENCE

Relipidated Tissue Factor Linked to Collagen Surfaces Potentiates Platelet Adhesion and Fibrin Formation in a Microfluidic Model of Vessel Injury

(2011) Thomas V. Colace et al.   BIOCONJUGATE CHEMISTRY

Dilutional Control of Prothrombin Activation at Physiologically Relevant Shear Rates

(2011) Laura M. Haynes et al.   BIOPHYSICAL JOURNAL

Well plate microfluidic system for investigation of dynamic platelet behavior under variable shear loads

(2011) Carolyn G. Conant et al.   BIOTECHNOLOGY AND BIOENGINEERING

In vitro modeling of the microvascular occlusion and thrombosis that occur in hematologic diseases using microfluidic technology

(2011) Michelle Tsai et al.   JOURNAL OF CLINICAL INVESTIGATION

Flow chamber-based assays to measure thrombus formation in vitro: requirements for standardization

(2011) M. ROEST et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A novel automated microchip flow-chamber system to quantitatively evaluate thrombus formation and antithrombotic agents under blood flow conditions

(2011) K. HOSOKAWA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Collagen surfaces to measure thrombus formation under flow: possibilities for standardization

(2011) J. W. M. HEEMSKERK et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Characterization of Collagen Thin Films for von Willebrand Factor Binding and Platelet Adhesion

(2011) Ryan R. Hansen et al.   LANGMUIR

Microfluidic devices for modeling cell–cell and particle–cell interactions in the microvasculature

(2011) Balabhaskar Prabhakarpandian et al.   MICROVASCULAR RESEARCH

The Prostaglandin E 2 Receptor EP4 Is Expressed by Human Platelets and Potently Inhibits Platelet Aggregation and Thrombus Formation

(2010) Sonia Philipose et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Thrombin Flux and Wall Shear Rate Regulate Fibrin Fiber Deposition State during Polymerization under Flow

(2010) K.B. Neeves et al.   BIOPHYSICAL JOURNAL

Diminished contact-dependent reinforcement of Syk activation underlies impaired thrombus growth in mice lacking Semaphorin 4D

(2010) K. M. Wannemacher et al.   BLOOD

Key role of glycoprotein Ib/V/IX and von Willebrand factor in platelet activation-dependent fibrin formation at low shear flow

(2010) J. M. E. M. Cosemans et al.   BLOOD

Synergism between platelet collagen receptors defined using receptor-specific collagen-mimetic peptide substrata in flowing blood

(2010) N. Pugh et al.   BLOOD

Shear-Mediated Platelet Adhesion Analysis in Less Than 100 μ L of Blood: Toward a POC Platelet Diagnostic

(2010) Nigel J Kent et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

P2Y12 or P2Y1 inhibitors reduce platelet deposition in a microfluidic model of thrombosis while apyrase lacks efficacy under flow conditions

(2010) S. F. Maloney et al.   Integrative Biology

Design Considerations for a Microfluidic Device to Quantify the Platelet Adhesion to Collagen at Physiological Shear Rates

(2009) Durga P. Sarvepalli et al.   ANNALS OF BIOMEDICAL ENGINEERING

Disruption of SEMA4D Ameliorates Platelet Hypersensitivity in Dyslipidemia and Confers Protection Against the Development of Atherosclerosis

(2009) Li Zhu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A physiologically realistic in vitro model of microvascular networks

(2009) Jenna M. Rosano et al.   BIOMEDICAL MICRODEVICES

A microfluidics device to monitor platelet aggregation dynamics in response to strain rate micro-gradients in flowing blood

(2009) Francisco Javier Tovar-Lopez et al.   LAB ON A CHIP

Macro- and microscale fluid flow systems for endothelial cell biology

(2009) Edmond W. K. Young et al.   LAB ON A CHIP

A shear gradient–dependent platelet aggregation mechanism drives thrombus formation

(2009) Warwick S Nesbitt et al.   NATURE MEDICINE

Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role

(2009) Alec A. Schmaier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A small-molecule inhibitor of integrin α2β1 introduces a new strategy for antithrombotic therapy

(2009) Jarmo Käpylä et al.   THROMBOSIS AND HAEMOSTASIS

Threshold Response of Initiation of Blood Coagulation by Tissue Factor in Patterned Microfluidic Capillaries Is Controlled by Shear Rate

(2008) Feng Shen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Determination of surface tissue factor thresholds that trigger coagulation at venous and arterial shear rates: amplification of 100 fM circulating tissue factor requires flow

(2008) U. M. Okorie et al.   BLOOD

Effects of Shear Rate on Propagation of Blood Clotting Determined Using Microfluidics and Numerical Simulations

(2008) Matthew K. Runyon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein C supports platelet binding and activation under flow: role of glycoprotein Ib and apolipoprotein E receptor 2

(2008) T. C. WHITE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Microfluidic focal thrombosis model for measuring murine platelet deposition and stability: PAR4 signaling enhances shear-resistance of platelet aggregates

(2008) K. B. NEEVES et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Microfluidic devices for studies of shear-dependent platelet adhesion

(2008) Edgar Gutierrez et al.   LAB ON A CHIP

A membrane-based microfluidic device for controlling the flux of platelet agonists into flowing blood

(2008) Keith B. Neeves et al.   LAB ON A CHIP