Review
Pharmacology & Pharmacy
Kai Wang, Qinhua Chen, Nanxin Liu, Jie Zhang, Xiaoyan Pan
Summary: One major issue in cancer treatment is resistance to chemotherapeutic drugs, often associated with abnormal blood vessels. Jain's vascular normalization theory has been applied effectively to drug-resistant tumor treatment. By using angiogenesis inhibitors, remodeling abnormal vessel structure and function can maximize the efficacy of chemotherapeutic drugs.
DRUG DISCOVERY TODAY
(2021)
Article
Cell Biology
Peng Zhang, Liang Chen, Fenfang Zhou, Zhiwen He, Gang Wang, Yongwen Luo
Summary: Prostate cancer (PCa) is a common male malignancy with unclear progression mechanisms. This study found that NRP1, highly expressed in PCa, was associated with poor prognosis in PCa patients. Functionally, NRP1 depletion inhibited PCa cell proliferation and migration, while NRP1 overexpression promoted these processes. Mechanistically, NRP1 was regulated by HIF1 alpha and interacted with EGFR, leading to EGFR phosphorylation and activation of the AKT signaling pathway, promoting PCa progression. Additionally, the NRP1 inhibitor EG01377 inactivated the EGFR/AKT signaling axis and suppressed PCa progression.
CELL DEATH & DISEASE
(2023)
Article
Medicine, Research & Experimental
Maryam Akbarzadeh, Ainaz Mihanfar, Shabnam Akbarzadeh, Bahman Yousefi, Maryam Majidinia
Summary: The PI3K/AKT/mTOR signaling pathway plays a crucial role in cancer and has been found to interact with miRNAs, which is important for understanding cancer biology.
Article
Medicine, Research & Experimental
Hongcheng Luo, Tingzhuang Yi, Deyou Huang, Xiaoping Chen, Xu Li, Qianquan Wan, Haineng Huang, Huadong Huang, Hongyu Wei, Ye Song, Tianshi Que, Rentong Hu, Huatuo Huang, Kunxiang Luo, Chuanyu Li, Chengjian Qin, Chuanhua Zheng, Chuanliu Lan, Wencheng Chen, Dan Zhou, Qisheng Luo
Summary: The study revealed that circ_PTN promotes DDP resistance in GBM cells through activating the PI3K/AKT pathway, with in vivo experiments demonstrating that circ_PTN silencing inhibits DDP resistance in GBM tumors.
MOLECULAR THERAPY NUCLEIC ACIDS
(2021)
Review
Biochemistry & Molecular Biology
Uwe Lendeckel, Farzaneh Karimi, Ruba Al Abdulla, Carmen Wolke
Summary: APN/CD13 is expressed in various cells/tissues and is associated with diverse physiological functions. Increased expression or activity of APN/CD13 has been described in various tumors, and is usually associated with reduced survival. The mechanisms of APN/CD13-mediated cellular effects have been largely determined.
Article
Oncology
Chuntao Li, Bo Chen, Junxia Zhang, Jingxuan Yang, Muzi Guo, Yu Ren, Zhijun Zhou, Kar-Ming Fung, Min Li, Liyang Zhang, Zhixiong Liu
Summary: SEM1 is highly expressed in gliomas and correlated with malignant features and poor prognosis. SEM1 plays a critical role in the proliferation, apoptosis, invasion, and migration of glioma cells through regulating the PI3K-Akt pathway. The SEM1 malignant regulatory network shows significant importance for the prognosis and treatment of gliomas.
Article
Cell Biology
Yitong Xu, Chenglong Wang, Xizi Jiang, Yao Zhang, Hongbo Su, Jun Jiang, Hongjiu Ren, Xueshan Qiu
Summary: KLHL38 plays a promoting role in non-small cell lung cancer, enhancing cell proliferation, migration, and invasion through activating the Akt signaling pathway, and is closely associated with the malignancy of tumors.
CELL DEATH & DISEASE
(2021)
Review
Oncology
Domenico Ribatti, Antonio Giovanni Solimando, Francesco Pezzella
Summary: Several anti-angiogenic drugs are approved for cancer treatment, but resistance and adverse effects may occur. Combining multiple anti-angiogenic molecules or using them in combination with other treatment regimens is indicated as alternative therapeutic strategies to overcome resistance. Comprehensive omics profiling is crucial for increasing clinical benefits and overcoming resistance to anti-angiogenic therapies.
Article
Biochemistry & Molecular Biology
Ruijing Chang, Yuan Su, Hongfang Kong, Fang Wang, Ying Xing, Lei Jiang, Hong Xin
Summary: This study indicates that disturbance of SEMP1 expression is associated with preeclampsia. SEMP1 levels were found to be downregulated in placental tissues of PE patients. Overexpression of SEMP1 enhanced the capability of trophoblast cells in proliferation, migration, and invasion.
MOLECULAR BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jing Guo, Yangyang Lv, Sheng Wang, Ziyi Peng, Ying Xie, Yixuan Wang, Hongmei Jiang, Xin Li, Mengqi Wang, Meilin Hu, Jiangpeng Mu, Jingya Wang, Yangyang Xie, Xiankui Cheng, Zhigang Zhao, Zhiqiang Liu
Summary: The hypoxic bone marrow microenvironment in multiple myeloma (MM) promotes chemoresistance to proteasome inhibitors (PIs). The expression of steroid receptor coactivator 3 (SRC-3) is increased at the posttranslational level in response to hypoxia stimulus. SENP1, a key modifier of SRC-3 stability, is identified and its depletion or inhibition overcomes chemoresistance to PIs in MM cells.
Review
Cell Biology
Ying-Chen Cheng, Yu-An Chang, Yi-Jen Chen, Hsu-Min Sung, Ivan Bogeski, Hong-Lin Su, Ya-Ling Hsu, Hui-Min David Wang
Summary: Different types of cells release extracellular vesicles (EVs) in the tumor microenvironment, affecting tumor growth, progression, and immune response. Recent studies have explored the potential application of EVs in cancer treatment. This review summarizes the mechanisms by which EVs regulate melanoma development and progression, and their potential use in therapy.
Article
Pharmacology & Pharmacy
Lei Jiang, Wenjun Wang, Zhanwu Li, Yao Zhao, Zhensheng Qin
Summary: The study revealed that NUPR1 was upregulated in human gastric cancer tissues and correlated with clinical features such as tumor size, stage, and lymph node metastasis. Depletion of NUPR1 inhibited invasion and EMT of gastric cancer cells and induced apoptosis. YAP activation was found to upregulate drug resistance in doxorubicin-resistant gastric cancer cells by regulating NUPR1 expression. Overexpression of NUPR1 reversed the effects of YAP knockdown on cell malignancy and drug resistance via the AKT and p21 pathway.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Nongyao Nonpanya, Kittipong Sanookpan, Keerati Joyjamras, Duangdao Wichadakul, Boonchoo Sritularak, Chatchai Chaotham, Pithi Chanvorachote
Summary: This study demonstrated that norcycloartocarpin from Artocarpus gomezianus interacts promisingly with Akt, inducing apoptosis and suppressing epithelial-to-mesenchymal transition in lung cancer cells. Its selective cytotoxicity profile, especially towards cancer cells, suggests its potential as a plant-derived anticancer agent.
Review
Genetics & Heredity
Botle Precious Setlai, Rodney Hull, Rui Manuel Reis, Cyril Agbor, Melvin Anyasi Ambele, Thanyani Victor Mulaudzi, Zodwa Dlamini
Summary: MicroRNAs (miRNA) are small non-coding RNAs that regulate oncogenes or tumor suppressor genes by suppressing gene translation or promoting mRNA translation into proteins. Circulating miRNAs can serve as prognostic markers for cancer, aiding in early detection. miRNA-related EMT can be targeted for therapeutic purposes in glioblastomas.
Article
Pharmacology & Pharmacy
Tianli Zhang, Mengmeng Liu, Qing Liu, Gary Guishan Xiao
Summary: Wogonin can enhance the sensitivity of pancreatic cancer cells to gemcitabine chemotherapy, possibly by promoting apoptosis through inhibiting the Akt signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Remco J. Hack, Gido Gravesteijn, Minne N. Cerfontaine, Mark A. Santcroos, Laura Gatti, Anna Kopczak, Anna Bersano, Marco Duering, Julie W. Rutten, Saskia A. J. Lesnik Oberstein
Summary: A novel three-tiered risk classification for NOTCH3 variants associated with CADASIL disease prediction has been identified in this study.
Article
Biochemistry & Molecular Biology
Gemma Gorla, Tatiana Carrozzini, Giuliana Pollaci, Antonella Potenza, Sara Nava, Francesco Acerbi, Paolo Ferroli, Silvia Esposito, Veronica Saletti, Emilio Ciusani, Aida Zulueta, Eugenio A. Parati, Anna Bersano, Laura Gatti, Ignazio G. Vetrano
Summary: This study aimed to assess the levels of circulating endothelial progenitor cells (cEPC) and the release of selected proteins in the plasma and CSF of pediatric MMA patients to clarify the pathogenesis and progression of the disease. The study found increased levels of cEPC in peripheral blood and an upregulation of angiogenic markers in CSF. These findings provide valuable insights into the disease's mechanism and progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Nadia Zaffaroni, Giovanni L. L. Beretta
Summary: Pyroptosis is a programmed cell death characterized by the rupture of the plasma membranes and release of cellular content leading to inflammatory reaction. Four cellular mechanisms inducing pyroptosis have been reported thus far. Pyroptosis plays roles in tumor initiation, progression, metastasis, treatment response, and patient outcome. Induction of pyroptosis has been reported in several tumor types following antitumor therapies, including melanoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Vittoria Nazzi, Niccolo Innocenti, Nicolo Castelli, Irene Tramacere, Marica Eoli, Vittoria Cojazzi, Laura Gatti, Francesco Acerbi, Jacopo Falco, Ignazio G. Vetrano
Summary: Peripheral nerve sheath tumors (PNST) mainly include schwannomas and neurofibromas. Surgical resection is the primary treatment, but distinguishing between intact functional nerve and the fibers from which the PNST arose can be challenging. Intraoperative tools to visualize these tumors could improve the success rate of gross-total resection.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell Biology
Valentina Zuco, Sandro Pasquali, Monica Tortoreto, Stefano Percio, Valentina Doldi, Marta Barisella, Paola Collini, Gian Paolo Dagrada, Silvia Brich, Patrizia Gasparini, Marco Fiore, Michela Casanova, Anna Maria Frezza, Alessandro Gronchi, Silvia Stacchiotti, Andrea Ferrari, Nadia Zaffaroni
Summary: This study used a patient-derived xenograft (PDX) model to evaluate the effectiveness of different drugs against desmoplastic small round cell tumor (DSRCT). It was found that doxorubicin, pazopanib, and larotrectenib had moderate antitumor effects, while trabectedin had higher activity. Vinorelbine, irinotecan, and eribulin achieved nearly complete tumor growth inhibition. The combination of irinotecan with either eribulin or trabectedin resulted in complete responses. This study highlights the importance of patient-derived preclinical models in exploring new treatments for DSRCT.
DISEASE MODELS & MECHANISMS
(2023)
Article
Biochemistry & Molecular Biology
Samuele Ciceri, Diego Colombo, Enrico M. A. Fassi, Patrizia Ferraboschi, Giovanni Grazioso, Paride Grisenti, Marco Iannone, Carlo Castellano, Fiorella Meneghetti
Summary: Elagolix sodium salt is the first orally active non-peptide gonadotropin-releasing hormone receptor antagonist for the treatment of hormone dependent diseases. A detailed NMR investigation was conducted to analyze the drug and its synthetic intermediates, allowing for the complete assignment of the NMR signals and determination of the stereochemical profile of the atropisomers. These results contribute to the understanding of atropisomerism in drug discovery and can be applied in the design of safer and more effective analogs.
Editorial Material
Oncology
Ignazio G. G. Vetrano, Pierpaolo Alongi, Laura Gatti
FRONTIERS IN ONCOLOGY
(2023)
Review
Pharmacology & Pharmacy
Cinzia Lanzi, Noemi Arrighetti, Sandro Pasquali, Giuliana Cassinelli
Summary: Soft tissue sarcomas (STSs) are rare mesenchymal malignancies characterized by distinctive molecular, histological, and clinical features. Underlying chromatin deregulation plays a major role in the development of STSs. The antagonistic interaction between BAFs and PRCs has been identified as a potential target for therapeutic intervention in certain types of STSs, such as epithelioid sarcoma (ES), extracranial extrarenal malignant rhabdoid tumors (eMRTs), and synovial sarcoma (SS).
BIOCHEMICAL PHARMACOLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Anna Bersano, Laura Gatti
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Antonella Potenza, Gemma Gorla, Tatiana Carrozzini, Anna Bersano, Laura Gatti, Giuliana Pollaci
Summary: Stroke is a leading cause of death and disability globally. It is important to find new circulating biomarkers that can distinguish and monitor cerebrovascular diseases leading to stroke. Biomarkers can provide additional information to improve diagnosis, prognosis, and identify potential therapeutic targets for personalized medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Tatiana Carrozzini, Giuliana Pollaci, Gemma Gorla, Antonella Potenza, Nicola Rifino, Francesco Acerbi, Ignazio G. G. Vetrano, Paolo Ferroli, Anna Bersano, Erica Gianazza, Cristina Banfi, Laura Gatti
Summary: Moyamoya angiopathy (MMA) is a rare cerebrovascular disease characterized by progressive steno-occlusive lesions and collateral vessel development. Surgical treatment, particularly indirect revascularization, is preferred. By performing proteomic characterization, a potential gene, Filamin A, was identified, suggesting a role in MMA pathogenesis. This study provides insights into the molecular understanding of this disabling intracranial vasculopathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Organic
Marco Zuccolo, Giulia Orsini, Martina Quaglia, Luca Mirra, Cristina Corno, Nives Carenini, Paola Perego, Diego Colombo
Summary: Bioactive anionic glycoglycerolipids based on 2-O-& beta;-d-glucosylglycerol were efficiently synthesized using N-oxyamides. The oxidation of the glucose moiety's primary hydroxyl group in the presence of N-oxyamide was achieved for the first time using a chemoenzymatic laccase/TEMPO procedure. The N-oxyamides showed higher inhibition of ovarian carcinoma IGROV-1 cell proliferation in serum-free medium, indicating increased antiproliferative activity compared to the corresponding esters.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Gemma Gorla, Giuliana Pollaci, Antonella Potenza, Tatiana Carrozzini, Isabella Canavero, Nicola Rifino, Benedetta Storti, Anna Bersano, Laura Gatti
JOURNAL OF NEUROCHEMISTRY
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Giuliana Pollaci, Antonella Potenza, Aida Zulueta, Gemma Gorla, Tatiana Carrozzini, Isabella Canavero, Benedetta Storti, Nicola Rifino, Marcella Catania, Giuseppe Di Fede, Anna Bersano, Laura Gatti
JOURNAL OF NEUROCHEMISTRY
(2023)