期刊
CURRENT MEDICINAL CHEMISTRY
卷 18, 期 32, 页码 5011-5021出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986711797535155
关键词
Aminopeptidase N; rational drug design; inhibitors; peptidomimetics; anti-tumor; structure activity relationship
资金
- national high technology research and development program of china (863 project) [2007AA02Z314, 2009ZX09103-118]
- National Nature Science Foundation of China [90713041, 30772654]
APN is an important zinc dependent metallo-exopeptidase, which can degrade the extracellular matrix, and plays an important role in tumor invasion, metastasis and angiogenesis. it has been considered as a suitable target for anti-cancer drug design. Recently, research of structure-based APN inhibitors is becoming an interesting field, and many APN inhibitors have been reported. Here we review a series of APN inhibitors and the recent progress in this field.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据