Article
Nutrition & Dietetics
Melissa M. Melough, Laura E. Murphy, J. Carolyn Graff, Karen J. Derefinko, Kaja Z. LeWinn, Nicole R. Bush, Daniel A. Enquobahrie, Christine T. Loftus, Mehmet Kocak, Sheela Sathyanarayana, Frances A. Tylavsky
Summary: The study found an association between gestational vitamin D levels and children's IQ at 4-6 years old, with no significant differences in this association between different racial groups.
JOURNAL OF NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Shufei Zeng, Chang Chu, Cornelia Doebis, Volker von Baehr, Berthold Hocher
Summary: There is a strong positive linear correlation between free 25(OH)D (f25(OH)D) and total 25(OH)D, making them useful for assessing vitamin D levels. The recommended threshold level for f25(OH)D is 8.499 pg/mL, corresponding to a target concentration of at least 30 ng/mL for t25(OH)D. The upper limit for vitamin D is still unclear, with most experts favoring a upper limit of 100 ng/mL for t25(OH)D.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Nutrition & Dietetics
Guowei Li, Likang Li, Jonathan D. Adachi, Ruoting Wang, Zebing Ye, Xintong Liu, Lehana Thabane, Gregory Y. H. Lip
Summary: This study found a quasi J-shaped relationship between serum circulating 25-hydroxyvitamin D (25(OH)D) level and risk of recurrent stroke in patients with a stroke history. The lowest risk of recurrent stroke was observed at a 25(OH)D level of approximately 60 nmol/L, which was associated with a 48% reduction in risk compared to a level of 10 nmol/L.
Article
Nutrition & Dietetics
RuTong Wang, Weijing Wang, Ping Hu, Ronghui Zhang, Xue Dong, Dongfeng Zhang
Summary: This study aimed to evaluate the association between dietary vitamin D intake and serum vitamin D concentrations with cognitive performance in older Americans. The results showed a positive association between dietary vitamin D intake, serum total 25-hydroxyvitamin D, and cognitive performance, with no significant gender differences in the associations. Further research is needed to clarify the effects of dietary vitamin D intake and specific serum D concentrations on cognitive performance.
Article
Nutrition & Dietetics
William B. Grant, Fatme Al Anouti, Barbara J. Boucher, Erdinc Dursun, Duygu Gezen-Ak, Edward B. Jude, Tatiana Karonova, Pawel Pludowski
Summary: Vitamin D-3 has important health benefits, but there is a lack of awareness among healthcare professionals and the general public, leading to suboptimal levels of serum 25-hydroxyvitamin D in most of the world's population. High-quality studies show that vitamin D may reduce the risk of cardiovascular disease, cancer, etc., but randomized controlled trials in vitamin D research have flaws.
Article
Nutrition & Dietetics
Sonja Soininen, Aino-Maija Eloranta, Ursula Schwab, Timo A. Lakka
Summary: The purpose of this study was to investigate the intake and sources of vitamin D, as well as the determinants of serum 25-hydroxyvitamin D (S-25(OH)D) in Finnish adolescents. The results showed that most adolescents had vitamin D intake at the recommended level, although a quarter did not meet the recommended intake and almost a third had low levels of S-25(OH)D. The main determinants of S-25(OH)D were vitamin D intake from supplements, consumption of milk products, consumption of meat products, travels to sunny countries, and average daylight time.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Nutrition & Dietetics
Naoko Tsugawa, Mayu Nishino, Akiko Kuwabara, Honami Ogasawara, Maya Kamao, Shunjiro Kobayashi, Junichi Yamamura, Satoshi Higurashi
Summary: The study found that the low vitamin D status in recent lactating mothers may have decreased the concentrations of vitamin D and 25OHD in breast milk, compared to the 1980s. This has important implications for improving the vitamin D status of lactating mothers and infants.
Article
Nutrition & Dietetics
Zhenyu Zhong, Guannan Su, Liping Du, Qingyun Zhou, Fuzhen Li, Wei Chi, Shengyun Liu, Meifen Zhang, Xianbo Zuo, Peizeng Yang
Summary: This study using Mendelian randomization found that genetically increased serum 25-hydroxyvitamin D levels were associated with a higher risk of Behcet's disease, with data from Chinese and Turkish cohorts supporting this conclusion. The contribution to Behcet's disease risk may increase with higher levels of vitamin D.
CLINICAL NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Frank Z. Stanczyk, Intira Sriprasert, Rachel Danis, Raj Pandian, Harpreet Matharu, Nicole Bender, Melissa Natavio
Summary: This study compared the effects of two combined oral contraceptive formulations on 25(OH)D levels and VDBP levels, revealing different impacts. LNG may have a suppressive effect on VDBP. Further research is needed to understand the influence of hormonal contraceptive formulations on vitamin D status and women's health.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Rebecca J. Moon, Laura D. F. Cooke, Stefania D'Angelo, Elizabeth M. Curtis, Philip Titcombe, Justin H. Davies, Keith M. Godfrey, Jane K. Cleal, Rohan M. Lewis, Cyrus Cooper, Nicholas C. Harvey
Summary: There is an association between specific single nucleotide polymorphisms (SNPs) in genes related to vitamin D metabolism pathway and cord blood 25(OH)D in both mothers and offspring, indicating a potential role of genetic factors in this relationship.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Multidisciplinary Sciences
Hsin-Ya Tang, Wang-Sheng Ko, Yuan-Horng Yan, Su-Chen Yu, Ya-ling Chiou
Summary: Shift nurses in Taiwan often experience 25(OH)D deficiency, sleep disturbances, depression, and fatigue. However, no significant correlation was found between 25(OH)D levels and mental health.
SCIENTIFIC REPORTS
(2022)
Article
Pediatrics
Simei Wang, Quanmei Xu, Anqi Wang, Fang Yuan, Xiaona Luo, Yilin Wang, Miao Guo, Yuanfeng Zhang, Wenjing Zhang, Xiaobing Ji, Yun Ren, Yucai Chen
Summary: This study found a correlation between 25-hydroxyvitamin D deficiency and tic disorders (TD) in Chinese children, but no correlation between 25-hydroxyvitamin D deficiency and the severity of TD. Additionally, the deficiency of 25-hydroxyvitamin D was most pronounced in children over the age of 9.
FRONTIERS IN PEDIATRICS
(2022)
Article
Endocrinology & Metabolism
Zhuohui Chen, Menghui Liu, Xingfeng Xu, Lixiang He, Peng Wang, Xiaojie Cai, Rihua Huang, Shaozhao Zhang, Xinghao Xu, Yuhui Lai, Yiquan Huang, Miaohong Li, Yifen Lin, Peihan Xie, Xinxue Liao, Xiaodong Zhuang, Yue Guo
Summary: This study investigated the joint association of serum 25-hydroxyvitamin D [25(OH)D] and klotho with mortality risk in American community-dwelling adults. The results showed that vitamin D-associated mortality risk is observed only with concurrently decreasing klotho, indicating that vitamin D metabolism dysfunction increases the risk of mortality.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Wolfgang Hogler, Katharina Tischlinger, William D. Fraser, Jonathan C. Y. Tang, Suma Uday
Summary: This study examined the impact of maternal socioeconomic status (SES) on newborn vitamin D levels. The results showed that newborns born in the summer had significantly higher vitamin D levels compared to those born in the winter. The study also found that living environment had a significant influence on newborn vitamin D levels.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Vali Musazadeh, Majid Keramati, Faezeh Ghalichi, Zeynab Kavyani, Zohre Ghoreishi, Kamar Allayl Alras, Naryman Albadawi, Abdullah Salem, Mohamed Ismail Albadawi, Raghad Salem, Ahmed Abu-Zaid, Meysam Zarezadeh, Rania A. Mekary
Summary: Meta-analyses on the relationship between vitamin D and depression showed inconsistent results. This umbrella meta-analysis confirms that vitamin D supplementation and higher serum vitamin D levels can significantly reduce the development and symptoms of depression based on the analysis of randomized controlled trials and cohort studies.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Immunology
Pawel Pludowski, Michael F. Holick, Stefan Pilz, Carol L. Wagner, Bruce W. Hollis, William B. Grant, Yehuda Shoenfeld, Elisabeth Lerchbaum, David J. Llewellyn, Katharina Kienreich, Maya Soni
AUTOIMMUNITY REVIEWS
(2013)
Article
Pediatrics
Kumaravel Rajakumar, Evelyn Cohen Reis, Michael F. Holick
CLINICAL PEDIATRICS
(2013)
Article
Endocrinology & Metabolism
Javier de las Heras, Kumaravel Rajakumar, SoJung Lee, Fida Bacha, Michael F. Holick, Silva A. Arslanian
Letter
Gastroenterology & Hepatology
Hannah L. Miller, Francis A. Farraye, Jennifer Coukos, Lauren A. Howard, Michael F. Holick, Arthur F. Stucchi, James M. Becker
INFLAMMATORY BOWEL DISEASES
(2013)
Article
Endocrinology & Metabolism
Rachael M. Biancuzzo, Nigel Clarke, Richard E. Reitz, Thomas G. Travison, Michael F. Holick
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2013)
Article
Endocrinology & Metabolism
J. M. Mata-Granados, J. R. Cuenca-Acevedo, M. D. Luque de Castro, M. F. Holick, J. M. Quesada-Gomez
ARCHIVES OF OSTEOPOROSIS
(2013)
Article
Nutrition & Dietetics
Uwe Groeber, Michael F. Holick
Review
Nutrition & Dietetics
Nipith Charoenngam, Michael F. Holick
Article
Nutrition & Dietetics
Nipith Charoenngam, Sara M. Alexanian, Caroline M. Apovian, Michael F. Holick
Summary: This study found that in COVID-19 patients without T2D, hyperglycemia may be associated with worse outcomes including mortality rate, ICU admission, and acute kidney injury. However, in patients with T2D, hyperglycemia was only associated with ICU admission and acute kidney injury.
Article
Pediatrics
Michael F. Holick, Arash Shirvani, Nipith Charoenngam
Summary: This case report described a male infant with multiple intrauterine fractures resembling osteogenesis imperfecta, whose genetic testing did not support a diagnosis of osteogenesis imperfecta, but identified a new genetic cause for these fractures.
Editorial Material
Nutrition & Dietetics
Michael F. Holick
Article
Nutrition & Dietetics
Ulrich Amon, Raul Yaguboglu, Madeleine Ennis, Michael F. Holick, Julian Amon
Summary: The study shows that high doses of orally applied vitamin D3 for the treatment of autoimmune diseases are safe with proper supervision by experienced physicians. The participants in the study did not experience hypercalcemia or impaired renal function while following a low-calcium diet and adequate fluid intake.
Review
Genetics & Heredity
Nipith Charoenngam, Aryan Nasr, Arash Shirvani, Michael F. Holick
Summary: Hereditary metabolic bone diseases encompass a diverse group of rare diseases with genetic abnormalities in skeletal homeostasis. This review examines 25 selected diseases and genetic variations of 78 genes, covering sclerosing bone disorders, disorders of defective bone mineralization, and disorder of bone matrix and cartilage formation. Advancements in molecular genetics have enabled accurate genetic diagnosis and novel therapeutic strategies for some diseases, but further research is needed for diseases with unclear genetic basis and pathophysiology.
Review
Nutrition & Dietetics
Michael F. F. Holick
Summary: McCollum discovered a fat-soluble nutrient with antirachitic activity and no vitamin A activity, which he named vitamin D. This vitamin has had significant health benefits for children and adults. This review explores the evolution and importance of vitamin D in land vertebrates, beginning with the connection between sunlight, vitamin D production, and the prevention of rickets.
Review
Nutrition & Dietetics
Pawel Pludowski, Beata Kos-Kudla, Mieczyslaw Walczak, Andrzej Fal, Dorota Zozulinska-Ziolkiewicz, Piotr Sieroszewski, Jaroslaw Peregud-Pogorzelski, Ryszard Lauterbach, Tomasz Targowski, Andrzej Lewinski, Robert Spaczynski, Miroslaw Wielgos, Jaroslaw Pinkas, Teresa Jackowska, Ewa Helwich, Artur Mazur, Marek Ruchala, Arkadiusz Zygmunt, Mieczyslaw Szalecki, Artur Bossowski, Justyna Czech-Kowalska, Marek Wojcik, Beata Pyrzak, Michal A. Zmijewski, Pawel Abramowicz, Jerzy Konstantynowicz, Ewa Marcinowska-Suchowierska, Andrius Bleizgys, Spirydon N. Karras, William B. Grant, Carsten Carlberg, Stefan Pilz, Michael F. Holick, Waldemar Misiorowski
Summary: It is found that vitamin D deficiency is prevalent among the Polish population based on epidemiological studies. To address this concern, a Polish multidisciplinary group reviewed the evidence and formulated recommendations for prevention and treatment of vitamin D deficiency. The final Polish recommendations included a range of serum vitamin D levels indicating deficiency, guidelines for prophylaxis and treatment, and the importance of improving the overall population's vitamin D status and treating at-risk patient groups.