Editorial Material
Plant Sciences
Ralf Welsch, Alisher Touraev, Klaus Palme
Summary: The fertilized egg is the starting point for multicellular organism development, plant cells have the ability to regenerate, and the fate of regenerating tissues is regulated by plant hormones.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Review
Pharmacology & Pharmacy
Wenjing Xiao, Qiaodan Zhou, Xudong Wen, Rui Wang, Ruijie Liu, Tingting Wang, Jianyou Shi, Yonghe Hu, Jun Hou
Summary: Cancer treatment remains a significant challenge globally, with epigenetic modification being identified as a key target for drug development. By adding chemical groups to the DNA backbone and modifying chromatin architecture through various enzymes, epigenetic drugs have shown promising effects in both preclinical and clinical studies. Developing small-molecule inhibitors targeting epigenetic modified enzymes has become a focus for future cancer therapy research.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Peiyuan Zhang, Xiaohui Liu, Daniel Abegg, Toru Tanaka, Yuquan Tong, Raphael I. Benhamou, Jared Baisden, Gogce Crynen, Samantha M. Meyer, Michael D. Cameron, Arnab K. Chatterjee, Alexander Adibekian, Jessica L. Childs-Disney, Matthew D. Disney
Summary: By reprogramming Dovitinib to target pre-miR-21, researchers successfully improved selectivity across different biomolecules and alleviated disease progression in mouse models of breast cancer and Alport Syndrome.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Medicine, Research & Experimental
Lihua Wang, Zheng Zhu, Qi Liang, Yecheng Tao, Gaowei Jin, Yaoyao Zhong, Jichen Dai, Ruixia Dai, Zhixiang Wang, Junbo Chen, Lingjie Zhou, Shouyu Ke, Bin Zheng, Linhua Lan, Xiaokun Lin, Tongke Chen
Summary: This study confirms that WZ35 is a small molecule glycolysis inhibitor that inhibits the proliferation activity of liver cancer cells through metabolic reprogramming. GLUT1-YAP has important reference significance for predicting disease progression stages in liver cancer patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Ke Wu, Eduard Karapetyan, John Schloss, Jaydutt Vadgama, Yong Wu
Summary: In this article, the recent advancements in small molecule drug design are outlined with a focus on structural perspective. Protein structure prediction methods are compared and the role of ligand binding pocket in structure-based drug design is explored. Various structural features such as functional groups, stereochemistry, and molecular weight are examined for optimizing drug candidates. Computational tools like molecular docking and virtual screening are discussed for predicting and refining drug candidate structures. Examples of drug candidates designed based on their molecular structure are presented and future directions in the field are discussed. Integrating structural information with other valuable data sources can improve the drug discovery process, leading to the identification of novel therapeutics with improved efficacy, specificity, and safety profiles.
DRUG DISCOVERY TODAY
(2023)
Review
Pharmacology & Pharmacy
Wenyue Zheng, Erkang Tian, Zhen Liu, Changhan Zhou, Pei Yang, Keyue Tian, Wen Liao, Juan Li, Changyu Ren
Summary: Angiotensin-converting enzyme inhibitors are drugs used to treat cardiovascular and kidney diseases. Researchers have been focusing on improving the selectivity of these drugs and developing novel ACE inhibitors to reduce their adverse effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Jingyi Wang, Shiling Chen, Chao Pan, Gaigai Li, Zhouping Tang
Summary: This review discusses the use of small molecules to directly reprogram somatic cells into neurons for the treatment of neurological diseases. The mechanisms of action of different small molecules, methods to screen small molecule cocktails, and approaches to detect their reprogramming efficiency are discussed. Future research efforts should focus on investigating the in vivo mechanisms of small molecule-mediated neuronal reprogramming under pathophysiological conditions, optimizing screening cocktails and dosing regimens, and identifying safe and effective delivery routes to promote neural regeneration in different neurological diseases.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Moon Kee Meang, Saesbyeol Kim, Ik-Hwan Kim, Han-Soo Kim, Byung-Soo Youn
Summary: This study found that the compound ONG41008 has both senogenic and senolytic potential, which can arrest uncontrolled proliferation in fibrogenesis or tumorigenesis. It induces cellular senescence and mitotic slippage in tumor cells, while showing no significant toxicity to normal cells. ONG41008 can distinguish between normal cells and aged or diseased cells and restore the important metabolic ratio in cancer cells. It could be a potential drug for fibrotic or tumorigenic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Yuxuan Zhang, Junnan Li, Nikolay Kornienko
Summary: Electrosynthetic technologies play a significant role in generating fuels and chemicals for today's society amidst a growing focus on renewable energy. The main challenges lie in discovering novel reaction routes and innovative catalytic systems to expand the scope of electrosynthesis.
CELL REPORTS PHYSICAL SCIENCE
(2021)
Review
Pharmacology & Pharmacy
Tristan S. Maurer, Martin Edwards, David Hepworth, Patrick Verhoest, Charlotte M. N. Allerton
Summary: Successful small-molecule drug design requires the right molecular target and a suitable molecule, and current drug design strategies have little room for improvement, which has led to inadequate safety and efficacy of molecular targets becoming the main problem in preclinical development. Therefore, drug designers now need to pay more attention to target selection and seek methods to accelerate the discovery of the next generation of medicines.
DRUG DISCOVERY TODAY
(2022)
Review
Medicine, Research & Experimental
Yingying Lu, Zhijia Li, Shuangqian Zhang, Tongtong Zhang, Yanjun Liu, Lan Zhang
Summary: Cellular mitophagy refers to the process in which cells selectively wrap and degrade damaged mitochondria through autophagy, thus maintaining mitochondrial and intracellular homeostasis. In recent years, mitophagy has gained attention as a research hotspot in the pathogenesis of various clinical diseases. It has been discovered that regulating mitophagy may open up new directions for disease treatment. Additionally, there have been reports of small molecule modulators of mitophagy, providing opportunities to understand the process and potential for therapeutic development.
Review
Developmental Biology
Sydney Leaman, Nicolas Marichal, Benedikt Berninger
Summary: Cellular identity can be reprogrammed through gene regulatory networks, and recent research suggests that this reprogramming can mitigate disease phenotypes.
Article
Chemistry, Multidisciplinary
Timothy Kench, Peter A. Summers, Marina K. Kuimova, James E. M. Lewis, Ramon Vilar
Summary: The efficacy of many drugs can be limited by undesirable properties, such as poor aqueous solubility, low bioavailability, and off-target interactions. Various drug carriers have been investigated to enhance the pharmacological profile of therapeutic agents. In this work, mechanical protection is used to cage a DNA-targeting metallodrug within a photodegradable rotaxane, which showed enhanced cell permeability and limited cytotoxicity within osteosarcoma cells compared to the free drug. Light activation led to a dramatic increase in cytotoxicity, arising from the translocation of Pt-II-salphen to the nucleus and its binding to DNA.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Chemistry, Multidisciplinary
Junling Yin, Ling Huang, Luling Wu, Jiangfeng Li, Tony D. James, Weiying Lin
Summary: The microenvironment within specific organelles plays a vital role in cellular processes and physiological functions. Monitoring and understanding the variations in the microenvironment is essential for identifying disease development. Progress has been made in developing fluorescent probes to study the microenvironment within specific cellular regions, but comprehensive research on small-molecule fluorescent chemosensors for cellular microenvironments is still needed.
CHEMICAL SOCIETY REVIEWS
(2021)
Article
Medicine, Research & Experimental
Isha Rakheja, Asgar Hussain Ansari, Arjun Ray, Dheeraj Chandra Joshi, Souvi Maiti
Summary: This study demonstrates that quercetin binds strongly to the triple-helix structure of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and modulates its functions. The binding of quercetin to MALAT1 is a spontaneous interaction with a stoichiometry of 1:1 and a negative change in free energy. Furthermore, quercetin downregulates the transcript levels of MALAT1 and reduces its expression in nuclear speckles, leading to modulation of downstream genes.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Biochemistry & Molecular Biology
Tao Nie, Xiaoyan Hui, Xuefei Gao, Baoming Nie, Liufeng Mao, Xiaofeng Tang, Ran Yuan, Kuai Li, Peng Li, Aimin Xu, Pengtao Liu, Sheng Ding, Weiping Han, Garth J. S. Cooper, Donghai Wu
BIOCHEMICAL JOURNAL
(2015)
Article
Cell Biology
Tianhua Ma, Jun Li, Yue Xu, Chen Yu, Tao Xu, Haixia Wang, Kai Liu, Nan Cao, Bao-ming Nie, Sai-yong Zhu, Shaohua Xu, Ke Li, Wan-guo Wei, Yuzhang Wu, Kun-liang Guan, Sheng Ding
NATURE CELL BIOLOGY
(2015)
Article
Cell & Tissue Engineering
Yu Zhang, Nan Cao, Yu Huang, C. Ian Spencer, Ji-dong Fu, Chen Yu, Kai Liu, Baoming Nie, Tao Xu, Ke Li, Shaohua Xu, Benoit G. Bruneau, Deepak Srivastava, Sheng Ding
Article
Endocrinology & Metabolism
Liufeng Mao, Baoming Nie, Tao Nie, Xiaoyan Hui, Xuefei Gao, Xiaoliang Lin, Xin Liu, Yong Xu, Xiaofeng Tang, Ran Yuan, Kuai Li, Peng Li, Ke Ding, Yu Wang, Aimin Xu, Jian Fei, Weiping Han, Pentao Liu, Lise Madsen, Karsten Kristiansen, Zhiguang Zhou, Sheng Ding, Donghai Wu
Article
Multidisciplinary Sciences
Nan Cao, Yu Huang, Jiashun Zheng, C. Ian Spencer, Yu Zhang, Ji-Dong Fu, Baoming Nie, Min Xie, Mingliang Zhang, Haixia Wang, Tianhua Ma, Tao Xu, Guilai Shi, Deepak Srivastava, Sheng Ding
Article
Multidisciplinary Sciences
Tao Nie, Xiaoyan Hui, Liufeng Mao, Baoming Nie, Kuai Li, Wei Sun, Xuefei Gao, Xiaofeng Tang, Yong Xu, Baishan Jiang, Zhengcao Tu, Peng Li, Ke Ding, Weiping Han, Shaoping Zhang, Aimin Xu, Sheng Ding, Pentao Liu, Adam Patterson, Garth Cooper, Donghai Wu
SCIENTIFIC REPORTS
(2016)
Article
Cell Biology
Baoming Nie, Tao Nie, Xiaoyan Hui, Ping Gu, Liufeng Mao, Kuai Li, Ran Yuan, Jiashun Zheng, Haixia Wang, Ke Li, Shibing Tang, Yu Zhang, Tao Xu, Aimin Xu, Donghai Wu, Sheng Ding
Article
Cell & Tissue Engineering
Kenji Kozuka, Ying He, Samantha Koo-Mccoy, Padmapriya Kumaraswamy, Baoming Nie, Karen Shaw, Priscilla Chan, Michael Leadbetter, Limin He, Jason G. Lewis, Ziyang Zhong, Dominique Charmot, Marwan Balaa, Andrew J. King, Jeremy S. Caldwell, Matthew Siegel
Article
Cell Biology
Baoming Nie, Ni Cheng, Mary C. Dinauer, Richard D. Ye
CELLULAR SIGNALLING
(2010)
Article
Biochemistry & Molecular Biology
Xiaoyan Jiang, Baoming Nie, Saili Fu, Jianguo Hu, Lan Yin, Lin Lin, Xiaofei Wang, Peihua Lu, Xiao-Ming Xu
JOURNAL OF MOLECULAR NEUROSCIENCE
(2009)
Article
Neurosciences
Bao-Ming Nie, Xiao-Yan Jiang, Jin-Xian Cai, Sai-Li Fu, Li-Min Yang, Lin Lin, Qin Hang, Pei-Lua Lu, Yang Lu
Article
Cell Biology
Andrew J. King, Matthew Siegel, Ying He, Baoming Nie, Ji Wang, Samantha Koo-McCoy, Natali A. Minassian, Qumber Jafri, Deng Pan, Jill Kohler, Padmapriya Kumaraswamy, Kenji Kozuka, Jason G. Lewis, Dean Dragoli, David P. Rosenbaum, Debbie O'Neill, Allein Plain, Peter J. Greasley, Ann-Cathrine Jonsson-Rylander, Daniel Karlsson, Margareta Behrendt, Maria Stromstedt, Tina Ryden-Bergsten, Thomas Knopfel, Eva M. Pastor Arroyo, Nati Hernando, Joanne Marks, Mark Donowitz, Carsten A. Wagner, R. Todd Alexander, Jeremy S. Caldwell
SCIENCE TRANSLATIONAL MEDICINE
(2018)
Article
Cell Biology
Haixia Wang, Nan Cao, C. Ian Spencer, Baoming Nie, Tianhua Ma, Tao Xu, Yu Zhang, Xiaojing Wang, Deepak Srivastava, Sheng Ding
Meeting Abstract
Gastroenterology & Hepatology
Helene Baribault, Jianhua Chao, Kenji Kozuka, I-Hsin Hsu, Limin He, Padmapriya Kumaraswamy, Matthew Siegel, Ying He, Baoming Nie, Samantha Koo-Mccoy, Christopher Carreras, Qumber Jafri, Christine Dowd, Patricia Finn, Jason Lewis, Rakesh Jain, Andrew King, Jeremy S. Caldwell
