Article
Neurosciences
Tim West, Kristopher M. Kirmess, Matthew R. Meyer, Mary S. Holubasch, Stephanie S. Knapik, Yan Hu, John H. Contois, Erin N. Jackson, Scott E. Harpstrite, Randall J. Bateman, David M. Holtzman, Philip B. Verghese, Ilana Fogelman, Joel B. Braunstein, Kevin E. Yarasheski
Summary: The development of a high-resolution mass spectrometry-based plasma biomarker test shows strong diagnostic performance in distinguishing brain amyloid status for Alzheimer's disease and may enhance the efficiency of enrolling participants into AD drug trials.
MOLECULAR NEURODEGENERATION
(2021)
Article
Clinical Neurology
David D. Ward, Lindsay M. K. Wallace, Kenneth Rockwood
Summary: This study aimed to investigate the association between health-deficit accumulation and the risks of MCI and dementia independently of the APOE genotype; the results showed that an increasing frailty index was associated with a higher risk of developing MCI and dementia, regardless of the presence of the APOE e4 allele.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Immunology
Sarah A. Cooley, Brittany Nelson, Anna Boerwinkle, Kevin E. Yarasheski, Kris M. Kirmess, Matthew R. Meyer, Suzanne E. Schindler, John C. Morris, Anne Fagan, Beau M. Ances, Jane A. O'Halloran
Summary: The plasma amyloid-beta (A beta) 42/A beta 40 ratio, a blood-based biomarker for brain amyloid in Alzheimer disease, is not abnormal in older cognitively normal or cognitively impaired people with HIV.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Cell Biology
Heather M. Wilkins, Xiaowan Wang, Blaise W. Menta, Scott J. Koppel, Rebecca Bothwell, Annette M. Becker, Heidi Anderson, Erin Schwartz, Dong Pei, Nanda K. Yellapu, Prabhakar Chalise, Cynthia M. Gouvion, Mohammad Haeri, Jeffrey M. Burns, Russell H. Swerdlow
Summary: The study revealed that the APOE ε4 genotype affects platelet and lymphocyte metabolism in Alzheimer's disease patients, showing lower platelet mitochondrial activity and higher lymphocyte apoptosis markers in APOE ε4 carriers. Proteins related to mitophagy and energy sensing were elevated in APOE ε4 lymphocytes, possibly representing compensatory changes. RNA sequencing also indicated activation of inflammatory pathways and modulation of bioenergetic signaling in APOE ε4 carriers.
Article
Clinical Neurology
Young Won Kim, Ismael Al-Ramahi, Amanda Koire, Stephen J. Wilson, Daniel M. Konecki, Samantha Mota, Shirin Soleimani, Juan Botas, Olivier Lichtarge
Summary: The study found that the roles of APOE e4 and APOE e2 in Alzheimer's disease are inconsistent, and identified potential genetic modifiers through comparing coding variations in different genes, which may provide robust predictive power for risk stratification and offer potential clues for new biomarkers and therapeutic interventions.
ALZHEIMERS & DEMENTIA
(2021)
Review
Chemistry, Analytical
Xingyun Liu, Yibiao Liu, Qiong Liu
Summary: Alzheimer's disease (AD) is a neurodegenerative disease characterized by memory loss and cognitive impairment. Early diagnosis is crucial for intervention and treatment effectiveness assessment, but current clinical methods are costly and inaccessible. Blood sample detection offers a less invasive and more accessible alternative, with various assays developed for the detection of AD biomarkers. Fluorescence-sensing techniques, with their low toxicity and high sensitivity, can not only detect biomarker levels in blood but also image them in the brain in real time. This review summarizes the recent development of fluorescent sensing platforms and their potential clinical applications.
Article
Clinical Neurology
Jing Qian, Rebecca A. Betensky, Bradley T. Hyman, Alberto Serrano-Pozo
Summary: The study found that compared to the APOE epsilon 3/epsilon 3 reference genotype, the APOE epsilon 2 and epsilon 4 alleles have opposite effects on the rate of cognitive decline. These effects are clinically relevant and largely independent of the differential APOE allele effects on AD and comorbid pathologies, indicating that APOE genotype contributes to the heterogeneity in the rate of clinical progression in AD.
Article
Neurosciences
Shanshan Wang, Shaofa Ke, Suzhi Liu, En Wang, Tengwei Pan
Summary: In this study, the relationships among plasma p-tau181, APOE epsilon 4, and cognitive performance in non-demented elderly individuals were investigated. The results showed that plasma p-tau181 was significantly associated with cognitive performance in APOE epsilon 4 carriers, and the interaction between APOE epsilon 4 and plasma p-tau181 had significant or marginally significant effects on cognitive performance after controlling for A beta status and diagnosis.
NEUROSCIENCE LETTERS
(2023)
Article
Cell Biology
Alexander M. Kulminski, Ethan Jain-Washburn, Elena Loiko, Yury Loika, Fan Feng, Irina Culminskaya, Alzheimer's Disease Neuroimaging Initiative Alzheimers Dis Neuroimaging Initiative
Summary: This study examined the associations of APOE alleles and polygenic profiles with cerebrospinal fluid and plasma biomarkers, revealing differential effects of specific alleles on different biomarkers.
Article
Multidisciplinary Sciences
Zeinab Fathipour-Azar, Akram Azad, Malahat Akbarfahimi, Saeed Behzadipour, Ghorban Taghizadeh
Summary: This study aimed to investigate whether symmetric and asymmetric bimanual coordination is impaired in Parkinson's disease patients with freezing of gait (PD + FOG) and whether dual-task and drug phases may affect bimanual coordination in these patients. PD + FOG patients demonstrated exacerbated impairments of bimanual coordination while performing goal-directed bimanual tasks, especially in asymmetric tasks and under dual-task conditions, highlighting the importance of rehabilitation interventions for bimanual tasks with different cognitive loads in these patients.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Clinical Neurology
Anuschka Silva-Spinola, Marisa Lima, Maria Joao Leitao, Catarina Bernardes, Joao Duraes, Diana Duro, Miguel Tabuas-Pereira, Isabel Santana, Ines Baldeiras
Summary: This study evaluated the potential of peripheral neurological biomarkers to predict progression to Alzheimer's disease in patients with mild cognitive impairment (MCI), and examined the relationship between blood and cerebrospinal fluid (CSF) markers. The results showed that levels of NfL, GFAP, and p-Tau181 in the blood were significantly higher in patients who progressed to Alzheimer's disease. Combining blood-based GFAP, NfL, and p-Tau181 may serve as a prognostic tool for MCI.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Yuto Uchida, Hirohito Kan, Keita Sakurai, Yoshihiko Horimoto, Emi Hayashi, Akihiko Iida, Nobuyuki Okamura, Kenichi Oishi, Noriyuki Matsukawa
Summary: The study aimed to examine the effect of APOE ε4 dose on BBB clearance function and its correlation with brain iron and beta-amyloid accumulation. The results showed that increased APOE ε4 dose was associated with decreased effective brain-waste clearance through the BBB.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Haibin Wu, Jiang Xu, Jiarong Sun, Jian Duan, Jinlin Xiao, Quan Ren, Pengfei Zhou, Jian Yan, Youping Li, Xiaoxing Xiong, Erming Zeng
Summary: This study aimed to identify novel serum biomarkers for Moyamoya disease (MMD). Through analysis of serum samples from MMD patients and healthy controls, differentially expressed proteins related to cholesterol metabolism were identified. APOE was found to be a potential biomarker for MMD.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Vincent Damotte, Sven J. van der Lee, Vincent Chouraki, Benjamin Grenier-Boley, Jeannette Simino, Hieab Adams, Giuseppe Tosto, Charles White, Natalie Terzikhan, Carlos Cruchaga, Maria J. Knol, Shuo Li, Susanna Schraen, Megan L. Grove, Claudia Satizabal, Najaf Amin, Claudine Berr, Steven Younkin, Rebecca F. Gottesman, Luc Buee, Alexa Beiser, David S. Knopman, Andre Uitterlinden, Charles DeCarli, Jan Bressler, Anita DeStefano, Jean-Francois Dartigues, Qiong Yang, Eric Boerwinkle, Christophe Tzourio, Myriam Fornage, M. Arfan Ikram, Philippe Amouyel, Phil de Jager, Christiane Reitz, Thomas H. Mosley, Jean-Charles Lambert, Sudha Seshadri, Cornelia M. van Duijn
Summary: The study identified associations with known major A beta-processing genes, such as APOE and BACE1, which strengthen the relevance of plasma A beta levels as an endophenotype of AD.
ALZHEIMERS & DEMENTIA
(2021)
Article
Neurosciences
Pamela Barhoun, Ian Fuelscher, Michael Do, Jason L. He, Soukayna Bekkali, Andris Cerins, George J. Youssef, Jacqueline Williams, Peter G. Enticott, Christian Hyde
Summary: The study aimed to clarify whether deficits in atypical hand rotation task performance in adults with DCD are specifically related to difficulties in motor imagery. The findings suggest that these deficits may indeed be attributed to specific difficulties engaging in motor imagery, rather than deficits in general mental rotation skills. These results offer further support for the internal modelling deficit hypothesis in DCD.
HUMAN MOVEMENT SCIENCE
(2021)
Article
Clinical Neurology
Adria Tort-Merino, Matti Laine, Natalia Valech, Jaume Olives, Maria Leon, Mirian Ecay-Torres, Ainara Estanga, Pablo Martinez-Lage, Juan Fortea, Raquel Sanchez-Valle, Lorena Rami, Antoni Rodriguez-Fornells
Summary: ALF, a rapid loss of information despite normal encoding, was found in APOE e4 carriers over three months, with a correlation to abnormal levels of CSF AD biomarkers. This suggests a detectable relationship between ALF and underlying AD pathophysiological processes in at-risk individuals.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)
Article
Geriatrics & Gerontology
Adria Tort-Merino, Natalia Valech, Matti Laine, Jaume Olives, Maria Leon, Mirian Ecay-Torres, Ainara Estanga, Pablo Martinez-Lage, Juan Fortea, Jose Luis Molinuevo, Raquel Sanchez-Valle, Antoni Rodriguez-Fornells, Lorena Rami
Summary: Individuals with high subjective cognitive decline ratings showed more pronounced accelerated long-term forgetting, especially in those with abnormal CSF A beta(42) levels. Higher SCD-Q scores were associated with higher forgetting rates on the AFE-T.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Psychiatry
Natalie L. Marchant, Thorsten Barnhofer, Roxane Coueron, Miranka Wirth, Antoine Lutz, Eider M. Arenaza-Urquijo, Fabienne Collette, Geraldine Poisnel, Harriet Demnitz-King, Ann-Katrin Schild, Nina Coll-Padros, Floriane Delphin-Combe, Tim Whitfield, Marco Schlosser, Julie Gonneaud, Julien Asselineau, Zuzana Walker, Pierre Krolak-Salmon, Jose Luis Molinuevo, Eric Frison, Gael Chetelat, Frank Jessen, Olga M. Klimecki
Summary: An 8-week mindfulness-based intervention did not show superiority in reducing subclinical anxiety symptoms compared to a health self-management program in older adults experiencing subjective cognitive decline. However, both groups showed reduced anxiety symptoms post-intervention and maintained these reductions at follow-up.
PSYCHOTHERAPY AND PSYCHOSOMATICS
(2021)
Review
Psychology, Clinical
Tim Whitfield, Thorsten Barnhofer, Rebecca Acabchuk, Avi Cohen, Michael Lee, Marco Schlosser, Eider M. Arenaza-Urquijo, Adriana Bottcher, Willoughby Britton, Nina Coll-Padros, Fabienne Collette, Gael Chetelat, Sophie Dautricourt, Harriet Demnitz-King, Travis Dumais, Olga Klimecki, Dix Meiberth, Ines Moulinet, Theresa Muller, Elizabeth Parsons, Lauren Sager, Lena Sannemann, Jodi Scharf, Ann-Katrin Schild, Edelweiss Touron, Miranka Wirth, Zuzana Walker, Ethan Moitra, Antoine Lutz, Sara W. Lazar, David Vago, Natalie L. Marchant
Summary: Mindfulness-based programs showed better cognitive performance in executive function and working memory domains compared to control groups. Studies on non-clinical samples and adults over 60 demonstrated significant effects.
NEUROPSYCHOLOGY REVIEW
(2022)
Article
Geriatrics & Gerontology
Farida Dakterzada, Ivan David Benitez, Adriano Targa, Albert Llado, Gerard Torres, Leila Romero, David de Gonzalo-Calvo, Anna Moncusi-Moix, Adria Tort-Merino, Raquel Huerto, Manuel Sanchez-de-la-Torre, Ferran Barbe, Gerard Pinol-Ripoll
Summary: This study found that lower levels of miR-342-5p in plasma were associated with faster cognitive decline in patients with mild AD after 2 years of follow-up, suggesting that this miRNA could serve as a potential blood-based biomarker for predicting cognitive decline in AD patients.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Clinical Neurology
Olin Janssen, Willemijn J. Jansen, Stephanie J. B. Vos, Merce Boada, Lucilla Parnetti, Tomasz Gabryelewicz, Tormod Fladby, Jose Luis Molinuevo, Sylvia Villeneuve, Jakub Hort, Stephane Epelbaum, Alberto Lleo, Sebastiaan Engelborghs, Wiesje M. van der Flier, Susan Landau, Julius Popp, Anders Wallin, Philip Scheltens, Marcel Olde Rikkert, Peter J. Snyder, Chris Rowe, Gael Chetelat, Agustin Ruiz, Marta Marquie, Elena Chipi, Steffen Wolfsgruber, Michael Heneka, Henning Boecker, Oliver Peters, Jonas Jarholm, Lorena Rami, Adria Tort-Merino, Alexa Pichet Binette, Judes Poirier, Pedro Rosa-Neto, Jiri Cerman, Bruno Dubois, Marc Teichmann, Daniel Alcolea, Juan Fortea, M. Belen Sanchez-Saudinos, Jarith Ebenau, Cornelia Pocnet, Marie Eckerstrom, Louisa Thompson, Victor Villemagne, Rachel Buckley, Samantha Burnham, Marion Delarue, Yvonne Freund-Levi, Asa K. Wallin, Inez Ramakers, Magda Tsolaki, Hilkka Soininen, Harald Hampel, Luiza Spiru, Betty Tijms, Rik Ossenkoppele, Frans R. J. Verhey, Frank Jessen, Pieter Jelle Visser
Summary: In addition to age, setting, and APOE ε4 carriership, specific characteristics of subjective cognitive decline may aid in identifying individuals with amyloid positivity.
ALZHEIMERS & DEMENTIA
(2022)
Article
Clinical Neurology
Jose Contador, Agnes Perez-Millan, Nuria Guillen, Adria Tort-Merino, Mircea Balasa, Neus Falgas, Jaume Olives, Magdalena Castellvi, Sergi Borrego-Ecija, Beatriz Bosch, Guadalupe Fernandez-Villullas, Oscar Ramos-Campoy, Anna Antonell, Nuria Bargallo, Raquel Sanchez-Valle, Roser Sala-Llonch, Albert Llado
Summary: Baseline hemispheric/regional CTh, ventricular and amygdalar volume, but not the hippocampus, predict two-year cognitive outcomes in Early-Onset Alzheimer's Disease (EOAD) patients.
JOURNAL OF NEUROLOGY
(2022)
Article
Oncology
Alba Ruiz-Ceamanos, Charles Spence, Jordi Navarra
Summary: Chemotherapy, as an aggressive cancer treatment, affects the eating behavior of patients by altering their sense of smell and taste, potentially leading to nutritional deficiencies. Not all patients experience these sensory alterations in the same way or intensity, and the individual differences in these effects have not been extensively studied. Future research should focus on addressing perceptual and sensory issues in a more personalized manner for cancer patients undergoing chemotherapy.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Geriatrics & Gerontology
Valentin Ourry, Natalie L. Marchant, Ann-Katrin Schild, Nina Coll-Padros, Olga M. Klimecki, Pierre Krolak-Salmon, Karine Goldet, Leslie Reyrolle, Romain Bachelet, Lena Sannemann, Dix Meiberth, Harriet Demnitz-King, Tim Whitfield, Maelle Botton, Julie Lebahar, Julie Gonneaud, Robin de Flores, Jose Luis Molinuevo, Frank Jessen, Denis Vivien, Vincent De la Sayette, Michael J. Valenzuela, Geraldine Rauchs, Miranka Wirth, Gael Chetelat, Eider M. Arenaza-Urquijo, The Medit-Ageing Res Grp
Summary: The study aimed to adapt and harmonise the Lifetime of Experiences Questionnaire (LEQ) across four European countries, assess its validity across countries, explore its association with brain and cognition, and begin to investigate between-country differences in life-course mental activities. The results showed that LEQ had a stable multidimensional structure across countries, was positively associated with cognition and neuroimaging, and revealed differences in leisure activities across the life-course among countries.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Psychology, Biological
Lara Fontana, Javier Albayay, Irune Fernandez-Prieto, Massimiliano Zampini
Summary: This study found that perceived odour edibility modulates olfactory habituation. The perceived odour intensity only decreased over time for nonfood odours, while the perceived odour pleasantness decreased significantly more across trials for food odours. These findings indicate that top-down factors, such as the edibility of odours, play a role in olfactory habituation.
QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY
(2023)
Article
Clinical Neurology
Jose Contador, Agnes Perez-Millan, Nuria Guillen, Jordi Sarto, Adria Tort-Merino, Mircea Balasa, Neus Falgas, Magdalena Castellvi, Sergi Borrego-Ecija, Jordi Junca-Parella, Beatriz Bosch, Guadalupe Fernandez-Villullas, Oscar Ramos-Campoy, Anna Antonell, Nuria Bargallo, Raquel Sanchez-Valle, Roser Sala-Llonch, Albert Llado
Summary: Sex differences exist in cognitive impairment, atrophy burden, and CSF tau levels in early-onset Alzheimer's disease, with female patients showing worse symptoms.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Tim Whitfield, Harriet Demnitz-King, Marco Schlosser, Thorsten Barnhofer, Eric Frison, Nina Coll-Padros, Sophie Dautricourt, Florence Requier, Marion Delarue, Julie Gonneaud, Olga M. Klimecki, Antoine Lutz, Leo Paly, Eric Salmon, Ann-Katrin Schild, Zuzana Walker, Frank Jessen, Gael Chetelat, Fabienne Collette, Miranka Wirth, Natalie L. Marchant
Summary: Non-pharmacological interventions can help maintain or improve cognition in individuals with SCD, reducing the risk of dementia.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Clinical Neurology
Gonzalo Forno, Jose Contador, Agnes Perez-Millan, Nuria Guillen, Neus Falgas, Jordi Sarto, Adria Tort-Merino, Magdalena Castellvi, Beatriz Bosch, Guadalupe Fernandez-Villullas, Mircea Balasa, Anna Antonell, Roser Sala-Llonch, Raquel Sanchez-Valle, Michael Hornberger, Albert Llado
Summary: This study assessed how the APOE genotype differentially affects cortical and subcortical memory structures in biomarker-confirmed early-onset (EOAD) and late-onset (LOAD) Alzheimer's disease patients. The results showed that the APOE genotype has a significant effect on grey matter volume, with LOAD APOE4 genotype mostly associated with cortical and temporal atrophy, while EOAD APOE4 genotype might have a more specific effect on subcortical structures (mammillary body). Therefore, the APOE genotype needs to be taken into account when classifying patients by age at onset.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Agnes Perez-Millan, Jose Contador, Jordi Junca-Parella, Beatriz Bosch, Laia Borrell, Adria Tort-Merino, Neus Falgas, Sergi Borrego-Ecija, Nuria Bargallo, Lorena Rami, Mircea Balasa, Albert Llado, Raquel Sanchez-Valle, Roser Sala-Llonch
Summary: Alzheimer's disease (AD) and frontotemporal dementia (FTD) are common causes of dementia with overlapping symptoms and brain signatures. This study used brain magnetic resonance imaging (MRI) and machine learning to accurately diagnose and classify AD and FTD. The algorithm achieved good accuracy in cross-sectional and longitudinal data.
HUMAN BRAIN MAPPING
(2023)
Article
Clinical Neurology
Adria Tort-Merino, Neus Falgas, Isabel E. Allen, Mircea Balasa, Jaume Olives, Jose Contador, Magdalena Castellvi, Jordi Junca-Parella, Nuria Guillen, Sergi Borrego-Ecija, Bea Bosch, Guadalupe Fernandez-Villullas, Oscar Ramos-Campoy, Anna Antonell, Lorena Rami, Raquel Sanchez-Valle, Albert Llado
Summary: This study aimed to explore the differences in cognitive function between early-onset and late-onset Alzheimer's disease. The results showed that patients with early-onset Alzheimer's disease had more severe deficits in visual perception, praxis, and executive tasks, and they experienced a faster cognitive decline.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
