Review
Nutrition & Dietetics
Catarina Cacador, Edite Teixeira-Lemos, Sofia Oliveira Martins, Fernando Ramos
Summary: The study investigated the potential correlation between nutritional status and polypharmacy, cognitive decline, and functional performance in institutionalized elders, finding a significant positive association between appropriate nutritional status and physical abilities, which can help prevent cognitive and functional decline. Nutritional status assessment is crucial for preventing health issues and implementing early intervention programs to avoid health decline.
Article
Horticulture
Zengheng Wang, Rui Liu, Liang Fu, Shutian Tao, Jianping Bao
Summary: Based on an observation of a Korla fragrant pear orchard, this study found that grass cultivation reduced soil fertility and plant nutrient content during the early stage of natural grass planting (1-2 years). However, with increased years of grassing, the overall nutrient content of soil, shoots, and leaves gradually increased, with a more significant effect in shallower soil layers. Grass cultivation also significantly increased the content of various nutrients in soil and plants. In conclusion, continuous grass cultivation improved soil quality, plant health, and nutritional status, effectively addressing the negative impact of long-term clean cultivation on pear orchards.
Review
Medicine, General & Internal
Aleksandra Medza, Agnieszka Szlagatys-Sidorkiewicz
Summary: This review summarizes the findings on the nutritional status of patients with celiac disease (CD). Malnutrition, including over- and undernutrition, is common in CD patients at diagnosis and during treatment. Clinical presentations of CD vary widely, and evaluating nutritional parameters is beneficial for defining dietary needs and developing a balanced diet. A gluten-free diet (GFD) is the cornerstone of CD therapy, improving nutritional status, but malnutrition and metabolic consequences may still occur.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Junaid Khan, Aparajita Chattopadhyay, Subhojit Shaw
Summary: Malnutrition poses a significant risk to older populations globally. This study examines the prevalence and risk factors of malnutrition among older adults in India. The study finds that overweight is more common among males and those aged below 60, while underweight is more prevalent among females and those aged 60 and above. The study also reveals that urban populations are less likely to be underweight and more likely to be overweight. Lower social and economic status is associated with higher likelihood of underweight, and factors such as infections and edentulism increase the risk of underweight among those aged 60 and above.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Junaid Khan, Aparajita Chattopadhyay, Subhojit Shaw
Summary: This study aims to estimate the prevalence of malnutrition among older adults aged 45-59 years and the elderly population aged 60 years and above, based on their socioeconomic and demographic characteristics. The study found that 25% of males and 37% of females below the age of 60 years are overweight, while 28% of males and 25% of females aged 60 years and above are underweight. Older adults from low economic and social strata are more likely to be underweight. Nutritional status among older adults is a complicated manifestation of multiple risk factors and requires potential nutritional intervention.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Simona Loddo, Francesco Salis, Samuele Rundeddu, Luca Serchisu, Maria Monica Peralta, Antonella Mandas
Summary: The study found that in elderly patients with poor nutritional status, the severity of comorbidities, STOPP and START alerts, and BEERS 2019 criteria were significantly worse. Additionally, patients with higher MNA scores had higher estimated 10-year survival rates and lower ADR risk scores.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Iwona Boniecka, Aneta Czerwonogrodzka-Senczyna, Anna Jeznach-Steinhagen, Krzysztof Pasnik, Dorota Szostak-Wegierek, Samir Zeair
Summary: Bariatric surgery is the most effective treatment for obesity and its complications, but failure to adhere to dietary recommendations can lead to unsatisfactory weight loss and metabolic disorders. This study aimed to evaluate the effects of bariatric surgery on anthropometric parameters and nutrient intake.
Article
Nutrition & Dietetics
Felipe Mozo-Alonso, Jose P. Novalbos-Ruiz, Juan C. Duran-Alonso, Amelia Rodriguez-Martin
Summary: A study in the Cadiz region of Spain focused on the nutritional status of individuals over 65 who are not institutionalized, revealing a high prevalence of overweight and obesity at 82.2%. The study also identified a negative relationship between physical activity, having full dinners, and the prevalence of overweight and obesity.
Article
Nutrition & Dietetics
Claudia D'Alessandro, Alessia Benedetti, Antonello Di Paolo, Domenico Giannese, Adamasco Cupisti
Summary: Interactions between drugs and food are important to consider, especially for patients with chronic kidney disease. Understanding these interactions and making necessary adjustments in diet and medication usage can help maintain patient quality of life and the effectiveness of drug therapy.
Article
Environmental Sciences
Alessandra Teglia, Daniela Di Baccio, Giorgio Matteucci, Andrea Scartazza, Bruno De Cinti, Francesco Mazzenga, Dario Ravaioli, Enrico Muzzi, Graziella Marcolini, Federico Magnani
Summary: Anthropogenic activities have resulted in an increase of nitrogen compounds in the atmosphere, affecting forest ecosystems. This study simulated the effects of nitrogen deposition in beech forests through controlled experiments in two contrasting climatic regions. The results showed that nitrogen addition had some impact on forest health, but no severe impairments were observed in the short term.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Tanika C. Shalders, Curtis Champion, Melinda A. Coleman, Peter Butcherine, Matt K. Broadhurst, Bryan Mead, Kirsten Benkendorff
Summary: Ocean warming and marine heatwaves can impact the nutritional quality of harvested marine resources, but the effects of different exposure durations and temperatures are not well understood. In this study, the nutritional quality of eastern school prawns was tested after short-term and longer-term exposures to projected ocean-warming temperatures and marine heatwaves. Results showed that the nutritional quality of the prawns remained resilient after short-term exposure, but changed after longer-term exposure. Additionally, the study highlighted the importance of exposure duration and sampling time in measuring the nutritional response of the species.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Clinical Neurology
Cody L. Goessl, Jeffrey J. VanWormer, Ram D. Pathak, Edward F. Ellerbeck, Daniel L. Kurz, Christie A. Befort
Summary: This analysis examined how the mental component score (MCS-12) from the Short Form health survey changed over 24 months in weight loss trial participants with vs. without treatment seeking for affective symptoms (TxASx) and by weight change quintiles. The results showed that participants with TxASx who lost the most weight had the largest increase in MCS-12 scores (+5.3 points [12%]), while participants without TxASx who gained the most weight had the largest decrease in MCS-12 scores (-1.8 points [-3%]).
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Nutrition & Dietetics
Zhen Liu, Di Xu, Wen-xiu Xu, Yin-jiao Fei, Dan-dan Wang, Fei Deng, Jin-hai Tang
Summary: This study investigates the relationships between different dietary patterns or nutritional status and mortality risk in individuals. The results suggest that higher healthy eating index and lower dietary inflammatory index are associated with lower mortality risk in people aged over 60 in the United States, while excessively low nutritional status increases the risk of death.
FRONTIERS IN NUTRITION
(2022)
Article
Horticulture
Fernando Ferrari Putti, Eduardo Festozo Vicente, Prinscilla Pamela Nunes Chaves, Luis Paulo Benetti Mantoan, Camila Pires Cremasco, Bruna Arruda, Juliane Cristina Forti, Josue Ferreira Silva, Marcelo Campos, Andre Rodrigues dos Reis, Luis Roberto Almeida Gabriel
Summary: Climate change is affecting vegetable production through changes in rainfall patterns and soil moisture. To mitigate this, technologies such as magnetically treated water are being explored to maintain ideal soil moisture for plant uptake. This study investigated the effect of magnetically treated water on lettuce biomass and nutrient uptake, finding that it improved nitrogen assimilation and resulted in higher agronomical characteristics and yield.
Article
Nutrition & Dietetics
Romina Mayra Lasagni Vitar, Filippo Bonelli, Paolo Rama, Giulio Ferrari
Summary: Keratoconus is a progressive corneal degeneration characterized by structural changes in the cornea. It is a multifactorial disease associated with genetic, environmental, nutritional, and metabolic factors. Nutritional and metabolic imbalances can greatly influence the initiation and progression of keratoconus.
Article
Materials Science, Biomaterials
Rodrigo Scopel, Manuel A. Falcao, Angelica Regina Cappellari, Fernanda B. Morrone, Silvia S. Guterres, Eduardo Cassel, Andrea M. Kasko, Rubem M. F. Vargas
Summary: In this study, vitamin D(3) functionalized hybrid lipid-polymer nanoparticles were synthesized to target melanoma cells. The nanoparticles showed efficient cellular uptake and hold promise as a delivery vehicle for melanoma treatment.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2022)
Article
Chemistry, Physical
Alexandre Timm do Espirito Santo, Leandro Martins Siqueira, Rafael Nolibos Almeida, Rubem Mario Figueiro Vargas, Gustavo do N. Franceschini, Mathias Andre Kunde, Angelica Regina Cappellari, Fernanda Bueno Morrone, Eduardo Cassel
Summary: This study aimed to improve the caffeine extraction process of yerba mate and successfully obtained decaffeinated yerba mate with maintained antioxidant properties. Furthermore, cell viability tests showed that extracts from decaffeinated yerba mate decreased cell viability in esophageal cancer cells.
JOURNAL OF SUPERCRITICAL FLUIDS
(2021)
Article
Pharmacology & Pharmacy
Aline Zaparte, Angelica R. Cappellari, Caroline A. Brandao, Julia B. de Souza, Thiago J. Borges, Luiza W. Kist, Mauricio R. Bogo, Luiz F. Zerbini, Luis Felipe Ribeiro Pinto, Talita Glaser, Maria Carolina B. Goncalves, Yahaira Naaldijk, Henning Ulrich, Fernanda B. Morrone
Summary: Esophageal cancer is a global disease with two main subtypes, esophageal squamous cell carcinoma and esophageal adenocarcinoma. Research shows that P2Y(2) receptor activation in esophageal cancer cells promotes cell proliferation and colony formation, while its blockade reduces these effects. Targeting P2Y(2) receptors may have therapeutic potential for esophageal cancer treatment.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Oncology
Thamiris Becker Scheffel, Nathalia Grave, Pedro Vargas, Fernando Mendonca Diz, Liliana Rockenbach, Fernanda Bueno Morrone
Summary: Glioblastoma is a highly malignant subtype of glioma, and the immune landscape within the tumor microenvironment plays a crucial role in influencing therapy outcomes. The presence of multiple immunosuppression pathways, particularly the adenosine pathway, poses significant obstacles to immune-based cancer therapies and can contribute to treatment resistance. Research focusing on immune checkpoints and the adenosine pathway may provide insights into potential targets for improving tumor treatment strategies.
FRONTIERS IN ONCOLOGY
(2021)
Article
Materials Science, Biomaterials
Micael Nunes Melo, Fernanda Menezes Pereira, Matheus Alves Rocha, Jesica Goncalves Ribeiro, Alexander Junges, Wesley Formentin Monteiro, Fernando Mendonca Diz, Rosane Angelica Ligabue, Fernanda Bueno Morrone, Patricia Severino, Alini Tinoco Fricks
Summary: In this study, chitosan and chitosan/polyethylene glycol nanoparticles were successfully used as carriers for encapsulating I3C, showing good stability and encapsulation efficiency. The nanoparticles were extensively characterized, demonstrating their potential application in cancer therapy.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Microscopy
Bruno Silveira Adami, Fernando Mendonca Diz, Gustavo Petry Oliveira Goncalves, Camille Kirinus Reghelin, Matheus Scherer, Artur Pereira Dutra, Ricardo Meurer Papaleo, Jarbas Rodrigues de Oliveira, Fernanda Bueno Morrone, Andrea Wieck, Leder Leal Xavier
Summary: The study demonstrates that quercetin inhibits proliferation and induces apoptosis and senescence in bladder cancer cells. It also causes morphological and mechanical alterations in the cells, including decreased cell viability, cytoplasmic retraction, and membrane condensation. The findings suggest a potential anticancer effect of quercetin through its impact on cellular morphology and mechanics.
Article
Cell Biology
Fernanda Valente Gheler, Angelica Regina Cappellari, Daiana Renck, Julia Brandt de Souza, Renan Oliveira de Melo, Barbara Zanesco Moehlecke, Carolina Aiko Moriguchi, Paula Engroff, Ana Paula Franco Lambert, Liliana Rockenbach, Fernanda Bueno Morrone
Summary: This study evaluated nucleotide hydrolysis in the plasma blood of breast cancer elderly patients, showing higher ATP and AMP hydrolysis levels in patients at the time of diagnosis compared to the control group, and significant reduction in CD73 activity after treatment. Results with a specific inhibitor showed inhibition of AMP hydrolysis.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Aline Machado Lucas, Americia F. M. L. Bento, Rubem Mario Figueiro Vargas, Thamiris Becker Scheffel, Liliana Rockenbach, Fernando Mendonca Diz, Angelica Regina Capellari, Fernanda B. Morrone, Eduardo Cassel
Summary: The methanolic fraction of Baccharis uncinella's supercritical extract demonstrated high antioxidant activity and antitumor effects against bladder cancer and glioblastoma cells, with lower toxicity to normal cells.
JOURNAL OF CO2 UTILIZATION
(2021)
Article
Biochemistry & Molecular Biology
Thamiris Becker Scheffel, Liliana Rockenbach, Fernanda Fernandes Cruz, Luiza Wilges Kist, Mauricio Reis Bogo, Juliete Nathali Scholl, Fabricio Figueiro, Guido Lenz, Fernanda Bueno Morrone
Summary: This study reveals the regulatory role of extracellular ATPase activity in the cytotoxicity and migration process of malignant gliomas.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Behavioral Sciences
Darlan Gusso, Fernanda Fernandes Cruz, Pamella Moreira Fritsch, Marilia Oberto Gobbo, Fernanda Bueno Morrone, Carla Denise Bonan
Summary: This study evaluated the perceived pain in zebrafish larvae by observing behavioral changes. The results showed that acetic acid induced behavioral changes in zebrafish larvae, and compounds such as ethanol, ibuprofen, and paracetamol could prevent these changes. In addition, antagonists and inhibitors of specific channels also prevented the behavioral changes induced by acetic acid. These findings suggest that zebrafish can serve as a translational model for studying pain, as their early developmental stages exhibit behavioral responses similar to mammals.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Cell Biology
Fabricia Dietrich, Angelica Regina Cappellari, Eduardo Cremonese Filippi-Chiela, Patricia Boni de Paula, Julia Brandt de Souza, Stefano Walter Agatti, Roberta Andrejew, Rafael Roesler, Fernanda Bueno Morrone, Ana Maria Oliveira Battastini
Summary: Through clinical data and in vitro experiments, we found that the P2X6 receptor plays a prognostic role in bladder cancer. High expression of P2X6 receptor is associated with increased survival rate in patients. After radiotherapy, P2X6 receptor expression is upregulated in T24 cells but not in RT4 cells.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Pedro Vargas, Thamiris Becker Scheffel, Fernando Mendonca Diz, Liliana Rockenbach, Nathalia Grave, Angelica Regina Cappellari, Luiza Wilges Kist, Mauricio Reis Bogo, Marcos Paulo Thome, Gabriel Fernandes Leal, Amanda de Fraga Dias, Fabricio Figueiro, Eduardo Cremonese Filippi-Chiela, Guido Lenz, Fernanda Bueno Morrone
Summary: This study investigated the role of the P2Y(12) receptor in the proliferation and migration of GBM cells and evaluated its expression in patients' data. The results showed that the P2Y(12) antagonist, ticagrelor, decreased the viability and proliferation of GBM cells and reduced colony formation and migration potentials. The expression of P2Y(12)R was found to be higher in glioma samples, suggesting its importance in glioma development.
PURINERGIC SIGNALLING
(2022)
Article
Multidisciplinary Sciences
Danieli B. Guerra, Elisa M. N. Oliveira, Amanda R. Sonntag, Patricia Sbaraine, Andre P. Fay, Fernanda B. Morrone, Ricardo M. Papaleo
Summary: This study compared the sensitization effects of gold nanoparticles and dextran-coated iron oxide nanoparticles in human glioblastoma cells. The results showed that gold nanoparticles had a higher sensitization effect, while dextran-coated iron oxide nanoparticles had a more modest effect. The nanoparticles were more effective in eliminating radioresistant glioblastoma cells.
SCIENTIFIC REPORTS
(2022)
Review
Pharmacology & Pharmacy
Nathalia Grave, Thamiris Becker Scheffel, Fernanda Fernandes Cruz, Liliana Rockenbach, Marcia Ines Goettert, Stefan Laufer, Fernanda Bueno Morrone
Summary: Gliomas are debilitating malignant brain tumors with limited response to therapies, driven by molecular abnormalities like mutations in regulatory networks. The MAPK pathway, particularly p38 MAPK activation, plays a crucial role in glioma cell invasion and metastasis, and is associated with tumor grade and chemotherapy resistance, underlining its potential as a therapeutic target.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Carla Fernanda Furtado Gardani, Eduardo Luiz Pedrazza, Victoria Santos Paz, Gabriele Goulart Zanirati, Jaderson Costa da Costa, Roberta Andrejew, Henning Ulrich, Juliete Nathali Scholl, Fabricio Figueiro, Liliana Rockenbach, Fernanda Bueno Morrone
Summary: This study investigated the expression of CD39 and CD73 enzymes in prostate cancer and their potential as therapeutic targets. The results showed higher levels of CD39 expression compared to CD73 in tissue samples and a correlation with Gleason score. In blood samples, CD39 expression in extracellular vesicles was significantly increased and positively correlated with ADP hydrolysis and Gleason score.
