Article
Chemistry, Analytical
Yu P. Zhang, Evgeniia Lobanova, Derya Emin, Sergey V. Lobanov, Antonina Kouli, Caroline H. Williams-Gray, David Klenerman
Summary: This study introduces a new method for the diagnosis of early Parkinson's disease. The results show that the proportion of soluble alpha-synuclein aggregates can distinguish between Parkinson's disease patients and control groups, with Parkinson's disease patients having a higher proportion of larger and rounder alpha-synuclein aggregates. By combining the number and morphology of the aggregates, a new biomarker with improved accuracy for early Parkinson's disease diagnosis was constructed.
ANALYTICAL CHEMISTRY
(2023)
Article
Engineering, Marine
Alexandre Lobo-da-Cunha, Angela Alves, Elsa Oliveira, Goncalo Calado
Summary: This study investigated the histological and ultrastructural features of the digestive system in Chaetopleura angulata and Acanthochitona fascicularis. Both species were found to be omnivorous, and the digestive tract epithelium consisted mainly of elongated absorptive cells with microvilli and cilia. These cells were involved in endocytosis, intracellular digestion, and storage of reserves. Secretory cells containing proteins and polysaccharides were present in the digestive tract, with distinct mucous cells and basophilic cells. Basal cells corresponding to enteroendocrine cells were also observed. The digestive tract wall consisted of muscle cells, nerves, and connective tissue.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2022)
Article
Plant Sciences
Hanna B. Margonska, Malgorzata Kozieradzka-Kiszkurno, Emilia Brzezicka, Lukasz P. Halinski, Kevin L. Davies, Monika M. Lipinska
Summary: Crepidium is a large genus of mainly pantropical orchids with limited information on pollination and floral morphology. Field observations show that the flowers are visited by various insects and have two forms of small liquid droplets on the lip surface. Through GC-MS analysis and microscopy examination, it was found for the first time that these species exhibit liquid secretion.
Review
Clinical Neurology
Jessica Alber, Edmund Arthur, Danielle Goldfarb, Jonathan Drake, Jerrold L. Boxerman, Brian Silver, Brian R. Ott, Lenworth N. Johnson, Peter J. Snyder
Summary: There is a correlation between retinal and cerebral microbleeds in CAA patients. Retinal microbleeds have a significant correlation with episodic memory performance in CAA patients. There were no significant group differences between CAA patients and cognitively normal older adults on retinal angiographic or structural measurements.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Lukas Sveikata, Andreas Charidimou, Anand Viswanathan
Summary: This article reviews the implications of aducanumab amyloid-beta immunotherapy for treating Alzheimer's disease with comorbid cerebral amyloid angiopathy. It discusses the potential impact of cerebral amyloid angiopathy on the effectiveness of immunotherapy and proposes strategies to identify it in patients considered for this treatment.
Review
Cell Biology
Rebecca M. Parodi-Rullan, Sabzali Javadov, Silvia Fossati
Summary: Alzheimer's disease and cerebral amyloid angiopathy are characterized by pathological features related to mitochondrial dysfunction, which activates inflammatory pathways leading to cerebrovascular inflammation and neurodegeneration, ultimately resulting in neuroinflammation and neurodegeneration.
Review
Cell Biology
Jurgen Roth, Douglas J. Taatjes
Summary: This article reviews the first ten years of publication in the journal "Histochemistry and Cell Biology" and highlights selected papers on enzyme, protein, and carbohydrate histochemistry. Furthermore, recent progress in identifying, quantifying, and precisely determining the tissue localization of proteins, lipids, and small molecules through the combination of spectroscopic techniques and histology is narrated.
HISTOCHEMISTRY AND CELL BIOLOGY
(2023)
Article
Neurosciences
Yang Yang, Alexey G. Murzin, Sew Peak-Chew, Catarina Franco, Holly J. Garringer, Kathy L. Newell, Bernardino Ghetti, Michel Goedert, Sjors H. W. Scheres
Summary: In this study, the structures of A beta 40 filaments in individuals with Alzheimer's disease and cerebral amyloid angiopathy were determined using electron cryo-microscopy. The findings revealed differences in the sequence assignment and interactions of A beta 40 peptides, redefining their fold. Additionally, distinct structures were observed between parenchymal deposits of A beta 42 and blood vessel deposits of A beta 40, supporting the idea that Alzheimer's disease and cerebral amyloid angiopathy are different A beta proteinopathies.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Review
Chemistry, Multidisciplinary
John H. Viles
Summary: The accumulation of amyloid-beta peptides (Aβ) is crucial in Alzheimer's disease development. The interaction between various Aβ assemblies and lipid membranes or membrane receptors result in increased membrane permeability and cellular homeostasis disruption, which plays a key role in the pathology of Alzheimer's disease. Aβ can affect lipid membranes in multiple ways, including a carpeting effect, a detergent effect, and the formation of Aβ ion-channel pores. Recent advancements in imaging techniques have improved our understanding of Aβ-induced membrane disruption. Understanding the relationship between different Aβ structures and membrane permeability will guide the development of therapeutics targeting Aβ cytotoxicity.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Neurosciences
Tsuyoshi Hamaguchi, Jee Hee Kim, Akane Hasegawa, Ritsuko Goto, Kenji Sakai, Kenjiro Ono, Yoshinori Itoh, Masahito Yamada
Summary: The study found that exogenous A beta seeds from different A beta pathologies induced A beta deposition in the blood vessels rather than the brain parenchyma, which might be the predominant feature of A beta pathology in iatrogenic transmission cases; Contamination of brain tissues from patients with little A beta pathology could lead to iatrogenic transmission of A beta pathology, emphasizing the urgent need for the development of inactivation methods to prevent such transmission.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Plant Sciences
Oluwatosin Temilade Adu, Yougasphree Naidoo, Temitope Samson Adu, Venkataramegowda Sivaram, Yaser Hassan Dewir, Hail Rihan
Summary: This study used light and electron microscopy techniques to examine the morphological and chemical features of secretory structures in Diospyros villosa, and identified medicinal compounds. These findings are important for establishing microscopic and pharmacognostic measures for future identification and verification of this herbal plant.
Article
Materials Science, Multidisciplinary
Diaa Massoud, Maged Fouda, Fayez Shaldoum, Barakat M. Alrashdi, Mervat Ahmed Abdrabou, Soha A. Soliman, Hanan H. Abd-Elhafeez, Mervat Hassan, Mohamed Abumandour
Summary: The present study investigated the microscopic features of the small intestine in the southern white-breasted hedgehog (Erinaceus concolor). The composition of the intestinal wall and the characteristics of villi varied across different segments of the small intestine. The findings provide a foundation for future research on the digestive system of hedgehogs and other mammalian species.
MICROSCOPY AND MICROANALYSIS
(2023)
Article
Materials Science, Multidisciplinary
Radan Elvis Matias de Oliveira, Fernanda Loffler Niemeyer Attademo, Ana Caroline Freitas Caetano de Sousa, Joao Vitor de Oliveira Gurgel, Marcela dos Santos Magalhaes, Carlos Eduardo Bezerra de Moura, Ana Bernadete Lima Fragoso, Flavio Jose de Lima Silva, Moacir Franco de Oliveira
Summary: The morphological studies on the digestive system of hawksbill turtle hatchlings revealed strong indications of adaptations to a carnivorous diet, shedding light on their feeding behavior in the wild.
MICROSCOPY AND MICROANALYSIS
(2022)
Article
Plant Sciences
Analu Zanotti-Avila, Valeria Ferreira Fernandes, Kallyne Ambrosio Barros, Valdnea Casagrande Dalvi, Aristea Alves Azevedo, Renata Maria Strozi Alves Meira
Summary: Unusual nectaries in Gentianaceae have unique anatomical features and their secretion and exudation mechanisms involve distinct organelles.
Article
Biochemistry & Molecular Biology
Cristine De Paula Nascimento-Castro, Elisa C. Winkelmann-Duarte, Gianni Mancini, Priscilla Gomes Welter, Evelini Placido, Marcelo Farina, Joana Gil-Mohapel, Ana Lucia S. Rodrigues, Andreza Fabro de Bem, Patricia S. Brocardo
Summary: Huntington's disease is a genetic neurodegenerative disease that affects motor, psychiatric, and cognitive functions. Recent evidence suggests that the emotional and cognitive deficits observed in patients with HD might be associated with hippocampal dysfunction. In this study using a HD mouse model, researchers found that mice in the late symptomatic stage exhibited depressive-like behavior and cognitive deficits. Additionally, they observed degenerative changes in the hippocampal dentate gyrus, including the presence of dark neurons and structural alterations in the rough endoplasmic reticulum and Golgi apparatus.
Article
Biochemistry & Molecular Biology
Loredan S. Niculescu, Natalia Simionescu, Elena V. Fuior, Camelia S. Stancu, Mihaela G. Carnuta, Madalina D. Dulceanu, Mina Raileanu, Emanuel Dragan, Anca V. Sima
MOLECULAR BIOLOGY REPORTS
(2018)
Article
Plant Sciences
Mihaela Georgiana Carnuta, Mariana Deleanu, Teodora Barbalata, Laura Toma, Mina Raileanu, Anca Volumnia Sima, Camelia Sorina Stancu
Article
Food Science & Technology
Loredan S. Niculescu, Madalina D. Dulceanu, Camelia S. Stancu, Mihaela G. Carnuta, Teodora Barbalata, Anca V. Sima
JOURNAL OF FUNCTIONAL FOODS
(2019)
Article
Food Science & Technology
Teodora Barbalata, Mariana Deleanu, Mihaela Georgiana Carnuta, Loredan Stefan Niculescu, Mina Raileanu, Anca Volumnia Sima, Camelia Sorina Stancu
MOLECULAR NUTRITION & FOOD RESEARCH
(2019)
Article
Medicine, Research & Experimental
Laura Toma, Gabriela M. Sanda, Mina Raileanu, Camelia S. Stancu, Loredan S. Niculescu, Anca V. Sima
Review
Biochemistry & Molecular Biology
Laura Toma, Gabriela Maria Sanda, Loredan Stefan Niculescu, Mariana Deleanu, Anca Volumnia Sima, Camelia Sorina Stancu
Article
Biochemistry & Molecular Biology
Teodora Barbalata, Oriana E. Moraru, Camelia S. Stancu, Yvan Devaux, Maya Simionescu, Anca V. Sima, Loredan S. Niculescu
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Multidisciplinary Sciences
Gabriela M. Sanda, Camelia S. Stancu, Mariana Deleanu, Laura Toma, Loredan S. Niculescu, Anca V. Sima
Summary: The uptake of modified lipoproteins by macrophages transforms them into foam cells, a characteristic feature of atherosclerotic plaques. This study shows that aggregated low-density lipoproteins (agLDL) induce excessive accumulation of cholesterol in macrophages, leading to mitochondrial dysfunction without triggering oxidative stress or endoplasmic reticulum stress. In contrast, oxidized LDL (oxLDL) generates oxidative stress, exacerbates mitochondrial dysfunction, and induces endoplasmic reticulum stress and apoptosis.
Article
Multidisciplinary Sciences
Teodora Barbalata, Lu Zhang, Madalina D. Dulceanu, Camelia S. Stancu, Yvan Devaux, Anca V. Sima, Loredan S. Niculescu
SCIENTIFIC REPORTS
(2020)
Review
Biochemistry & Molecular Biology
Laura Toma, Camelia Sorina Stancu, Anca Volumnia Sima
Summary: Studies have shown that diabetes and its vascular complications are related to endothelial cell dysfunction, leading to cardiovascular diseases as the main cause of death and disability in diabetic patients. Through the action of high blood sugar and advanced glycation end products, EC dysfunction is induced, affecting endothelial cells and exacerbating vascular complications.
Article
Biochemistry & Molecular Biology
Teodora Barbalata, Oriana E. Moraru, Camelia S. Stancu, Anca V. Sima, Loredan S. Niculescu
Summary: The study revealed a significant correlation between miR-223-3p levels and age in CAS patients, with higher expression in patients over 65 years old. Plasma miR-223-3p levels were significantly correlated with HDL-related proteins, serving as predictive factors for the aggravation of CAS in elderly patients.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Gabriela M. Sanda, Laura Toma, Teodora Barbalata, Oriana E. Moraru, Loredan S. Niculescu, Anca Sima, Camelia S. Stancu
Summary: In patients with peripheral artery disease (PAD), high-density lipoprotein (HDL) function is impaired due to multiple modifications of associated proteins, with the presence of diabetes mellitus (DM) exacerbating these changes. Plasma levels of clusterin (CLU), myeloperoxidase (MPO), and paraoxonase 1 (PON1) may serve as indicators of HDL dysfunction and contribute to risk stratification in PAD patients.
Article
Biochemistry & Molecular Biology
Laura Toma, Teodora Barbalata, Gabriela M. Sanda, Loredan S. Niculescu, Anca V. Sima, Camelia S. Stancu
Summary: Transcriptional activation of endogenous ApoAI or PON1 in enterocytes can increase their gene and protein expression, as well as secretion in CM. This activation also stimulates ABCA1/G8 and SR-BI, and upregulates PPAR gamma, LXRs, and SIRT1, thereby reducing inflammation and oxidative stress in EC.
Article
Medicine, General & Internal
Alina Ioana Scarlatescu, Teodora Barbalata, Anca Volumnia Sima, Camelia Stancu, Loredan Stefan Niculescu, Miruna Mihaela Micheu
Summary: In this study, the prognostic role of myocardial work indices and a group of miRNAs in young patients with STEMI was assessed. The results showed that both myocardial work indices and certain miRNAs have the potential to be used as prognostic markers for adverse events after acute myocardial infarction.
Article
Biochemistry & Molecular Biology
Teodora Barbalata, Alina Scarlatescu, Gabriela M. Sanda, Laura Toma, Camelia S. Stancu, Maria Dorobantu, Miruna M. Micheu, Anca Sima, Loredan S. Niculescu
Summary: This study aimed to assess the potential of circulating microRNAs, cell-free DNA, and mitochondrial DNA as prognostic tools for unfavorable outcomes in ST-segment elevation myocardial infarction (STEMI). The results showed that the levels of miRNAs, cfDNA, and mtDNA were highest at hospital discharge, and these levels were increased in STEMI patients with major adverse cardiovascular events. Combination of mtDNA and miR-142-3p levels had the highest predictive value for MACE. These findings suggest that increased plasma levels of mtDNA, along with miR-142-3p, could be used as predictive markers for unfavorable outcomes in STEMI patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)