Immunologic Effects of Vitamin D on Human Health and Disease

The Effect of Various Doses of Oral Vitamin D3 Supplementation on Gut Microbiota in Healthy Adults: A Randomized, Double-blinded, Dose-response Study

(2020) NIPITH CHAROENNGAM et al.   ANTICANCER RESEARCH

Variable Genomic and Metabolomic Responses to Varying Doses of Vitamin D Supplementation

(2020) ARASH SHIRVANI et al.   ANTICANCER RESEARCH

Vitamin D and Endothelial Function

(2020) Do-Houn Kim et al.   Nutrients

Low Levels of Vitamin D Promote Memory B Cells in Lupus

(2020) Erin A. Yamamoto et al.   Nutrients

Environmental Exposures and Autoimmune Diseases: Contribution of Gut Microbiome

(2020) M. Firoze Khan et al.   Frontiers in Immunology

COVID-19 is Out of Proportion in African Americans. This Will Come as No Surprise…

(2020) Mona N. Fouad et al.   AMERICAN JOURNAL OF MEDICINE

Obesity and its Implications for COVID‐19 Mortality

(2020) William Dietz et al.   Obesity

Gut Microbiome, Intestinal Permeability, and Tissue Bacteria in Metabolic Disease: Perpetrators or Bystanders?

(2020) Rima M. Chakaroun et al.   Nutrients

Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths

(2020) William B. Grant et al.   Nutrients

Vitamin D and intestinal homeostasis: Barrier, microbiota, and immune modulation

(2020) Hana. M.A. Fakhoury et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Fracture Risk in Patients With Inflammatory Bowel Disease

(2019) Jonas F. Ludvigsson et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

The Role of Vitamin D in Inflammatory Bowel Disease: Mechanism to Management

(2019) Jane Fletcher et al.   Nutrients

Vitamin D as a Principal Factor in Mediating Rheumatoid Arthritis-Derived Immune Response

(2019) Muhammad M. Aslam et al.   Biomed Research International

Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions

(2019) Daniel David Bikle et al.   Frontiers in Endocrinology

Vitamin D Supplementation and Prevention of Type 2 Diabetes

(2019) Anastassios G. Pittas et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oral vitamin D3 supplementation increases serum fibroblast growth factor 23 concentration in vitamin D-deficient patients: a systematic review and meta-analysis

(2019) N. Charoenngam et al.   OSTEOPOROSIS INTERNATIONAL

The Vitamin D Binding Protein and Inflammatory Injury: A Mediator or Sentinel of Tissue Damage?

(2019) Richard R. Kew   Frontiers in Endocrinology

Vitamin D status and risk of incident tuberculosis disease: A nested case-control study, systematic review, and individual-participant data meta-analysis

(2019) Omowunmi Aibana et al.   PLOS MEDICINE

Vitamin D receptor activation regulates microglia polarization and oxidative stress in spontaneously hypertensive rats and angiotensin II-exposed microglial cells: Role of renin-angiotensin system

(2019) Changmeng Cui et al.   Redox Biology

Protective effects of vitamin D against injury in intestinal epithelium

(2019) Carol Lee et al.   PEDIATRIC SURGERY INTERNATIONAL

Disassociation of Vitamin D’s Calcemic Activity and Non-calcemic Genomic Activity and Individual Responsiveness: A Randomized Controlled Double-Blind Clinical Trial

(2019) Arash Shirvani et al.   Scientific Reports

Inflammatory Bowel Disease: A Potential Result from the Collusion between Gut Microbiota and Mucosal Immune System

(2019) Bei Yue et al.   Microorganisms

Early High-Dose Vitamin D3 for Critically Ill, Vitamin D–Deficient Patients

(2019)   NEW ENGLAND JOURNAL OF MEDICINE

The ongoing D-lemma of vitamin D supplementation for nonskeletal health and bone health

(2019) Nipith Charoenngam et al.   Current Opinion in Endocrinology Diabetes and Obesity

Vitamin D in inflammatory bowel disease

(2018) John Gubatan et al.   CURRENT OPINION IN GASTROENTEROLOGY

Oral vitamin D3 supplementation for chronic plaque psoriasis: a randomized, double-blind, placebo-controlled trial

(2018) Michelle A. Ingram et al.   JOURNAL OF DERMATOLOGICAL TREATMENT

Vitamin D administration leads to a shift of the intestinal bacterial composition in Crohn's disease patients, but not in healthy controls

(2018) Holger Schäffler et al.   Journal of Digestive Diseases

The concept of the personal vitamin D response index

(2018) Carsten Carlberg et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Serum 25-Hydroxyvitamin D Values and Risk of All-Cause and Cause-Specific Mortality: A Population-Based Cohort Study

(2018) Daniel V. Dudenkov et al.   MAYO CLINIC PROCEEDINGS

The Death D-fying Vitamin

(2018) Michael F. Holick   MAYO CLINIC PROCEEDINGS

Meta-Analysis of the Association between Vitamin D Receptor Polymorphisms and the Risk of Autoimmune Thyroid Disease

(2018) Xue-Ren Gao et al.   International Journal of Endocrinology

Vitamin D levels correlate with lymphocyte subsets in elderly patients with age-related diseases

(2018) Xudong Mao et al.   Scientific Reports

The global tuberculosis epidemic and progress in care, prevention, and research: an overview in year 3 of the End TB era

(2018) Katherine Floyd et al.   Lancet Respiratory Medicine

Vitamin D Attenuates Endothelial Dysfunction in Uremic Rats and Maintains Human Endothelial Stability

(2018) Marc Vila Cuenca et al.   Journal of the American Heart Association

Linking gut microbiota, metabolic syndrome and economic status based on a population-level analysis

(2018) Yan He et al.   Microbiome

Developing a vaccine for type 1 diabetes by targeting coxsackievirus B

(2018) Heikki Hyöty et al.   Expert Review of Vaccines

Vitamin D for the treatment of multiple sclerosis: a meta-analysis

(2018) Laurie McLaughlin et al.   JOURNAL OF NEUROLOGY

Efficacy of vitamin D in treatment of inflammatory bowel disease

(2018) Jinzhong Li et al.   MEDICINE

Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease

(2018) JoAnn E. Manson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy and Safety of 22-Oxa-Calcitriol in Patients with Rheumatoid Arthritis: A Phase II Trial

(2018) Chaohong Li et al.   MEDICAL SCIENCE MONITOR

HLA-DRB1*15 association with multiple sclerosis is confirmed in a multigenerational Italian family

(2017) Lorena Mosca   FUNCTIONAL NEUROLOGY

Cathelicidins display conserved direct antiviral activity towards rhinovirus

(2017) Filipa Henderson Sousa et al.   PEPTIDES

Vitamin D and its role in psoriasis: An overview of the dermatologist and nutritionist

(2017) Luigi Barrea et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data

(2017) Adrian R Martineau et al.   BMJ-British Medical Journal

Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data

(2017) Adrian R Martineau et al.   BMJ-British Medical Journal

Effector T helper cell populations are elevated in the bone marrow of rheumatoid arthritis patients and correlate with disease severity

(2017) Shufeng Li et al.   Scientific Reports

Climates on incidence of childhood type 1 diabetes mellitus in 72 countries

(2017) Yin-ling Chen et al.   Scientific Reports

Active vitamin D3, 1,25-(OH)2D3, protects against macrovasculopathy in a rat model of type 2 diabetes mellitus

(2016) R. Ma et al.   GENETICS AND MOLECULAR RESEARCH

The Associations Between the Polymorphisms of Vitamin D Receptor and Coronary Artery Disease

(2016) Shuai Lu et al.   MEDICINE

Vitamin D Signaling through Induction of Paneth Cell Defensins Maintains Gut Microbiota and Improves Metabolic Disorders and Hepatic Steatosis in Animal Models

(2016) Danmei Su et al.   Frontiers in Physiology

Vitamin D and the Immune System

(2016) Cynthia Aranow   JOURNAL OF INVESTIGATIVE MEDICINE

Vitamin D

(2016) Michael F. Holick   JOURNAL OF INVESTIGATIVE MEDICINE

Membrane Core-Specific Antimicrobial Action of Cathelicidin LL-37 Peptide Switches Between Pore and Nanofibre Formation

(2016) Mahdi Shahmiri et al.   Scientific Reports

High-dose vitamin D3 in adults with pulmonary tuberculosis: a double-blind randomized controlled trial

(2015) Nestan Tukvadze et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Cholecalciferol supplementation improves suppressive capacity of regulatory T-cells in young patients with new-onset type 1 diabetes mellitus — A randomized clinical trial

(2015) Gerlies Treiber et al.   CLINICAL IMMUNOLOGY

Effect of Cholecalciferol Supplementation on Vitamin D Status and Cathelicidin Levels in Sepsis

(2015) Sadeq A. Quraishi et al.   CRITICAL CARE MEDICINE

Role of vitamin D in cytotoxic T lymphocyte immunity to pathogens and cancer

(2015) Surojit Sarkar et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

1,25-Dihydroxy-vitamin D3 regulates NK-cell cytotoxicity, cytokine secretion, and degranulation in women with recurrent pregnancy losses

(2015) Kuniaki Ota et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Adjunctive vitamin D for treatment of active tuberculosis in India: a randomised, double-blind, placebo-controlled trial

(2015) Peter Daley et al.   LANCET INFECTIOUS DISEASES

Type 1 diabetes epidemic in Finland is triggered by zinc-containing amorphous silica nanoparticles

(2015) S.K. Junnila   MEDICAL HYPOTHESES

High-dose Vitamin D3 Supplementation in Children and Young Adults with HIV

(2015) Virginia A. Stallings et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Vitamin D: A New Promising Therapy for Congenital Ichthyosis

(2015) Gomathy Sethuraman et al.   PEDIATRICS

Effect of vitamin D on the recurrence rate of rheumatoid arthritis

(2015) JUNXIA YANG et al.   Experimental and Therapeutic Medicine

Vitamin D and 1,25(OH)2D Regulation of T cells

(2015) Margherita Cantorna et al.   Nutrients

An Evaluation of High-Dose Vitamin D for Rheumatoid Arthritis

(2015) Karen E. Hansen et al.   JCR-JOURNAL OF CLINICAL RHEUMATOLOGY

Significant Effects of Oral Phenylbutyrate and Vitamin D3 Adjunctive Therapy in Pulmonary Tuberculosis: A Randomized Controlled Trial

(2015) Akhirunnesa Mily et al.   PLoS One

Dietary Vitamin D and Its Metabolites Non-Genomically Stabilize the Endothelium

(2015) Christopher C. Gibson et al.   PLoS One

Randomized Controlled Trial of Calcitriol in Severe Sepsis

(2014) David E. Leaf et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Vitamin D-binding protein controls T cell responses to vitamin D

(2014) Martin Kongsbak et al.   BMC IMMUNOLOGY

Polymorphisms of the vitamin D receptor gene and the risk of inflammatory bowel disease: a meta-analysis

(2014) L. Wang et al.   GENETICS AND MOLECULAR RESEARCH

Effect of High-Dose Vitamin D3on Hospital Length of Stay in Critically Ill Patients With Vitamin D Deficiency

(2014) Karin Amrein et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Advances in the cellular immunological pathogenesis of type 1 diabetes

(2014) Min Li et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

1,25-Dihydroxyvitamin D3 Induces CCR10 Expression in Terminally Differentiating Human B Cells

(2014) A.-K. Shirakawa et al.   JOURNAL OF IMMUNOLOGY

The Effects of 1,25-Dihydroxyvitamin D3on In Vitro Human NK Cell Development from Hematopoietic Stem Cells

(2014) Matthew A. Weeres et al.   JOURNAL OF IMMUNOLOGY

Regulation of the extrarenal CYP27B1-hydroxylase

(2014) John S. Adams et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Inflammatory Conditions Induce IRES-Dependent Translation of cyp24a1

(2014) Daniela Rübsamen et al.   PLoS One

Systematic review and meta-analysis on vitamin D receptor polymorphisms and cancer risk

(2014) Yeqiong Xu et al.   TUMOR BIOLOGY

Vitamin D accelerates clinical recovery from tuberculosis: results of the SUCCINCT Study [Supplementary Cholecalciferol in recovery from tuberculosis]. A randomized, placebo-controlled, clinical trial of vitamin D supplementation in patients with pulmonary tuberculosis’

(2013) Nawal Salahuddin et al.   BMC INFECTIOUS DISEASES

A randomized placebo-controlled trial of alphacalcidol on the preservation of beta cell function in children with recent onset type 1 diabetes

(2013) Asal Ataie-Jafari et al.   CLINICAL NUTRITION

Incidence of Type 1 Diabetes in Finland

(2013) Valma Harjutsalo et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Vitamin D for Health: A Global Perspective

(2013) Arash Hossein-nezhad et al.   MAYO CLINIC PROCEEDINGS

Vitamin D Is a Regulator of Endothelial Nitric Oxide Synthase and Arterial Stiffness in Mice

(2013) Olena Andrukhova et al.   MOLECULAR ENDOCRINOLOGY

Influence of Vitamin D Status and Vitamin D3 Supplementation on Genome Wide Expression of White Blood Cells: A Randomized Double-Blind Clinical Trial

(2013) Arash Hossein-nezhad et al.   PLoS One

Primary Vitamin D Target Genes Allow a Categorization of Possible Benefits of Vitamin D3 Supplementation

(2013) Carsten Carlberg et al.   PLoS One

Role of vitamin D in flare ups of rheumatoid arthritis

(2013) A. Dehghan et al.   ZEITSCHRIFT FUR RHEUMATOLOGIE

Vitamin D Intake and Risk of Type 1 Diabetes: A Meta-Analysis of Observational Studies

(2013) Jia-Yi Dong et al.   Nutrients

Vitamin D and Immune Function

(2013) Barbara Prietl et al.   Nutrients

The Vitamin D Receptor and T Cell Function

(2013) Martin Kongsbak et al.   Frontiers in Immunology

Effect of Cholecalciferol as Adjunctive Therapy With Insulin on Protective Immunologic Profile and Decline of Residual β-Cell Function in New-Onset Type 1 Diabetes Mellitus

(2012) Mônica A. L. Gabbay et al.   ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE

Vitamin D and polymorphisms of VDR gene in patients with systemic lupus erythematosus

(2012) Odirlei André Monticielo et al.   CLINICAL RHEUMATOLOGY

Vitamin D status indicators in indigenous populations in East Africa

(2012) Martine F. Luxwolda et al.   EUROPEAN JOURNAL OF NUTRITION

Vitamin D metabolism, functions and needs: from science to health claims

(2012) S. Battault et al.   EUROPEAN JOURNAL OF NUTRITION

The human cathelicidin LL-37 inhibits influenza A viruses through a mechanism distinct from that of surfactant protein D or defensins

(2012) S. Tripathi et al.   JOURNAL OF GENERAL VIROLOGY

Global Epidemiology of Psoriasis: A Systematic Review of Incidence and Prevalence

(2012) Rosa Parisi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Deficiency of serum concentration of 25-hydroxyvitamin D in psoriatic patients: A case-control study

(2012) Jacinto Orgaz-Molina et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Vitamin D Responsive Elements within the HLA-DRB1 Promoter Region in Sardinian Multiple Sclerosis Associated Alleles

(2012) Eleonora Cocco et al.   PLoS One

Is the north to south gradient in inflammatory bowel disease a global phenomenon?

(2012) Michael Schultz et al.   Expert Review of Gastroenterology & Hepatology

Vitamin D and rheumatoid arthritis

(2012) Ifigenia Kostoglou-Athanassiou et al.   Therapeutic Advances in Endocrinology and Metabolism

The Acute Respiratory Distress Syndrome: Pathogenesis and Treatment

(2011) Michael A. Matthay et al.   Annual Review of Pathology-Mechanisms of Disease

1,25-dihydroxyvitamin D3 impairs NF-κB activation in human naïve B cells

(2011) Kerstin Geldmeyer-Hilt et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

1α,25-Dihydroxycholecalciferol Induces Nitric Oxide Production in Cultured Endothelial Cells

(2011) Claudio Molinari et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Higher Predicted Vitamin D Status Is Associated With Reduced Risk of Crohn's Disease

(2011) Ashwin N. Ananthakrishnan et al.   GASTROENTEROLOGY

Use of a novel vitamin D bioavailability test demonstrates that vitamin D absorption is decreased in patients with quiescent crohnʼs disease1,2,3

(2011) F. A. Farraye et al.   INFLAMMATORY BOWEL DISEASES

Supplementation of 1,25 dihydroxy vitamin D3 in patients with treatment naive early rheumatoid arthritis: a randomised controlled trial

(2011) Kiran GOPINATH et al.   International Journal of Rheumatic Diseases

Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline

(2011) Michael F. Holick et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Vitamin D and the anti-viral state

(2011) Jeremy A. Beard et al.   JOURNAL OF CLINICAL VIROLOGY

Latitude is significantly associated with the prevalence of multiple sclerosis: a meta-analysis

(2011) S. Simpson et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

High-dose vitamin D3 during intensive-phase antimicrobial treatment of pulmonary tuberculosis: a double-blind randomised controlled trial

(2011) Adrian R Martineau et al.   LANCET

Axonal Damage in Multiple Sclerosis

(2011) Jeffery D. Haines et al.   MOUNT SINAI JOURNAL OF MEDICINE

Antiviral Activity and Increased Host Defense against Influenza Infection Elicited by the Human Cathelicidin LL-37

(2011) Peter G. Barlow et al.   PLoS One

Vitamin D, invariant natural killer T-cells and experimental autoimmune disease

(2011) Margherita T. Cantorna et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Efficacy of Vitamin D in patients with active rheumatoid arthritis receiving methotrexate therapy

(2011) Mansour Salesi et al.   RHEUMATOLOGY INTERNATIONAL

Mycobacterium Tuberculosis Infection and Inflammation: what is Beneficial for the Host and for the Bacterium?

(2011) Smitha J. Sasindran et al.   Frontiers in Microbiology

Regulation of Phosphate Homeostasis by PTH, Vitamin D, and FGF23

(2010) Clemens Bergwitz et al.   Annual Review of Medicine

Vitamin D and the intracrinology of innate immunity

(2010) Martin Hewison   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Serum 25-Hydroxyvitamin D and the Incidence of Acute Viral Respiratory Tract Infections in Healthy Adults

(2010) James R. Sabetta et al.   PLoS One

Vitamin D3 down-regulates intracellular Toll-like receptor 9 expression and Toll-like receptor 9-induced IL-6 production in human monocytes

(2010) L. J. Dickie et al.   RHEUMATOLOGY

Vitamin D as Supplementary Treatment for Tuberculosis

(2009) Christian Wejse et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Direct and Indirect Induction by 1,25-Dihydroxyvitamin D3of the NOD2/CARD15-Defensin β2 Innate Immune Pathway Defective in Crohn Disease

(2009) Tian-Tian Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ligation of TLR9 induced on human IL-10–secreting Tregs by 1α,25-dihydroxyvitamin D3 abrogates regulatory function

(2009) Zoë Urry et al.   JOURNAL OF CLINICAL INVESTIGATION

1,25-Dihydroxyvitamin D3 Is an Autonomous Regulator of the Transcriptional Changes Leading to a Tolerogenic Dendritic Cell Phenotype

(2009) L. Szeles et al.   JOURNAL OF IMMUNOLOGY

1,25-Dihydroxyvitamin D3 and IL-2 Combine to Inhibit T Cell Production of Inflammatory Cytokines and Promote Development of Regulatory T Cells Expressing CTLA-4 and FoxP3

(2009) L. E. Jeffery et al.   JOURNAL OF IMMUNOLOGY

Calcitriol Suppresses Antiretinal Autoimmunity through Inhibitory Effects on the Th17 Effector Response

(2009) J. Tang et al.   JOURNAL OF IMMUNOLOGY

Vitamin D-Directed Rheostatic Regulation of Monocyte Antibacterial Responses

(2009) J. S. Adams et al.   JOURNAL OF IMMUNOLOGY

Circulating Th17, Th22, and Th1 Cells Are Increased in Psoriasis

(2009) Shinji Kagami et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Expression of the Multiple Sclerosis-Associated MHC Class II Allele HLA-DRB1*1501 Is Regulated by Vitamin D

(2009) Sreeram V. Ramagopalan et al.   PLoS Genetics

1,25-dihydroxyvitamin D3promotes IL-10 production in human B cells

(2008) Guido Heine et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Low serum vitamin D levels and tuberculosis: a systematic review and meta-analysis

(2008) K. E Nnoaham et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY