Review
Plant Sciences
Yutaro Shimizu, Tomohiro Uemura
Summary: Membrane trafficking is crucial for organelle maintenance and function, and the TGN plays a critical role as a sorting station. Recent studies have identified distinct subdomains of the TGN for different trafficking pathways.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Plant Sciences
Emi Ito, Tomohiro Uemura
Summary: This article mainly introduces the basic principles of membrane traffic and its diversity in plants. Through the study of regulators in the trans-Golgi network, it summarizes their functions in different transport pathways and their roles in plant development and environmental stimuli.
JOURNAL OF PLANT RESEARCH
(2022)
Article
Plant Sciences
Qijiang Cao, Wei Zhang, Xinyan Liu, Yan Li
Summary: In Arabidopsis, the AtFTCD-L protein is localized on the TGN vesicles in root cap cells and plays a role in regulating root growth and extracellular secretion of mucilage components.
Article
Plant Sciences
Alastair J. J. McGinness, Jennifer Schoberer, Charlotte Pain, Federica Brandizzi, Verena Kriechbaumer
Summary: In plant cells, the endoplasmic reticulum (ER) and Golgi bodies are closely connected and recent research has shown dynamic connections between pre-cis-Golgi cisternae and ERES. Fine tubular structures observed between the ER and Golgi as well as between the ER and ERES may be involved in stabilizing the physical connection between ER and ERES/Golgi cisternae, and may also play a role in cargo transport from the ER to Golgi bodies.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Cell Biology
Torsten W. B. Goetz, Dmytro Puchkov, Veronika Lysiuk, Janine Luetzkendorf, Alexander G. Nikonenko, Christine Quentin, Martin Lehmann, Stephan J. Sigrist, Astrid G. Petzoldt
Summary: This study demonstrates that mutations in the small GTPase Rab2 lead to accumulation of presynaptic material in the neuronal cell body, resulting in neurotransmission deficits. This abnormal assembly process is dependent on Rab2-regulated protein export and sorting at the trans-Golgi, ultimately affecting neurotransmission.
JOURNAL OF CELL BIOLOGY
(2021)
Review
Anatomy & Morphology
Irina S. Sesorova, Ivan D. Dimov, Alexandre D. Kashin, Vitaly V. Sesorov, Natalia R. Karelina, Maria A. Zdorikova, Galina Beznoussenko, Alexander A. Mironov
Summary: The article provides an in-depth analysis of the process of lipid transcytosis through mammalian enterocytes and their absorption into lymph. It outlines the key steps involved in the process, including the role of cellular organelles and their interactions, leading to the functional outcomes of lipid transport.
Editorial Material
Biotechnology & Applied Microbiology
Christiaan M. de Bloeme, Robin W. Jansen, Mark R. L. Krul, Ernst-Jan Geutjes
Summary: Analyzing the history of oncology deals can assist bioentrepreneurs in determining the optimal timing for partnerships and exits, as well as identifying the types of investors likely to show interest.
NATURE BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Patricia Franzka, Svenja Caren Schueler, Takfarinas Kentache, Robert Storm, Andrea Bock, Istvan Katona, Joachim Weis, Katrin Buder, Christoph Kaether, Christian A. Hubner
Summary: Proteins of the secretory pathway undergo glycosylation in the ER and Golgi apparatus. Mutations in GMPPA can cause AAMR syndrome with various symptoms. Loss of GMPPA leads to Golgi fragmentation, altered protein abundance, reduced furin activity, and increased retention of alpha-DG.
Article
Virology
Kannu Priya Pandey, Yan Zhou
Summary: The NLRP3 inflammasome is an important immune response against influenza A virus (IAV) infection. This study investigates the role of TGN dispersion and a viral protein, M2, in the activation of the NLRP3 inflammasome during IAV infection.
Article
Biochemistry & Molecular Biology
Naini Chakraborty, Bhawik Kumar Jain, Samruddhi Shembekar, Dibyendu Bhattacharyya
Summary: This study investigates the potential functional link between ER-mitochondria encounter structures (ERMES) and ER exit sites (ERES). The disruption of either ERMES or ERES affects the other, and a chaperone protein, Djp1, is found to regulate mitochondrial protein import in the ERES-ERMES proximal region.
Article
Biology
Jonas Birkelund Nilsson, Saghar Kaabinejadian, Hooman Yari, Bjoern Peters, Carolina Barra, Loren Gragert, William Hildebrand, Morten Nielsen
Summary: This study addresses the prediction of HLA-DQ antigen presentation and the contribution of trans-only variants in shaping the HLA-DQ immunopeptidome. By integrating immunoinformatics data mining models with mass spectrometry immunopeptidomics data, the study demonstrates improved predictive power and molecular coverage for models trained with novel HLA-DQ data. The study also reveals the limited contribution of trans-only HLA-DQ variants to the overall HLA-DQ immunopeptidome.
COMMUNICATIONS BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Kamari Weaver, Rachid Skouta
Summary: This review provides a comprehensive overview of the research on GPX4, highlighting its role as a potential therapeutic target.
Article
Cell Biology
Cheng Zhang, Hong-Ming Ma, Shuang-Shu Dong, Na Zhang, Ping He, Meng-Kai Ge, Li Xia, Jian-Xiu Yu, Qiang Xia, Guo-Qiang Chen, Shao-Ming Shen
Summary: PTEN alpha and PTEN beta proteins are cleaved into two fragments by Furin enzyme after secretion into the extracellular space. Although these cleaved fragments cannot enter cells, the purified C-terminal fragment has a tumor-suppressive role in vivo. Therefore, the C-terminal fragment may be a potential exogenous agent for cancer treatment.
CELL DEATH & DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Saori Noguchi, Shigeomi Shimizu
Summary: GOMED is an autophagy-like proteolysis mechanism that preferentially degrades Golgi-trafficking proteins, including insulin granules in pancreatic beta-cells and ceruloplasmin in neurons, and is involved in various physiological events. Although it morphologically resembles canonical autophagy, GOMED functions differently as it degrades different substrates and uses different membrane sources, with core molecules that are completely distinct.
Editorial Material
Biochemistry & Molecular Biology
Anna Stoeckl
Summary: A recent study has uncovered the neural basis of the exceptional color vision in the Asian swallowtail butterfly, which relies on two circuit motifs: color opponency of photoreceptors and broadband color integration by lamina neurons.
Article
Cell Biology
Mihaela Anitei, Christoph Stange, Cornelia Czupalla, Christian Niehage, Kai Schuhmann, Pia Sala, Aleksander Czogalla, Theresia Pursche, Uenal Coskun, Andrej Shevchenko, Bernard Hoflack
Article
Cell Biology
Mihaela Anitei, Ramu Chenna, Cornelia Czupalla, Milan Esner, Sara Christ, Steffi Lenhard, Kerstin Korn, Felix Meyenhofer, Marc Bickle, Marino Zerial, Bernard Hoflack
JOURNAL OF CELL SCIENCE
(2014)
Article
Neurosciences
Mihaela Anitei, Ann E. Cowan, Steven E. Pfeiffer, Rashmi Bansal
JOURNAL OF NEUROSCIENCE RESEARCH
(2009)
Article
Cell Biology
Thorsten Baust, Mihaela Anitei, Cornelia Czupalla, Iryna Parshyna, Line Bourel, Christoph Thiele, Eberhard Krause, Bernard Hoflack
MOLECULAR BIOLOGY OF THE CELL
(2008)
Review
Biochemistry & Molecular Biology
Mihaela Anitei, Thomas Wassmer, Christoph Stange, Bernard Hoflack
MOLECULAR MEMBRANE BIOLOGY
(2010)
Correction
Cell Biology
Mihaela Anitei, Christoph Stange, Irina Parshina, Thorsten Baust, Annette Schenck, Graca Raposo, Tomas Kirchhausen, Bernard Hoflack
NATURE CELL BIOLOGY
(2010)
Article
Cell Biology
Mihaela Anitei, Christoph Stange, Irina Parshina, Thorsten Baust, Annette Schenck, Graca Raposo, Tomas Kirchhausen, Bernard Hoflack
NATURE CELL BIOLOGY
(2010)
Review
Cell Biology
Mihaela Anitei, Bernard Hoflack
NATURE CELL BIOLOGY
(2012)
Article
Multidisciplinary Sciences
Tobias Heckel, Cornelia Czupalla, Ana Isabel Expirto Santo, Mihaela Anitei, Maria Arantzazu Sanchez-Fernandez, Kerstin Mosch, Eberhard Krause, Bernard Hoflack
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2009)
Meeting Abstract
Neurosciences
M. Anitei, M. Ifrim, M-A. Ewart, A. E. Cowan, J. H. Carson, R. Bansal, S. E. Pfeiffer
NEURON GLIA BIOLOGY
(2007)
Review
Cell Biology
M Anitei, M Ifrim, MA Ewart, AE Cowan, JH Carson, R Bansal, SE Pfeiffer
JOURNAL OF CELL SCIENCE
(2006)
Meeting Abstract
Biochemistry & Molecular Biology
M Anitei, MF Ifrim, R Bansal, J Carson, SE Pfeiffer
JOURNAL OF NEUROCHEMISTRY
(2005)
Meeting Abstract
Biochemistry & Molecular Biology
M Anitei, MF Ifrim, MA Ewart, R Bansal, JH Carson, SE Pfeiffer
JOURNAL OF NEUROCHEMISTRY
(2005)