Article
Geriatrics & Gerontology
Yen Ying Lim, Nawaf Yassi, Lisa Bransby, Scott Ayton, Rachel F. Buckley, Dhamidhu Eratne, Dennis Velakoulis, Qiao-Xin Li, Christopher Fowler, Colin L. Masters, Paul Maruff
Summary: This study aimed to determine the relationship between the APOE ε4 allele and biomarkers of Alzheimer's disease in cerebrospinal fluid and neuroimaging, as well as cognition. The results showed that APOE ε4 carriers had lower levels of Aβ42 and higher levels of tau and neurofilament light in the CSF, as well as poorer cognitive performance.
NEUROBIOLOGY OF AGING
(2023)
Review
Biochemistry & Molecular Biology
Yuanxin Zhao, Buhan Liu, Jian Wang, Long Xu, Sihang Yu, Jiaying Fu, Xiaoyu Yan, Jing Su
Summary: Neuroinflammation mediated by microglia is a common feature in neurodegenerative diseases. The accumulation of Aβ and tau proteins can disrupt the metabolism of microglia, leading to neuroinflammation.
Article
Geriatrics & Gerontology
Amelia D. Hines, Stephanie McGrath, Amanda S. Latham, Breonna Kusick, Lisa Mulligan, McKenzie L. Richards, Julie A. Moreno
Summary: Canine cognitive dysfunction (CCD) syndrome is a naturally occurring disease in aged dogs, similar to Alzheimer's disease (AD) in humans, but little is known about the pathological aging of the canine brain. In this study, we found increased glial cells, neuroinflammation, and accumulation of proteins associated with neurodegenerative diseases in the brains of aged canines. We also identified a potential predictor for CCD, phosphorylation of tau at threonine 217.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Huiqin Zhang, Wei Wei, Ming Zhao, Lina Ma, Xuefan Jiang, Hui Pei, Yu Cao, Hao Li
Summary: Extracellular neuritic plaques and intracellular neurofibrillary tangles, composed of amyloid-beta and phosphorylated tau protein respectively, are hallmark proteins of Alzheimer's disease. The interactions between these proteins have been extensively studied, with A beta accelerating tau phosphorylation, tau mediating A beta toxicity, and potential synergistic effects on microglial cells and astrocytes. Understanding these interactions may lead to new interventions against Alzheimer's disease.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Michela Marcatti, Anna Fracassi, Mauro Montalbano, Chandramouli Natarajan, Balaji Krishnan, Rakez Kayed, Giulio Taglialatela
Summary: This study demonstrates that Tau oligomers become the main synaptotoxic species in late-stage Alzheimer's disease (AD), supporting the hypothesis that targeting Tau oligomers may be the most effective therapeutic approach for clinically manifest AD.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Environmental Sciences
Mostafa M. Elhady, Sara A. Adly, Husam A. Elshebiny, Said S. Moselhy
Summary: This study evaluated the levels of serum S100B and amyloid beta in patients with organophosphate (OP) intoxication to determine their sensitivity and specificity in assessing the severity of neurological damage. The results showed a positive correlation between S100B and amyloid beta levels, while there was a negative correlation between pseudocholinesterase activity and both markers. The levels of S100B and amyloid beta were significantly elevated in the patient group compared to the control group. The diagnostic accuracy of S100B was found to be higher than that of amyloid beta in distinguishing between moderate and severe OP intoxication. These findings suggest that changes in S100B and amyloid beta levels are directly related to the severity of OP intoxication.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Clinical Neurology
Nicolai Franzmeier, Rik Ossenkoppele, Matthias Brendel, Anna Rubinski, Ruben Smith, Atul Kumar, Niklas Mattsson-Carlgren, Olof Strandberg, Marco Duering, Katharina Buerger, Martin Dichgans, Oskar Hansson, Michael Ewers
Summary: The study found that carriers of the BIN1 rs744373 risk allele showed faster global tau-PET accumulation and accelerated tau-PET accumulation at higher A beta levels. In the ADNI sample, the effects of rs744373 on cognitive decline were mediated by faster global tau-PET accumulation.
ALZHEIMERS & DEMENTIA
(2022)
Article
Neurosciences
Yuta Takaichi, James K. Chambers, Kei Takahashi, Yoshiyuki Soeda, Riki Koike, Etsuko Katsumata, Chiaki Kita, Fuko Matsuda, Makoto Haritani, Akihiko Takashima, Hiroyuki Nakayama, Kazuyuki Uchida
Summary: The study found that pinniped species naturally accumulate A beta and tau with aging, similar to the human AD pathology.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Review
Medicine, Research & Experimental
Yan Zheng, Limin Zhang, Jinge Zhao, Lingyun Li, Minxuan Wang, Peifeng Gao, Qing Wang, Xiaoling Zhang, Weizhi Wang
Summary: Alzheimer's disease is an irreversible neurodegenerative disease with challenges in early diagnosis and treatment. The 3-β amyloid protein is an important biomarker, and aptamers play a crucial role in AD theranostics.
Article
Neurosciences
Meiting Li, Nan Cai, Liang Gu, Lijun Yao, Decheng Bi, Weishan Fang, Zhijian Lin, Yan Wu, Hong Xu, Hui Li, Zhangli Hu, Xu Xu
Summary: Genipin shows promising effects on inhibiting Tau aggregation and Aβ generation through multiple molecular mechanisms, making it a potential therapeutic agent or nutraceutical for Alzheimer's disease.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Neurosciences
Joseph R. Winer, Allison Morehouse, Laura Fenton, Theresa M. Harrison, Lylian Ayangma, Mark Reed, Samika Kumar, Suzanne L. Baker, William J. Jagust, Matthew P. Walker
Summary: This study found that early-stage tau and Aβ deposition in Alzheimer's disease can impact sleep, with tau burden leading to worse objective sleep and Aβ burden associated with decreased self-reported sleep quality. Aβ deposition also predicts a mismatch between objective and subjective sleep evaluation, with individuals underestimating their sleep, which is further linked to worse executive function.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Heidi I. L. Jacobs, Adrienne O'Donnell, Claudia L. Satizabal, Cristina Lois, Daniel Kojis, Bernard J. Hanseeuw, Emma Thibault, Justin S. Sanchez, Rachel F. Buckley, Qiong Yang, Charles DeCarli, Ron Killiany, Muralidharan Sargurupremraj, Reisa A. Sperling, Keith A. Johnson, Alexa S. Beiser, Sudha Seshadri
Summary: The study found that lower volumes of the medulla, pons, or midbrain were associated with greater neocortical amyloid burden. However, no associations were found between brainstem volumes and tau deposition.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Review
Neurosciences
Vanlalrinchhani Varte, Jeremy W. Munkelwitz, Diego E. Rincon-Limas
Summary: Alzheimer's disease (AD) is a common neurodegenerative dementia, but there are currently no effective therapies available. AD is characterized by the accumulation of amyloid beta (A beta) and hyperphosphorylated tau, leading to mitochondrial dysfunction. The mechanisms linking mitochondrial dysfunction to AD are still largely unknown. This review discusses how studying mitochondrial biology in the fruit fly Drosophila melanogaster can provide insights into these mechanisms and potential therapeutic strategies.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Tuan D. Samdin, Chelsea R. Jones, Gretchen Guaglianone, Adam G. Kreutzer, J. Alfredo Freites, Michal Wierzbicki, James S. Nowick
Summary: This study investigates the arrangement, assembly, and function of beta-hairpins formed by the beta-amyloid peptide Aβ in oligomers. By synthesizing beta-hairpin peptides and conducting various experiments, the structure and function of the oligomers were revealed, and their relationship with membrane disruption and cell apoptosis was explored.
Article
Neurosciences
Hee-Jeong Choi, Jin-Hee Park, Yoo Joo Jeong, Jeong-Woo Hwang, Soojung Lee, Heeyong Lee, Eunyoung Seol, Ik-whi Kim, Byung-Yoon Cha, Jinsoo Seo, Minho Moon, Hyang-Sook Hoe
Summary: The study found that intraperitoneal injection of donepezil can reduce the number of Aβ plaques in the brain and decrease glial cell activation in 5xFAD mice. However, it has little effect on tau pathology.
Review
Geriatrics & Gerontology
Abhijit Kale, Amit Sharma, Alexandra Stolzing, Pierre-Yves Desprez, Judith Campisi
Article
Oncology
Luis Marques, Adiv A. Johnson, Alexandra Stolzing
EXPERIMENTAL CELL RESEARCH
(2020)
Editorial Material
Endocrinology & Metabolism
Johannes Boltze, Nadine Didwischus, Martha Merrow, Robert Dallmann, Nikolaus Plesnila
Summary: A recent study found that the occurrence of stroke in humans peaks in the morning, which can influence the therapeutic impact of neuroprotective paradigms. Understanding the role of time of day in stroke could potentially lead to new paradigms in stroke chronopathophysiology research. Taking into account individuals' chronotypes may enhance the efficacy of experimental therapies in stroke.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Review
Cell Biology
Tesfahun Dessale Admasu, Michael Rae, Alexandra Stolzing
Summary: Cellular senescence is a stable cell cycle arrest state in response to stress or damage, which can limit the replication of old, damaged, and precancerous cells in the short term. Secondary senescence refers to the induction of non-senescent cells to undergo senescence by primary senescent cells, through paracrine and juxtacrine mechanisms.
AGEING RESEARCH REVIEWS
(2021)
Article
Clinical Neurology
Patrick Lyden, Alastair Buchan, Johannes Boltze, Marc Fisher
Summary: Despite years of research, ischemic stroke remains a major public health concern, and STAIR XI workshop addressed challenges such as redefining neuroprotection paradigm, using tissue window for patient selection, and proposing target window for therapies targeting elements of the neurovascular unit at different times.
Article
Clinical Neurology
Daiane Aparecida Spiess, Raquel Maria Pereira Campos, Luciana Conde, Nadine Didwischus, Johannes Boltze, Rosalia Mendez-Otero, Pedro Moreno Pimentel-Coelho
Summary: This study investigated the therapeutic effects of AMD3100 on neonatal hypoxic-ischemic encephalopathy (HIE) and found that it did not improve structural and functional outcomes in a rat HIE model.
Article
Clinical Neurology
Theodore E. Liston, Aldric Hama, Johannes Boltze, Russell B. Poe, Takahiro Natsume, Ikuo Hayashi, Hiroyuki Takamatsu, William S. Korinek, James D. Lechleiter
Summary: This study demonstrates the therapeutic effect of AST-004 agonist in the treatment of acute ischemic stroke in a nonhuman primate model. AST-004 reduces lesion volume and increases penumbra volume. The changes are correlated with unbound AST-004 concentrations in the plasma and cerebrospinal fluid as well as estimated brain A1R and A3R occupancy.
Review
Medicine, General & Internal
Marietta Zille, Tracy D. Farr, Richard F. Keep, Christine Roemer, Guohua Xi, Johannes Boltze
Summary: Intracerebral haemorrhage (ICH) is a common type of stroke that contributes to mortality and disability globally. Despite progress in surgical interventions and acute ICH management, there is a lack of effective therapies to improve patient outcomes. Recent research has uncovered new pathophysiological mechanisms underlying ICH, but gaps in animal models hinder their application. This review emphasizes the importance of understanding ICH etiology, the role of the haematoma, inflammation, and post-ICH pathology, as well as the involvement of other cell types and organs in successful interventions.
Article
Neurosciences
Xia Jin, Peiying Li, Dominik Michalski, Shen Li, Yueman Zhang, Jukka Jolkkonen, Lili Cui, Nadine Didwischus, Wei Xuan, Johannes Boltze
Summary: This review explores the incidence, related problems, and underlying pathophysiological mechanisms of perioperative stroke. Based on the analysis, we evaluate the potential use of experimental stroke treatments, such as neuroprotective approaches, cell therapies, and conditioning medicine strategies. However, the lack of established guidelines or multicenter clinical research initiatives currently limits the thorough investigation of these treatment methods.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Clinical Neurology
Johannes Boltze, Miguel A. Perez-Pinzon
Summary: Local and systemic inflammation play a significant role in stroke risk factors and outcomes. Neuroimmunology research is important for understanding the mechanisms of stroke and finding potential therapeutic targets.
Editorial Material
Medicine, General & Internal
Marietta Zille, Nikolaus Plesnila, Johannes Boltze
Editorial Material
Cardiac & Cardiovascular Systems
Eldrin F. Lewis, Christine Beaty, Johannes Boltze, Khadijah Breathett, Walter K. Clair, Lisa de Las Fuentes, Utibe R. Essien, Heather Goodell, H. E. Hinson, Kiarri N. Kershaw, Joshua W. Knowles, Sula Mazimba, Mahasin Mujahid, Henry E. Okafor, Kyung Woo Park, Jonathan Schultz
Review
Endocrinology & Metabolism
Dan Huang, Yunlu Guo, Xiaoyu Guan, Lijun Pan, Ziyu Zhu, Zeng'ai Chen, Rick M. Dijkhuizen, Marco Duering, Fang Yu, Johannes Boltze, Peiying Li
Summary: Cognitive impairment (CI) is a significant health concern in aging populations and is often associated with vascular cognitive impairment (VCI). Reduced cerebral blood flow (CBF) plays a critical role in the progression of VCI, and arterial spin labeling (ASL) is a non-invasive MRI technique that can accurately assess CBF. Recent advancements in ASL have improved its usability and led to an increased application in identifying high-risk VCI patients. ASL, when combined with other imaging modalities and biomarkers, shows great potential in early detection and prevention strategies for VCI.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Endocrinology & Metabolism
Ming-Xuan Cao, Jia Xiao, Hua-Min Qin, Zhi-Hong Wang, Johannes Boltze, Shu-Xin Liu, Shen Li
Summary: This study aimed to investigate the factors influencing cerebral atrophy (CA) in maintenance-hemodialysis patients and establish a prediction nomogram. Differences in brain volumes were found between hemodialysis patients and healthy controls, and potential factors influencing CA were screened. A nomogram based on the negative correlation of Kt/V and hemoglobin levels with CA degree was established and showed good predictive value with AUROC of 0.759 for the training group and 0.804 for the validation group.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Editorial Material
Endocrinology & Metabolism
Yunlu Guo, Peiying Li, Johannes Boltze
Summary: Cerebrovascular dysfunction and diseases are leading causes of mortality, morbidity, and decreased quality of life for patients. This special collection presents recent research on the mechanisms, diagnosis, and treatments of cerebrovascular diseases, with a focus on cerebroprotective strategies during acute and chronic cerebral ischemia and predicting stroke risk and unfavorable outcomes. It also explores emerging treatment targets and management strategies to improve clinical outcomes for patients with cerebrovascular diseases.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)